Elevated levels of DNA methylation at the OPRM1 promoter in blood and sperm from male opioid addicts

Journal of Opioid Management

Volumn 7, Issue 4, 2011, Pages 258-264

  Chorbov, Vesselin M ^a   Todorov, Alexandre A ^a   Lynskey, Michael T ^a   Cicero, Theodore J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CpG island; DNA methylation; Opioid dependence; OPRM1

Indexed keywords

OPIATE;

ADULT; ARTICLE; BLOOD; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA EXTRACTION; DNA METHYLATION; EPIGENETICS; GENE; GENE SILENCING; HUMAN; HUMAN TISSUE; INHERITANCE; KRUSKAL WALLIS TEST; MALE; OPIATE ADDICTION; OPRM1 GENE; PATERNALISM; PROMOTER REGION; SPERM;

ADULT; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; CPG ISLANDS; DISCRIMINANT ANALYSIS; DNA METHYLATION; GENETIC PREDISPOSITION TO DISEASE; HEREDITY; HEROIN DEPENDENCE; HUMANS; MALE; MISSOURI; OPIOID-RELATED DISORDERS; PEDIGREE; PROMOTER REGIONS, GENETIC; RECEPTORS, OPIOID, MU; SEQUENCE ANALYSIS, DNA; SPERMATOZOA; UP-REGULATION;

EID: 80052696722     PISSN: 15517489     EISSN: None     Source Type: Journal    
DOI: 10.5055/jom.2011.0067     Document Type: Article

References (25)

1. Cadoret RJ, Troughton E, O'Gorman TW, et al.: An adoption study of genetic and environmental factors in drug abuse. Arch Gen Psychiatry. 1986; 43(12): 1131-1136. (Pubitemid 17184442)
2. Kendler KS, Jacobson KC, Prescott CA, et al.: Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins. Am J Psychiatry. 2003; 160(4): 687-695. (Pubitemid 41079601)
3. Eriksson PS, Ronnback L, Hansson E: Do persistent morphine effects involve interactions with the genome? Drug Alcohol Depend. 1989; 24(1): 39-43.
4. Champagne F, Meaney MJ: Like mother, like daughter: Evidence for non-genomic transmission of parental behavior and stress responsivity. Prog Brain Res. 2001; 133: 287-302.
5. Uhl GR, Drgon T, Johnson C, et al.: Molecular genetics of addiction and related heritable phenotypes: Genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects. Ann N Y Acad Sci. 2008; 1141: 318-381.
6. Bird AP, Wolffe AP: Methylation-induced repression - Belts, braces, and chromatin. Cell. 1999; 99(5): 451-454. (Pubitemid 129746827)
7. Fahrner JA, Eguchi S, Herman JG, et al.: Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. Cancer Res. 2002; 62(24): 7213-7218. (Pubitemid 36025241)
8. Herman JG, Baylin SB: Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med. 2003; 349(21): 2042-2054. (Pubitemid 37448928)
9. Antequera F: Structure, function and evolution of CpG island promoters. Cell Mol Life Sci. 2003; 60(8): 1647-1658.
10. Nielsen DA, Yuferov V, Hamon S, et al.: Increased OPRM1 DNA methylation in lymphocytes of methadone-maintained former heroin addicts. Neuropsychopharmacology. 2009; 34(4): 867-873.
11. Nielsen DA, Hamon S, Yuferov V, et al.: Ethnic diversity of DNA methylation in the OPRM1 promoter region in lymphocytes of heroin addicts. Hum Genet. 2010; 127(6): 639-649.
12. Hwang CK, Song KY, Kim CS, et al.: Evidence of endogenous μ opioid receptor regulation by epigenetic control of the promoters. Mol Cell Biol. 2007; 27(13): 4720-4736.
13. Agirregoitia E, Valdivia A, Carracedo A, et al.: Expression and localization of δ-, κ-, and μ-opioid receptors in human spermatozoa and implications for sperm motility. J Clin Endocrinol Metab. 2006; 91(12): 4969-4975. (Pubitemid 44917336)
14. Cicero TJ, Davis LA, LaRegina MC, et al.: Chronic opiate exposure in the male rat adversely affects fertility. Pharmacol Biochem Behav. 2002; 72(1-2): 157-163. (Pubitemid 34251322)
15. Cicero TJ, Meyer ER, Wiest WG, et al.: Effects of chronic morphine administration on the reproductive system of the male rat. J Pharmacol Exp Ther. 1975; 192(3): 542-548.
16. Houshdaran S, Cortessis VK, Siegmund K, et al.: Widespread epigenetic abnormalities suggest a broad DNA methylation erasure defect in abnormal human sperm. PLoS One. 2007; 2(12): e1289.
17. McLellan AT, Luborsky L, Woody GE, et al.: An improved diagnostic evaluation instrument for substance abuse patients. The Addiction Severity Index. J Nerv Ment Dis. 1980; 168(1): 26-33.
18. Benjamini Y, Hochberg Y: Controlling the false discovery rate: A practical and powerful approach to multiple testing. J R Stat Soc B. 1995; 57(1): 289-300.
19. Oakes CC, La Salle S, Smiraglia DJ, et al.: Developmental acquisition of genome-wide DNA methylation occurs prior to meiosis in male germ cells. Dev Biol. 2007; 307(2): 368-379. (Pubitemid 47001363)
20. Li H, Liu H, Wang Z, et al.: The role of transcription factors Sp1 and YY1 in proximal promoter region in initiation of transcription of the μ opioid receptor gene in human lymphocytes. J Cell Biochem. 2008; 104(1): 237-250.
21. Hwang CK, Kim CS, Kim do K, et al.: Up-regulation of the μ-opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells. Mol Pharmacol. 2010; 78(1): 58-68.
22. Weber M, Schubeler D: Genomic patterns of DNA methylation: Targets and function of an epigenetic mark. Curr Opin Cell Biol. 2007; 19(3): 273-280. (Pubitemid 46899512)
23. Tian M, Broxmeyer HE, Fan Y, et al.: Altered hematopoiesis, behavior, and sexual function in μ opioid receptor-deficient mice. J Exp Med. 1997; 185(8): 1517-1522. (Pubitemid 27187610)
24. Novikova SI, He F, Bai J, et al.: Maternal cocaine administration in mice alters DNA methylation and gene expression in hippocampal neurons of neonatal and prepubertal offspring. PLoS One. 2008; 3(4): e1919.
25. Renthal W, Nestler EJ: Chromatin regulation in drug addiction and depression. Dialogues Clin Neurosci. 2009; 11(3): 257-268.