Lectin domains of polypeptide GalNAc transferases exhibit glycopeptide binding specificity

Journal of Biological Chemistry

Volumn 286, Issue 37, 2011, Pages 32684-32696

  Pedersen, Johannes W ^a   Bennett, Eric P ^b   Schjoldager, Katrine T B G ^a   Meldal, Morten ^c   Holmér, Andreas P ^a   Blixt, Ola ^a   Cló, Emiliano ^a   Levery, Steven B ^a   Clausen, Henrik ^a   Wandall, Hans H ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c CARLSBERG LABORATORY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ACCEPTOR SITES; BINDING PROPERTIES; BINDING SPECIFICITIES; CATALYTIC DOMAINS; GLYCOPEPTIDES; GLYCOSYLATED; O-GLYCOSYLATION; PEPTIDE SEQUENCES; PRIMARY FUNCTIONS; SEQUENCE RECOGNITION;

BINDING ENERGY; DNA SEQUENCES; ESTERIFICATION; GLYCOSYLATION; PEPTIDES;

ENZYMES;

ALPHA N ACETYLGALACTOSAMINYLTRANSFERASE; ALPHA N ACETYLGALACTOSAMINYLTRANSFERASE 1; ALPHA N ACETYLGALACTOSAMINYLTRANSFERASE 2; ALPHA N ACETYLGALACTOSAMINYLTRANSFERASE 3; GLYCOPEPTIDE; LECTIN; MUCIN 1; MUCIN 2; MUCIN 4; MUCIN 5AC; MUCIN 6; MUCIN 7; N ACETYLGALACTOSAMINYLTRANSFERASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; ENZYME BINDING; ENZYME GLYCOSYLATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; MOLECULAR LIBRARY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; SEQUENCE ANALYSIS; STEREOCHEMISTRY;

GLYCOPEPTIDES; GLYCOSYLATION; HUMANS; LECTINS; MUCINS; N-ACETYLGALACTOSAMINYLTRANSFERASES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY;

EID: 80052780640     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.273722     Document Type: Article

References (57)

