Altered mRNA expression of monoaminergic candidate genes in the blood of children with attention deficit hyperactivity disorder and autism spectrum disorder

World Journal of Biological Psychiatry

Volumn 12, Issue SUPPL. 1, 2011, Pages 104-108

  Taurines, Regina ^a   Grünblatt, Edna ^b   Schecklmann, Martin ^c   Schwenck, Christina ^d   Albantakis, Laura ^a   Reefschläger, Lennart ^a   Walitza, Susanne ^b   Renner, Tobias ^a   Gerlach, Manfred ^a   Thome, Johannes ^e   Romanos, Marcel ^f  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF REGENSBURG   (Germany)

^d GOETHE UNIVERSITY   (Germany)

^e UNIVERSITY OF ROSTOCK   (Germany)

^f LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Attention deficit hyperactivity disorder (ADHD); Autism spectrum disorder (ASD); D5 (DRD4, DRD5); Dopamine receptor D4; MRNA expression

Indexed keywords

DOPAMINE 4 RECEPTOR; DOPAMINE 5 RECEPTOR; MESSENGER RNA; TRYPTOPHAN HYDROXYLASE;

ADOLESCENT; ARTICLE; ATTENTION DEFICIT DISORDER; AUTISM; BLOOD SAMPLING; CHILD; COMORBIDITY; CONTROLLED STUDY; DISEASE MARKER; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PATHOPHYSIOLOGY;

ADOLESCENT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; COMORBIDITY; FEMALE; GENE EXPRESSION; GENETIC ASSOCIATION STUDIES; GENETIC MARKERS; HUMANS; MALE; RECEPTORS, DOPAMINE D4; RECEPTORS, DOPAMINE D5; REFERENCE VALUES; RNA, MESSENGER;

EID: 80052764999     PISSN: 15622975     EISSN: 18141412     Source Type: Journal    
DOI: 10.3109/15622975.2011.600297     Document Type: Article

References (30)

