New insights into glioma classification based on isocitrate dehydrogenase 1 and 2 gene status

Brain Tumor Pathology

Volumn 28, Issue 3, 2011, Pages 203-208

  Shibahara, Ichiyo ^a   Sonoda, Yukihiko ^a   Kanamori, Masayuki ^a   Saito, Ryuta ^a   Kumabe, Toshihiro ^a   Tominaga, Teiji ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Astrocytoma; Glioblastoma; IDH1; Oligodendroglioma; Pilocytic astrocytoma

Indexed keywords

B RAF KINASE; ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE ISOENZYME; UNCLASSIFIED DRUG;

BRAF GENE; CANCER CLASSIFICATION; CANCER DIAGNOSIS; CANCER GRADING; CANCER SURVIVAL; CONFERENCE PAPER; DIAGNOSTIC ERROR; GENE; GENE FUNCTION; GENE MUTATION; GENETIC MARKER; GLIOBLASTOMA; GLIOMA; HUMAN; ISOCITRATE DEHYDROGENASE 1 GENE; ISOCITRATE DEHYDROGENASE 2 GENE; ONCOGENE; OVERALL SURVIVAL; PILOCYTIC ASTROCYTOMA; PRIMARY GLIOBLASTOMA; PROGNOSIS; SECONDARY GLIOBLASTOMA; TUMOR SUPPRESSOR GENE;

ADOLESCENT; BRAIN NEOPLASMS; GLIOMA; HUMANS; ISOCITRATE DEHYDROGENASE; MUTATION; PATHOLOGY, MOLECULAR; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 80052712328     PISSN: 14337398     EISSN: 1861387X     Source Type: Journal    
DOI: 10.1007/s10014-011-0050-4     Document Type: Conference Paper

References (49)

