α2-Adrenoceptor-Mediated Inhibition of Catecholamine Release from the Adrenal Medulla of Spontaneously Hypertensive Rats is Preserved in the Early Stages of Hypertension

Basic and Clinical Pharmacology and Toxicology

Volumn 109, Issue 4, 2011, Pages 253-260

  Moura, Eduardo ^a,b   Pinto, Carina E ^a   Caló, Ana ^a   Serrão, Maria P ^a   Afonso, Joana ^a   Vieira Coelho, Maria A ^a,b  

^a University of Porto   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DIMETHYL 4 PHENYLPIPERAZINIUM IODIDE; ADRENALIN; ALPHA 2A ADRENERGIC RECEPTOR; ALPHA 2B ADRENERGIC RECEPTOR; ALPHA 2C ADRENERGIC RECEPTOR; MEDETOMIDINE; MESSENGER RNA; NORADRENALIN; ALPHA 2 ADRENERGIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT;

ADRENAL MEDULLA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATECHOLAMINE RELEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE COURSE; HYPERTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; SPONTANEOUSLY HYPERTENSIVE RAT; ANIMAL; DRUG EFFECT; METABOLISM; PATHOLOGY; WISTAR KYOTO RAT;

RATTUS;

ADRENAL MEDULLA; ANIMALS; DIMETHYLPHENYLPIPERAZINIUM IODIDE; EPINEPHRINE; HYPERTENSION; MALE; MEDETOMIDINE; NICOTINIC ANTAGONISTS; NOREPINEPHRINE; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 80052687362     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2011.00712.x     Document Type: Article

References (46)

