Modulatory effects of inflammation and therapy on GDF-5 expression in rheumatoid arthritis synovium

Scandinavian Journal of Rheumatology

Volumn 37, Issue 6, 2008, Pages 401-409

  Bramlage, C P ^a   Kaps, C ^b   Ungethum, U ^b   Bramlage, P ^c   Koziolek, M ^a   Wessels, J ^a   Krenn, V ^d   Pruss A ^b   Muller G A ^a   Strutz, F ^a   Burmester, G R ^b   Haupl T ^b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d Institute of Pathology   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE MODIFYING ANTIRHEUMATIC DRUG; GLUCOCORTICOID; GROWTH DIFFERENTIATION FACTOR 5; INTERLEUKIN 1BETA; METHOTREXATE; PREDNISOLONE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; BLOOD CELL; CELL ASSAY; CELL STIMULATION; CHEMOTAXIS; CLINICAL ARTICLE; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; IN SITU HYBRIDIZATION; MACROPHAGE; MACROPHAGE MIGRATION; MICROARRAY ANALYSIS; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVIUM;

ADULT; AGED; AGED, 80 AND OVER; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; CELL MIGRATION ASSAYS, MACROPHAGE; CYTOKINES; DOWN-REGULATION; FIBROBLASTS; GENE EXPRESSION; GLUCOCORTICOIDS; GROWTH DIFFERENTIATION FACTOR 5; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSION; IN SITU HYBRIDIZATION; METHOTREXATE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREDNISOLONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SYNOVIAL MEMBRANE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 56249110601     PISSN: 03009742     EISSN: 15027732     Source Type: Journal    
DOI: 10.1080/03009740802120010     Document Type: Article

References (33)

