Role of cGMP and cAMP in the hemodynamic response to intrathecal sildenafil administration

Clinics

Volumn 66, Issue 8, 2011, Pages 1407-1411

  Bombarda, Gabriela ^a   Sabino, João Paulo J ^a   da Silva, Carlos Alberto A ^a   Fazan Jr , Rubens ^a   Salgado, Maria Cristina O ^a   Salgado, Helio C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Forskolin; Lumbar sympathetic activity; Phosphodiesterase 5; Spinal cord; Sympathetic preganglionic neurons

Indexed keywords

8 BROMO CYCLIC GMP; 8-BROMOCYCLIC GMP; BUCLADESINE; CYCLIC GMP; DRUG DERIVATIVE; FORSKOLIN; PIPERAZINE DERIVATIVE; PURINE DERIVATIVE; SILDENAFIL; SULFONE; VASODILATOR AGENT;

ANIMAL; ARTICLE; BLOOD PRESSURE; DRUG EFFECT; HEART RATE; INTRASPINAL DRUG ADMINISTRATION; MALE; RAT; WISTAR RAT;

ANIMALS; BLOOD PRESSURE; BUCLADESINE; CYCLIC GMP; FORSKOLIN; HEART RATE; INJECTIONS, SPINAL; MALE; PIPERAZINES; PURINES; RATS; RATS, WISTAR; SULFONES; VASODILATOR AGENTS;

EID: 80052736396     PISSN: 18075932     EISSN: None     Source Type: Journal    
DOI: 10.1590/S1807-59322011000800017     Document Type: Article

References (25)

