Recent advances in trace analysis of pharmaceutical genotoxic impurities

Journal of Pharmaceutical and Biomedical Analysis

Volumn 51, Issue 5, 2010, Pages 999-1014

  Liu, David Q ^a   Sun, Mingjiang ^a   Kord, Alireza S ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Chemical derivatization; Coordination ion spray mass spectrometry; Genotoxic impurities; Matrix deactivation; Method development; Trace analysis; Unstable reactive analytes

Indexed keywords

2 CHLOROETHANOL; ALCOHOL; ALKANESULFONIC ACID DERIVATIVE; ALKYLHALIDE DERIVATIVE; CHLORBUTOL; CHLOROETHYLOXYETHANOL; EPOXIDE; FORMALDEHYDE; HALIDE; HYDRAZINE DERIVATIVE; HYDROPEROXIDE DERIVATIVE; MESYLIC ACID ETHYL ESTER; NELFINAVIR; PAZOPANIB; UNCLASSIFIED DRUG;

CARCINOGEN TESTING; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CHROMATOPHORE; DRUG CONTAMINATION; DRUG IMPURITY; DRUG MANUFACTURE; GAS CHROMATOGRAPHY; GENOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEPARATION TECHNIQUE;

CHEMISTRY TECHNIQUES, ANALYTICAL; DRUG CONTAMINATION; DRUG STABILITY; EQUIPMENT DESIGN; HUMANS; MOLECULAR STRUCTURE; MUTAGENS; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; STRUCTURE-ACTIVITY RELATIONSHIP; TECHNOLOGY, PHARMACEUTICAL;

EID: 72749101941     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.11.009     Document Type: Review

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