Stereoselective synthesis of F-ring saturated estrone-derived inhibitors of hedgehog signaling based on cyclopamine

Organic Letters

Volumn 13, Issue 18, 2011, Pages 4786-4789

  Zhang, Zhihui ^a   Baubet, Valérie ^b   Ventocilla, Christian ^a   Xiang, Chaomei ^b   Dahmane, Nadia ^b   Winkler, Jeffrey D ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPAMINE; DRUG DERIVATIVE; ESTRONE; SONIC HEDGEHOG PROTEIN; VERATRUM ALKALOID;

ANIMAL; ARTICLE; CELL LINE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; CYCLIZATION; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM; SIGNAL TRANSDUCTION; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; CELL LINE; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; ESTRONE; HEDGEHOG PROTEINS; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; SIGNAL TRANSDUCTION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VERATRUM ALKALOIDS;

EID: 80052709987     PISSN: 15237060     EISSN: 15237052     Source Type: Journal    
DOI: 10.1021/ol2017966     Document Type: Article

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