A family of UDP-GalNAc: Polypeptide N-acetylgalactosaminyl-transferases control the initiation of mucin-type O-linked glycosylation

Glycobiology

Volumn 6, Issue 6, 1996, Pages 635-646

  Clausen, Henrik ^a   Bennett, Eric P ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

GalNAc transferases; Glycosyltransferases; Mucins; O glycosylation

Indexed keywords

GLYCOSYLTRANSFERASE;

CHROMOSOMAL LOCALIZATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME PURIFICATION; GENE EXPRESSION; GENETIC ANALYSIS; GLYCOSYLATION; HISTOCHEMISTRY; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; CHROMOSOME MAPPING; GLYCOSYLATION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MOLECULAR SEQUENCE DATA; MUCINS; N-ACETYLGALACTOSAMINYLTRANSFERASES; SEQUENCE ALIGNMENT;

EID: 0029854393     PISSN: 09596658     EISSN: None     Source Type: Journal    
DOI: 10.1093/glycob/6.6.635     Document Type: Review

References (82)

1. Bendiak, B. and Schachter, H. (1987) Control of glycoprotein synthesis. Purification of UDP-N-acetylglucosamine: alpha-D-mannoside beta 1-2. J. Biol. Chem., 262, 5775-5783.
2. Bennett, E.P., Steffensen, R., Clausen, H., Weghuis, D.O. and van Kessel, D.G. (1995a) Genomic cloning of the human histo-blood group ABO locus. Biochem. Biophys. Res. Commun., 206, 318-325.
3. Bennett, E.P., van Kessel, A.G. and Clausen, H. (1995b) Characterization of two members of a UDP-GalNAc peptide N-acetylgalactosaminyl transferase family. Glycoconjugate J. 12.
4. Bennett, E.P., Hassan, H. and Clausen, H. (1996) cDNA cloning and expression of a novel human UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T3. J. Biol. Chem., 271, 17006-17012.
5. Bierhuizen, M.F.A., Maemura, K., Kudo, S. and Fukuda, M. (1995) Genomic organization of crore 2 and I branching beta-1, 6-N-acetylglucosaminyltransferases. Implication for evolution of the beta-1, 6-N-acetylglucosaminyltransferase gene family. Glycobiology, 5, 417-425.
6. Boeggeman, E.E., Balaji, P.V. and Qasba, P.K. (1995) Functional domain of bovine beta-1, 4galactosyltransferase. Glycoconjugate J., 12, 865-878.
7. Bourdon, M.A., Krusius, T., Campbell, S., Schwartz, N.B. and Ruoslahti, E. (1987) Proc. Natl. Acad. Sci. USA. 84, 3194-3198
8. Brodbeck, U., Denton, W.L., Tanahashi, N. and Ebner, K.E. (1967) The isolation and identification of the B protein of lactose synthetase as alpha-lactalbumin. J. Biol. Chem., 242, 1391-1397.
9. Clausen, H., Pallesen, T., White, T., Wandall, H. and Hansen, J.-E.S. (1994) Simple mucin type O-glycans of HIV: enzymatic prediction of glycosylation sites for vaccine construction. In Bock, K. and Clausen, H. (eds.). Complex Carbohydrates in Drug Research. Structural and Functional Aspects. Munksgaard, Copenhagen, pp. 297-310
10. Crommie, D. and Rosen, S.D. (1995) Biosynthesis of GlyCAM-1. a mucin-like ligand for L-selectin. J. Biol. Chem., 270, 22614-22624.
11. Datta, A.K. and Paulson, J.C. (1995) The sialyltransferase sialylmotif participates in binding the donor substrate CMP-NeuAc. J. Biol. Chem., 270, 1497-1500.
12. Deschuyteneer, M., Eckhardt, A.E., Roth, J. and Hill, R.L. (1988) The subcellular localization of apomucin and nonreducing terminal N-acetylgalactosamine in porcine submaxillary glands. J. Biol. Chem., 263, 2452-2459.
13. DO, K.-Y., Do, S.-I. and Cummings, R.D. (1995) Alpha-Lactalbumin induces bovine milk beta1, 4-Galactosyltransferase to utilize UDP-GalNAc. J. Biol. Chem., 270, 18447-18451.
14. Drickamer, K. (1993) A conserved disulphide bond in sialyltransferases. Glycobiology, 3, 2-3.
