The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis

Journal of Nephrology

Volumn 24, Issue 5, 2011, Pages 647-655

  Bramlage, Carsten P ^a   Müller, Gerhard A ^a   Tampe, Björn ^a   Bevanda, Jelena ^a   Maatouk, Imad ^a   Koziolek, Michael ^a   Lange, Katharina ^a   Ahrens, Katharina ^b   Schmid, Holger ^c   Cohen, Clemens D ^d   Bramlage, Peter ^b   Kretzler, Matthias ^e   Strutz, Frank ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b Institute for Cardiovascular Pharmacology and Epidemiology   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

BMP 5; HK 2 cells; Nephrosclerosis

Indexed keywords

ANGIOTENSIN II; BONE MORPHOGENETIC PROTEIN 5; BONE MORPHOGENETIC PROTEIN RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; APOPTOSIS; ARTICLE; CELL MIGRATION; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTENSIVE NEPHROSCLEROSIS; KIDNEY TUBULE CELL; MALE; MONONUCLEAR CELL; NEPHROSCLEROSIS; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

AGED; ANGIOTENSIN II; APOPTOSIS; BIOPSY; BONE MORPHOGENETIC PROTEIN 5; BONE MORPHOGENETIC PROTEIN RECEPTORS; CELL LINE; CELL MOVEMENT; DOWN-REGULATION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HUMANS; HYPERTENSION; IMMUNOHISTOCHEMISTRY; KIDNEY TUBULES; MALE; MIDDLE AGED; NEPHROSCLEROSIS; REAL-TIME POLYMERASE CHAIN REACTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80052689321     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: 10.5301/JN.2011.6330     Document Type: Article

References (18)

1. Dudley AT, Lyons KM, Robertson EJ. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev. 1995;9:2795-2807.
2. Luo G, Hofmann C, Bronckers AL, Sohocki M, Bradley A, Karsenty G. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev. 1995;9:2808-2820.
3. Morrissey J, Hruska K, Guo G, Wang S, Chen Q, Klahr S. Bone morphogenetic protein-7 improves renal fibrosis and accelerates the return of renal function. J Am Soc Nephrol. 2002;13(Suppl 1):S14-S21.
4. Vukicevic S, Basic V, Rogic D, et al. Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat. J Clin Invest. 1998;102:202-214.
5. Zeisberg M, Hanai J, Sugimoto H, et al. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med. 2003;9:964-968.
6. Kingsley DM, Bland AE, Grubber JM, et al. The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily. Cell. 1992;71:399-410.
7. Zhao GQ. Consequences of knocking out BMP signaling in the mouse. Genesis. 2003;35:43-56.
8. Dudley AT, Robertson EJ. Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos. Dev Dyn. 1997;208:349-362.
9. Ozkaynak E, Schnegelsberg PN, Jin DF, et al. Osteogenic protein-2: a new member of the transforming growth factorbeta superfamily expressed early in embryogenesis. J Biol Chem. 1992;267:25220-25227.
10. Bramlage CP, Haupl T, Kaps C, et al. Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis. Arthritis Res Ther. 2006;8:R58.
11. Cohen CD, Frach K, Schlondorff D, Kretzler M. Quantitative gene expression analysis in renal biopsies: a novel protocol for a high-throughput multicenter application. Kidney Int. 2002;61:133-140.
12. Koziolek MJ, Schmid H, Cohen CD, et al. Potential role of fractalkine receptor expression in human renal fibrogenesis. Kidney Int. 2007;72:599-607. Published online June 20, 2007.
13. Ryan MJ, Johnson G, Kirk J, Fuerstenberg SM, Zager RA, Torok-Storb B. HK-2: an immortalized proximal tubule epithelial cell line from normal adult human kidney. Kidney Int. 1994;45:48-57.
14. Hagemann T, Robinson SC, Schulz M, Trumper L, Balkwill FR, Binder C. Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNFalpha dependent up-regulation of matrix metalloproteases. Carcinogenesis. 2004;25:1543-1549.
15. Strutz F, Zeisberg M, Ziyadeh FN, et al. Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation. Kidney Int. 2002;61:1714-1728.
16. Wetzel P, Haag J, Campean V, et al. Bone morphogenetic protein-7 expression and activity in the human adult normal kidney is predominantly localized to the distal nephron. Kidney Int. 2006;70:717-723.
17. Yanagita M. Modulator of bone morphogenetic protein activity in the progression of kidney diseases. Kidney Int. 2006;70:989-993.
18. Bramlage CP, Kaps C, Ungethum U, et al. Modulatory effects of inflammation and therapy on GDF-5 expression in rheumatoid arthritis synovium. Scand J Rheumatol. 2008;37:401-409.