1. H Yan DW Parsons G Jin R McLendon BA Rasheed W Yuan I Kos I Batinic-Haberle S Jones GJ Riggins H Friedman A Friedman D Reardon J Herndon KW Kinzler VE Velculescu B Vogelstein DD Bigner 2009 IDH1 and IDH2 mutations in gliomas N Engl J Med 360 765 773 19228619 10.1056/NEJMoa0808710 1:CAS:528:DC%2BD1MXitFWru7o%3D
2. Y Sonoda T Kumabe T Nakamura R Saito M Kanamori Y Yamashita H Suzuki T Tominaga 2009 Analysis of IDH1 and IDH2 mutations in Japanese glioma patients Cancer Sci 100 1996 1998 19765000 10.1111/j.1349-7006.2009.01270.x 1:CAS:528:DC%2BD1MXht12qs7bP
3. ER Mardis L Ding DJ Dooling DE Larson MD McLellan K Chen DC Koboldt RS Fulton KD Delehaunty SD McGrath LA Fulton DP Locke VJ Magrini RM Abbott TL Vickery JS Reed JS Robinson T Wylie SM Smith L Carmichael JM Eldred CC Harris J Walker JB Peck F Du AF Dukes GE Sanderson AM Brummett E Clark JF McMichael RJ Meyer JK Schindler CS Pohl JW Wallis X Shi L Lin H Schmidt Y Tang C Haipek ME Wiechert JV Ivy J Kalicki G Elliott RE Ries JE Payton P Westervelt MH Tomasson MA Watson J Baty S Heath WD Shannon R Nagarajan DC Link MJ Walter TA Graubert JF DiPersio RK Wilson TJ Ley 2009 Recurring mutations found by sequencing an acute myeloid leukemia genome N Engl J Med 361 1058 1066 19657110 10.1056/NEJMoa0903840 1:CAS:528:DC%2BD1MXhtFaltLvL
4. MR Kang MS Kim JE Oh YR Kim SY Song SI Seo JY Lee NJ Yoo SH Lee 2009 Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers Int J Cancer 125 353 355 19378339 10.1002/ijc.24379 1:CAS:528: DC%2BD1MXms1amu70%3D
5. T Sjoblom S Jones LD Wood DW Parsons J Lin TD Barber D Mandelker RJ Leary J Ptak N Silliman S Szabo P Buckhaults C Farrell P Meeh SD Markowitz J Willis D Dawson JK Willson AF Gazdar J Hartigan L Wu C Liu G Parmigiani BH Park KE Bachman N Papadopoulos B Vogelstein KW Kinzler VE Velculescu 2006 The consensus coding sequences of human breast and colorectal cancers Science 314 268 274 16959974 10.1126/science.1133427 (Pubitemid 44571966)
6. SW Park NG Chung JY Han HS Eom JY Lee NJ Yoo SH Lee 2009 Absence of IDH2 codon 172 mutation in common human cancers Int J Cancer 125 2485 2486 19530255 10.1002/ijc.24647 1:CAS:528:DC%2BD1MXhtFOkt7%2FE
7. DW Parsons S Jones X Zhang JC Lin RJ Leary P Angenendt P Mankoo H Carter IM Siu GL Gallia A Olivi R McLendon BA Rasheed S Keir T Nikolskaya Y Nikolsky DA Busam H Tekleab LA Diaz Jr J Hartigan DR Smith RL Strausberg SK Marie SM Shinjo H Yan GJ Riggins DD Bigner R Karchin N Papadopoulos G Parmigiani B Vogelstein VE Velculescu KW Kinzler 2008 An integrated genomic analysis of human glioblastoma multiforme Science 321 1807 1812 18772396 10.1126/science.1164382 1:CAS:528:DC%2BD1cXhtFCrtLrE
8. RG Verhaak KA Hoadley E Purdom V Wang Y Qi MD Wilkerson CR Miller L Ding T Golub JP Mesirov G Alexe M Lawrence M O'Kelly P Tamayo BA Weir S Gabriel W Winckler S Gupta L Jakkula HS Feiler JG Hodgson CD James JN Sarkaria C Brennan A Kahn PT Spellman RK Wilson TP Speed JW Gray M Meyerson G Getz CM Perou DN Hayes 2010 Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1 Cancer Cell 17 98 110 20129251 10.1016/j.ccr.2009.12.020 1:CAS:528: DC%2BC3cXkvFKgsL4%3D
9. Cancer Genome Atlas Research Network 2008 Comprehensive genomic characterization defines human glioblastoma genes and core pathways Nature (Lond) 455 1061 1068 10.1038/nature07385
10. MJ van den Bent HJ Dubbink Y Marie AA Brandes MJ Taphoorn P Wesseling M Frenay CC Tijssen D Lacombe A Idbaih R van Marion JM Kros WN Dinjens T Gorlia M Sanson 2010 IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group Clin Cancer Res 16 1597 1604 20160062 10.1158/1078-0432.CCR-09-2902
11. W Wick C Hartmann C Engel M Stoffels J Felsberg F Stockhammer MC Sabel S Koeppen R Ketter R Meyermann M Rapp C Meisner RD Kortmann T Pietsch OD Wiestler U Ernemann M Bamberg G Reifenberger A von Deimling M Weller 2009 NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide J Clin Oncol 27 5874 5880 19901110 10.1200/JCO.2009.23.6497 1:CAS:528:DC%2BC3cXhtVWis7g%3D
12. C Hartmann J Meyer J Balss D Capper W Mueller A Christians J Felsberg M Wolter C Mawrin W Wick M Weller C Herold-Mende A Unterberg JW Jeuken P Wesseling G Reifenberger A von Deimling 2009 Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1, 010 diffuse gliomas Acta Neuropathol 118 469 474 19554337 10.1007/s00401-009-0561-9
13. S Zhao Y Lin W Xu W Jiang Z Zha P Wang W Yu Z Li L Gong Y Peng J Ding Q Lei KL Guan Y Xiong 2009 Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha Science 324 261 265 19359588 10.1126/science.1170944 1:CAS:528:DC%2BD1MXktFals7g%3D
14. L Dang DW White S Gross BD Bennett MA Bittinger EM Driggers VR Fantin HG Jang S Jin MC Keenan KM Marks RM Prins PS Ward KE Yen LM Liau JD Rabinowitz LC Cantley CB Thompson MG Vander Heiden SM Su 2009 Cancer-associated IDH1 mutations produce 2-hydroxyglutarate Nature (Lond) 462 739 744 10.1038/nature08617 1:CAS:528:DC%2BD1MXhsVGlurzE
15. B Yang C Zhong Y Peng Z Lai J Ding 2010 Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H Cell Res 20 1188 1200 20975740 10.1038/cr.2010.145 1:CAS:528:DC%2BC3cXhtlKjtbfI
16. LB Bralten NK Kloosterhof R Balvers A Sacchetti L Lapre M Lamfers S Leenstra H de Jonge JM Kros EE Jansen EA Struys C Jakobs GS Salomons SH Diks M Peppelenbosch A Kremer CC Hoogenraad PA Sillevis Smitt PJ French 2011 IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo Ann Neurol 69 455 463 21446021 10.1002/ana.22390 1:CAS:528:DC%2BC3MXls1Omtbo%3D
17. MJ Seltzer BD Bennett AD Joshi P Gao AG Thomas DV Ferraris T Tsukamoto CJ Rojas BS Slusher JD Rabinowitz CV Dang GJ Riggins 2010 Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1 Cancer Res 70 8981 8987 21045145 10.1158/0008-5472.CAN-10-1666 1:CAS:528: DC%2BC3cXhsVWmsL3N
18. G Tabatabai R Stupp MJ van den Bent ME Hegi JC Tonn W Wick M Weller 2010 Molecular diagnostics of gliomas: the clinical perspective Acta Neuropathol 120 585 592 20862485 10.1007/s00401-010-0750-6 1:CAS:528:DC%2BC3cXhtlSjtrfI
19. MJ Riemenschneider JW Jeuken P Wesseling G Reifenberger 2010 Molecular diagnostics of gliomas: state of the art Acta Neuropathol 120 567 584 20714900 10.1007/s00401-010-0736-4 1:CAS:528:DC%2BC3cXhtlSjt77M
20. T Watanabe S Nobusawa P Kleihues H Ohgaki 2009 IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas Am J Pathol 174 1149 1153 19246647 10.2353/ajpath.2009.080523 1:CAS:528:DC%2BD1MXksVOksLY%3D
21. H Yan DD Bigner V Velculescu DW Parsons 2009 Mutant metabolic enzymes are at the origin of gliomas Cancer Res 69 9157 9159 19996293 10.1158/0008-5472. CAN-09-2650 1:CAS:528:DC%2BD1MXhsFGrtbrE
22. H Ohgaki P Kleihues 2009 Genetic alterations and signaling pathways in the evolution of gliomas Cancer Sci 100 2235 2241 19737147 10.1111/j.1349-7006. 2009.01308.x 1:CAS:528:DC%2BD1MXhsFOltrvN
23. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds) (2007) WHO classification of tumours of the central nervous system. International Agency for Research on Cancer (IARC), Lyon
24. C Hartmann B Hentschel W Wick D Capper J Felsberg M Simon M Westphal G Schackert R Meyermann T Pietsch G Reifenberger M Weller M Loeffler A von Deimling 2010 Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas Acta Neuropathol 120 707 718 21088844 10.1007/s00401-010-0781-z
25. G Toedt S Barbus M Wolter J Felsberg B Tews F Blond MC Sabel S Hofmann N Becker C Hartmann H Ohgaki A von Deimling OD Wiestler M Hahn P Lichter G Reifenberger B Radlwimmer 2011 Molecular signatures classify astrocytic gliomas by IDH1 mutation status Int J Cancer 128 1095 1103 20473936 10.1002/ijc.25448 1:CAS:528:DC%2BC3cXhs1ajs7jK
26. M Sanson Y Marie S Paris A Idbaih J Laffaire F Ducray S El Hallani B Boisselier K Mokhtari K Hoang-Xuan JY Delattre 2009 Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas J Clin Oncol 27 4150 4154 19636000 10.1200/JCO.2009.21.9832 1:CAS:528:DC%2BD1MXhtF2jtLrP
27. S Nobusawa T Watanabe P Kleihues H Ohgaki 2009 IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas Clin Cancer Res 15 6002 6007 19755387 10.1158/1078-0432.CCR-09-0715 1:CAS:528: DC%2BD1MXhtF2ltbbL
28. K Ichimura DM Pearson S Kocialkowski LM Backlund R Chan DT Jones VP Collins 2009 IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas Neurooncology 11 341 347 1:CAS:528: DC%2BD1MXhtV2qur%2FF
29. J Balss J Meyer W Mueller A Korshunov C Hartmann A von Deimling 2008 Analysis of the IDH1 codon 132 mutation in brain tumors Acta Neuropathol 116 597 602 18985363 10.1007/s00401-008-0455-2 1:CAS:528:DC%2BD1cXhtlyhsbfN
30. M Labussiere A Idbaih XW Wang Y Marie B Boisselier C Falet S Paris J Laffaire C Carpentier E Criniere F Ducray S El Hallani K Mokhtari K Hoang-Xuan JY Delattre M Sanson 2010 All the 1p19q codeleted gliomas are mutated on IDH1 or IDH2 Neurology 74 1886 1890 20427748 10.1212/WNL.0b013e3181e1cf3a 1:CAS:528:DC%2BC3cXntF2gtbw%3D
31. YH Kim S Nobusawa M Mittelbronn W Paulus B Brokinkel K Keyvani U Sure K Wrede Y Nakazato Y Tanaka A Vital L Mariani R Stawski T Watanabe U De Girolami P Kleihues H Ohgaki 2010 Molecular classification of low-grade diffuse gliomas Am J Pathol 177 2708 2714 21075857 10.2353/ajpath.2010.100680
32. M Weller J Felsberg C Hartmann H Berger JP Steinbach J Schramm M Westphal G Schackert M Simon JC Tonn O Heese D Krex G Nikkhah T Pietsch O Wiestler G Reifenberger A von Deimling M Loeffler 2009 Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network J Clin Oncol 27 5743 5750 19805672 10.1200/JCO.2009.23.0805 1:CAS:528: DC%2BC3cXhtVWisbg%3D
33. P Metellus B Coulibaly C Colin AM de Paula A Vasiljevic D Taieb A Barlier B Boisselier K Mokhtari XW Wang A Loundou F Chapon S Pineau L Ouafik O Chinot D Figarella-Branger 2010 Absence of IDH mutation identifies a novel radiologic and molecular subtype of WHO grade II gliomas with dismal prognosis Acta Neuropathol 120 719 729 21080178 10.1007/s00401-010-0777-8
34. HJ Dubbink W Taal R van Marion JM Kros I van Heuvel JE Bromberg BA Zonnenberg CB Zonnenberg TJ Postma JM Gijtenbeek W Boogerd FH Groenendijk PA Smitt WN Dinjens MJ van den Bent 2009 IDH1 mutations in low-grade astrocytomas predict survival but not response to temozolomide Neurology 73 1792 1795 19933982 10.1212/WNL.0b013e3181c34ace 1:CAS:528:DC%2BD1MXhsVaks77K
35. Jones DT, Mulholland SA, Pearson DM, Malley DS, Openshaw SW, Lambert SR, Liu L, Backlund LM, Ichimura K, Collins VP (2011) Adult grade II diffuse astrocytomas are genetically distinct from and more aggressive than their paediatric counterparts. Acta Neuropathol doi: 10.1007/s00401-011-0810-6
36. DN Louis H Ohgaki OD Wiestler WK Cavenee PC Burger A Jouvet BW Scheithauer P Kleihues 2007 The 2007 WHO classification of tumours of the central nervous system Acta Neuropathol 114 97 109 17618441 10.1007/s00401-007- 0243-4 (Pubitemid 47103521)
