메뉴 건너뛰기




Volumn 6, Issue 10, 2008, Pages 1607-1620

RhoA silencing reverts the resistance to doxorubicin in human colon cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; DOXORUBICIN; GLYCOPROTEIN P; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MULTIDRUG RESISTANCE PROTEIN 3; NITRIC OXIDE SYNTHASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA;

EID: 54249105822     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-08-0251     Document Type: Article
Times cited : (47)

References (43)
  • 1
    • 0028224534 scopus 로고
    • Cell biological mechanisms of multidrug resistance in tumors
    • Simon SM, Schindler M. Cell biological mechanisms of multidrug resistance in tumors. Proc Natl Acad Sci U S A 1994;91:3497-504.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 3497-3504
    • Simon, S.M.1    Schindler, M.2
  • 2
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • Gottesman MM, Fojo T, Bates SE. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2002;2:48-58.
    • (2002) Nat Rev Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 3
    • 0242331206 scopus 로고    scopus 로고
    • Drug resistance reversal-are we getting closer?
    • Baird RD, Kaye SB. Drug resistance reversal-are we getting closer? Eur J Cancer 2003;39:2450-61.
    • (2003) Eur J Cancer , vol.39 , pp. 2450-2461
    • Baird, R.D.1    Kaye, S.B.2
  • 4
    • 0014683936 scopus 로고
    • Cardiac toxicity of daunorubicin
    • Bonadonna G, Monfardini S. Cardiac toxicity of daunorubicin. Lancet 1969;1:837.
    • (1969) Lancet , vol.1 , pp. 837
    • Bonadonna, G.1    Monfardini, S.2
  • 5
    • 33644854484 scopus 로고    scopus 로고
    • Rho GTPases: Promising cellular targets for novel anticancer drugs
    • Fritz G, Kaina B. Rho GTPases: promising cellular targets for novel anticancer drugs. Curr Cancer Drug Targets 2006;6:1-14.
    • (2006) Curr Cancer Drug Targets , vol.6 , pp. 1-14
    • Fritz, G.1    Kaina, B.2
  • 7
    • 29044440878 scopus 로고    scopus 로고
    • Anti-angiogenic and anti-inflammatory effects of statins: Relevance to anti-cancer therapy
    • Dulak J, Józkowicz A. Anti-angiogenic and anti-inflammatory effects of statins: relevance to anti-cancer therapy. Curr Cancer Drug Targets 2005;5:579-94.
    • (2005) Curr Cancer Drug Targets , vol.5 , pp. 579-594
    • Dulak, J.1    Józkowicz, A.2
  • 8
    • 0030003252 scopus 로고    scopus 로고
    • MDR1 expression in solid tumours
    • Goldstein LJ. MDR1 expression in solid tumours. Eur J Cancer 1996;32:1039-50.
    • (1996) Eur J Cancer , vol.32 , pp. 1039-1050
    • Goldstein, L.J.1
  • 9
    • 12544258857 scopus 로고    scopus 로고
    • Nitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug efflux
    • Riganti C, Miraglia E, Viarisio D, et al. Nitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug efflux. Cancer Res 2005;65:516-25.
    • (2005) Cancer Res , vol.65 , pp. 516-525
    • Riganti, C.1    Miraglia, E.2    Viarisio, D.3
  • 11
    • 0142200264 scopus 로고    scopus 로고
    • RhoA negatively regulates cytokine-mediated inducible nitric oxide synthase expression in brain-derived transformed cell lines: Negative regulation of IKKα
    • Rattan R, Giri S, Singh AK, Singh I. RhoA negatively regulates cytokine-mediated inducible nitric oxide synthase expression in brain-derived transformed cell lines: negative regulation of IKKα. Free Radic Biol Med 2003;39:1037-50.
    • (2003) Free Radic Biol Med , vol.39 , pp. 1037-1050
    • Rattan, R.1    Giri, S.2    Singh, A.K.3    Singh, I.4
  • 12
    • 11844269840 scopus 로고    scopus 로고
    • Phosphorylation of NF-κB and IκB proteins: Implications in cancer and inflammation
    • Viatour P, Merville MP, Bours V, Chariot A. Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation. Trends Biochem Sci 2005;30:43-52.
    • (2005) Trends Biochem Sci , vol.30 , pp. 43-52
    • Viatour, P.1    Merville, M.P.2    Bours, V.3    Chariot, A.4
  • 14
    • 0042357102 scopus 로고    scopus 로고
    • Differential phosphorylation of the signal-responsive domain of IκBα and IκBβ by IKB kinases
    • Wu C, Ghosh S. Differential phosphorylation of the signal-responsive domain of IκBα and IκBβ by IKB kinases. J Biol Chem 2003;278:31980-7.