1. Clausen, H., and Bennett, E. P. (1996) Glycobiology 6, 635-646
2. Gerken, T. A., Ten Hagen, K. G., and Jamison, O. (2008) Glycobiology 18, 861-870
3. Wandall, H. H., Hassan, H., Mirgorodskaya, E., Kristensen, A. K., Roepstorff, P., Bennett, E. P., Nielsen, P. A., Hollingsworth, M. A., Burchell, J., Taylor-Papadimitriou, J., and Clausen, H. (1997) J. Biol. Chem. 272, 23503-23514
4. Wojczyk, B. S., Stwora-Wojczyk, M. M., Hagen, F. K., Striepen, B., Hang, H. C., Bertozzi, C. R., Roos, D. S., and Spitalnik, S. L. (2003) Mol. Biochem. Parasitol. 131, 93-107
5. Heise, N., Singh, D., van der Wel, H., Sassi, S. O., Johnson, J. M., Feasley, C. L., Koeller, C. M., Previato, J. O., Mendonça-Previato, L., and West, C. M. (2009) Glycobiology 19, 918-933
6. Schwientek, T., Bennett, E. P., Flores, C., Thacker, J., Hollmann, M., Reis, C. A., Behrens, J., Mandel, U., Keck, B., Schäfer, M. A., Haselmann, K., Zubarev, R., Roepstorff, P., Burchell, J. M., Taylor-Papadimitriou, J., Hollingsworth, M. A., and Clausen, H. (2002) J. Biol. Chem. 277, 22623-22638
7. Mandel, U., Hassan, H., Therkildsen, M. H., Rygaard, J., Jakobsen, M. H., Juhl, B. R., Dabelsteen, E., and Clausen, H. (1999) Glycobiology 9, 43-52
8. Tian, E., and Ten Hagen, K. G. (2006) Glycobiology 16, 83-95
9. Ten Hagen, K. G., Fritz, T. A., and Tabak, L. A. (2003) Glycobiology 13,1R-16R1R-16R
10. Tian, E., and Ten Hagen, K. G. (2007) J. Biol. Chem. 282, 606-614
11. Zhang, L., Zhang, Y., and Hagen, K. G. (2008) J. Biol. Chem. 283, 34076-34086
12. Tenno, M., Ohtsubo, K., Hagen, F. K., Ditto, D., Zarbock, A., Schaerli, P., von Andrian, U. H., Ley, K., Le, D., Tabak, L. A., and Marth, J. D. (2007) Mol. Cell. Biol. 27, 8783-8796
13. Miwa, H. E., Gerken, T. A., Jamison, O., and Tabak, L. A. (2010) J. Biol. Chem. 285, 1208-1219
14. Kato, K., Jeanneau, C., Tarp, M. A., Benet-Pagès, A., Lorenz-Depiereux, B., Bennett, E. P., Mandel, U., Strom, T. M., and Clausen, H. (2006) J. Biol. Chem. 281, 18370-18377
15. Topaz, O., Shurman, D. L., Bergman, R., Indelman, M., Ratajczak, P., Mizrachi, M., Khamaysi, Z., Behar, D., Petronius, D., Friedman, V., Zelikovic, I., Raimer, S., Metzker, A., Richard, G., and Sprecher, E. (2004) Nat. Genet. 36, 579-581
16. Guda, K., Moinova, H., He, J., Jamison, O., Ravi, L., Natale, L., Lutterbaugh, J., Lawrence, E., Lewis, S., Willson, J. K., Lowe, J. B., Wiesner, G. L., Parmigiani, G., Barnholtz-Sloan, J., Dawson, D. W., Velculescu, V. E., Kinzler, K. W., Papadopoulos, N., Vogelstein, B., Willis, J., Gerken, T. A., and Markowitz, S. D. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 12921-12925
17. Wagner, K. W., Punnoose, E. A., Januario, T., Lawrence, D. A., Pitti, R. M., Lancaster, K., Lee, D., von Goetz, M., Yee, S. F., Totpal, K., Huw, L., Katta, V., Cavet, G., Hymowitz, S. G., Amler, L., and Ashkenazi, A. (2007) Nat. Med. 13, 1070-1077
18. Herr, P., Korniychuk, G., Yamamoto, Y., Grubisic, K., and Oelgeschläger, M. (2008) Development 135, 1813-1822
19. Fakhro, K. A., Choi, M., Ware, S. M., Belmont, J. W., Towbin, J. A., Lifton, R. P., Khokha, M. K., and Brueckner, M. (2011) Proc. Natl. Acad. Sci. U.S.A. 108, 2915-2920
20. Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J., Johansen, C. T., Fouchier, S. W., Isaacs, A., Peloso, G. M., Barbalic, M., Ricketts, S. L., Bis, J. C., Aulchenko, Y. S., Thorleifsson, G., Feitosa, M. F., Chambers, J., Orho-Melander, M., Melander, O., Johnson, T., Li, X., Guo, X., Li, M., Shin Cho, Y., Jin, Go, M., Jin Kim, Y., Lee, J. Y., Park, T., Kim, K., Sim, X., Twee-Hee Ong, R., Croteau-Chonka, D. C., Lange, L. A., Smith, J. D., Song, K., Hua