15. Elhammer, A. and Kornfeld, S. (1986) Purification and characterization of UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferase from bovine colostrum and murine lymphoma BW5147 cells. J. Biol. Chem, 261, 5249-5255.
16. Elhammer, Å.P., Poorman, R.A., Brown, E., Maggiora, L.L., Hoogerheide, J.G. and Kozdy, J.J. (1993) The specificity of UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase as inferred from a database of in vivo substrates and from in vitro glycosylation of proteins and peptides J. Biol. Chem., 266, 10029-10038.
17. Elliott, S., Bartley, T., Delorme, E., Derby, P., Hunt, R., Lorenzini, T., Parker, V., Rohde, M.F. and Stoney, K. (1994) Structural requirements for addition of O-linked carbohydrate to recombinant erythroportin. Biochemistry, 33, 11237-11245.
18. Fontenot, J.D., Tjandra, N., Bu, D., Ho, C., Montelaro, R.C. and Finn, O.J. (1994) Biophysical characterization of one-, two-, and three-tandem repeats of human mucin (muc-1) protein core. Cancer Res., 53, 5386-5394.
19. Gooley, A.A. and Williams, K.L. (1994) Towards characterizing O-glycans: the relative merits of in vivo and in vitro approaches in seeking peptide motifs specifying O-glycosylation sites. Glycobiology, 4, 413-417.
20. Gooley, A.A., classon, B.J., Marchalek, R. and Williams, K.L. (1991) Glycosylation sites identified by detection of glycosylated amino acids released from Edman degradation: the identification of Xaa-Pro-Xaa-Xaa As a motif for Thr-O-glycosylation. Biochem. Biophys. Res. Commun., 178, 1194-1201.
21. Hagen, F.K., Wuyckhuyse Van, B. and Tabak, L.A. (1993) Purification, cloning, and expression of a bovine UDP-GalNAc: popypeptide N-acetylgalactosaminyltransferase. J. Biol. Chem., 268, 18960-18965.
22. Hagen, F.K., Gregoire, C.A. and Tabak, L.A. (1994) Molecular cloning of the cDNA and 5′ genomic DNA sequence of a rat UDP-GalNAc:polypeptide N-acetylgalactosammyltransferase. Glycobiology, 4, 739.
23. Hagen, F.K., Gregoire, C.A. and Tabak, L.A. (1995) Cloning and sequence homology of a rat UDP-GalNAc: polypeptide N-acetylgalactosaminylrransferase. Glycoconjugate J., 12, 901-909.
24. Hagopian, A. and Eylar, E.H. (1968) Glycoprotein biosynthesis: studies on the receptor specificity of the polypeptidyl: N-acetylgalactosaminyl transferase from bovine submaxillary glands. Arch. Biochem. Biophys., 128, 422-433.
25. Hagopian, A. and Eylar, E.H. (1969) Glycoprotein biosynthesis the purification and characterization of a polypeptide: N-acetylgalactosaminyl transferase from bovine submaxillary glands. Arch. Biochem. Biophys., 129, 515-524.
26. Haluwanger, R.S., Blomberg, M.A. and Han, G.W. (1992) Glycosylation of nuclear and cytoplasmic proteins. Purification and characterization of a uridine diphospho-N-acetylglucosamine: polypeptide beta-N-acetylglucosaminyltransferase. J. Biol. Chem., 267, 9005-9013.
27. Hansen, J.E.S., Clausen, H., Hu, S.L., Nielsen, J.O. and Olofsson, S. (1992) An 0-lmked carbohydrate neutralization epitope of HIV-1 gp120 is expressed by HIV-1 env gene recombinant vaccinia virus. Arch. Virol., 126, 11-20.
28. Harris, R.J. and Spellman, M.W. (1993) 0-linked fucose and other post-translational modifications unique to EGF modules Glycobiology, 3, 219-224.
29. Hemon, T.R., Macher, B.A., Anaraki, F. and Galili, U. (1994) Defining the minimal size of catalytically active primate alpha 1, 3 galactosyltransferase: structure-function studies on the recombinant truncated enzyme. Glycobiology. 4, 193-201.
