Evaluation of anti-inflammatory and antioxidant activities of stem bark of Toddalia asiatica (L.) Lam. using different experimental models

Global Journal of Pharmacology

Volumn 5, Issue 2, 2011, Pages 67-72

  Balasubramaniam, A ^a   Manivannan, R ^a   Paramaguru, R ^b   Vijayakumar, M ^b  

^a JKK Nataraja College of Pharmacy   (India)

^b CSIR NATIONAL BOTANICAL RESEARCH INSTITUTE   (India)

Author keywords

Cotton pellet granuloma method; Free radical scavenging activity; Toddalia asiatica

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ACETYLSALICYLIC ACID; ALCOHOL; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; DICLOFENAC; FERROUS ION; HYDROXYL RADICAL; NITRIC OXIDE; PLANT EXTRACT; TODDALIA ASIATICA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BARK; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SCREENING; DRY WEIGHT; EXPERIMENTAL MODEL; FEMALE; GRANULOMA; IC 50; INFLAMMATION; IRON CHELATION; MALE; MEDICINAL PLANT; NONHUMAN; PAW EDEMA; PLANT STEM; RAT; TODDALIA ASIATICA; TREATMENT RESPONSE;

EID: 80052672939     PISSN: 19920075     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Fernandez, M., B. Heras, M. Garcia and A. Villar, 2001. New insights in to the mechanism of action of the anti-inflammatory triterpene lupeol. J. Pharmacy and Pharmacol, 53: 1533-1539.
2. Conner, E.M. and M.B. Grisham, 1996. Inflammation, free radicals and Antioxidants. Nutrition, 12: 274.
3. Salvemini, D. and J.L. Masferrer, 1996. Interaction of nitricoxide with cyclooxygenase: in vitro, ex vitro and in vivo studies. Methods in Enzymol, 269: 12-25.
4. Yesilada, E., O. Ustun, E. Sezik, Y. Takaishi, Y. Ono and G. Honda, 1997. Inhibitory effect of Turkish folk remedies on inflammatory cytokines: interleukin-1-alpha, interleukin-1-beta and tumour necrosis factor-alpha. J. Ethnopharmacol., 58(1): 59-73.
5. Vane, J.R. and R.M. Botting, 1995. A better understanding of anti-inflammatory drugs based on isoforms of cyclooxygenase. Advances in Prostaglandins Thromboxanes Leukotriene Res., 23:41-48.
6. Sreelakshmi, R., P.G. Latha, M.M. Arafat, S. Shyamal, VJ. Shine, G.I. Anuja, S.R. Suja and S. Rajasekharan, 2007. Anti-inflammatory, analgesic and anti-lipid peroxidation studies on stem bark of Ficus religiosa Linn. Natural Product Radiance, 6(5): 377-381.
7. Duraipandiyan, V. and S. Ignacimuthu, 2009. Antibacterial and Antifungal activity of Flindersine isolated from the traditional medicinal plant Toddalia asiatica (L.) Lam. J. Ethnopharmacol., 123(3): 494-498.
8. Iwasaki, H., T. Okabe, K. Takara, T. Toda, M. Shimatam and H. Oku, 2010. Tumor-Selective cytotoxicity of benzo[c]phenanthridine derivatives from Toddalia asiatica (L.) Lam. Cancer Chemotheraphy and Pharmacol., 65(4): 719-726.
9. Muregi, F.W., A. Ishih, T. Miyase, T. Suzuki, H. Kino, T. Amano, G.M. Mkoji and M. Terada, 2007. Antimalarial activity of methanolic extracts from plants used in Kenyan ethnomedicine. J. Ethnopharmacol., 111(1): 190-195.
10. Lu Sy, Y.J. Qiao, P.G. Xiao and X.H. Tan, 2005. Identification of antiviral activity of Toddalia asiatica (L.) against influenza type A virus. Zhongguo Zhong Yao Za Zhi, 30(13): 998-1001.
11. Winter, C.A., E.A. Risley and G.W. Nuss, 1962. Carrageenan-induced oedema in hindpaw of the rat as an assay for anti-inflammatory drugs. Proceedings of the society for Experimental Biology and Medicine, 11:544-547.
