The functions of Septins in Mammals

The Septins

Volumn , Issue , 2008, Pages 187-209

  Froese, Carol D ^a   Trimble, William S ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Cytokinesis; Cytoskeleton; Diffusion barrier; Phagocytosis; Polarity; Scaffolding; Septin complexes; Septin filaments

Indexed keywords

EID: 80052850262     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470779705.ch8     Document Type: Chapter

References (101)

1. Amir, S., Wang, R., Matzkin, H. et al. (2006) MSF-A interacts with hypoxia-inducible factor-lalpha and augments hypoxia-inducible factor transcriptional activation to affect tumorigenicity and angiogenesis. Cancer Research, 66, 856-66.
2. Andrews, H.K., Zhang, Y.Q., Trotta, N. and Broadie, K. (2002) Drosophila seclO is required from hormone secretion but not general exocytosis or neurotransmission. Traffic, 3, 906-21.
3. Barr, A.M., Young, C.E., Sawada, K. et al. (2004) Abnormalities of presynaptic protein CDCrel-1 in striatum of rats reared in social isolation: relevance to neural connectivity in schizophrenia. The European Journal of Neuroscience, 20, 303-7.
4. Beites, C.L., Campbell, K.A. and Trimble, W.S. (2005) The septin Sept5/CDCrel-1 competes with alpha-SNAP for binding to the SNARE complex. The Biochemical Journal, 385, 347-53.
5. Beites, C.L., Xie, H., Bowser, R. and Trimble, W.S. (1999) The septin CDCrel-1 binds syntaxin and inhibits exocytosis. Nature Neuroscience, 2, 434-39.
6. Briggs, M.W. and Sacks, D.B. (2003) IQGAP proteins are integral components of cytoskeletal regulation. EMBO Reports, 4, 571-74.
7. Caltagarone, J., Rhodes, J., Honer, W.G. and Bowser, R. (1998) Location of a novel septin protein, hCDCrel-1 in neurons of human brain. Neuroreport, 9, 2907-12.
8. Casamayor, A. and Snyder, M. (2003) Molecular dissection of a yeast septin: distinct domains are required for septin interaction, localization, and function. Molecular and Cellular Biology, 23, 2762-77.
9. Cesario, M.M. and Bartles, J.R. (1994) Compartmentalization, processing and redistribution of the plasma membrane protein CE9 on rodent spermatozoa. Relationship of the annulus to domain boundaries in the plasma membrane of the tail. Journal of Cell Science, 107, 561-70.
10. Chacko, A.D., Hyland, R.L., McDade, S.S. et al. (2005) SEPT9_4 expression induces morphological change, increased motility and disturbed polarity. The Journal of Pathology, 206, 458-65.
11. Dent, J., Kato, K., Peng, X.R. et al. (2002) A prototypic platelet septin and its participation in secretion. Proceedings of the National Academy of Sciences of the United States of America, 99, 3064-69.
12. Dobbelaere, J. and Barral, Y. (2004) Spatial coordination of cytokinetic events by compartmentalization of the cell cortex. Science, 305, 393-96.
13. Douglas, L.M., Alvarez, F.J., McCreary, C. and Konopka, J.B. (2005) Septin function in yeast model systems and pathogenic fungi. Eukaryotic Cell, 4, 1503-12.
14. Drees, B.L., Sundin, B., Brazeau, E. et al. (2001) A protein interaction map for cell polarity development. The Journal of Cell Biology, 154, 549-71.
15. Emoto, K., Inadome, H., Kanaho, Y. et al. (2005) Local change in phospholipid composition at the cleavage furrow is essential for completion of cytokinesis. The Journal of Biological Chemistry, 280, 37901-907.
16. Field, C.M., Al-Awar, O., Rosenblatt, J. et al. (1996) A purified Drosophila septin complex forms filaments and exhibits GTPase activity. The Journal of Cell Biology, 133, 605-16.
17. Field, S.J., Madson, N., Kerr, M.L. et al. (2005) Ptdlns(4,5)P2 functions at the cleavage furrow during cytokinesis. Current Biology, 9, 1407-12.
