Molecular pathophysiology of neurodegenerative disease caused by γpKC mutations

World Journal of Biological Psychiatry

Volumn 12, Issue SUPPL. 1, 2011, Pages 95-98

  Sakai, Norio ^a   Saito, Naoaki ^b   Seki, Takahiro ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b KOBE UNIVERSITY   (Japan)

Author keywords

Neurodegeneration; Protein kinase C; Spinocerebellar ataxia

Indexed keywords

OLIGOMER; PROTEIN KINASE C ALPHA;

ARTICLE; DENDRITE; ENZYME ACTIVITY; ENZYME LOCALIZATION; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GENE EXPRESSION; GENE MUTATION; MOLECULAR PATHOLOGY; PURKINJE CELL; SPINOCEREBELLAR ATAXIA TYPE 14; SPINOCEREBELLAR DEGENERATION;

APOPTOSIS; CELL AGGREGATION; CELLS, CULTURED; DENDRITES; DNA MUTATIONAL ANALYSIS; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GENETIC PREDISPOSITION TO DISEASE; MUTATION, MISSENSE; NERVE DEGENERATION; PROTEIN KINASE C; PURKINJE CELLS; SIGNAL TRANSDUCTION; SPINOCEREBELLAR DEGENERATIONS; TRANSLOCATION, GENETIC;

EID: 80052771873     PISSN: 15622975     EISSN: 18141412     Source Type: Journal    
DOI: 10.3109/15622975.2011.598688     Document Type: Article

References (22)

1. Adachi N, Kobayashi T, Takahashi H, Kawasaki T, Shirai Y, Ueyama T, et al. 2008. Enzymological analysis of mutant protein kinase Cy causing spinocerebellar ataxia type 14 and dysfunction in Ca 2+ homeostasis. J Biol Chem 283: 19854-19863.
2. Chen C, Kano M, Abeliovich A, Chen L, Bao S, Kim JJ, et al. 1995. Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice. Cell 83:1233-1242. (Pubitemid 26007813)
3. Chen DH, Brkanac Z, Verlinde CL, Tan XJ, Bylenok L, Nochlin D, et al. 2003. Missense mutations in the regulatory domain of PKC gamma: a new mechanism for dominant nonepisodic cerebellar ataxia. Am J Hum Genet 72:839-849. (Pubitemid 36403304)
4. Chen DH, Cimino PJ, Ranum LP, Zoghbi HY, Yabe I, Schut L, et al. 2005. The clinical and genetic spectrum of spinocerebellar ataxia 14. Neurology 64:1258-1260.
5. Crowe JH. 2007. Trehalose as a "chemical chaperone": fact and fantasy. Adv Exp Med Biol 594:143-158.
6. Durr A. 2010. Autosomal dominant cerebellar ataxias: poly-glutamine expansions and beyond. Lancet Neurol 9:885-894.
7. Glabe CG. 2006. Common mechanisms of amyloid oligomer pathogenesis in degenerative disease. Neurobiol Aging 27:570-575. (Pubitemid 43290525)
8. Hiramoto K, Kawakami H, Inoue K, Seki T, Maruyama H, Morino H, et al. 2006. Identification of a new family of spinocerebellar ataxia type 14 in the Japanese spinocerebellar ataxia population by the screening of PRKCG exon 4. Mov Disord 21:1355-1360. (Pubitemid 44613285)
9. Nishizuka Y 1995. Protein kinase C and lipid signaling for sustained cellular responses. Faseb J 9:484-496.
10. Paulson HL. 2009. The spinocerebellar ataxias. J Neuroophthal-mol 29:227-237.
11. Ross CA, Pickart CM. 2004. The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases. Trends Cell Biol 14:703-711. (Pubitemid 39572556)
12. Ross CA, Poirier MA. 2004. Protein aggregation and neurode-generative disease. Nat Med 10(Suppl):S10-17.
13. Saito N, Shirai Y. 2002. Protein kinase C gamma (PKC gamma): function of neuron specific isotype. J Biochem (Tokyo) 132:683-687. (Pubitemid 35408489)
14. Sakai N, Sasaki K, Ikegaki N, Shirai Y, Ono Y, Saito N. 1997. Direct visualization of the translocation of the gamma-subspecies of protein kinase C in living cells using fusion proteins with green fluorescent protein. J Cell Biol 139:1465-1476. (Pubitemid 28013667)
15. Sakai N, Tsubokawa H, Matsuzaki M, Kajimoto T, Takahashi E, Ren Y, et al. 2004. Propagation of gammaPKC transloca-tion along the dendrites of Purkinje cell in gammaPKC-GFP transgenic mice. Genes Cells 9:945-957. (Pubitemid 39369026)
16. Seki T, Adachi N, Ono Y, Mochizuki H, Hiramoto K, Amano T, et al. 2005. Mutant protein kinase Cgamma found in spinocerebellar ataxia type 14 is susceptible to aggregation and causes cell death. J Biol Chem 280:29096-29106. (Pubitemid 41161360)
17. Seki T, Takahashi H, Adachi N, Abe N, Shimahara T, Saito N, et al. 2007. Aggregate formation of mutant protein kinase C gamma found in spinocerebellar ataxia type 14 impairs ubiquitin-proteasome system and induces endoplasmic reti-culum stress. Eur J Neurosci 26:3126-3140. (Pubitemid 350135178)
18. Seki T, Shimahara T, Yamamoto K, Abe N, Amano T, Adachi N, et al. 2009. Mutant gammaPKC found in spinocerebellar ataxia type 14 induces aggregate-independent maldevelopment of dendrites in primary cultured Purkinje cells. Neurobiol Dis 33:260-273.
19. Seki T, Abe-Seki N, Kikawada T, Takahashi H, Yamamoto K, Adachi N, et al. 2010. Effect of trehalose on the properties of mutant gamma PKC, which causes spinocerebellar ataxia type 14, in neuronal cell lines and cultured Purkinje cells. J Biol Chem 285:33252-33264.
20. Shirai Y, Sakai N, Saito N. 1998. Subspecies-specific targeting mechanism of protein kinase C. Jpn J Pharmacol 78:411-417. (Pubitemid 29052062)
21. Tanaka M, Machida Y, Niu S, Ikeda T, Jana NR, Doi H, et al. 2004. Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease. Nat Med 10:148-154. (Pubitemid 38524884)
22. Yamamoto K, Seki T, Adachi N, Takahashi T, Tanaka S, Hide I, et al. 2010. Mutant protein kinase C gamma that causes spinocerebellar ataxia type 14 (SCA14) is selectively degraded by autophagy. Genes Cells 15:425-438.