Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation

Journal of Immunology

Volumn 187, Issue 5, 2011, Pages 2696-2701

  Kang, Ju Gyeong ^a   Amar, Marcelo J ^a   Remaley, Alan T ^a   Kwon, Jaeyul ^b   Blackshear, Perry J ^c   Wang, Ping Yuan ^a   Hwang, Paul M ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; TRISTETRAPROLIN; TUMOR NECROSIS FACTOR; ZINC FINGER PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; ATHEROSCLEROTIC PLAQUE; CACHEXIA; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE MODEL; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VIVO STUDY; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN SYNTHESIS; WILD TYPE;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BASE SEQUENCE; CHEMOKINE CCL3; FEMALE; HUMANS; IMMUNOPRECIPITATION; INFLAMMATION; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSFECTION; TRISTETRAPROLIN;

EID: 80052648818     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1101149     Document Type: Article

References (43)

1. Anderson, P. 2010. Post-transcriptional regulons coordinate the initiation and resolution of inflammation. Nat. Rev. Immunol. 10: 24-35.
2. Stumpo, D. J., W. S. Lai, and P. J. Blackshear. 2010. Inflammation: cytokines and RNA-based regulation. WIREs RNA 1: 60-80.
3. Carballo, E., W. S. Lai, and P. J. Blackshear. 1998. Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science 281: 1001-1005. (Pubitemid 28399252)
4. Taylor, G. A., E. Carballo, D. M. Lee, W. S. Lai, M. J. Thompson, D. D. Patel, D. I. Schenkman, G. S. Gilkeson, H. E. Broxmeyer, B. F. Haynes, and P. J. Blackshear. 1996. A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity 4: 445-454. (Pubitemid 26354654)
5. Carrick, D. M., W. S. Lai, and P. J. Blackshear. 2004. The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis. Arthritis Res. Ther. 6: 248-264. (Pubitemid 39490013)
6. Hansson, G. K. 2005. Inflammation, atherosclerosis, and coronary artery disease. N. Engl. J. Med. 352: 1685-1695.
7. Libby, P., P. M. Ridker, G. K. Hansson; Leducq Transatlantic Network on Atherothrombosis. 2009. Inflammation in atherosclerosis: from pathophysiology to practice. J. Am. Coll. Cardiol. 54: 2129-2138.
8. Patino, W. D., J. G. Kang, S. Matoba, O. Y. Mian, B. R. Gochuico, and P. M. Hwang. 2006. Atherosclerotic plaque macrophage transcriptional regulators are expressed in blood and modulated by tristetraprolin. Circ. Res. 98: 1282-1289. (Pubitemid 43948083)
9. Maurer, M., and E. Von Stebut. 2004. Macrophage inflammatory protein-1. Int. J. Biochem. Cell Biol. 36: 1882-1886. (Pubitemid 38760018)
10. Menten, P., A. Wuyts, and J. Van Damme. 2002. Macrophage inflammatory protein-1. Cytokine Growth Factor Rev. 13: 455-481. (Pubitemid 35303816)
11. Gerard, C., and B. J. Rollins. 2001. Chemokines and disease. Nat. Immunol. 2: 108-115. (Pubitemid 33707927)
12. Charo, I. F., and R. M. Ransohoff. 2006. The many roles of chemokines and chemokine receptors in inflammation. N. Engl. J. Med. 354: 610-621. (Pubitemid 43209108)
13. Gladue, R. P., M. F. Brown, and S. H. Zwillich. 2010. CCR1 antagonists: what have we learned from clinical trials. Curr. Top. Med. Chem. 10: 1268-1277.
14. Hayes, I. M., N. J. Jordan, S. Towers, G. Smith, J. R. Paterson, J. J. Earnshaw, A. G. Roach, J. Westwick, and R. J. Williams. 1998. Human vascular smooth muscle cells express receptors for CC chemokines. Arterioscler. Thromb. Vasc. Biol. 18: 397-403. (Pubitemid 28125634)
15. Moos, M. P., N. John, R. Gräbner, S. Nossmann, B. Günther, R. Vollandt, C. D. Funk, B. Kaiser, and A. J. Habenicht. 2005. The lamina adventitia is the major site of immune cell accumulation in standard chow-fed apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 25: 2386-2391. (Pubitemid 41552659)
16. Iwamoto, T., H. Okamoto, Y. Toyama, and S. Momohara. 2008. Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients. FEBS J. 275: 4448-4455.
17. Jones, K. L., J. J. Maguire, and A. P. Davenport. 2011. Chemokine receptor CCR5: From AIDS to atherosclerosis. Br. J. Pharmacol. 162: 1453-1469.
18. Ku, I. A., J. B. Imboden, P. Y. Hsue, and P. Ganz. 2009. Rheumatoid arthritis: model of systemic inflammation driving atherosclerosis. Circ. J. 73: 977-985.
19. Zipfel, P. F., J. Balke, S. G. Irving, K. Kelly, and U. Siebenlist. 1989. Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors. J. Immunol. 142: 1582-1590. (Pubitemid 19086325)