    • (2003) J Biol Chem , vol.278 , pp. 31980-31987
    • Wu, C.1    Ghosh, S.2
  • 15
    • 26944491533 scopus 로고    scopus 로고
    • Activation of NF-κB following detachment delays apoptosis in intestinal epithelial cells
    • Yan SR, Joseph RR, Rosen K, et al. Activation of NF-κB following detachment delays apoptosis in intestinal epithelial cells. Oncogene 2005;24:6482-91.
    • (2005) Oncogene , vol.24 , pp. 6482-6491
    • Yan, S.R.1    Joseph, R.R.2    Rosen, K.3
  • 16
    • 0008632564 scopus 로고
    • Expression of a full length cDNA for the human MDR1 gene confers resistance to colchicines, doxorubicin and vinblastine
    • Ueda K, Cardarelli C, Gottesman MM, Pastan I. Expression of a full length cDNA for the human MDR1 gene confers resistance to colchicines, doxorubicin and vinblastine. Proc Natl Acad Sci U S A 1987;84:3004-8.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 3004-3008
    • Ueda, K.1    Cardarelli, C.2    Gottesman, M.M.3    Pastan, I.4
  • 17
    • 0027095653 scopus 로고
    • Overexpression of a transporter gene in a multidrug-resistant human lung cancer line
    • Cole SP, Bhardwaj G, Gerlach JH, et al. Overexpression of a transporter gene in a multidrug-resistant human lung cancer line. Science 1992;258:1650-4.
    • (1992) Science , vol.258 , pp. 1650-1654
    • Cole, S.P.1    Bhardwaj, G.2    Gerlach, J.H.3
  • 19
    • 0037358040 scopus 로고    scopus 로고
    • Overcoming multidrug resistance in cancer: An update on the clinical strategy of inhibiting P-glycoprotein
    • Thomas H, Coley HM. Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting P-glycoprotein. Cancer Causes Control 2003;10:159-65.
    • (2003) Cancer Causes Control , vol.10 , pp. 159-165
    • Thomas, H.1    Coley, H.M.2
  • 20
    • 1542328234 scopus 로고    scopus 로고
    • The IKK/NF-κB activation pathway - a target for prevention and treatment of cancer
    • Greten FR, Karin M. The IKK/NF-κB activation pathway - a target for prevention and treatment of cancer. Cancer Lett 2004;206:193-9.
    • (2004) Cancer Lett , vol.206 , pp. 193-199
    • Greten, F.R.1    Karin, M.2
  • 21
    • 33644946838 scopus 로고    scopus 로고
    • Simvastatin prevents oxygen and glucose deprivation/reoxygenation-induced death of cortical neurons by reducing the production and toxicity of 4-hydroxy-2E-nonenal
    • Lim JH, Lee J-C, Lee YH, et al. Simvastatin prevents oxygen and glucose deprivation/reoxygenation-induced death of cortical neurons by reducing the production and toxicity of 4-hydroxy-2E-nonenal. J Neurochem 2006;97:140-50.
    • (2006) J Neurochem , vol.97 , pp. 140-150
    • Lim, J.H.1    Lee, J.-C.2    Lee, Y.H.3
  • 22
    • 33846896918 scopus 로고    scopus 로고
    • Simvastatin potentiates TNF-α-induced apoptosis through the down-regulation of NF-κB-dependent antiapoptotic gene products: Role of IκB-α kinase and TGFβ-activated kinase-1
    • Ahn KS, Sethi G, Aggarwal BB. Simvastatin potentiates TNF-α-induced apoptosis through the down-regulation of NF-κB-dependent antiapoptotic gene products: role of IκB-α kinase and TGFβ-activated kinase-1. J Immunol 2007;178:2507-16.
    • (2007) J Immunol , vol.178 , pp. 2507-2516
    • Ahn, K.S.1    Sethi, G.2    Aggarwal, B.B.3
  • 23
    • 33644834412 scopus 로고    scopus 로고
    • The role of Rho-associated kinase in differential regulation by statins of interleukin-1β- and lipopolysaccharide-mediated nuclear factor κB activation and inducible nitricoxide synthase gene expression in vascular smooth muscle cells
    • Wei CY, Huang KC, Chou YH, Hsieh PF, Lin KH, Lin WW. The role of Rho-associated kinase in differential regulation by statins of interleukin-1β- and lipopolysaccharide-mediated nuclear factor κB activation and inducible nitricoxide synthase gene expression in vascular smooth muscle cells. Mol Pharmacol 2006;69:960-7.