Zhao, J., Yuan, X., Luan, J., Lamina, C., Ziegler, A., Zhang, W., Zee, R. Y., Wright, A. F., Witteman, J. C., Wilson, J. F., Willemsen, G., Wichmann, H. E., Whitfield, J. B., Waterworth, D. M., Wareham, N. J., Waeber, G., Vollenweider, P., Voight, B. F., Vitart, V., Uitterlinden, A. G., Uda, M., Tuomilehto, J., Thompson, J. R., Tanaka, T., Surakka, I., Stringham, H. M., Spector, T. D., Soranzo, N., Smit, J. H., Sinisalo, J., Silander, K., Sijbrands, E. J., Scuteri, A., Scott, J., Schlessinger, D., Sanna, S., Salomaa, V., Saharinen, J., Sabatti, C., Ruokonen, A., Rudan, I., Rose, L. M., Roberts, R., Rieder, M., Psaty, B. M., Pramstaller, P. P., Pichler, I., Perola, M., Penninx, B. W., Pedersen, N. L., Pattaro, C., Parker, A. N., Pare, G., Oostra, B. A., O'Donnell, C. J., Nieminen, M. S., Nickerson, D. A., Montgomery, G. W., Meitinger, T., McPherson, R., McCarthy, M. I., McArdle, W., Masson, D., Martin, N. G., Marroni, F., Mangino, M., Magnusson, P. K., Lucas, G., Luben, R., Loos, R. J., Lokki, M. L., Lettre, G., Langenberg, C., Launer, L. J., Lakatta, E. G., Laaksonen, R., Kyvik, K. O., Kronenberg, F., König, I. R., Khaw, K. T., Kaprio, J., Kaplan, L. M., Johansson, A., Jarvelin, M. R., Janssens, A. C., Ingelsson, E., Igl, W., Kees Hovingh, G., Hottenga, J. J., Hofman, A., Hicks, A. A., Hengstenberg, C., Heid, I. M., Hayward, C., Havulinna, A. S., Hastie, N. D., Harris, T. B., Haritunians, T., Hall, A. S., Gyllensten, U., Guiducci, C., Groop, L. C., Gonzalez, E., Gieger, C., Freimer, N. B., Ferrucci, L., Erdmann, J., Elliott, P., Ejebe, K. G., Döring, A., Dominiczak, A. F., Demissie, S., Deloukas, P., de Geus, E. J., de Faire, U., Crawford, G., Collins, F. S., Chen, Y. D., Caulfield, M. J., Campbell, H., Burtt, N. P., Bonnycastle, L. L., Boomsma, D. I., Boekholdt, S. M., Bergman, R. N., Barroso, I., Bandinelli, S., Ballantyne, C. M., Assimes, T. L., Quertermous, T., Altshuler, D., Seielstad, M., Wong, T. Y., Tai, E. S., Feranil, A. B., Kuzawa, C. W., Adair, L. S., Taylor, H. A., Jr., Borecki, I. B., Gabriel, S. B., Wilson, J. G., Holm, H., Thorsteinsdottir, U., Gudnason, V., Krauss, R. M., Mohlke, K. L., Ordovas, J. M., Munroe, P. B., Kooner, J. S., Tall, A. R., Hegele, R. A., Kastelein, J. J., Schadt, E. E., Rotter, J. I., Boerwinkle, E., Strachan, D. P., Mooser, V., Stefansson, K., Reilly, M. P., Samani, N. J., Schunkert, H., Cupples, L. A., Sandhu, M. S., Ridker, P. M., Rader, D. J., van Duijn, C. M., Peltonen, L., Abecasis, G. R., Boehnke, M., and Kathiresan, S. (2010) Nature 466, 707-713
21. Schjoldager, K. T., Vester-Christensen, M. B., Bennett, E. P., Levery, S. B., Schwientek, T., Yin, W., Blixt, O., and Clausen, H. (2010) J. Biol. Chem. 285, 36293-36303
22. Fritz, T. A., Hurley, J. H., Trinh, L. B., Shiloach, J., and Tabak, L. A. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 15307-15312
23. Fritz, T. A., Raman, J., and Tabak, L. A. (2006) J. Biol. Chem. 281, 8613-8619
24. Wandall, H. H., Irazoqui, F., Tarp, M. A., Bennett, E. P., Mandel, U., Takeuchi, H., Kato, K., Irimura, T., Suryanarayanan, G., Hollingsworth, M. A., and Clausen, H. (2007) Glycobiology 17, 374-387
25. Kubota, T., Shiba, T., Sugioka, S., Furukawa, S., Sawaki, H., Kato, R., Wakatsuki, S., and Narimatsu, H. (2006) J. Mol. Biol. 359, 708-727
26. Hassan, H., Reis, C. A., Bennett, E. P., Mirgorodskaya, E., Roepstorff, P., Hollingsworth, M. A., Burchell, J., Taylor-Papadimitriou, J., and Clausen, H. (2000) J. Biol. Chem. 275, 38197-38205
27. Tenno, M., Kézdy, F. J., Elhammer, A. P., and Kurosaka, A. (2002) Biochem. Biophys. Res. Commun. 298, 755-759
28. Imberty, A., Piller, V., Piller, F., and Breton, C. (1997) Protein Eng. 10, 1353-1356
29. Raman, J., Fritz, T. A., Gerken, T. A., Jamison, O., Live, D., Liu, M., and Tabak, L. A. (2008) J. Biol. Chem. 283, 22942-22951
30. Perrine, C. L., Ganguli, A., Wu, P., Bertozzi, C. R., Fritz, T. A., Raman, J., Tabak, L. A., and Gerken, T. A. (2009) J. Biol. Chem. 284, 20387-20397