18. Finger, F.P. (2004) Reining in cytokinesis with a septin corral. BioEssays, 27, 5-8.
19. Frazier, J.A., Wong, M.L., Longtine, M.S. et al., (1998) Polymerization of purified yeast septins: evidence that organized filament arrays may not be required for septin function. Journal of Cell Biology, 143, 737-749.
20. Fujishima, K., Kiyonar, H., Kurisu, J. et al. (2007) targeted disruption of Sept3, a het-eromeric assembly partner of Sept5 and Sept7 in axons, has no effect on developing CNS neurons. Journal of Neurochemistry, 102, 77-92.
21. Gottfried, Y., Rotem, A., Lotan, R. et al. (2004) The mitochondrial ARTS protein promotes apoptosis through targeting XIAP. The EMBO Journal, 23, 1627-35.
22. Hartwell, L.H. (1971) Genetic control of the cell division cycle in yeast. IV. Genes controlling bud emergence and cytokinesis. Experimental Cell Research, 60, 265-76.
23. Hazuka, C.D., Foletti, D.L., Hsu, S.C. et al. (1999) The sec6/8 complex is located at neurite outgrowth and axon synapse-assembly domains. The Journal of Neuroscience, 19, 1324-34.
24. Hime, G.R., Brill, J.A. and Fuller, M.T. (1996) Assembly of ring canals in the male germ line from structural components of the contractile ring. Journal of Cell Science, 109, 2779-88.
25. Honer, W.G., Hu, L. and Davies, P. (1993) Human synaptic proteins with a heterogeneous distribution in cerebellum and visual cortex. Brain Research, 609, 9-20.
26. Hsu, S.C., Hazuka, C.D., Roth, R. et al. (1998) Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. Neuron, 20, 1111-22.
27. Huang, Y.-W., Surka, M.C., Reynaud, D. et al. (2006) GTP binding and hydrolysis kinetics of human septin 2. The FEBS Journal, 273, 3248-60.
28. Huang, Y.-W., Yan, M. Collins, R.F., et al. (2008) Mammalian septins are required for phagosome formation. Molecular Biology of the Cell, 19, 1717-26.
29. Ihara, M., Kinoshita, A., Yamada, S. et al. (2005) Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa. Developmental Cell, 8, 343-52.
30. Ihara, M., Yamasaki, N., Hagiwara, A. et al. (2007) Sept4, a component of presynap-tic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity. Neuron, 53, 519-33.
31. Ito, H., Iwamoto, I., Morishita, R. et al. (2005) Possible role of Rho/Rhotekin signaling in mammalian septin organization. Oncogene, 24, 7064-72.
32. Joberty, G., Perlungher, R.R., Sheffield, P.J. et al. (2001) Borg proteins control septin organization and are negatively regulated by Cdc42. Nature Cell Biology, 3, 861-66.
33. John, C.M., Hite, R.K., Weirich, C.S. et al. (2007) The Caenorhabditis elegans septin complex is nonpolar. The EMBO Journal, 26, 3296-307.
34. Joo, E., Surka, M.C. and Trimble, W.S. (2007) Mammalian Sept2 is required for scaffolding non-muscle myosin II and its kinases. Developmental Cell, 13, 677-90.
35. Joo, E., Tsang, C.W. and Trimble, W.S. (2005) Septins: traffic control at the cytokinesis intersection. Traffic, 6, 626-34.
36. Kim, C.S., Seol, S.K., Song, O.K. et al. (2007) An RNA-binding protein hnRNP A1 and a scaffold protein septin 6 facilitate HCV replication. Journal of Virology, 81, 3852-65.
37. Kinoshita, M., Field, C.M., Coughlin, M.L. et al. (2002) Self-and actin-templated assembly of mammalian septins. Developmental Cell, 3, 791-802.
38. Kinoshita, N., Kimura, K., Matsumoto, N. et al. (2004) Mammalian septin Sept2 modulates the activity of GLAST, a glutamate transporter in astrocytes. Genes to Cells, 9, 1-14.
