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Volumn 1217, Issue 3, 2010, Pages 302-306
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Enhancing the detection sensitivity of trace analysis of pharmaceutical genotoxic impurities by chemical derivatization and coordination ion spray-mass spectrometry
a
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Author keywords
Chemical derivatization; Coordination ion spray MS; Genotoxic impurity; Trace analysis
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Indexed keywords
ALKYL CHLORIDES;
ANALYTE DETECTION;
ANALYTES;
ANALYTICAL APPROACH;
CHEMICAL DERIVATIZATION;
DETECTION SENSITIVITY;
DRUG DEVELOPMENT;
ELECTROSPRAY IONIZATION SOURCES;
GENOTOXIC IMPURITIES;
GENOTOXIC IMPURITY;
ION ADDUCTS;
IONIZATION EFFICIENCY;
NEUTRAL ANALYTES;
NEUTRAL MOLECULES;
NON-VOLATILE;
TRACE LEVEL;
CHLORINE COMPOUNDS;
DRUG PRODUCTS;
ELECTROSPRAY IONIZATION;
IMPURITIES;
IONIZATION;
MASS SPECTROMETERS;
MASS SPECTROMETRY;
METAL IONS;
PARTICLE DETECTORS;
SUGAR (SUCROSE);
TRACE ANALYSIS;
2 (5 BROMO 2,3 DIFLUOROPHENOXYMETHYL)OXIRANE;
ALKYL GROUP;
ALPHA CHLOROHYDRIN;
AMMONIA;
BIS(2 CHLOROETHYL) ETHER;
CHEMICAL COMPOUND;
CHLORIDE;
EPOXIDE;
GLYCIDYL TOSYLATE;
HALIDE;
METAL ION;
NUCLEOPHILE;
POTASSIUM ION;
SODIUM ION;
UNCLASSIFIED DRUG;
AFFINITY LABELING;
ANALYTIC METHOD;
ARTICLE;
CHEMICAL ANALYSIS;
CHEMICAL COMPOSITION;
CHEMICAL STRUCTURE;
CONTROLLED STUDY;
COORDINATION ION SPRAY MASS SPECTROMETRY;
DERIVATIZATION;
DIAGNOSTIC ACCURACY;
DRUG IMPURITY;
ELECTROCHEMICAL DETECTION;
IONIZATION;
MASS SPECTROMETRY;
PRIORITY JOURNAL;
SUBSTITUTION REACTION;
CHEMISTRY TECHNIQUES, ANALYTICAL;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
DRUG CONTAMINATION;
EPOXY COMPOUNDS;
METALS, ALKALI;
MUTAGENS;
REPRODUCIBILITY OF RESULTS;
SENSITIVITY AND SPECIFICITY;
SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;
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EID: 72449146371
PISSN: 00219673
EISSN: None
Source Type: Journal
DOI: 10.1016/j.chroma.2009.11.048 Document Type: Article |
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Times cited : (48)
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References (25)
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