    • (2006) Mol Pharmacol , vol.69 , pp. 960-967
    • Wei, C.Y.1    Huang, K.C.2    Chou, Y.H.3    Hsieh, P.F.4    Lin, K.H.5    Lin, W.W.6
  • 24
    • 34548723474 scopus 로고    scopus 로고
    • RhoA regulation of NF-κB activation is mediated by COX-2-dependent feedback inhibition of IKK in kidney epithelial cells
    • Polk WW, Ellis ME, Kushleika JV, Simmonds PL, Woods JS. RhoA regulation of NF-κB activation is mediated by COX-2-dependent feedback inhibition of IKK in kidney epithelial cells. Am J Physiol Cell Physiol 2007;293:C1160-70.
    • (2007) Am J Physiol Cell Physiol , vol.293
    • Polk, W.W.1    Ellis, M.E.2    Kushleika, J.V.3    Simmonds, P.L.4    Woods, J.S.5
  • 25
    • 33750939673 scopus 로고    scopus 로고
    • RhoA-mediated, tumor necrosis factor α-induced activation of NF-κB in rheumatoid synoviocytes. Inhibitory effect of simvastatin
    • Xu H, Liu P, Liang L, et al. RhoA-mediated, tumor necrosis factor α-induced activation of NF-κB in rheumatoid synoviocytes. Inhibitory effect of simvastatin. Arthritis Rheum 2006;54:3441-51.
    • (2006) Arthritis Rheum , vol.54 , pp. 3441-3451
    • Xu, H.1    Liu, P.2    Liang, L.3
  • 26
    • 34548308458 scopus 로고    scopus 로고
    • Simvastatin enhances induction of inducible nitric oxide synthase in 3T3-L1 adipocytes
    • Araki S, Dobashi K, Asayama K, Shirahata A. Simvastatin enhances induction of inducible nitric oxide synthase in 3T3-L1 adipocytes. Free Radic Res 2007;41:1028-34.
    • (2007) Free Radic Res , vol.41 , pp. 1028-1034
    • Araki, S.1    Dobashi, K.2    Asayama, K.3    Shirahata, A.4
  • 28
    • 0035864344 scopus 로고    scopus 로고
    • Inhibition of NF-κB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) and doxorubicin
    • Arlt A, Vorndamm J, Breitenbroich M, et al. Inhibition of NF-κB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) and doxorubicin. Oncogene 2001;20:859-68.
    • (2001) Oncogene , vol.20 , pp. 859-868
    • Arlt, A.1    Vorndamm, J.2    Breitenbroich, M.3
  • 29
    • 0034192390 scopus 로고    scopus 로고
    • Inducible chemoresistance to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor-κB activation
    • Cusack JC, Liu R, Baldwin AS. Inducible chemoresistance to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor-κB activation. Cancer Res 2000;60:2323-30.
    • (2000) Cancer Res , vol.60 , pp. 2323-2330
    • Cusack, J.C.1    Liu, R.2    Baldwin, A.S.3
  • 30
    • 0037427122 scopus 로고    scopus 로고
    • NF-κB transcription factor induce drug resistance through MDR1 expression in cancer cells
    • Bentires-Alj M, Barbu V, Fillet M, et al. NF-κB transcription factor induce drug resistance through MDR1 expression in cancer cells. Oncogene 2003;22:90-7.
    • (2003) Oncogene , vol.22 , pp. 90-97
    • Bentires-Alj, M.1    Barbu, V.2    Fillet, M.3
  • 31
    • 0034662496 scopus 로고    scopus 로고
    • Huang Y, Johnson K, Norris J, Fan W. NF-κB/IκB signalling pathway may contribute to the mediation of paclitaxel-induced apoptosis in solid tumor cells. Cancer Res 2000;60:4426-32.
    • Huang Y, Johnson K, Norris J, Fan W. NF-κB/IκB signalling pathway may contribute to the mediation of paclitaxel-induced apoptosis in solid tumor cells. Cancer Res 2000;60:4426-32.
  • 32
    • 0033573850 scopus 로고    scopus 로고
    • Negative regulation of MDR1 promoter activity in MCF-7, but not in multidrug resistant MCF-7/Adr cells by cross-coupled NF-κB/p65 and c-Fos transcription factors and their interaction with the CAAT region
    • Ogretmen B, Safa AR. Negative regulation of MDR1 promoter activity in MCF-7, but not in multidrug resistant MCF-7/Adr cells by cross-coupled NF-κB/p65 and c-Fos transcription factors and their interaction with the CAAT region. Biochemistry 1999;38:2189-99.
    • (1999) Biochemistry , vol.38 , pp. 2189-2199
    • Ogretmen, B.1    Safa, A.R.2
  • 33
    • 4444282702 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion mediated drug resistance (CAM-DR) in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase
    • Schmidmaier R, Baumann P, Simsek M, Dayyani F, Emmerich B, Meinhardt G. The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion mediated drug resistance (CAM-DR) in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase. Blood 2004;104:1825-32.