39. Kinoshita, M., Kumar, S., Mizoguchi, A. et al. (1997) Nedd5, a mammalian septin, is a novel cytoskeletal component interacting with actin-based structures. Genes and Development, 11, 1535-47.
40. Kinoshita, A., Noda, M. and Kinoshita, M. (2000) Differential localization of septins in the mouse brain. The Journal of Comparative Neurology, 428, 223-39.
41. Kirby, M.L. and Bockman, D.E. (1984) Neural crest and normal development: a new perspective. The Anatomical Record, 209, 1-6.
42. Kissel, H., Georgescu, M.M., Larisch, S. et al. (2005) The Sept4 septin locus is required for sperm terminal differentiation in mice. Developmental Cell, 8, 353-64.
43. Kouranti, I., Sachse, M., Arouche, N. et al. (2006) Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis. Current Biology, 16, 1719-25.
44. Kremer, B.E., Adang, L.A. and Macara, I.G. (2007) Septins regulate actin organization and cell cycle arrest through SOCS7-mediated nuclear accumulation of NCK. Cell, In press.
45. Kremer, B.E., Haystead, T. and Macara, I.G. (2005) Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4. Molecular Biology of the Cell, 16, 4648-59.
46. Kumar, S., Tomooka, Y., Noda, M. (1992) Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochemical and Biophysical Research Communications, 185, 1155-61.
47. Langevin, J., Morgan, M.J., Rosse, C. et al. (2005) Drosophila exocyst components Sec5, Sec6 and Sec15 regulate DE-cadherin trafficking from recycling endosomes to the plasma membrane. Developmental Cell, 9, 355-76.
48. Larisch, S., Yi, Y., Lotan, R. et al. (2000) A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. Nature Cell Biology, 2, 915-21.
49. Lin, C.W., Tu, P.F., Hsiao, N.W. et al. (2007) Identification of a novel septin 4 protein binding to human herpesvirus 8 kaposin A protein using a phage display cDNA library. Journal of Virological Methods, 143, 65-72.
50. Low, S.H., Li, X., Miura, M. et al. (2003) Syntaxin 2 and endobrevin are required for the terminal step of cytokinesis in mammalian cells. Developmental Cell, 4, 753-59.
51. Macara, I.G. (2004) Parsing the polarity code. Nature Reviews in Molecular Cell Biology, 5, 220-31.
52. Martinez, C., Corral, J., Dent, J.A. et al. (2006) Platelet septin complexes form rings and associate with the microtubular network. Journal of Thrombosis and Haemostasis, 4, 1388-95.
53. Martinez, C. and Ware, J. (2004) Mammalian Septin Function in Hemostasis and Beyond Society for Experimental Biology and Medicine, pp. 1111-19.
54. Matsumura, F. (2005) Regulation of myosin II during cytokinesis in higher eukaryotes. Trends in Cell Biology, 15, 371-77.
55. McIlhatton, M.A., Burrows, J.F., Donaghy, P.G. et al. (2001) Genomic organization, complex splicing pattern and expression of a human septin gene on chromosome 17q25.3. Oncogene, 20, 5930-39.
56. Mendoza, M., Hyman, A.A. and Glotzer, M. (2002) GTP binding induces filament assembly of a reconstituted septin. Current Biology, 12, 1858-63.
57. Munson, M. and Novick, P. (2006) The exocyst defrocked, a frame work of rods revealed. Nature Structural and Molecular Biology, 13, 577-81.
58. Murphy, K.C., Jones, L.A. and Owen, M.J. (1999) High rates of schizophrenia in adults with velo-cardio-facial syndrome. Archives of General Psychiatry, 56, 940-45.
59. Murthy, M., Garza, D., Scheller, R.H. and Schwarz, T.L. (2003) Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists. Neuron, 37, 433-47.
60. Nagata, K., Asano, T., Nozawa, Y. and Inagaki, M. (2004) Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11. The Journal of Biological Chemistry, 279 (53), 55895-904.
61. Nagata, K. and Inagaki, M. (2005) Cytoskeletal modification of Rho guanine nucleotide exchange factor activity: Identification of a Rho guanine nucleotide exchange factor as a binding partner for Sept9b, a mammalian septin. Oncogene, 24, 65-76.