1. Fazan Jr R, Huber DA, Silva CA, Dias da Silva VJ, Salgado MCO, Salgado HC. Sildenafil acts on the central nervous system increasing sympathetic activity. J Appl Physiol. 2008;104:1683-9, doi: 10.1152/japplphysiol.01142.2007.
2. Guyenet PG. The sympathetic control of blood pressure. Nat Rev Neurosci. 2006;7:335-46, doi: 10.1038/nrn1902.
3. Simms AE, Paton JF, Pickering AE. Disinhibition of the cardiac limb of the arterial baroreflex in rat: a role for metabotropic glutamate receptors in the nucleus tractus solitarii. J Physiol. 2006;575:727-38, doi: 10.1113/ jphysiol.2006.112672.
4. Chen QH, Toney GM. Excitability of paraventricular nucleus neurones that project to the rostral ventrolateral medulla is regulated by smallconductance Ca2+-activated K+ channels. J Physiol. 2009;587:4235-47, doi: 10.1113/jphysiol.2009.175364.
5. Collister JP, Nahey DB. The cardiovascular response of normal rats to dual lesion of the subfornical organ and area postrema at rest and to chronic losartan. Brain Res. 2009;1302:118-24, doi: 10.1016/j.brainres.2009.09.021.
6. Boolell M, Allen MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM, et al. Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res. 1996;8:47-52.
7. Zusman RM. Cardiovascular data on sildenafil citrate: introduction. Am J Cardiol. 1999;83:1C-2C, doi: 10.1016/S0002-9149(99)00041-7.
8. Zusman RM, Morales A, Glasser DB, Osterloh IH. Overall cardiovascular profile of sildenafil citrate. Am J Cardiol. 1999;83:35C-44C, doi: 10.1016/ S0002-9149(99)00046-6.
9. Kloner RA. Cardiovascular risk and sildenafil. Am J Cardiol. 2000;86:57F-61F, doi: 10.1016/S0002-9149(00)00895-X.
10. Lin CS, Lin G, Xin ZC, Lue TF. Expression, distribution and regulation of phosphodiesterase 5. Curr Pharm Des. 2006;12:3439-57, doi: 10.2174/138161206778343064.
11. Uthayathas S, Karuppagounder SS, Thrash BM, Parameshwaran K, Suppiramaniam V, Dhanasekaran M. Versatile effects of sildenafil: recent pharmacological applications. Pharmacol Rep. 2007;59:150-63.
12. Bischoff E. Potency, selectivity, and consequences of nonselectivity of PDE inhibition. Int J Impot Res. 2004;16Suppl 1:S11-4., doi: 10.1038/sj.ijir.3901208.
13. Kim NN, Huang Y, Moreland RB, Kwak SS, Goldstein I, Traish A. Crossregulation of intracellular cGMP and cAMP in cultured human corpus cavernosum smooth muscle cells. Mol Cell Biol Res Commun. 2000;4:10-4, doi: 10.1006/mcbr.2000.0249.
14. Uckert S, Hedlund P, Waldkirch E, Sohn M, Jonas U, Andersson KE, et al. Interactions between cGMP-and cAMP-pathways are involved in the regulation of penile smooth muscle tone. World J Urol. 2004;22:261-6, doi: 10.1007/s00345-003-0394-4.
15. Kass DA, Takimoto E, Nagayama T, Champion HC. Phosphodiesterase regulation of nitric oxide signaling. Cardiovasc Res. 2007;75:303-14, doi:10.1016/j.cardiores.2007.02.031.
16. Malik V, Holobotovskyy VV, Phillips JK, McKitrick DJ, Arnolda LF. Intrathecal cGMP elicits pressor responses and maintains mean blood pressure during haemorrhage in anaesthetized rats. J Physiol. 2007;581:543-52, doi: 10.1113/jphysiol.2006.125690.
17. Prado WA. Antinociceptive potency of intrathecal morphine in the rat tail flick test: a comparative study using acute lumbar catheter in rats with or without a chronic atlanto-occipital catheter. J Neurosci Methods. 2003;129:33-39, doi: 10.1016/S0165-0270(03)00197-3.
18. Storkson RV, Kjorsvik A, Tjolsen A, Hole K. Lumbar catheterization of the spinal subarachnoid space in the rat. J Neurosci Methods. 1996;65:167-72, doi: 10.1016/0165-0270(95)00164-6.
19. Arnolda LF, McKitrick DJ, Llewellyn-Smith IJ, Minson JB. Nitric Oxide limits pressor responses to sympathetic activation in rat spinal cord. Hypertension. 2000;36:1089-92.
20. Phillips BG, Kato M, Pesek CA, Winnicki M, Narkiewicz K, Davison D, et al. Sympathetic activation by sildenafil. Circulation. 2000;102:3068-73.
21. Piccirillo G, Nocco M, Lionetti M, Moise A, Naso C, Marigliano V, et al. Effects of sildenafil citrate (viagra) on cardiac repolarization and on autonomic control in subjects with chronic heart failure. Am Heart J. 2002;143:703-10, doi: 10.1067/mhj.2002.121547.
22. Choi J, Farley JM. Effects of 8-bromo-cyclic GMP on membrane potential of single swine tracheal smooth muscle cells. J Pharmacol Exp Ther. 1998;285:588-94.
23. Patil CS, Singh VP, Kulkarni SK. Peripheral and central activation of nitric oxide-cyclic GMP pathway by sildenafil. Inflammopharmacology. 2005;13:467-78, doi: 10.1163/156856005774649359.
24. Stief CG, Uckert S, Becker AJ, Harringer W, Truss MC, Forssmann WG, et al. Effects of sildenafil on cAMP and cGMP levels in isolated human cavernous and cardiac tissue. Urology. 2000;55:146-50, doi: 10.1016/ S0090-4295(99)00371-4.
25. Botha P, Parry G, Dark JH, Macgowan GA. Acute hemodynamic effects of intravenous sildenafil citrate in congestive heart failure: comparison of phosphodiesterase type-3 and-5 inhibition. J Heart Lung Transplant. 2009;28:676-82, doi: 10.1016/j.healun.2009.04.013.