1. Achenbach TM, Edelbrock CS. 1981. Behavioral problems and competencies reported by parents of normal and disturbed children aged four through sixteen. Monogr Soc Res Child Dev 46:1-82.
2. Asghari V, Schoots O, van Kats S, Ohara K, Jovanovic V, Guan HC, et al. 1994. Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes. Mol Pharmacol 46:364-373. (Pubitemid 24271434)
3. Asghari V, Sanyal S, Buchwaldt S, Paterson A, Jovanovic V, Van Tol HH. 1995. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J Neurochem 65:1157-1165.
4. Boelte S, Poustka F. 2006. FSK-Fragebogen zur Sozialen Kommunikation, Bern: Huber.
5. Boelte S, Rühl D, Schmoetzer G, Poustka F. 2006. ADI-R-Diagnostisches Interview fuer Autismus-Revidiert. Bern: Huber.
6. Brookes K, Xu X, Chen W, Zhou K, Neale B, Lowe N, et al. 2006. The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry 11:934-953. (Pubitemid 44470216)
7. Del Campo N, Chamberlain SR, Sahakian BJ, Robbins TW. 2011. The roles of dopamine and noradrenaline in the pathophysiology and treatment of attention-deficit/hyperactivity disorder. Biol Psychiatry 69:e145-157.
8. Döpfner M, Görtz-Dorten A, Lehmkuhl G. 2008. DISYPS II Diagnostik-System für psychische Störungen nach ICD-10 und DSM-IV für Kinder und Jugendliche II. Bern: Hans Huber AG.
9. Emanuele E, Boso M, Cassola F, Broglia D, Bonoldi I, Mancini L, et al. 2010. Increased dopamine DRD4 receptor mRNA expression in lympho cytes of musicians and autistic individuals: bridging the music-autism connection. Neuro Endocrinol Lett 31:122-125.
10. Ferrari M, Termine C, Franciotta D, Castiglioni E, Pagani A, Lanzi G, et al. 2008. Dopaminergic receptor D5 mRNA expression is increased in circulating lymphocytes of Tourette syndrome patients. J Psychiatr Res 43:24-29.
11. Faraone SV, Biederman J. 1998. Neurobiology of attention-deficit hyperactivity disorder. Biol Psychiatry 44:951-958. (Pubitemid 28545223)
12. Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick JJ, Holmgren MA, et al. 2005. Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry 57:1313-1323. (Pubitemid 40798551)
13. Frieling H, Römer KD, Scholz S, Mittelbach F, Wilhelm J, De Zwaan M, Jacoby GE, Kronhuber J, Hillemacher T, Bleich S. 2010. Epigenetic dysregulation of dopaminergic genes in eating disorders. Int J Eat Disord 43:577-583.
14. Froehlich TE, McGough JJ, Stein MA. 2010. Progress and promise of attention-deficit hyperactivity disorder pharmacogenetics. CNS Drugs 24:99-117.
15. Gizer IR, Ficks C, Waldman ID. 2009. Candidate gene studies of ADHD: a meta-analytic review. Hum Genet 126:51-90.
16. Ilani T, Ben-Shachar D, Strous RD, Mazor M, Sheinkman A, Kotler M, et al. 2001. A peripheral marker for schizophrenia: Increased levels of D3 dopamine receptor mRNA in blood lymphocytes. Proc Natl Acad Sci USA 98:625-628. (Pubitemid 32105093)
17. Kwak YT, Koo MS, Choi CH, Sunwoo I. 2001. Change of dopamine receptor mRNA expression in lymphocyte of schizophrenic patients. BMC Med Genet 2:3.
18. Li J, Wang Y, Zhou R, Zhang H, Yang L, Wang B, et al. 2006. Association between tryptophan hydroxylase gene polymorphisms and attention deficit hyperactivity disorder in Chinese Han population. Am J Med Genet B Neuropsychiatr Genet 141B:126-129. (Pubitemid 43214785)
19. Lord C, Rutter M, Le Couteur A. 1994. Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 24:659-685. (Pubitemid 24309810)
20. Lord C, Rutter M, Goode S, Hemsbergen J, Jordan H, Mawhood L, et al. 1989. Autism Diagnostic Observation Schedule: A standardized observation of communicative and social behaviour. J Autism Dev Disord 19:185-212. (Pubitemid 19176529)
21. Mehler-Wex C, Duvigneau JC, Hartl RT, Ben-Shachar D, Warnke A, Gerlach M. 2006. Increased mRNA levels of the mitochondrial complex I 75-kDa subunit. A potential peripheral marker of early onset schizophrenia? Eur Child Adolesc Psychiatry 15:504-507. (Pubitemid 46020536)
22. Renner TJ, Gerlach M, Romanos M, Herrmann M, Reif A, Fallgatter AJ, Lesch KP. 2008. [Neurobiology of attent ion-deficit hyperactivity disorder]. Nervenarzt 79:771-781 (in German).
23. Rocca P, De Leo C, Eva C, Marchiaro L, Milani AM, Musso R, et al. 2002. Decrease of the D4 dopamine receptor messenger RNA expression in lymphocytes from patients with major depression. Prog Neuropsychopharmacol Biol Psychiatry 26: 1155-60. (Pubitemid 35256109)
24. Ruehl D, Boelte S, Feineis-Matthews S, Poustka F. 2004. ADOS-Diagnostische Beobachtungsskala fuer Autistische Stoerungen. Bern: Huber.
25. Rutter M, Bailey A, Berument SK, Le Couteur A, Lord C, Pickles A. 2003. Social communication questionnaire (SCQ). Los Angeles, CA: Western Psychological Services.
26. Solanto MV. 1998. Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyper-activity disorder: a review and integration. Behav Brain Res 94: 127-152. (Pubitemid 28352470)
27. Stiensmeier-Pelster J, Schürmann M, Duda K. 2000. Depres-sionsinventar für Kinder und Jugendliche.
28. Urhan-Kucuk M, Erdal ME, Ozen ME, Kul S, Herken H. 2011. Is the dopamine D3 receptor mRNA on blood lymphocytes help to for identification and subtyping of schizophrenia? Mol Biol Rep 38:2569-2572.
29. Vogel M, Pfeifer S, Schaub RT, Grabe HJ, Barnow S, Freyberger HJ, et al. 2004. Decreased levels of dopamine D3 receptor mRNA in schizophrenic and bipolar patients. Neuropsychobio logy 50:305-310. (Pubitemid 39482670)
30. Walitza S, Renner TJ, Dempfle A, Konrad K, Wewetzer Ch, Halbach A, et al. 2005. Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder. Mol Psychiatry 10: 1126-1132. (Pubitemid 43251103)