62. Nagata, K., Kawajiri, A., Matsui, S. et al. (2003) Filament formation of MSF-A, a mammalian septin, in human mammary epithelial cells, depends on interactions with microtubules. The Journal of Biological Chemistry, 278, 18538-43.
63. Neufield, T.P. and Rubin, G.M. (1994) The Drosophila peanut gene is required for cytokinesis and encodes a protein similar to yeast putative bud neck filament proteins. Cell, 77, 371-79.
64. Nhyuen, T.Q., Sawa, H., Okano, H. and White, J.G. (2000) The C. elegans septin genes, unc-59 and unc-61 are required for normal morphogenensis but have no essential function in embryogenesis. Journal of Cell Science, 113, 3825-37.
65. Nottenberg, C., Gallatin, W.M. and John, T.S. (1990) Lymphocyte HEV adhesion variants differ in the expression of multiple gene sequences. Gene, 95, 279-84.
66. Novick, R., Field, C. and Schekman, R. (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell, 21, 205-15.
67. Ono, R., Ihara, M., Nakajima, H. et al. (2005) Disruption of Sept6, a fusion partner gene of Mixed Lineage Leukemia (MLL), does not affect the ontogeny, leukemoge-nesis induced by MLL-SEPT6, or the phenotype induced by the loss of September 4. Molecular and Cellular Biology, 25, 10965-78.
68. Pan, F., Malmberg, R.L. and Momany, M. (2007) Analysis of septins across kingdoms reveals orthology and new motifs. BMC Evolutionary Biology, 7, 103-19.
69. Peng, X.R., Jia, Z., Zhang, Y. et al. (2002) The septin CDCrel-1 is dispensable for normal development and neurotransmitter release. Molecular and Cellular Biology, 22, 378-87.
70. Peterson, E.A., Kalikin, L.M., Steels, J.D. et al. (2007) Characterization of a testis-specific septin, SEPT14, a novel testis-specific septin. Mammalian Genome, 18, 796-807.
71. Pizarro-Cerdá, J., Jonquières, R., Gouin, E. et al. (2002) Distinct protein patterns associated with Listeria monocytogenes InlA-or InlB-phagosomes. Cellular Microbiology, 4, 101-15.
72. Richman, T.J., Sawyer, M.M. and Johnson, D.I. (1999) The Cdc42p GTPase is involved in a G2/M morphogenetic checkpoint regulating the apical-isotropic switch and nuclear division in yeast. The Journal of Biological Chemistry, 274, 16861-70.
73. Rodriguez-Boulan, E., Kreitzer, G. and Musch, A. (2005) Organization of vesicular trafficking in epithelia. Nature Reviews in Molecular Cell Biology, 5, 233-47.
74. Rodriguez-Escudero, I., Roelants, F.M., Thorner, J. et al. (2005) Reconstitution of the mammalian P13K/PTEN/Akt pathway in yeast. The Biochemical Journal, 390, 613-23.
75. Rossman, K.L., Der, C.J. and Sondek, J. (2005) GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nature Reviews in Molecular Cell Biology, 6, 167-80.
76. Satoh, K., Takeuchi, M., Oda, Y. et al. (2002) Identification of activity regulated proteins in the postsynaptic density fraction. Genes and Cells, 7, 187-97.
77. Schmidt, K. and Nichols, B.J. (2004a) Functional interdependence between septin and actin cytoskeleton. BMC Cell Biology, 5, 43-55.
78. Schmidt, K. and Nichols, B.J. (2004b) A barrier to lateral diffusion in the cleavage furrow of dividing mammalian cells. Current Biology, 14, 1002-6.
79. Siegrist, S.E. and Doe, C.Q. (2007) Microtubule-induced cortical cell polarity. Genes and Development, 21, 483-96.
80. Sheffield, P.J., Oliver, C.J., Kremer, B.E. et al. (2003) Borg/septin interactions and the assembly of mammalian septin heterodimers, trimers, and filaments. The Journal of Biological Chemistry, 278, 3483-88.