30. Hennet, T., Hagen, F.K., Tabak, L.A., Marth, J.D. (1995) T-cell-specific deletion of a polypeptide N-acetylgalactosaminyltransferase gene by site-directed recombination. Proc. Natl. Acad. Sci. USA, 92, 12070-12074.
31. Hill, H.D., Schwyzer, M., Steinman, H.M. and Hill, R.L. (1977) Ovine submaxillary mucin. J. Biol. Chem., 252, 3799-3804.
32. Holmes, E.H., Xu, Z., Sherwood, A.L. and Macher, B.A. (1995) Structure-function analysis of human alpha 1-3fucosylltransferases. J. Biol. Chem., 270, 8145-8151.
33. Homa, F.L., Hollanders, T., Lehman, D.J., Thomsen, D.R. and Elhammer, A.P. (1993) Isolation and expression of a cDNA clone encoding a bovine UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase. J. Biol. Chem., 268, 12609-12616.
34. Joziasse, D.H. (1992) Mammalian glycosyltransferases: genomic organization and protein structure. Glycobiology, 9, 271-277.
35. Kastuni, L., Eshleman, J.R., Wunner, W.H. and Shakin-Eshleman, S.H. (1995) The hydroxy amino acid in an asn-X-Ser/Thr sequon can influence N-linked core glycosylation efficiency and the level of expression of a cell surface glycoprotein. J. Biol. Chem., 270, 14756-14761.
36. Kleene, R. and Berger, E.G. (1993) The molecular and cell biology of glycosyltransferases. Biochim. Biophys. Acta., 1154, 283-325.
37. Lis, H. and Sharon, N. (1993) Protein glycosylation. Structural and functional aspects. Eur J. Biochem, 218, 1-27.
38. Livingston, B.D. and Paulson, J.C. (1993) Polymerase chain reaction cloning of a developmentally regulated member of the sialyltransferase gene family. J. Biol. Chem., 268, 11504-11507
39. Lussier, M., Gentzsch, M. Sdieu, A.-M., Bussey, H. and Tanner, W. (1995) Protein O-glycosylation in yeast. J. Biol. Chem., 270, 2770-2775.
40. Marshall, R.D. (1972) Glycoproteins. Annu. Rev. Biochem., 41, 673-702.
41. McGuire, E.J. and Roseman, S. (1967) Enzymatic synthesis of the protein-hexosamine linkage in sheep submaxillary mucin. J. Biol. Chem., 242, 3745-3755.
42. Merkle, R.K., Helland, D.E., Welles, J.L., Shilatifard, A., Haseltine, W.A. and Cummings, R.D. (1991) gp120 of HIV-I synthesized by persistently infected molt-3 cells is terminally glycosylated: evidence that cleavage of gp120 occurs subsequent to oligosacchande processing Arch. Biochem. Biophys., 290, 248-257.
43. Meurer, J.A., Naylor, J.M., Baker, C.A., Thomsen, D.R., Homa, F.L. and Elhammer.Å.P. (1995) cDNA cloning, expression, and chromosomal localization of a human UDP-GalNAc: polypeptide, N-acetylgalactosaminyltransferase. J. Biochem, 118, 568-574.
44. Meurer, J.A., Drong, R.F., Homa, F.L., Slightom, J.L. and Elhammer, Å.P. (1996) Organization of a human UDP-GalNAc: polypeptide, N-acetylgalactos-aminyltransferase gene and a related processed pseudogene. Glycobiology, 6, 231-241.
45. Nehrke, K., Hagen, F.K. and Tabak, L.A. (1996) Charge distribution of flanking amino acids influences O-glycan acquisition in vivo. J. Biol. Chem., 12, 7061-7065.
46. Nishimori, I., Johnson, N.R., Sanderson, S.D., Perini, F., Mountjoy, K., Cemy, R.L., Gross, M.L. and Hollingsworth, M.A. (1994a) Influence of acceptor substrate primary amino acid sequence on the activity of human UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferase. J. Biol. Chem., 269, 16123-16130.
47. Nishimori, I., Perini, F., Mountjoy, K.P., Sanderson, S.D., Johnson, N.R., Cerny, R.L., Gross, M.L., Fontenot, J.D. and Holiingsworth, M.A. (1994b) N-Acetylgalactosamine glycosylation of Muc1 tandem repeat peptides by pancreatic tumor cell extracts. Cancer Res., 54, 3738-3744.
