Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis

Science

Volumn 300, Issue 5619, 2003, Pages 647-650

  Spruck, Charles H ^a   De Miguel, Maria P ^b   Smith, Adrian P L ^a   Ryan, Aimee ^c,e   Stein, Paula ^d   Schultz, Richard M ^d   Lincoln, A Jeannine ^b   Donovan, Peter J ^b   Reed, Steven I ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOMES; YEAST;

MAMMALIAN HOMOLOGS;

PROTEINS;

BINDING PROTEIN; CYCLIN DEPENDENT KINASE; PROTEIN CKS2; UNCLASSIFIED DRUG;

MICROBIOLOGY; PROTEIN;

ANAPHASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE; FEMALE; GERM CELL; INFERTILITY; MALE; MEIOSIS; METAPHASE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROPHASE; PROTEIN FUNCTION;

ANAPHASE; ANIMALS; APOPTOSIS; CDC2-CDC28 KINASES; CDC28 PROTEIN KINASE, S CEREVISIAE; CHROMOSOME SEGREGATION; CYCLIN A; CYCLIN B; EPIDIDYMIS; FEMALE; GENE TARGETING; IN SITU HYBRIDIZATION; INFERTILITY, FEMALE; INFERTILITY, MALE; MALE; MEIOSIS; METAPHASE; MICE; MUTATION; OOCYTES; OVARY; RECOMBINATION, GENETIC; RNA, MESSENGER; SPERMATOCYTES; SPERMATOGENESIS; TESTIS;

ANIMALIA; MAMMALIA;

EID: 0242500260     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1084149     Document Type: Article

References (20)

1. J. Y. Lee, T. L. Orr-Weaver, Annu. Rev. Cell Dev. Biol. 17, 753 (2001).
2. T. L. Orr-Weaver, Science 285, 344 (1999).
3. K. Nasmyth, Science 297, 559 (2002).
4. S. Moreno, J. Hayles, P. Nurse, Cell 58, 361 (1989).
5. Y. Tang, S. I. Reed, Genes Dev. 7, 822 (1993).
6. D. Patra, W. G. Dunphy, Genes Dev. 10, 1503 (1996).
7. H. E. Richardson, C. S. Stueland, J. Thomas, P. Russell, S. I. Reed, Genes Dev. 4, 1332 (1990).
8. C. Spruck et al., Mol. Cell 7, 639 (2001).
9. D. Gonoth, et al., Nature Cell Biol. 3, 321 (2001).
10. Materials and Methods are available as supporting material on Science online.
11. D. Patra, W. G. Dunphy, Genes Dev. 12, 2549 (1998).
12. D. L. Pittman et al., Mol. Cell 1, 697 (1998).
13. C. Barlow et al., Development 125, 4007 (1998).
14. M. L. Watson et al., Proc. Natl. Acad. Sci. U.S.A. 95, 14361 (1998).
15. D. J. Dix et al. Proc. Natl. Acad. Sci. U.S.A. 93, 3264 (1996).
16. Y. Hirao, J. J. Eppig, Development 124, 5107 (1997).
17. S. M. Baker et al., Nature Genet. 13, 336 (1996).
18. L. M. Woods et al., J. Cell Biol. 145, 1395 (1999).
19. S. M. Lipkin et al., Nature Genet. 31, 385 (2002).
20. C.H.S. is supported by a special fellow award from the Leukemia and Lymphoma Society of America. We are grateful to C. Palancar for help with mouse husbandry and genotyping, M. A. Handel for the kind gift of the Corl-specific antibody, and A. D. Pyle, P. B. Moens, and P.A. Hunt for useful protocols and advice. This work was supported by NIH grants HD22681 (R.M.S.), HD38252 (P.J.D.), and CA74224 (S.I.R.).