81. Shih, H.P., Hales, K.G., Pringle, J.R. and Peifer, M. (2002) Identification of septin-interacting proteins and characterization of the Smt3/SUMO-conjugation system in Drosophila. Journal of Cell Science, 15, 1259-71.
82. Sirajuddin, M., Farkasovsky, M., Hauer, F. et al. (2007) Structural insight into filament formation by mammalian septins. Nature, 449, 311-15
83. Spiliotis, E.T., Kinoshita, M. and Nelson, W.J. (2005) A mitotic septin scaffold required from mammalian chromosome congression and segregation. Science, 307, 1781-1785.
84. Steels, J.D., Estey, M.P., Froese, C.D. et al. (2007) Septin 12 is a component of the sperm annulus. Cell Motility and the Cytoskeleton, 64, 794-807.
85. Surka, M.C., Tsang, C.W. and Trimble, W.S. (2002) The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis. Molecular Biology of the Cell, 13, 3532-45.
86. Suzuki, C., Daigo, Y., Ishikawa, N. et al. (2005) ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by the involvement in the phsophoinsitide-3-kinase/AKT pathway. Cancer Research, 65, 11314-25.
87. Tada, T., Simonetta, A., Batterton, M. et al. (2007) Role of septin cytoskeleton in spine morphogenesis and dendrite development in neurons. Current Biology, 17, 1752-58.
88. Takahashi, S., Inatome, R., Yamamura, H. and Yanagia, S. (2003) Isolation and expression of a novel mitochondrial septin that interacts with CRMP/CRAM in the developing neurones. Genes and Cells, 8, 81-93.
89. Tanaguchi, M., Taoka, M., Itakura, M. et al. (2007) Phosphorylation of adult type Sept5 (CDCrel-1) by cyclin-dependent kinase 5 inhibits interaction with sytaxin-1. The Journal of Biological Chemistry, 282, 7869-76.
90. Tjandra, H., Compton, J. and Kellogg, D. (1998) Control of mitotic events by the Cdc42 GTPase, the Clb2 cyclin and a member of the PAK kinase family. Current Biology, 8, 991-1000.
91. Ulrich, H.D. (2005) Mutual interactions between the SUMO and the ubiquitin systems: a plea of no contest. Trends in Cell Biology, 15, 525-32.
92. Vega, I.E. and Hsu, S.C. (2003) The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cells. Neuroreport, 14, 31-37.
93. Versele, M. and Thorner, J. (2005) Some assembly required: yeast septins provide the instruction manual. Trends in Cell Biology, 15, 414-24.
94. Vrabioiu, A.M. and Mitchison, T.J. (2006) Structural insights into yeast septin organization from polarized fluorescence microscopy. Nature, 443, 466-69.
95. Walikonis, R.S., Jensen, O.N., Mann, M. et al. (2000) Identification of proteins in the postsynaptic density fraction by mass spectrometry. The Journal of Neuroscience, 20, 4069-80.
96. Wang, S. and Hsu, S.C. (2006) The molecular mechanisms of the mammalian exocyst complex in exocytosis. Biochemical Society Transactions, 34, 687-90.
97. Wilson, G.M., Fielding, A.B., Simon, G.C. et al. (2005) The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis. Molecular Biology of the Cell, 16, 849-60.
98. Xie, H., Surka, M., Howard, J. and Trimble, W.S. (1999) Characterization of the mammalian septin H5: distinct patterns of cytoskeletal and membrane association from other septin proteins. Cell Motility and the Cytoskeleton, 43, 52-62.
99. Xie, Y., Vessey, J.P., Konecna, A. et al. (2007) The GTP-binding protein septin 7 is critical for dendrite branching and dendritic-spine morphology. Current Biology, 17, 1746-51.
100. Yoshimura, T., Arimura, N. and Kaibuchi, K. (2006) Signaling networks in neuronal polarization. The Journal of Neuroscience, 26, 10626-30.
101. Zhang, J., Kong, C., Xie, H. et al. (1999) Phosphatidylinositol polyphosphate binding to the mammalian septin H5 is modulated by GTP. Current Biology, 9, 1458-67.