Role of the pyridine nitrogen in pyridoxal 5′-phosphate catalysis: Activity of three classes of PLP enzymes reconstituted with deazapyridoxal 5′-phosphate

Journal of the American Chemical Society

Volumn 133, Issue 37, 2011, Pages 14823-14830

  Griswold, Wait R ^a   Toney, Michael D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ALANINE RACEMASE; ASPARTATE AMINOTRANSFERASE; CATALYZED REACTIONS; COFACTORS; ELECTROPHILICITY; ENZYME ACTIVE SITES; ISOSTERIC; NEUTRAL STATE; NITROGEN METABOLISM; PROTONATED; PROTONATES; PYRIDINE NITROGEN; PYRIDINE RINGS; RESONANCE STABILIZATION; VITAMIN B-6;

ALDEHYDES; AMINO ACIDS; CATALYSIS; FUNCTIONAL GROUPS; NITROGEN; PHENOLS; PROTONATION; PYRIDINE;

ENZYMES;

1 DEAZAPYRIDOXAL 5 PHOSPHATE; ALANINE RACEMASE; ALDEHYDE; ASPARTATE AMINOTRANSFERASE; CYSTEINE SYNTHASE; DEAZAPYRIDOXAL 5 PHOSPHATE; NITROGEN; PHENOL; PHOSPHATE; PYRIDINE; PYRIDOXAL 5 PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; ELECTROPHILICITY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; KINETICS; NITROGEN METABOLISM; PROTON TRANSPORT; RACEMIZATION; TRANSAMINATION;

ALANINE RACEMASE; ASPARTATE AMINOTRANSFERASES; BENZALDEHYDES; CATALYSIS; CYSTEINE SYNTHASE; GEOBACILLUS STEAROTHERMOPHILUS; KINETICS; NITROGEN; PHOSPHORIC ACID ESTERS; PYRIDINES; PYRIDOXAL PHOSPHATE; SALMONELLA TYPHIMURIUM; VITAMIN B COMPLEX;

EID: 80052819676     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja2061006     Document Type: Article

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