1. Knaus AE, Muthig V, Schickinger S, Moura E, Beetz N, Gilsbach R et al. Alpha2-adrenoceptor subtypes - unexpected functions for receptors and ligands derived from gene-targeted mouse models. Neurochem Int 2007;51:277-81.
2. Gilsbach R, Roser C, Beetz N, Brede M, Hadamek K, Haubold M et al. Genetic dissection of alpha2-adrenoceptor functions in adrenergic versus nonadrenergic cells. Mol Pharmacol 2009;75:1160-70.
3. Vieira-Coelho MA, Serrao MP, Afonso J, Pinto CE, Moura E. Catecholamine synthesis and metabolism in the central nervous system of mice lacking alpha-adrenoceptor subtypes. Br J Pharmacol 2009;158:726-37.
4. Brede M, Nagy G, Philipp M, Sorensen JB, Lohse MJ, Hein L. Differential control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor subtypes. Mol Endocrinol 2003;17:1640-6.
5. Lymperopoulos A, Rengo G, Funakoshi H, Eckhart AD, Koch WJ. Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure. Nat Med 2007;13:315-23.
6. Moura E, Afonso J, Hein L, Vieira-Coelho MA. Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. Br J Pharmacol 2006;149:1049-58.
7. Moura E, Pinto CE, Serrao MP, Afonso J, Vieira-Coelho MA. Adrenal alpha(2)-adrenergic receptors in the aging normotensive and spontaneously hypertensive rat. Neurobiol Aging 2010 [Epub ahead of print].
8. Anderson EA, Sinkey CA, Lawton WJ, Mark AL. Elevated sympathetic nerve activity in borderline hypertensive humans. Evidence from direct intraneural recordings. Hypertension 1989;14:177-83.
9. Esler M. The sympathetic system and hypertension. Am J Hypertens 2000;13:99S-105S.
10. Mancia G, Grassi G, Giannattasio C, Seravalle G. Sympathetic activation in the pathogenesis of hypertension and progression of organ damage. Hypertension 1999;34:724-8.
11. Cabassi A, Vinci S, Calzolari M, Bruschi G, Borghetti A. Regional sympathetic activity in pre-hypertensive phase of spontaneously hypertensive rats. Life Sci 1998;62:1111-8.
12. Trippodo NC, Frohlich ED. Similarities of genetic (spontaneous) hypertension man and rat. Circ Res 1981;48:309-19.
13. Reja V, Goodchild AK, Phillips JK, Pilowsky PM. Tyrosine hydroxylase gene expression in ventrolateral medulla oblongata of WKY and SHR: a quantitative real-time polymerase chain reaction study. Auton Neurosci 2002;98:79-84.
14. Zugck C, Lossnitzer D, Backs J, Kristen A, Kinscherf R, Haass M. Increased cardiac norepinephrine release in spontaneously hypertensive rats: role of presynaptic alpha-2A adrenoceptors. J Hypertens 2003;21:1363-9.
15. Korner P, Bobik A, Oddie C, Friberg P. Sympathoadrenal system is critical for structural changes in genetic hypertension. Hypertension 1993;22:243-52.
16. Lee RM, Borkowski KR, Leenen FH, Tsoporis J, Coughlin M. Combined effect of neonatal sympathectomy and adrenal demedullation on blood pressure and vascular changes in spontaneously hypertensive rats. Circ Res 1991;69:714-21.
17. Borkowski KR, Quinn P. The effect of bilateral adrenal demedullation on vascular reactivity and blood pressure in spontaneously hypertensive rats. Br J Pharmacol 1983;80:429-37.
18. Borkowski KR, Quinn P. Adrenaline and the development of spontaneous hypertension in rats. J Auton Pharmacol 1985;5:89-100.
19. Borkowski KR. Effect of adrenal demedullation and adrenaline on hypertension development and vascular reactivity in young spontaneously hypertensive rats. J Auton Pharmacol 1991;11:1-14.
20. Moura E, Pinho Costa PM, Moura D, Guimaraes S, Vieira-Coelho MA. Decreased tyrosine hydroxylase activity in the adrenals of spontaneously hypertensive rats. Life Sci 2005;76:2953-64.
21. Moura E, Afonso J, Serrao MP, Vieira-Coelho MA. Effect of clonidine on tyrosine hydroxylase activity in the adrenal medulla and brain of spontaneously hypertensive rats. Basic Clin Pharmacol Toxicol 2009;104:113-21.
22. Trendelenburg AU, Sutej I, Wahl CA, Molderings GJ, Rump LC, Starke K. A re-investigation of questionable subclassifications of presynaptic alpha2-autoreceptors: rat vena cava, rat atria, human kidney and guinea-pig urethra. Naunyn Schmiedebergs Arch Pharmacol 1997;356:721-37.
23. Gilsbach R, Brede M, Beetz N, Moura E, Muthig V, Gerstner C et al. Heterozygous alpha 2C-adrenoceptor-deficient mice develop heart failure after transverse aortic constriction. Cardiovasc Res 2007;75:728-37.
