Cks85A and Skp2 interact to maintain diploidy and promote growth in Drosophila

Developmental Biology

Volumn 358, Issue 1, 2011, Pages 213-223

  Ghorbani, Mohammad ^a   Vasavan, Biju ^a   Kraja, Emona ^a   Swan, Andrew ^a  

^a UNIVERSITY OF WINDSOR   (Canada)

Author keywords

Cell cycle; Cks; Drosophila; Genome instability; SCF; Skp2

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 85A; PROTEIN P27; REPLICATION LICENSING FACTOR CDT1; S PHASE KINASE ASSOCIATED PROTEIN 2; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIVISION; CKS1 GENE; CONTROLLED STUDY; DEVELOPMENT; DEVELOPMENTAL GENE; DIPLOIDY; DNA REPLICATION; DROSOPHILA; GENE LOSS; MITOSIS; MUTANT; NONHUMAN; NULL ALLELE; PHENOTYPE; PLOIDY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; SKP2 GENE;

ANIMALIA; MAMMALIA;

EID: 80052646656     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2011.07.031     Document Type: Article

References (35)

1. Arias E.E., Walter J.C. Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells. Genes Dev 2007, 21:497-518.
2. de Nooij J.C., Letendre M.A., Hariharan I.K. A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis. Cell 1996, 87:1237-1247.
3. Dietzl G., Chen D., Schnorrer F., Su K.-C., Barinova Y., Fellner M., Gasser B., Kinsey K., Oppel S., Scheiblauer S., Couto A., Marra V., Keleman K., Dickson B.J. A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature 2007, 448:151.
4. Donovan P.J., Reed S.I. Germline exclusion of Cks1 in the mouse reveals a metaphase I role for Cks proteins in male and female meiosis. Cell Cycle 2003, 2:275-276.
5. Ganoth D., Bornstein G., Ko T.K., Larsen B., Tyers M., Pagano M., Hershko A. The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. Nat. Cell. Biol. 2001, 3:321-324.
6. Gatti M., Bonaccorsi S., Pimpinelli S. Looking at Drosophila mitotic chromosomes. Methods Cell Biol. 1994, 44:371-391.
7. Hao B., Zheng N., Schulman B.A., Wu G., Miller J.J., Pagano M., Pavletich N.P. Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. Mol. Cell 2005, 20:9-19.
8. Hayashi S. A Cdc2 dependent checkpoint maintains diploidy in Drosophila. Development 1996, 122:1051-1058.
9. Hershko D.D. Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer. Cancer 2008, 112:1415-1424.
10. Knoblich J.A., Sauer K., Jones L., Richardson H., Saint R., Lehner C.F. Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation. Cell 1994, 77:107-120.
11. Lane M.E., Sauer K., Wallace K., Jan Y.N., Lehner C.F., Vaessin H. Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development. Cell 1996, 87:1225-1235.
12. Lee L.A., Orr-Weaver T.L. Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues. Annu. Rev. Genet. 2003, 37:545-578.
13. Li X., Zhao Q., Liao R., Sun P., Wu X. The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation. J. Biol. Chem. 2003, 278:30854-30858.
14. Martinsson-Ahlzen H.S., Liberal V., Grunenfelder B., Chaves S.R., Spruck C.H., Reed S.I. Cyclin-dependent Kinase Associated Proteins Cks1 and Cks2 are Essential During Early Embryogenesis and for Cell Cycle Progression in Somatic Cells. Mol. Cell Biol. 2008, 28:5698-5709.
15. Murphy T.D. Drosophila skpA, a component of SCF ubiquitin ligases, regulates centrosome duplication independently of cyclin E accumulation. J. Cell Sci. 2003, 116:2321-2332.
16. Nakayama K.I., Nakayama K. Ubiquitin ligases: cell-cycle control and cancer. Nat. Rev. Cancer 2006, 6:369-381.
