A radiotherapy technique to limit dose to neural progenitor cell niches without compromising tumor coverage

Journal of Neuro-Oncology

Volumn 104, Issue 2, 2011, Pages 579-587

  Redmond, Kristin J ^a   Achanta, Pragathi ^a   Grossman, Stuart A ^a   Armour, Michael ^a   Reyes, Juvenal ^a   Kleinberg, Lawrence ^a   Tryggestad, Erik ^a   Quinones Hinojosa, Alfredo ^a   Ford, Eric C ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Intensity modulated radiation therapy; Ki 67; Neural progenitor cells; Neural stem cell niches; Neurocognitive toxicity

Indexed keywords

KI 67 ANTIGEN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; BRAIN TUMOR; C57BL 6 MOUSE; CANCER RADIOTHERAPY; CELL COUNT; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DENTATE GYRUS; DOSIMETRY; FEASIBILITY STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTENSITY MODULATED RADIATION THERAPY; MALE; MOUSE; NEURAL STEM CELL; NONHUMAN; PRIMARY TUMOR; RETROSPECTIVE STUDY; SHAM PROCEDURE; SUBVENTRICULAR ZONE; TISSUE SECTION; TREATMENT PLANNING;

ANIMALS; BRAIN NEOPLASMS; CRANIAL IRRADIATION; FEASIBILITY STUDIES; FEMALE; GLIOBLASTOMA; HUMANS; MALE; MICE; MICE, INBRED C57BL; NEURAL STEM CELLS; RADIOTHERAPY DOSAGE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RADIOTHERAPY, COMPUTER-ASSISTED; RETROSPECTIVE STUDIES; STEM CELL NICHE;

EID: 80052638736     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-011-0530-8     Document Type: Article

References (36)

