Tablets based on compressed zein microspheres for sustained oral administration: Design, pharmacokinetics, and clinical study

Journal of Biomaterials Applications

Volumn 26, Issue 2, 2011, Pages 195-208

  Gong, Sheng Ju ^a   Sun, Shi Xuan ^a   Sun, Qing Shen ^a   Wang, Jin Ye ^a   Liu, Xin Ming ^b   Liu, Guo Yan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

ivermectin; oral administration.; pharmacokinetics; tablets based on compressed zein microspheres; zein

Indexed keywords

CLINICAL EFFICACY; CLINICAL STUDY; DOSAGE FORMS; DRUG DELIVERY SYSTEM; HYDROPHOBIC PROTEIN; IVERMECTIN; ORAL ADMINISTRATION; PHYSIOLOGICAL CONDITION; TABLETS BASED ON COMPRESSED ZEIN MICROSPHERES; ZEIN MICROSPHERES;

BIOCHEMISTRY; DRUG DELIVERY; PATIENT TREATMENT; PHARMACOKINETICS;

MICROSPHERES;

ANTIPARASITIC AGENT; IVERMECTIN; MICROSPHERE; ZEIN;

ANIMAL; ARTICLE; BLOOD; CHEMISTRY; DELAYED RELEASE FORMULATION; DOG; DOG DISEASE; ORAL DRUG ADMINISTRATION; TABLET;

ADMINISTRATION, ORAL; ANIMALS; ANTIPARASITIC AGENTS; DELAYED-ACTION PREPARATIONS; DOG DISEASES; DOGS; IVERMECTIN; MICROSPHERES; TABLETS; ZEIN;

EID: 80052676037     PISSN: 08853282     EISSN: 15308022     Source Type: Journal    
DOI: 10.1177/0885328210363504     Document Type: Article

References (22)

1. Shukla, R. and Cheryan, M. Zein: The Industrial Protein from Corn, Ind. Crops Prod., 2001: 14: 171-192. (Pubitemid 32826511)
2. Bernstein, H., Morrel, E., Mathlowitz, E., Schwaller, K. and Thomas, R. Protein Microspheres and Methods of Using Them. US Patent No. 5679377 ; 1997.
3. Liu, L.S., Kende, M., Ruthel, G., Fishman, M.L. and Hicks, K.B. Pectin/Zein Beads for Potential Colon-Specific Drug Delivery: Synthesis and In Vitro Evaluation, Drug Deliv., 2006: 13: 417-423. (Pubitemid 44470221)
4. Liu, X.M., Sun, Q.S., Wang, H.J., Zhang, L. and Wang, J.Y. Microspheres of Corn Protein, Zein, for an Ivermectin Drug Delivery System, Biomater., 2005: 26: 109-115. (Pubitemid 38759476)
5. Lifschitz, A., Virkel, G., Sallovitz, J. et al. Comparative Distribution of Ivermectin and Doramectin to Parasite Location Tissues in Cattle, Vet. Parasitol., 2000: 87: 327-338.
6. Lo, P.K., Fink, D.W., Williams, J.B. and Blodinger, J. Pharmacokinetic Studies of Ivermectin: Effects of Formulation, Vet. Res. Commun., 1985: 9: 251-268. (Pubitemid 16239520)
7. Lifschitz, A., Virkel, G., Pis, A. et al. Ivermectin Disposition Kinetics after Subcutaneous and Intramuscular Administration of an Oil-based Formulation to Cattle, Vet. Parasitol., 1999: 86: 203-215. (Pubitemid 29425805)
8. Scott, E.W., Kinabo, L.D. and McKellar, Q.A. Pharmacokinetics of Ivermectin after Oral or Percutaneous Administration to Adult Milking Goats, J. Vet. Pharmacol. Ther., 1990: 13: 432-435.
9. Laffont, C.M., Alvinerie, M., Bousquet-Mélou, A. and Toutain, P.L. Licking Behaviour and Environmental Contamination Arising from Pour-on Ivermectin for Cattle, Int. J. Parasitol., 2001: 31: 1687-1692. (Pubitemid 33152825)
10. Lespine, A., Sutra, J.F., Dupuy, J. and Alvinerie, M. Eprinomectinin in Goat: Assessment of Subcutaneous Administration, Parasitol. Res., 2003: 89: 120-122. (Pubitemid 36057047)
11. Gokbulut, C., Karademir, U., Boyacioglu, M. and McKellar, Q.A. Comparative Plasma Dispositions of Ivermectin and Doramectin Following Subcutaneous and Oral Administration in Dogs, Vet. Parasitol., 2006: 135: 347-354. (Pubitemid 43117016)
12. Mueller, R.S. Treatment Protocols for Demodicosis: An Evidence-based Review, Vet. Dermatol., 2004: 15: 75-89. (Pubitemid 38482372)
13. Wang, H.J., Lin, Z.X., Liu, X.M., Sheng, S.Y. and Wang, J.Y. Heparin-loaded Zein Microsphere Film and Hemocompatibility, J. Control. Release, 2005: 105: 120-131.
14. Kurita, T., Miyagishima, A., Nozawa, Y., Sadzuka, Y. and Sonobe, T. A Dosage Design of Mitomycin C Tablets Containing Finely Powdered Green Tea, Int. J. Pharm., 2004: 275: 279-283. (Pubitemid 38481540)
15. Ristic, Z., Medleau, L., Paradis, M. and White-Weithers, N.E. Ivermectin for Treatment of Generalized Demodicosis in Dogs, J. Am. Vet. Med. Assoc., 1995: 207: 1308-1310.
16. Cerkvenik, V., Grabnar, I., Skubic, V. et al. Ivermectin Pharmacokinetics in Lactating Sheep, Vet. Parasitol., 2002: 104: 175-185. (Pubitemid 34102383)
17. Gayrard, V., Alvinerie, M. and Toutain, P.L. Comparison of Pharmacokinetic Profiles of Doramectin and Ivermectin Pour-on Formulations in Cattle, Vet. Parasitol., 1999: 81: 47-55. (Pubitemid 29017664)
18. Gokbulut, C., Karademir, U. and Boyacioglu, M. Comparison of Plasma Pharmacokinetic Profile of Ivermectin Following Administration of Subcutaneous Injection (Baymec (R)) and Oral Tablet (Efektin (R)) in Goats, J. Vet. Pharmacol. Ther., 2007: 30: 489-491. (Pubitemid 47366610)
19. Simovic, S., Hui, H., Song, Y., Davey, A.K., Rades, T. and Prestidge, C.A. An Oral Delivery System for Indomethicin Engineered from Cationic Lipid Emulsions and Silica Nanoparticles, J. Control. Release, 2010: in press.
20. Karakurum, M.C., Ural, K., Cingi, C.C., Guzel, M., Haydardedeoglu, A.E. and Borku, M.K. Evaluation of Ivermectin Tablets in the Treatment of Generalized Canine Demodicosis, Rev. Med. Vet., 2007: 158: 380-383. (Pubitemid 47393472)
21. Dourmishev, A., Serafimova, D. and Dourmishev, L. Efficacy and Tolerance of Oral Ivermectin in Scabies, J. Eur. Acad. Dermatol. Venereol., 1998: 11: 247-251. (Pubitemid 29010431)
22. Dunyo, S.K., Nkrumah, F.K. and Simonsen, P.E. Single-dose Treatment of Wuchereria Bancrofti Infections with Ivermectin and Albendazole Alone or in Combination: Evaluation of the Potential for Control at 12 Months After Treatment, Trans. R. Soc. Trop. Med. Hyg., 2000: 94: 437-443. (Pubitemid 30662358)