37. Kim YH, Lachuer J, Mittelbronn M, Paulus W, Brokinkel B, Keyvani K, Sure U, Wrede K, Nobusawa S, Nakazato Y, Tanaka Y, Vital A, Mariani L, Ohgaki H (2011) Alterations in the RB1 pathway in low-grade diffuse gliomas lacking common genetic alterations. Brain Pathol doi: 10.1111/j.1750-3639.2011.00492.x
38. A Korshunov J Meyer D Capper A Christians M Remke H Witt S Pfister A von Deimling C Hartmann 2009 Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma Acta Neuropathol 118 401 405 19543740 10.1007/s00401-009-0550-z 1:CAS:528:DC%2BD1MXptVGjt7c%3D
39. DT Jones S Kocialkowski L Liu DM Pearson LM Backlund K Ichimura VP Collins 2008 Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas Cancer Res 68 8673 8677 18974108 10.1158/0008-5472.CAN-08-2097 1:CAS:528:DC%2BD1cXhtlSktbfM
40. Horbinski C, Kofler J, Yeaney G, Camelo-Piragua S, Venneti S, Louis DN, Perry A, Murdoch G, Nikiforova M (2011) Isocitrate dehydrogenase 1 analysis differentiates gangliogliomas from infiltrative gliomas. Brain Pathol doi: 10.1111/j.1750-3639.2011.00480.x
41. IF Pollack RL Hamilton RW Sobol MN Nikiforova MA Lyons-Weiler WA Laframboise PC Burger DJ Brat MK Rosenblum EJ Holmes T Zhou RI Jakacki 2011 IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children's Oncology Group Childs Nerv Syst 27 87 94 20725730 10.1007/s00381-010-1264-1
42. K Garber 2010 Oncometabolite? IDH1 discoveries raise possibility of new metabolism targets in brain cancers and leukemia J Natl Cancer Inst 102 926 928 20576929 10.1093/jnci/djq262 1:CAS:528:DC%2BC3cXptlegsL0%3D
43. NK Kloosterhof LB Bralten HJ Dubbink PJ French MJ van den Bent 2011 Isocitrate dehydrogenase-1 mutations: a fundamentally new understanding of diffuse glioma? Lancet Oncol 12 83 91 20615753 10.1016/S1470-2045(10)70053-X 1:CAS:528:DC%2BC3MXhtF2ktQ%3D%3D
44. Y Fu R Huang J Du R Yang N An A Liang 2010 Glioma-derived mutations in IDH: from mechanism to potential therapy Biochem Biophys Res Commun 397 127 130 20510884 10.1016/j.bbrc.2010.05.115 1:CAS:528:DC%2BC3cXotVChtbk%3D
45. +-dependent isocitrate dehydrogenase J Biol Chem 282 13385 13394 17350954 10.1074/jbc.M700303200 1:CAS:528:DC%2BD2sXks1GgsLc%3D (Pubitemid 47100548)
46. H Noushmehr DJ Weisenberger K Diefes HS Phillips K Pujara BP Berman F Pan CE Pelloski EP Sulman KP Bhat RG Verhaak KA Hoadley DN Hayes CM Perou HK Schmidt L Ding RK Wilson D Van Den Berg H Shen H Bengtsson P Neuvial LM Cope J Buckley JG Herman SB Baylin PW Laird K Aldape 2010 Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma Cancer Cell 17 510 522 20399149 10.1016/j.ccr.2010.03.017 1:CAS:528: DC%2BC3cXmslKqsr0%3D
47. ME Hegi AC Diserens T Gorlia MF Hamou N de Tribolet M Weller JM Kros JA Hainfellner W Mason L Mariani JE Bromberg P Hau RO Mirimanoff JG Cairncross RC Janzer R Stupp 2005 MGMT gene silencing and benefit from temozolomide in glioblastoma N Engl J Med 352 997 1003 15758010 10.1056/NEJMoa043331 1:CAS:528:DC%2BD2MXit1Wktro%3D (Pubitemid 40349502)
48. DJ Brat WF Seiferheld A Perry EH Hammond KJ Murray AR Schulsinger MP Mehta WJ Curran 2004 Analysis of 1p, 19q, 9p, and 10q as prognostic markers for high-grade astrocytomas using fluorescence in situ hybridization on tissue microarrays from Radiation Therapy Oncology Group trials Neurooncology 6 96 103 1:CAS:528:DC%2BD2cXjs1Sqtbw%3D (Pubitemid 38455755)
49. C Dehais F Laigle-Donadey Y Marie M Kujas J Lejeune A Benouaich-Amiel M Pedretti M Polivka KH Xuan J Thillet JY Delattre M Sanson 2006 Prognostic stratification of patients with anaplastic gliomas according to genetic profile Cancer (Phila) 107 1891 1897 10.1002/cncr.22211 1:CAS:528:DC%2BD28Xht1Cms7fI (Pubitemid 44582960)