Effects of glutathione-depleting drug buthionine sulfoximine and aging on activity of endothelium-derived relaxing and contracting factors in carotid artery of sprague-dawley rats

Journal of Cardiovascular Pharmacology

Volumn 58, Issue 3, 2011, Pages 272-283

  Denniss, Steven G ^a   Levy, Andrew S ^a   Rush, James W E ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

aging; Buthionine sulfoximine; EDCF; EDRF; GSH; vasomotor dysfunction

Indexed keywords

ACETYLCHOLINE; BUTHIONINE SULFOXIMINE; CYCLOOXYGENASE 1; ENDOTHELIUM DERIVED CONSTRICTING FACTOR; ENDOTHELIUM DERIVED RELAXING FACTOR; GLUTATHIONE; MANGANESE TETRAKIS(1 METHYL 4 PYRIDYL)PORPHYRIN TETRATOSYLATE HYDROXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PROSTAGLANDIN SYNTHASE; REACTIVE OXYGEN METABOLITE; TEMPOL; UNCLASSIFIED DRUG;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; BLOOD PRESSURE; COMMON CAROTID ARTERY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; LIVER; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TREATMENT DURATION; VASCULAR TISSUE; VASODILATATION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; AGING; ANIMALS; BLOOD PRESSURE; BUTHIONINE SULFOXIMINE; CAROTID ARTERY, COMMON; DRUG ADMINISTRATION SCHEDULE; ENDOTHELIUM, VASCULAR; ENDOTHELIUM-DEPENDENT RELAXING FACTORS; ENZYME INHIBITORS; GLUTATHIONE; HEART RATE; HEMODYNAMICS; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; VASOCONSTRICTOR AGENTS;

EID: 80052770761     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3182239f36     Document Type: Article

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