1. TB Johannesen HH Lien KH Hole K Lote 2003 Radiological and clinical assessment of long-term brain tumour survivors after radiotherapy Radiother Oncol 69 suppl. 2 169 176 14643954 10.1016/S0167-8140(03)00192-0 (Pubitemid 37485876)
2. JH Silber J Radcliffe V Peckham, et al. 1992 Whole-brain irradiation and decline in intelligence: the influence of dose and age on IQ score J Clin Oncol 10 suppl. 9 1390 1396 1517781 1:STN:280:DyaK38zovV2mtQ%3D%3D (Pubitemid 23059921)
3. MD Ris R Packer J Goldwein D Jones-Wallace JM Boyett 2001 Intellectual outcome after reduced-dose radiation therapy plus adjuvant chemotherapy for medulloblastoma: a children's cancer group study J Clin Oncol 19 suppl. 15 3470 3476 11481352 1:STN:280:DC%2BD3MvjtlOmsw%3D%3D (Pubitemid 32730083)
4. E Hoppe-Hirsch L Brunet F Laroussinie, et al. 1995 Intellectual outcome in children with malignant tumors of the posterior fossa: influence of the field of irradiation and quality of surgery Childs Nerv Syst 11 suppl. 6 340 346 7671269 10.1007/BF00301666 1:STN:280:DyaK2MvgtFahuw%3D%3D
5. J Schatz JH Kramer A Ablin KK Matthay 2000 Processing speed, working memory, and IQ: a developmental model of cognitive deficits following cranial radiation therapy Neuropsychology 14 suppl. 2 189 200 10791859 10.1037/0894-4105.14.2.189 1:STN:280:DC%2BD3c3ltVGhsw%3D%3D
6. S Penitzka S Steinvorth S Sehlleier M Fu M Wannenmacher F Wenz 2002 Assessment of cognitive functions after prophylactic and therapeutic whole brain irradiation using neuropsychological testing Strahlenther Onkol 178 suppl. 5 252 258 12082684 10.1007/s00066-002-0878-y (Pubitemid 34534807)
7. E Tada JM Parent DH Lowenstein JR Fike 2000 X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats Neuroscience 99 suppl. 1 33 41 10924950 10.1016/S0306-4522(00)00151-2 1:CAS:528:DC%2BD3cXlt1Kis7w%3D (Pubitemid 30495550)
8. S Mizumatsu ML Monje DR Morhardt R Rola TD Palmer JR Fike 2003 Extreme sensitivity of adult neurogenesis to low doses of X-irradiation Cancer Res 63 suppl. 14 4021 4027 12874001 1:CAS:528:DC%2BD3sXlsFOju78%3D (Pubitemid 36917922)
9. ML Monje H Toda TD Palmer 2003 Inflammatory blockade restores adult hippocampal neurogenesis Science 302 suppl. 5651 1760 1765 14615545 10.1126/science.1088417 1:CAS:528:DC%2BD3sXpsVWnsro%3D (Pubitemid 37505739)
10. TM Madsen PEG Kristjansen TG Bolwig G Wörtwein 2003 Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat Neuroscience 119 suppl. 3 635 642 12809684 10.1016/S0306-4522(03)00199-4 1:CAS:528:DC%2BD3sXksValtL8%3D (Pubitemid 36694791)
11. R Rola J Raber A Rizk, et al. 2004 Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice Exp Neurol 188 suppl. 2 316 330 15246832 10.1016/j.expneurol.2004.05.005 1:CAS:528:DC%2BD2cXlsFygtbY%3D (Pubitemid 38891593)
12. MD Saxe F Battaglia J Wang, et al. 2006 Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus Proc Natl Acad Sci USA 103 suppl. 46 17501 17506 17088541 10.1073/pnas.0607207103 1:CAS:528:DC%2BD28Xht1OjsrfP (Pubitemid 44788998)
13. G Winocur JM Wojtowicz M Sekeres JS Snyder S Wang 2006 Inhibition of neurogenesis interferes with hippocampus-dependent memory function Hippocampus 16 suppl. 3 296 304 16411241 10.1002/hipo.20163
14. FH Gage 2000 Mammalian neural stem cells Science 287 suppl. 5457 1433 1438 10688783 10.1126/science.287.5457.1433 1:CAS:528:DC%2BD3cXhsV2qtrg%3D (Pubitemid 30127128)
15. A Quinones-Hinojosa N Sanai M Soriano-Navarro, et al. 2006 Cellular composition and cytoarchitecture of the adult human subventricular zone: a niche of neural stem cells J Comp Neurol 494 suppl. 3 415 434 16320258 10.1002/cne.20798 (Pubitemid 41794059)
16. N Sanai AD Tramontin A Quinones-Hinojosa, et al. 2004 Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration Nature 427 suppl. 6976 740 744 14973487 10.1038/nature02301 1:CAS:528:DC%2BD2cXhtlajsr0%3D (Pubitemid 38294593)
17. A Arvidsson T Collin D Kirik Z Kokaia O Lindvall 2002 Neuronal replacement from endogenous precursors in the adult brain after stroke Nat Med 8 suppl. 9 963 970 12161747 10.1038/nm747 1:CAS:528:DC%2BD38Xms1aitrs%3D (Pubitemid 35033700)
18. GE Goings V Sahni FG Szele 2004 Migration patterns of subventricular zone cells in adult mice change after cerebral cortex injury Brain Res 996 suppl. 2 213 226 14697499 10.1016/j.brainres.2003.10.034 1:CAS:528:DC%2BD3sXpvF2ls7o%3D (Pubitemid 38022018)
19. S François M Bensidhoum M Mouiseddine, et al. 2006 Local irradiation not only induces homing of human mesenchymal stem cells at exposed sites but promotes their widespread engraftment to multiple organs: a study of their quantitative distribution after irradiation damage Stem Cells 24 suppl. 4 1020 1029 16339642 10.1634/stemcells.2005-0260 (Pubitemid 44464735)
20. M Mouiseddine S François A Semont, et al. 2007 Human mesenchymal stem cells home specifically to radiation-injured tissues in a non-obese diabetes/severe combined immunodeficiency mouse model Br J Radiol 80 suppl. SPEC. ISS. 1 S49 S55 17704326 10.1259/bjr/25927054 1:CAS:528:DC%2BD2sXht1CnsrfN (Pubitemid 47517799)
21. JR Fike R Rola CL Limoli 2007 Radiation response of neural precursor cells Neurosurg Clin N Am 18 suppl. 1 115 127 17244559 10.1016/j.nec.2006.10.010 (Pubitemid 46161195)
22. Panagiotakos G, Alshamy G, Chan B et al (2007) Long-term impact of radiation on the stem cell and oligodendrocyte precursors in the brain. PLoS ONE 2(suppl. 7):e588
23. JW Hopewell JB Cavanagh 1972 Effects of X irradiation on the mitotic activity of the subependymal plate of rats Br J Radiol 45 suppl. 534 461 465 5029031 10.1259/0007-1285-45-534-461 1:STN:280:DyaE387ptFarsg%3D%3D
24. L Iuvone P Mariotti C Colosimo F Guzzetta A Ruggiero R Riccardi 2002 Long-term cognitive outcome, brain computed tomography scan, and magnetic resonance imaging in children cured for acute lymphoblastic leukemia Cancer 95 suppl. 12 2562 2570 12467071 10.1002/cncr.10999 (Pubitemid 35424043)
25. PG Lesnik KT Ciesielski BL Hart EC Benzel JA Sanders 1998 Evidence for cerebellar-frontal subsystem changes in children treated with intrathecal chemotherapy for leukemia: enhanced data analysis using an effect size model Arch Neurol 55 suppl. 12 1561 1568 9865801 10.1001/archneur.55.12.1561 1:STN:280:DyaK1M%2FotFequw%3D%3D
26. DP Waber NJ Tarbell CM Kahn RD Gelber SE Sallan 1992 The relationship of sex and treatment modality to neuropsychologic outcome in childhood acute lymphoblastic leukemia J Clin Oncol 10 suppl. 5 810 817 1569453 1:STN:280:DyaK383jsFKktA%3D%3D
27. SJ Bakke A Fossen I Storm-Mathiesen SO Lie 1993 Long-term cerebral effects of CNS chemotherapy in children with acute lymphoblastic leukemia Pediatr Hematol Oncol 10 suppl. 3 267 270 8217544 10.3109/08880019309029495 1:STN:280:DyaK2c%2FjtFGjsA%3D%3D (Pubitemid 23246437)
28. SA Grossman CS Reinhard HL Loats 1989 The intracerebral penetration of intraventricularly administered methotrexate: a quantitative autoradiographic study J Neurooncol 7 suppl. 4 319 328 2585028 10.1007/BF02147089 1:STN:280:DyaK3c%2FmtlKktA%3D%3D (Pubitemid 19267993)
29. A Ghia WA Tomé S Thomas, et al. 2007 Distribution of brain metastases in relation to the hippocampus: implications for neurocognitive functional preservation Int J Radiat Oncol Biol Phys 68 suppl. 4 971 977 17446005 10.1016/j.ijrobp.2007.02.016 (Pubitemid 47048581)
30. AN Gutiérrez DC Westerly WA Tomé, et al. 2007 Whole brain radiotherapy with hippocampal avoidance and simultaneously integrated brain metastases boost: a planning study Int J Radiat Oncol Biol Phys 69 suppl. 2 589 597 17869672 (Pubitemid 47380106)
31. IJ Barani LW Cuttino SH Benedict, et al. 2007 Neural stem cell-preserving external-beam radiotherapy of central nervous system malignancies Int J Radiat Oncol Biol Phys 68 suppl. 4 978 985 17467925 10.1016/j.ijrobp.2007.01.064 (Pubitemid 47048580)
32. V Gondi R Tollakanahalli M Mehta, et al. 2010 Hippocampal-sparing whole brain radiotherapy: a "how-to" technique using helical tomotherapy and linear accelerated based intensity-modulated radiotherapy Int J Radiat Oncol Biol Phys 78 4 1244 1252 20598457 10.1016/j.ijrobp.2010.01.039
33. J Wong E Armour P Kazanzides, et al. 2008 High-resolution, small animal radiation research platform with X-ray tomographic guidance capabilities Int J Radiat Oncol Biol Phys 71 suppl. 5 1591 1599 18640502 10.1016/j.ijrobp.2008.04. 025 (Pubitemid 351978175)
34. E Tryggestad M Armour I Iordachita F Verhaegen JW Wong 2009 A comprehensive system for dosimetric commissioning and Monte Carlo validation for the small animal radiation research platform Phys Med Biol 54 suppl. 17 5341 5357 19687532 10.1088/0031-9155/54/17/017 1:STN:280:DC%2BD1MrmtFCksg%3D%3D
35. DWO Rogers BA Faddegon GX Ding C Ma J We TR Mackie 1995 BEAM: a Monte Carlo code to simulate radiotherapy treatment units Med Phys 22 suppl. 5 503 524 7643786 10.1118/1.597552 1:STN:280:DyaK2MzntFGgsQ%3D%3D
36. N Kee S Sivalingam R Boonstra JM Wojtowicz 2002 The utility of Ki-67 and BrdU as proliferative markers of adult neurogenesis J Neurosci Methods 115 suppl. 1 97 105 11897369 10.1016/S0165-0270(02)00007-9 1:CAS:528: DC%2BD38XhvVWmu7k%3D (Pubitemid 34202283)