12. Meier, R., W. Schuller and P. Desaulles, 1950. Studies on the Anti-Inflammatory, Analgesic and Antipyretic Properties of Andrographis echioides Nees. Experientia, 6: 469-471.
13. Vogel, H., 2002. Drug Discovery and Evaluation: Pharmacological assays. Springer Newyork, pp: 670.
14. Blois, M.S., 1958. Antioxidant determinations by the use of stable free radical. Nature, 26: 1199.
15. Sreejayan Rao, M.N.A., 1997. Nitricoxide scavenging by curcuminoids. J. Pharmacy and Pharmacol., 49: 105-107.
16. Nash, T., 1953. The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. The J. Biochemistry, 55: 416.
17. Govmdharajan, R., M. Vijayakumar, Ch. V. Rao, A.K.S. Rawat, A. Shirwaikar, S. Mehrotra and P. Puspangadan, 2003. Antioxidant potential of Anogeissus latifolia. Biological and Pharmaceutical Bulletin, 27: 1266-1269.
18. El-Shenawy, S.M., O.M. Abdel-Salam, A.R. Baiuomy, S. El-Baeran and M.S. Arbid, 2002. Effect of Buspirone on Inflammation, Pain and Gastric injury in mice. Pharmacological Research, 46: 235-243.
19. Vinegar, R., W. Schreiber and R. Hugo, 1969. Biophasic development of carrageenan odema in rats. Journal of Pharmacology and Experimental Therapeutics, 166(56): 96-103.
20. Tatiya, A.U., A.K. Saluja and S.J. Surana, 2008. Evaluation of anti-oxidant and anti-inflammatory activity of stem bark of Bridelia airy-shawii in rats. J. Natural Remedies, 8(1): 18-23.
21. Boughton-Smith, N.K., A.M. Deakin, R.L. Follenfant, B.J. Whittle and L.G. Garland, 1993. Role of oxygen radicals and arachidonic acid metabolites in the reverse passive Arthus reaction and carrageenin paw edema in the rat. British J. Pharmacol, 110: 896-902.
22. Garcia, L.J., LNakamura, M.P. Leite and M. Rocha e silva, 1973. Pharmacological analysis of the acute inflammatory process induced in rat's paw by local injection of carrageenan and by heating. British J. Pharmacol, 48: 88-96.
23. Nagarajan, N.S., V.Nandagopalan, R. Senthamoral, J.M. Christiana and A.M. Ismail, 2005. Studies on Anti-inflammatory activity of Dalhergia malabarcia (prain). Pharmacology and Toxicol, 6(1): 45-49.
24. Di Rosa, M., 1969. Biological properties of carrageenan. J. Pharmacy and Pharmacol, 53: 1533-1539.
25. Chawla, A.S., B.S. Kaith, S.S.Handa, A.K. Sharma and S.K. Balbir, 1987. Plant anti-inflammatory agents. J. Scientific and Industrial Res., 46: 214-223.
26. Grisham, M.B., 1992. Reactive oxygen metabolism. In Reactive Metabolites of Oxygen and Nitrogen in Biology and Medicine, Eds., Grisham, M.B., R.G. Landers Company, Austin, pp: 39.
27. Rice-Evans, C.A. and N.J. Miler, 1996. Antioxidant activities of flavonoids as bioactive components of food. Biochemical Society Transactions, 24: 790-795.
28. Kuo, S.M., P.S. Leavitt and C.P. Lin, 1998. Dietary flavonoids interact with trace element metals and affect metallothionein level in human intestinal cells. Biological Trace Element Res., 63: 135-153.
29. Korhonen, R., A. Lahit, H. Kankaanranta and E. Moilanen, 2005. Nitricoxide production and signaling in inflammation. Current Drug Targets-Inflammation and Allergy, 4(4): 487-493.
30. Pawar, C.R., V.S. Gulecha, M. Mohan, V.S. Kasture and S.C. Pal, 2008. Anti-inflammatory activity of heartwood extracts of Caesalpinia pulcherrima (Caesalpiniceae). J. Natural Remedies, 8(1): 72-75.
31. Diener, W., U. Mischke, D. Kayser and E. Schlede, 1995. The evaluation of the OECD modified version of acute toxicity class method (oral). Archieves of Toxicol, 69: 729-34.