48. O'Connell, B., Tabak, L.A. and Ramasubbu, N. (1991) The influence of flanking sequences on O-glycosylation. Biochem. Biophys. Res. Commun., 180, 1024-1030.
49. O'Connell, B.C. and Tabak, L.A. (1993) A comparison of serine and threonine O-glycosylation by UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase. J. Dent. Res., 72, 1554-1558.
50. O'Connell, B.C., Hagen, F.K. and Tabak, L.A. (1992) The influence of flanking sequence on the O-glycosylation of threonine in vitro. J. Biol. Chem., 267, 25010-25018.
51. Parekh, R.B. (1994) Site-specific protein glycosylation. Adv. Drug. Del. Rev., 13, 251-266.
52. Pascale, M.C., Erra, M.C., Malagolini, N., Serafini-Cessi, F., Leone, A. and Bonatti, S. (1992) Post-translational processing of an O-glycosylated protein, the human CD8 glycoprotein. during the intracellular transport to the plasma membrane. J. Biol. Chem., 267, 25196-25201.
53. Paulson, J.C. and Colley, K.J. (1989) Glycosyltransferases. Structure, localization, and control of cell type-specific glycosylation. J. Biol. Chem., 264, 17615-17618.
54. Perez-Vilar, J., Hidalgo, J. and Velasco, A. (1991) Presence of terminal N-acetylgalactosamine residues in subrogions of the endoplasmic reticulum is influenced by cell differentiation in culture. J. Biol. Chem., 266, 23967-23976.
55. Piller, F. and Piller, V. (1993) Structural characterization of mucin-type O-linked oligosaccharides. In Fukuda, M. and Kobata, A. (eds.), Glycobiology: A Practical Approach. IRL. Oxford, pp. 291-328.
56. Piller, V., Piller, F. and Fukuda, M. (1990) Biosynthesis of truncated O-glycans in the T cell line jurkat. Localization of O-glycan initiation. J. Biol. Chem., 265, 9264-9271.
57. Plummer, T.H., Tarentino, A.L. and Hauer, C.R. (1995) Novel, specific O-glycosylation of secreted Flavobacterium meningosepticum proteins. J. Biol. Chem., 270, 13192-13196.
58. Prockop, D.J., Kivirikko, K.I., Tuderman, L. and Guzman, N.A. (1979) Medical progress. The biosynthesis of collagen and its disorders. N. Engl. J. Med., 301, 13-23.
59. Roseman, S. (1970) The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion. Chem. Phys. Lipids, 5, 270-297.
60. Roth, J. (1984) Cytochemical localization of terminal N-acetyl-D-galactosamine residues in cellular compartments of intestinal goblet cells: implications for the topology of O-glycosylation. J. Cell Biol., 98, 399-406.
61. Roth, J., Wang, Y., Eckhardt, A.E. and Hill, R.L. (1994) Subcellular localization of the UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-mediated O-glycosylation reaction in the submaxillary gland. Proc. Natl. Acad. Sci. USA, 91, 8935-8939.
62. Rottger, S., Bennett, E.P., White, T., Clausen, H. and Nilsson, T. (1996) Expression and immunolocalisation of three human N-acetylgalactosaminyltransferases in HeLa cells. 4th International Workshop on Carcinoma-Associated Mucins, Cambridge.
63. Sadler, J.E. (1984) Biosynthesis of glycoproteins: formation of O-linked oligosaccharides. In Ginsburg.V. and Robbins, P.W. (eds.). Biology of Carbohydrates. John Wiley & Sons, New York, pp. 199-331.
64. Schachter, H. (1994) Molecular cloning of glycosyltransferase genes. In Fukuda, M. and Hindsgaul, O. (eds.). Molecular Glycobiology. IRL, Oxford, pp. 88-162.
65. Schweizer, A., Clausen, H., van Meer, G. and Hauri, H.-P. (1994) Localization of O-glycans initiation, sphingomyelin synthesis, and glycosylceramide synthesis in Vero cells with respect to the endoplasmic reticulum-Golgi intermediate compartment. J. Biol. Chem., 269, 4035-4041.
