Deficits in spatial learning and nicotinic-acetylcholine receptors in older, spontaneously hypertensive rats

Neuroscience

Volumn 101, Issue 2, 2000, Pages 357-368

  Terry Jr , A V ^a,b   Hernandez, C M ^a   Buccafusco, J J ^a,b   Gattu, M ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

bungarotoxin; Autoradiography; Cholinergic; E pibatidine; Hypertension; Memory

Indexed keywords

ALPHA BUNGAROTOXIN; CHOLINERGIC RECEPTOR; EPIBATIDINE; NICOTINIC RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; BRAIN BLOOD FLOW; CONDITIONING; CONTROLLED STUDY; LEARNING; MAZE TEST; MEMORY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; SPATIAL ORIENTATION; SPONTANEOUSLY HYPERTENSIVE RAT;

ACETYLCHOLINE; AGING; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BLOOD PRESSURE; BRAIN; BUNGAROTOXINS; HEART RATE; IODINE RADIOISOTOPES; LEARNING DISORDERS; MALE; MAZE LEARNING; PHENOTYPE; PYRIDINES; RADIOLIGAND ASSAY; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECEPTORS, NICOTINIC; SPACE PERCEPTION; SWIMMING; TRITIUM;

EID: 0034619586     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(00)00377-8     Document Type: Article

References (41)

1. Plasma membrane ordering agent (PF-68) reduces neurotransmitter uptake and release and produces learning and memory deficits in rats
2. Nicotinic binding in rat brain: Autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-alpha-bungarotoxin
3. The flexible use of multiple cue relationships in spatial navigation: A comparison of water maze performance following hippocampal, medial septal, prefrontal cortex, or posterior parietal cortex lesions
4. A neuronal nicotinic acetylcholine receptor subunit (alpha 7) is developmentally regulated and forms a homo-oligomeric channel blocked by alpha-BTX
5. Dissociation of hippocampal and striatal contributions to spatial navigation in the water maze
6. Changes in nicotinic acetylcholine receptor subunit mRNAs and nicotinic binding in spontaneously hypertensive stroke prone rats
7. Cognitive impairment in spontaneously hypertensive rats: Role of central nicotinic receptors. Part I
8. Cognitive impairment in spontaneoously hypertensive rats: Role of central nicotinic receptors. Part II
9. Muscarinic and nicotinic contributions to cognitive function and cortical blood flow
10. Distribution of nicotinic cholinergic receptors in the rat tel- and diencephalon: A quantitative receptor autoradiographical study using [3H]-acetylcholine, [alpha-125I]bungarotoxin and [3H]nicotine
11. Lern- und Gedachtnissprozesse wahrend der postnatalen Ontogenese von Ratten mit sponaer Hypertnie
12. Memory and nicotinic acetylcholine receptor (nAChR) deficits in Dahl salt sensitive rats
13. Cerebral blood flow in hypertensive patients: An initial report of reduced and compensatory blood flow responses during performance of two cognitive tasks
14. Augmented response to intrathecal nicotinic agonists in spontaneous hypertension
15. Passive-Avoidance behavior of spontaneously hypertensive rats
16. Cardiovascular response to microinjection of physostigmine and choline into the dorsal medullary site of the rat
17. Nicotinic acetylcholine involvement in cognitive function in animals
18. Nicotinic agonists modulate basal forebrain control of cortical cerebral blood flow in anesthetized rats
19. Long-term ACE inhibition doubles lifespan of hypertensive rats
20. Late treatment with ramipril increases survival in old spontaneously hypertensive rats
21. Genetically related rats with differences in hippocampal uptake of norepinephrine and maze performance
22. Hippocampal and nonhippocampal contributions to place learning in rats
23. The neuropharmacological and neurochemical basis of place learning in the Morris water maze
24. Effects of aging and hypertension on learning, memory and activity in rats
25. Impaired maze learning and cerebral glucose utilization in aged hypertensive rats
26. Development of a water-maze procedure for studying spatial learning in the rat
27. Deficits of spatial learning and working memory in spontaneously hypertensive rats
28. Neuronal nicotinic receptors in the human brain
29. An autoradiographic analysis of cholinergic receptors in mouse brain after chronic nicotine treatment
30. [3H]epibatidine labels nicotinic receptors in rat brain: An autoradiographic study
31. Nicotinic receptor subtypes in human brain ageing, Alzheimer and Lewy body diseases
32. Behavioral validation of the spontaneously hypertensive rat (SHR) as an animal model of attention-deficit/hyperactivity disorder (AD/HD)
33. Brain alpha-bungarotoxin binding protein cDNAs and MAbs reveal subtypes of this branch of the ligand-gated ion channel gene superfamily
34. Developmental aspect of 2-way shuttlebox avoidance in the spontaneously hypertensive and normtensive rat
35. Two-way shuttlebox and lever-press avoidance in the spontaneously hypertensive and normotensive rat
36. Ranitidine analog, JWS-USC-75IX, enhances memory-related task performance in rats
37. Impaired learning and memory in mature spontaneously hypertensive rats
38. Brain nicotinic cholinoreceptor binding in spontaneous hypertension
39. Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors