Testin, a novel binding partner of the calcium-sensing receptor, enhances receptor-mediated Rho-kinase signalling

Biochemical and Biophysical Research Communications

Volumn 412, Issue 4, 2011, Pages 584-589

  Magno, Aaron L ^a,b   Ingley, Evan ^a   Brown, Suzanne J ^b   Conigrave, Arthur D ^c   Ratajczak, Thomas ^a,b   Ward, Bryan K ^a,b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Calcium sensing receptor; ERK signalling; LIM domain; Rho signalling; Testin; Yeast two hybrid screen

Indexed keywords

CALCIUM SENSING RECEPTOR; LIM KINASE 1; METHYLTESTOSTERONE; RHO KINASE;

ANIMAL CELL; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVITY; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; ZINC FINGER MOTIF;

AMINO ACID SEQUENCE; ANIMALS; CYTOSKELETAL PROTEINS; HEK293 CELLS; HUMANS; IMMUNOPRECIPITATION; LIM DOMAIN PROTEINS; MICE; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CALCIUM-SENSING; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 80052645238     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.07.132     Document Type: Article

References (21)

1. Brown E.M., MacLeod R.J. Extracellular calcium sensing and extracellular calcium signalling. Physiol. Rev. 2001, 81:239-297.
2. Magno A.L., Ward B.K., Ratajczak T. The calcium-sensing receptor: a molecular perspective. Endocr. Rev. 2011, 32:3-30.
3. Huang C., Miller R.T. The calcium-sensing receptor and its interacting proteins. J. Cell Mol. Med. 2007, 11:923-934.
4. Tsai S., Bartelmez S., Sitnicka E., et al. Lymphohematopoietic progenitors immortalized by a retroviral vector harboring a dominant-negative retinoic acid receptor can recapitulate lymphoid, myeloid, and erythroid development. Genes Dev. 1994, 8:2831-2841.
5. Coutts A.S., MacKenzie E., Griffith E., et al. TES is a novel focal adhesion protein with a role in cell spreading. J. Cell Sci. 2003, 116:897-906.
6. Garvalov B.K., Higgins T.E., Sutherland J.D., et al. The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions. J. Cell Biol. 2003, 161:33-39.
7. Ward B.K., Magno A.L., Davis E.A., et al. Functional deletion of the calcium-sensing receptor in a case of neonatal severe hyperparathyroidism. J. Clin. Endocrinol. Metab. 2004, 89:3721-3730.
8. Yamauchi K., Holt K., Pessin J.E. Phosphatidylinositol 3-kinase functions upstream of Ras and Raf in mediating insulin stimulation of c-fos transcription. J. Biol. Chem. 1993, 268:14597-14600.
9. Ingley E., Sarna M.K., Beaumont J.G., et al. HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells. J. Biol. Chem. 2000, 275:7887-7893.
10. Carrello A., Ingley E., Minchin R.F., et al. The common tetratricopeptide repeat acceptor site for steroid receptor-associated immunophilins and hop is located in the dimerization domain of Hsp90. J. Biol. Chem. 1999, 274:2682-2689.
11. Lee H.J., Mun H.C., Lewis N.C., et al. Allosteric activation of the extracellular Ca2+-sensing receptor by l-amino acids enhances ERK1/2 phosphorylation. Biochem. J. 2007, 404:141-149.
12. Ward B.K., Magno A.L., Blitvich B.J., et al. Novel mutations in the calcium-sensing receptor gene associated with biochemical and functional differences in familial hypocalciuric hypercalcaemia. Clin. Endocrinol. 2006, 64:580-587.
13. Pi M., Spurney R.F., Tu Q., et al. Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor. Endocrinology 2002, 143:3830-3838.
14. Griffith E., Coutts A.S., Black D.M. Characterisation of chicken TES and its role in cell spreading and motility. Cell Motil. Cytoskeleton 2004, 57:133-142.
15. Griffith E., Coutts A.S., Black D.M. RNAi knockdown of the focal adhesion protein TES reveals its role in actin stress fibre organisation. Cell Motil. Cytoskeleton 2005, 60:140-152.
16. Zhang M., Breitwieser G. High affinity interaction with Filamin A protects against calcium-sensing receptor degradation. J. Biol. Chem. 2005, 280:11140-11146.
17. Sarti M., Sevignani C., Calin G.A., et al. Adenoviral transduction of TESTIN gene into breast and uterine cancer cell lines promotes apoptosis and tumor reduction in vivo. Clin. Cancer Res. 2005, 11:806-813.
18. Sun Y.H., Liu M.N., Li H., et al. Calcium-sensing receptor induces rat neonatal ventricular cardiomyocyte apoptosis. Biochem. Biophys. Res. Commun. 2006, 350:942-948.
19. Rey O., Young S.H., Yuan J.Z., et al. Amino acid-stimulated Ca2+ oscillations produced by the Ca2+-sensing receptor are mediated by a phospholipase C/inositol 1, 4, 5-trisphosphate-independent pathway that requires G12, Rho, Filamin-A, and the actin cytoskeleton. J. Biol. Chem. 2005, 280:22875-22882.
20. Davies S.L., Gibbons C.E., Vizard T., et al. Ca2+-sensing receptor induces Rho kinase-mediated actin stress fiber assembly and altered cell morphology but not in response to aromatic amino acids. Am. J. Physiol.-Cell Physiol. 2006, 290:C1543-C1551.
21. Saidak Z., Boudot C., Abdoune R., et al. Extracellular calcium promotes the migration of breast cancer cells through the activation of the calcium sensing receptor. Exp. Cell. Res. 2009, 315:2072-2080.