17. Nakayama K., Nagahama H., Minamishima Y.A., Matsumoto M., Nakamichi I., Kitagawa K., Shirane M., Tsunematsu R., Tsukiyama T., Ishida N., Kitagawa M., Nakayama K., Hatakeyama S. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J. 2000, 19:2069-2081.
18. Nakayama K., Nagahama H., Minamishima Y.A., Miyake S., Ishida N., Hatakeyama S., Kitagawa M., Iemura S., Natsume T., Nakayama K.I. Skp2-mediated degradation of p27 regulates progression into mitosis. Dev. Cell. 2004, 6:661-672.
19. Patra D., Dunphy W.G. Xe-p9, a Xenopus Suc1/Cks homolog, has multiple essential roles in cell cycle control. Genes Dev. 1996, 10:1503-1515.
20. Patra D., Dunphy W.G. Xe-p9, a Xenopus Suc1/Cks protein, is essential for the Cdc2-dependent phosphorylation of the anaphase-promoting complex at mitosis. Genes Dev. 1998, 12:2549-2559.
21. Pearson N.J., Cullen C.F., Dzhindzhev N.S., Ohkura H. A pre-anaphase role for a Cks/Suc1 in acentrosomal spindle formation of Drosophila female meiosis. EMBO Rep. 2005, 6:1058-1063.
22. Pines J. Cell cycle: reaching for a role for the Cks proteins. Curr. Biol. 1996, 6:1399-1402.
23. Polinko E.S., Strome S. Depletion of a Cks homolog in C. elegans embryos uncovers a post-metaphase role in both meiosis and mitosis. Curr. Biol. 2000, 10:1471-1474.
24. Richardson H.E., Stueland C.S., Thomas J., Russell P., Reed S.I. Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe. Genes Dev. 1990, 4:1332-1344.
25. Sigrist S.J., Lehner C.F. Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles. Cell 1997, 90:671-681.
26. Spruck C., Strohmaier H., Watson M., Smith A.P., Ryan A., Krek T.W., Reed S.I. A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. Mol. Cell 2001, 7:639-650.
27. Spruck C.H., de Miguel M.P., Smith A.P., Ryan A., Stein P., Schultz R.M., Lincoln A.J., Donovan P.J., Reed S.I. Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis. Science 2003, 300:647-650.
28. Storchova Z., Pellman D. From polyploidy to aneuploidy, genome instability and cancer. Nat. Rev. Mol. Cell Biol. 2004, 5:45-54.
29. Swan A., Schupbach T. The Cdc20 (Fzy)/Cdh1-related protein, Cort, cooperates with Fzy in cyclin destruction and anaphase progression in meiosis I and II in Drosophila. Development 2007, 134:891-899.
30. Swan A., Barcelo G., Schupbach T. Drosophila Cks30A interacts with Cdk1 to target Cyclin A for destruction in the female germline. Development 2005, 132:3669-3678.
31. Weigmann K., Cohen S.M., Lehner C.F. Cell cycle progression, growth and patterning in imaginal discs despite inhibition of cell division after inactivation of Drosophila Cdc2 kinase. Development 1997, 124:3555-3563.
32. Whittaker A.J., Royzman I., Orr-Weaver T.L. Drosophila double parked: a conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase transcripts. Genes Dev. 2000, 14:1765-1776.
33. Wolthuis R., Clay-Farrace L., van Zon W., Yekezare M., Koop L., Ogink J., Medema R., Pines J. Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A. Mol. Cell 2008, 30:290-302.
34. Xu S., Abbasian M., Patel P., Jensen-Pergakes K., Lombardo C.R., Cathers B.E., Xie W., Mercurio F., Pagano M., Giegel D., Cox S. Substrate Recognition and Ubiquitination of SCFSkp2/Cks1 E3 Ligase. J. Biol. Chem. 2007, 282:15462-15470.
35. Zielke N., Querings S., Rottig C., Lehner C., Sprenger F. The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles. Genes Dev. 2008, 22:1690.