20. Sauer, I., B. Schaljo, C. Vogl, I. Gattermeier, T. Kolbe, M. Müller, P. J. Blackshear, and P. Kovarik. 2006. Interferons limit inflammatory responses by induction of tristetraprolin. Blood 107: 4790-4797. (Pubitemid 43882630)
21. Ghosh, S., M. J. Hoenerhoff, N. Clayton, P. Myers, D. J. Stumpo, R. R. Maronpot, and P. J. Blackshear. 2010. Left-sided cardiac valvulitis in tristetraprolin-deficient mice: the role of tumor necrosis factor alpha. Am. J. Pathol. 176: 1484-1493.
22. Saha, S., A. B. Sparks, C. Rago, V. Akmaev, C. J. Wang, B. Vogelstein, K. W. Kinzler, and V. E. Velculescu. 2002. Using the transcriptome to annotate the genome. Nat. Biotechnol. 20: 508-512. (Pubitemid 34495940)
23. Audic, S., and J. M. Claverie. 1997. The significance of digital gene expression profiles. Genome Res. 7: 986-995. (Pubitemid 27487763)
24. Héron-Milhavet, L., M. Haluzik, S. Yakar, O. Gavrilova, S. Pack, W. C. Jou, A. Ibrahimi, H. Kim, D. Hunt, D. Yau, et al. 2004. Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice. Endocrinology 145: 4667-4676. (Pubitemid 39281460)
25. Sakuma, S., F. Nishigaki, K. Magari, T. Ogawa, S. Miyata, Y. Ohkubo, and T. Goto. 2001. FK506 is superior to methotrexate in therapeutic effects on advanced stage of rat adjuvant-induced arthritis. Inflamm. Res. 50: 509-514. (Pubitemid 32999714)
26. Park, J. Y., P. Y. Wang, T. Matsumoto, H. J. Sung, W. Ma, J. W. Choi, S. A. Anderson, S. C. Leary, R. S. Balaban, J. G. Kang, and P. M. Hwang. 2009. p53 improves aerobic exercise capacity and augments skeletal muscle mitochondrial DNA content. Circ. Res. 105: 705-712.
27. Bakheet, T., B. R. Williams, and K. S. Khabar. 2003. ARED 2.0: an update of AU-rich element mRNA database. Nucleic Acids Res. 31: 421-423. (Pubitemid 36150418)
28. Lai, W. S., E. Carballo, J. R. Strum, E. A. Kennington, R. S. Phillips, and P. J. Blackshear. 1999. Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA. Mol. Cell. Biol. 19: 4311-4323. (Pubitemid 29242006)
29. Carballo, E., and P. J. Blackshear. 2001. Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin- deficiency syndrome. Blood 98: 2389-2395.
30. Whitacre, C. C. 2001. Sex differences in autoimmune disease. Nat. Immunol. 2: 777-780.
31. Chen, Y. L., Y. L. Huang, N. Y. Lin, H. C. Chen, W. C. Chiu, and C. J. Chang. 2006. Differential regulation of ARE-mediated TNFalpha and IL-1beta mRNA stability by lipopolysaccharide in RAW264.7 cells. Biochem. Biophys. Res. Commun. 346: 160-168.
32. Hansson, G. K., and A. Hermansson. 2011. The immune system in atherosclerosis. Nat. Immunol. 12: 204-212.
33. Plump, A. 1997. Atherosclerosis and the mouse: a decade of experience. Ann. Med. 29: 193-198. (Pubitemid 27292527)
34. Paigen, B., P. A. Holmes, D. Mitchell, and D. Albee. 1987. Comparison of atherosclerotic lesions and HDL-lipid levels in male, female, and testosterone-treated female mice from strains C57BL/6, BALB/c, and C3H. Atherosclerosis 64: 215-221. (Pubitemid 17047164)
35. Daugherty, A. 2002. Mouse models of atherosclerosis. Am. J. Med. Sci. 323: 3-10. (Pubitemid 34650115)
36. Chintalacharuvu, S. R., J. X. Wang, J. M. Giaconia, and C. Venkataraman. 2005. An essential role for CCL3 in the development of collagen antibody-induced arthritis. Immunol. Lett. 100: 202-204. (Pubitemid 41262021)
37. Fan, J., N. M. Heller, M. Gorospe, U. Atasoy, and C. Stellato. 2005. The role of post-transcriptional regulation in chemokine gene expression in inflammation and allergy. Eur. Respir. J. 26: 933-947. (Pubitemid 41632053)
38. Hao, S., and D. Baltimore. 2009. The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules. Nat. Immunol. 10: 281-288.
39. Pharoah, D. S., H. Varsani, R. W. Tatham, K. R. Newton, W. De Jager, B. J. Prakken, N. Klein, and L. R. Wedderburn. 2006. Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells. Arthritis Res. Ther. 8: R50.
40. -/- mice. J. Immunol. 184: 3087-3097.
41. Carballo, E.,W. S. Lai, and P. J. Blackshear. 2000. Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability. Blood 95: 1891-1899. (Pubitemid 30151623)
42. Xia, L., J. Lu, and W. Xiao. 2011. Blockage of TNF-α by infliximab reduces CCL2 and CCR2 levels in patients with rheumatoid arthritis. J. Investig. Med. In press.
43. Taylor, P. C., A. M. Peters, E. Paleolog, P. T. Chapman, M. J. Elliott, R. McCloskey, M. Feldmann, and R. N. Maini. 2000. Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis. Arthritis Rheum. 43: 38-47. (Pubitemid 30368211)