66. Shaper, N.L., Lin, S.-P., Joziasse, D.H., Kim, D. and Yang-Feng, T.L. (1992) Assignment of two human alpha-1, 3-galactosyltransferase gene sequences (GGTA1 and GGTA1P) to chromosomes 9q33-q34 and 12q14-q15. Genomics, 12, 613-615.
67. Serensen, T., White, T., Wandall, H.H., Kristensen, A.K., Roepstorff, P. and Clausen, H. (1995) UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase. Identification and separation of two distinct transferase activities. J. Biol. Chem., 270, 24166-24173.
68. Springer, T.A. (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell, 76, 301-314.
69. Stadie, T.R.E., Chai, W., Lawson, A.M., Byfield, P.G.H. and Hanisch, F.-G. (1995) Studies on the order and site specificity of GalNAc transfer to MUC1 tandem repeats by UDP-GaLNAc:polypeptide N-acetylgalactosaminyltransferase from milk or mammary carcinoma cells. Eur. J. Biochem., 229, 140-147.
70. Strahl-Bolsinger, S., Immervoll, T., Deutzmann, R. and Tanner, W. (1993) PMT1, the gene for a key enzyme of protein O-glycosylation in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA. 90, 8164-8168.
71. Sugiura, M., Kawasaki, T. and Yamashina, I. (1982) Purification and characterization of UDP-GalNAc:polypeptide N-acetylgalactosamine transferase from an ascites hepatoma, AH 66. J. Biol. Chem., 257, 9501-9507.
72. Tooze, S.A., Tooze, J. and Warren, G. (1988) Site of addition of N-acetyl-galactosamine to the E1 glycoprotein of mouse hepatitis virus-A59. J Cell Biol, 106, 1475-1487.
73. Varki, A. (1993) Biological roles of oligosaccharides. all of the theories are correct. Glycobiology, 3, 97-130.
74. Wang, Y., Abernethy, J.L., Eckhardt, A.E. and Hill, R.L. (1992) Purification and characterization of a UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase specific for glycosylation of threonine residues. J. Biol. Chem., 267, 12709-12716.
75. Wang, Y., Agrwall, N., Eckhardt, A.E., Stevens, R.D. and Hill, R.L. (1993) The acceptor substrate specificity of porcine submaxillary UDP-GalKAc: polypeptide N-acetylgalactosammyltransferase is dependent on the amino acid sequences adjacent to serine and threonine residues. J. Biol. Chem., 268, 22979-22983.
76. Wang, Y., Wong, S.S., Fukuda, M.N., Zu, H., Lio, Z., Tang, Q. and Appert, H.E. (1994) Identification of functional cysteine residues in human galactosyltransferase. Biochem. Biophys. Res. Commun., 204, 701-709.
77. Weston, B.W., Smith, P.L., Kelly, R.J. and Lowe, J.B. (1992) Molecular cloning of a fourth member of a human alpha (13)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes. J. Biol. Chem., 267, 24575-24584.
78. White, T., Bennett, E.P., Takio, K., Sorensen, T., Bonding, N. and Clausen, H. (1995) Purification and cDNA cloning of a human UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase. J. Biol. Chem., 270, 24156-24165.
79. Wilson, B.S., Palade, G.E. and Farquhar, M.G. (1993) Endoplasmic reticulumthrough-Golgi transport assay based on O-glycosylation of native glycophorin in permeabilized erythroleukemia cells: role for Gi3, Proc. Natl. Acad. Sci. USA. 90, 1681-1685.
80. Wilson, I.B.H., Gavel, Y. and von Heijne, G. (1991) Amino acid distributions around O-linked glycosylation sites. Biochem. J., 275, 529-534.
81. Yadav, S.P. and Brew, K. (1991) Structure and function in galactosyltransferase. Sequence locations of alpha-lactalbumin bindins site, thiol groups, and disulfide bond. J. Biol. Chem., 266, 698-703.
82. Yoshida, A., Hara, T., Ikenaga, H. and Takeuchi, M. (1995) Cloning and expression of a porcine UDP-GalNAc: polypeptide N-acetylgalactosaminyl transferase. Glycoconjugate J., 12, 824-828.