1. BramLage CP, Haupl T, Kaps C, Ungethum U, Krenn V, Pruss A, et al. Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis. Arthritis Res Ther 2006;8:R58.
2. Kaps C, BramLage C, Smolian H, Haisch A, Ungethum U, Burmester GR, et al. Bone morphogenetic proteins promote cartilage differentiation and protect engineered artificial cartilage from fibroblast invasion and destruction. Arthritis Rheum 2002;46:149-62.
3. BramLage CP, Haupl T, Kaps C, BramLage P, Muller GA, Strutz F. Bone morphogenetic proteins in the skeletal system [in German]. Z Rheumatol 2005;64:416-22.
4. Allen JB, Manthey CL, Hand AR, Ohura K, Ellingsworth L, Wahl SM. Rapid onset synovial inflammation and hyperplasia induced by transforming growth factor beta. J Exp Med 1990;171:231-47.
5. Wolfman NM, Hattersley G, Cox K, Celeste AJ, Nelson R, Yamaji N, et al. Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family. J Clin Invest 1997;100:321-30.
6. van Beuningen HM, Glansbeek HL, van der Kraan PM, van den Berg WB. Differential effects of local application of BMP-2 or TGF-beta 1 on both articular cartilage composition and osteophyte formation. Osteoarthritis Cartilage 1998;6:306-17.
7. Merino R, Macias D, Ganan Y, Economides AN, Wang X, Wu Q, et al. Expression and function of Gdf-5 during digit skeletogenesis in the embryonic chick leg bud. Dev Biol 1999;206:33-45.
8. Storm EE, Kingsley DM. GDF5 coordinates bone and joint formation during digit development. Dev Biol 1999;209:11-27.
9. Kingsley DM, Bland AE, Grubber JM, Marker PC, Russell LB, Copeland NG, et al. The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily. Cell 1992;71:399-410.
10. Buxton P, Edwards C, Archer CW, Francis-West P. Growth/differentiation factor-5 (GDF-5) and skeletal development. J Bone Joint Surg Am 2001;83-A Suppl 1(Pt 1):S23-30.
11. Edwards CJ, Francis-West PH. Bone morphogenetic proteins in the development and healing of synovial joints. Semin Arthritis Rheum 2001;31:33-42.
12. Coleman CM, Tuan RS. Functional role of growth/differentiation factor 5 in chondrogenesis of limb mesenchymal cells. Mech Dev 2003;120:823-36.
13. Katayama R, Wakitani S, Tsumaki N, Morita Y, Matsushita I, Gejo R, et al. Repair of articular cartilage defects in rabbits using CDMP1 gene-transfected autologous mesenchymal cells derived from bone marrow. Rheumatology (Oxford) 2004;43:980-5.
14. Simank HG, Sergi C, Jung M, Adolf S, Eckhardt C, Ehemann V, et al. Effects of local application of growth and differentiation factor-5 (GDF-5) in a full-thickness cartilage defect model. Growth Factors 2004;22:35-43.
15. Miyamoto Y, Mabuchi A, Shi D, Kubo T, Takatori Y, Saito S, et al. A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis. Nat Genet 2007;39:529-33.
16. Cuchacovich M, Soto L, Edwardes M, Gutierrez M, Llanos C, Pacheco D, et al. Tumour necrosis factor (TNF)alpha -308 GIG promoter polymorphism and TNFalpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis. Scand J Rheumatol 2006;35:435-40.
17. Kim HR, Kim HS, Park MK, Cho ML, Lee SH, Kim HY. The clinical role of IL-23p19 in patients with rheumatoid arthritis. Scand J Rheumatol 2007;36:259-64.
18. Morita Y, Fukazawa T, Hirashima M, Kaga K, Kusaoi M, Morita T, et al. The effect of methotrexate (MTX) on expression of signalling lymphocytic activation molecule (SLAM) in patients with rheumatoid arthritis (RA) and its role in the regulation of cytokine production. Scand J Rheumatol 2006;35:268-72.
19. Vergunst CE, van de Sande MG, Lebre MC, Tak PP. The role of chemokines in rheumatoid arthritis and osteoarthritis. Scand J Rheumatol 2005;34:415-25.
20. Lories RJ, Derese I, Ceuppens JL, Luyten FP. Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis. Arthritis Rheum 2003;48:2807-18.
21. Cinelli M, Guiducci S, Del Rosso A, Pignone A, Del Rosso M, Fibbi G, et al. Piascledine modulates the production of VEGF and TIMP-1 and reduces the invasiveness of rheumatoid arthritis synoviocytes. Scand J Rheumatol 2006;35:346-50.
22. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
23. Krenn V, Morawietz L, Burmester GR, Haupl T. Synovialitis score: histopathological grading system for chronic rheumatic and non-rheumatic synovialitis [in Germani]. Z Rheumatol 2005;64:334-42.
24. Strutz F, Zeisberg M, Ziyadeh FN, Yang CQ, Kalluri R, Muller GA, et al. Role of basic fibroblast growth factor-2 in epithelialmesenchymal transformation. Kidney Tnt 2002;61:1714-28.
25. Kaps C, Frauenschuh S, Endres M, Ringe J, Haisch A, Lauber J, et al. Gene expression profiling of human articular cartilage grafts generated by tissue engineering. Biomaterials 2006;27:3617-30.
26. Nagai H, Miyamoto Y, Nakata A, Hatakeyama S, Twanami Y, Fukuda M. Isolation and characterization of synovial cells from the human temporomandibular joint. J Oral Pathol Med 2006;35:104-10.
27. Bobacz K, Gruber R, Soleiman A, Graninger WB, Luyten FP, Erlacher L. Cartilage-derived morphogenetic protein-1 and -2 are endogenously expressed in healthy and osteoarthritic human articular chondrocytes and stimulate matrix synthesis. Osteoarthritis Cartilage 2002;10:394-401.
28. Rountree RB, Schoor M, Chen H, Marks ME, Harley V, Mishina Y, et al. BMP receptor signaling is required for postnatal maintenance of articular cartilage. PLoS Biol 2004;2:e355.
29. Nishitoh H, Ichijo H, Kimura M, Matsumoto T, Makishima F, Yamaguchi A, et al. Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5. J Biol Chem 1996;271:21345-52.
30. Simank HG, Manggold J, Sebald W, Ries R, Richter W, Ewerbeck V, et al. Bone morphogenetic protein-2 and growth and differentiation factor-5 enhance the healing of necrotic bone in a sheep model. Growth Factors 2001;19:247-57.
31. Gould SE, Day M, Jones SS, Dorai H. BMP-7 regulates chemokine, cytokine, and hemodynamic gene expression in proximal tubule cells. Kidney Tnt 2002;61:51-60.
32. Leclerc N, Luppen CA, Ho VV, Nagpal S, Hacia JG, Smith E, et al. Gene expression profiling of glucocorticoid-inhibited osteoblasts. J Mol Endocrinol 2004;33:175-93.
33. Ferraccioli G, Casatta L, Bartoli E. Increase of bone mineral density and anabolic variables in patients with rheumatoid arthritis resistant to methotrexate after cyclosporin A therapy. J Rheumatol 1996;23:1539-42.