Gas-phase derivatization via the Meerwein reaction for selective and sensitive LC-MS analysis of epoxides in active pharmaceutical ingredients

Journal of Pharmaceutical and Biomedical Analysis

Volumn 56, Issue 5, 2011, Pages 1106-1111

  Wu, Lianming ^a   Liu, David Q ^a   Vogt, Frederick G ^a   Kord, Alireza S ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Atmospheric pressure ionizations; Epoxides; Ethylnitrilium ion; Gas phase Meerwein reaction; Genotoxin analysis

Indexed keywords

EPOXIDE;

ARTICLE; CHEMICAL REACTION; DENSITY FUNCTIONAL THEORY; DRUG STRUCTURE; GAS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEERWEIN REACTION; PRIORITY JOURNAL;

EPOXY COMPOUNDS; GASES; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 80052790634     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.07.044     Document Type: Article

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