31. Pedersen, J. W., Blixt, O., Bennett, E. P., Tarp, M. A., Dar, I., Mandel, U., Poulsen, S. S., Pedersen, A. E., Rasmussen, S., Jess, P., Clausen, H., and Wandall, H. H. (2011) Int. J. Cancer 128, 1860-1871
32. Wandall, H. H., Blixt, O., Tarp, M. A., Pedersen, J. W., Bennett, E. P., Mandel, U., Ragupathi, G., Livingston, P. O., Hollingsworth, M. A., Taylor-Papadimitriou, J., Burchell, J., and Clausen, H. (2010) Cancer Res. 70, 1306-1313
33. White, T., Bennett, E. P., Takio, K., Sørensen, T., Bonding, N., and Clausen, H. (1995) J. Biol. Chem. 270, 24156-24165
34. Bennett, E. P., Hassan, H., Mandel, U., Mirgorodskaya, E., Roepstorff, P., Burchell, J., Taylor-Papadimitriou, J., Hollingsworth, M. A., Merkx, G., van Kessel, A. G., Eiberg, H., Steffensen, R., and Clausen, H. (1998) J. Biol. Chem. 273, 30472-30481
35. Mirgorodskaya, E., Hassan, H., Wandall, H. H., Clausen, H., and Roepstorff, P. (1999) Anal. Biochem. 269, 54-65
36. Pedersen, J. W., Blixt, O., Bennett, E. P., Tarp, M. A., Dar, I., Mandel, U., Poulsen, S. S., Pedersen, A. E., Rasmussen, S., Jess, P., Clausen, H., and Wandall, H. H. (2011) Int. J. Cancer 128, 1860-1871
37. Blixt, O., Cló, E., Nudelman, A. S., Sørensen, K. K., Clausen, T., Wandall, H. H., Livingston, P. O., Clausen, H., and Jensen, K. J. (2010) J. Proteome Res. 9, 5250-5261
38. Meldal, M. (1992) Tetrahedron Lett. 33, 3077-3080
39. Meldal, M. (1994) Methods 6, 417-424
40. Olsen, J. V., Macek, B., Lange, O., Makarov, A., Horning, S., and Mann, M. (2007) Nat. Methods 4, 709-712
41. Zhang, Y., Ficarro, S. B., Li, S., and Marto, J. A. (2009) J. Am. Soc. Mass Spectrom. 20, 1425-1434
42. McAlister, G. C., Berggren, W. T., Griep-Raming, J., Horning, S., Makarov, A., Phanstiel, D., Stafford, G., Swaney, D. L., Syka, J. E., Zabrouskov, V., and Coon, J. J. (2008) J. Proteome Res. 7, 3127-3136
43. Swaney, D. L., McAlister, G. C., Wirtala, M., Schwartz, J. C., Syka, J. E., and Coon, J. J. (2007) Anal. Chem. 79, 477-485
44. Sørensen, T., White, T., Wandall, H. H., Kristensen, A. K., Roepstorff, P., and Clausen, H. (1995) J. Biol. Chem. 270, 24166-24173
45. Paroutis, P., Touret, N., and Grinstein, S. (2004) Physiology 19, 207-215
46. Dupont, C., Roberge, M., Shareck, F., Morosoli, R., and Kluepfel, D. (1998) Biochem. J. 330, 41-45
47. Fujimoto, Z., Kuno, A., Kaneko, S., Kobayashi, H., Kusakabe, I., and Mizuno, H. (2002) J. Mol. Biol. 316, 65-78
48. Thobhani, S., Ember, B., Siriwardena, A., and Boons, G. J. (2003) J. Am. Chem. Soc. 125, 7154-7155
49. Tenno, M., Saeki, A., Kézdy, F. J., Elhammer, A. P., and Kurosaka, A. (2002) J. Biol. Chem. 277, 47088-47096
50. Sheehan, J. K., Kirkham, S., Howard, M., Woodman, P., Kutay, S., Brazeau, C., Buckley, J., and Thornton, D. J. (2004) J. Biol. Chem. 279, 15698-15705
51. Collins, B. E., Blixt, O., Bovin, N. V., Danzer, C. P., Chui, D., Marth, J. D., Nitschke, L., and Paulson, J. C. (2002) Glycobiology 12, 563-571
52. Iwasaki, H., Zhang, Y., Tachibana, K., Gotoh, M., Kikuchi, N., Kwon, Y. D., Togayachi, A., Kudo, T., Kubota, T., and Narimatsu, H. (2003) J. Biol. Chem. 278, 5613-5621
53. Bertini, I., Calderone, V., Fragai, M., Jaiswal, R., Luchinat, C., Melikian, M., Mylonas, E., and Svergun, D. I. (2008) J. Am. Chem. Soc. 130, 7011-7021
54. Gerken, T. A., Raman, J., Fritz, T. A., and Jamison, O. (2006) J. Biol. Chem. 281, 32403-32416
55. Gerken, T. A., Jamison, O., Perrine, C. L., Collette, J. C., Moinova, H., Ravi, L., Markowitz, S. D., Shen, W., Patel, H., and Tabak, L. A. (2011) J. Biol. Chem. 286, 14493-14507
56. Röttger, S., White, J., Wandall, H. H., Olivo, J. C., Stark, A., Bennett, E. P., Whitehouse, C., Berger, E. G., Clausen, H., and Nilsson, T. (1998) J. Cell Sci. 111, 45-60
57. Voynow, J. A., and Rubin, B. K. (2009) Chest 135, 505-512