    • (2004) Blood , vol.104 , pp. 1825-1832
    • Schmidmaier, R.1    Baumann, P.2    Simsek, M.3    Dayyani, F.4    Emmerich, B.5    Meinhardt, G.6
  • 34
    • 0037380839 scopus 로고    scopus 로고
    • Small interfering RNA-induced suppression of MDR1 (P-glycoprotein) restores sensitivity to multidrug-resistant cancer cells
    • Wu H, Hait WN, Yang JM. Small interfering RNA-induced suppression of MDR1 (P-glycoprotein) restores sensitivity to multidrug-resistant cancer cells. Cancer Res 2003;63:1515-19.
    • (2003) Cancer Res , vol.63 , pp. 1515-1519
    • Wu, H.1    Hait, W.N.2    Yang, J.M.3
  • 35
    • 0037526598 scopus 로고    scopus 로고
    • Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi)
    • Nieth C, Priebsch A, Stege A, Lage H. Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi). FEBS Lett 2003;545:144-50.
    • (2003) FEBS Lett , vol.545 , pp. 144-150
    • Nieth, C.1    Priebsch, A.2    Stege, A.3    Lage, H.4
  • 36
    • 4243068680 scopus 로고    scopus 로고
    • Complete reversal of multidrug resistance by stable expression of small interfering RNAs targeting MDR1
    • Yague E, Higgins CF, Raguz S. Complete reversal of multidrug resistance by stable expression of small interfering RNAs targeting MDR1. Gene Ther 2004;11:1170-74.
    • (2004) Gene Ther , vol.11 , pp. 1170-1174
    • Yague, E.1    Higgins, C.F.2    Raguz, S.3
  • 37
    • 19944432271 scopus 로고    scopus 로고
    • Anti-RhoA and Anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo
    • Pillè JY, Denoyelle C, Varet J, et al. Anti-RhoA and Anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo. Mol Ther 2005;11:267-74.
    • (2005) Mol Ther , vol.11 , pp. 267-274
    • Pillè, J.Y.1    Denoyelle, C.2    Varet, J.3
  • 38
    • 33846169452 scopus 로고    scopus 로고
    • Intravenous delivery of anti-RhoA small interfering RNA loaded in nanoparticles of chitosan in mice: Safety and efficacy in xenografted aggressive breast cancer
    • Pillè JY, Li H, Blot E, et al. Intravenous delivery of anti-RhoA small interfering RNA loaded in nanoparticles of chitosan in mice: safety and efficacy in xenografted aggressive breast cancer. Hum Gene Ther 2006;17:1019-26.
    • (2006) Hum Gene Ther , vol.17 , pp. 1019-1026
    • Pillè, J.Y.1    Li, H.2    Blot, E.3
  • 39
    • 3042616417 scopus 로고    scopus 로고
    • Simian virus 40 infection downregulates the expression of nitric oxide synthase in human mesothelial cells
    • Aldieri E, Orecchia S, Ghigo D, et al. Simian virus 40 infection downregulates the expression of nitric oxide synthase in human mesothelial cells. Cancer Res 2004;64:4082-84.
    • (2004) Cancer Res , vol.64 , pp. 4082-4084
    • Aldieri, E.1    Orecchia, S.2    Ghigo, D.3
  • 40
    • 33846849033 scopus 로고    scopus 로고
    • Identification of a classic cytokine-induced enhancer upstream in the human iNOS promoter
    • Guo Z, Shao L, Du Q, Soo Park K, Geller DA. Identification of a classic cytokine-induced enhancer upstream in the human iNOS promoter. FASEB J 2006;21:535-42.
    • (2006) FASEB J , vol.21 , pp. 535-542
    • Guo, Z.1    Shao, L.2    Du, Q.3    Soo Park, K.4    Geller, D.A.5
  • 41
    • 0002719981 scopus 로고
    • Red cell metabolism
    • New York: Grune & Stratton;
    • Beutler E. Red cell metabolism. A manual of biochemical methods. New York: Grune & Stratton; 1971. p. 56-68.
    • (1971) A manual of biochemical methods , pp. 56-68
    • Beutler, E.1
  • 42
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-59.
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 43
    • 20144378327 scopus 로고    scopus 로고
    • Control of P-glycoprotein activity by membrane cholesterol amounts and their relation to multidrug resistance in human CEM leukemia cells
    • Gayet L, Dayan G, Barakat S, et al. Control of P-glycoprotein activity by membrane cholesterol amounts and their relation to multidrug resistance in human CEM leukemia cells. Biochemistry 2005;44:4499-509.
    • (2005) Biochemistry , vol.44 , pp. 4499-4509
    • Gayet, L.1    Dayan, G.2    Barakat, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.