24. Nagayama T, Matsumoto T, Yoshida M, Suzuki-Kusaba M, Hisa H, Kimura T et al. Role of cholinergic receptors in adrenal catecholamine secretion in spontaneously hypertensive rats. Am J Physiol 1999;277:R1057-62.
25. Miranda-Ferreira R, de Pascual R, de Diego AM, Caricati-Neto A, Gandia L, Jurkiewicz A et al. Single-vesicle catecholamine release has greater quantal content and faster kinetics in chromaffin cells from hypertensive, as compared with normotensive, rats. J Pharmacol Exp Therap 2008;324:685-93.
26. Lim DY, Jang SJ, Park DG. Comparison of catecholamine release in the isolated adrenal glands of SHR and WKY rats. Auton Autacoid Pharmacol 2002;22:225-32.
27. Gattu M, Terry AV Jr, Pauly JR, Buccafusco JJ. Cognitive impairment in spontaneously hypertensive rats: role of central nicotinic receptors. Part II. Brain Res 1997;771:104-14.
28. Gattu M, Pauly JR, Boss KL, Summers JB, Buccafusco JJ. Cognitive impairment in spontaneously hypertensive rats: role of central nicotinic receptors. I. Brain Res 1997;771:89-103.
29. Hernandez CM, Hoifodt H, Terry AV Jr. Spontaneously hypertensive rats: further evaluation of age-related memory performance and cholinergic marker expression. J Psychiatry Neurosci 2003;28:197-209.
30. Terry AV Jr, Hernandez CM, Buccafusco JJ, Gattu M. Deficits in spatial learning and nicotinic-acetylcholine receptors in older, spontaneously hypertensive rats. Neuroscience 2000;101:357-68.
31. Hohnadel EJ, Hernandez CM, Gearhart DA, Terry AV Jr. Effect of repeated nicotine exposure on high-affinity nicotinic acetylcholine receptor density in spontaneously hypertensive rats. Neurosci Lett 2005;382:158-63.
32. Marley PD. Desensitization of the nicotinic secretory response of adrenal chromaffin cells. Trends Pharmacol Sci 1988;9:102-7.
33. Thoren P, Ricksten SE. Recordings of renal and splanchnic sympathetic nervous activity in normotensive and spontaneously hypertensive rats. Clin Sci (Lond) 1979;57(Suppl 5):197s-9s.
34. Yamamoto J, Nakai M, Natsume T. Cardiovascular responses to acute stress in young-to-old spontaneously hypertensive rats. Hypertension 1987;9:362-70.
35. Eisenhofer G, Rundquist B, Aneman A, Friberg P, Dakak N, Kopin IJ et al. Regional release and removal of catecholamines and extraneuronal metabolism to metanephrines. J Clin Endocrinol Metab 1995;80:3009-17.
36. Esler M, Kaye D, Thompson J, Jennings G, Cox H, Turner A et al. Effects of aging on epinephrine secretion and regional release of epinephrine from the human heart. J Clin Endocrinol Metab 1995;80:435-42.
37. Armour JA. The role of peripheral autonomic neurons in cardiac regulation. In: Ardell JL, Armour JA (eds). Neurocardiology. Oxford University Press, New York, 1994;219-44.
38. Huang MH, Friend DS, Sunday ME, Singh K, Haley K, Austen KF et al. An intrinsic adrenergic system in mammalian heart. J Clin Invest 1996;98:1298-303.
39. Eisenhofer G, Kopin IJ, Goldstein DS. Catecholamine metabolism: a contemporary view with implications for physiology and medicine. Pharmacol Rev 2004;56:331-49.
40. Tsunoda M, Imai K. An assay for determination of rat adrenal catechol-O-methyltransferase activity: comparison of spontaneously hypertensive rats and Wistar-Kyoto rats. Anal Bioanal Chem 2004;380:887-90.
41. Tsuda K, Kusuyama Y, Hano T, Kuchii M, Nishio I, Masuyama Y. Alteration of presynaptic alpha 2-mediated inhibition of norepinephrine release in perfused mesenteric arteries of young and adult spontaneously hypertensive rats. J Hypertens Suppl 1984;2:S95-7.
42. Tsuda K, Kuchii M, Nishio I, Masuyama Y. Presynaptic alpha 2-adrenoceptor mediated regulation of norepinephrine release in perfused mesenteric vasculatures in young and adult spontaneously hypertensive rats. Jpn Circ J 1987;51:25-32.
43. Guimaraes S, Moura D. Vascular adrenoceptors: an update. Pharmacol Rev 2001;53:319-56.
44. Doggrell SA. Functional beta1- and beta2-adrenoceptors in the left and right atrium of pre-hypertensive rats. J Pharmacy Pharmacol 2002;54:1407-12.
45. Doggrell SA, Surman AJ. Functional beta-adrenoceptors in the left atrium of normotensive and hypertensive rats. J Auton Pharmacol 1994;14:425-36.
46. Boesen EI, Lambert GW, Anderson WP, Kett MM. Pre-weaning carvedilol treatment in spontaneously hypertensive rats. Eur J Pharmacol 2004;486:183-8.