메뉴 건너뛰기




Volumn 39, Issue 5, 2011, Pages 903-916

Ameliorative effects of ethanolic leaf extract of azadirachta indica on renal histologic alterations in streptozotocin-induced diabetic rats

Author keywords

Azadirachta indica; Diabetes Mellitus; Glomerulosclerosis; Hyperglycemia; Kidney; Neem

Indexed keywords

AZADIRACHTA INDICA EXTRACT; CREATININE; GLUCOSE; GLUCOSE OXIDASE; METFORMIN; ORAL ANTIDIABETIC AGENT; PARAFFIN; UREA;

EID: 80052631914     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X11009299     Document Type: Article
Times cited : (16)

References (43)
  • 1
    • 77954182398 scopus 로고    scopus 로고
    • Chronic treatment with ethanolic leaf extract of Azadirachta indica ameliorates lesions of pancreatic islets in streptozotocin diabetes
    • Akinola, O.B., E.A. Caxton-Martins and L. Dini. Chronic treatment with ethanolic leaf extract of Azadirachta indica ameliorates lesions of pancreatic islets in streptozotocin diabetes. Int. J. Morphol. 28: 292-302, 2010.
    • (2010) Int. J. Morphol. , vol.28 , pp. 292-302
    • Akinola, O.B.1    Caxton-Martins, E.A.2    Dini, L.3
  • 2
    • 1942473768 scopus 로고    scopus 로고
    • Quercetin, an anti-oxidant bioflavonoid, attenuates diabetic nephropathy in rats
    • DOI 10.1111/j.1440-1681.2004.03982.x
    • Anjaneyulu, M. and K. Chopra. Quercetin, an antioxidant bioflavonoid, attenuates diabetic nephropathy in rats. Clin. Exp. Pharmacol. Physiol. 31: 244-248, 2004. (Pubitemid 38507865)
    • (2004) Clinical and Experimental Pharmacology and Physiology , vol.31 , Issue.4 , pp. 244-248
    • Anjaneyulu, M.1    Chopra, K.2
  • 4
    • 59449089222 scopus 로고    scopus 로고
    • Diabetes in Sub-Saharan Africa: Kenya, Mali, Mozambique, Nigeria, South Africa and Zambia
    • Azevedo, M. and S. Alla. Diabetes in Sub-Saharan Africa: Kenya, Mali, Mozambique, Nigeria, South Africa and Zambia. Int. J. Diabetes Dev. Ctries. 28: 101-108, 2008.
    • (2008) Int. J. Diabetes Dev. Ctries. , vol.28 , pp. 101-108
    • Azevedo, M.1    Alla, S.2
  • 5
    • 0030011644 scopus 로고    scopus 로고
    • Possible mechanism of antihyperglycemic effect of Azadirachta indica leaf extract. Part IV
    • DOI 10.1016/0306-3623(95)02070-5
    • Chattopadhyay, R.R. Possible mechanism of antihyperglycaemic effect of Azadirachta indica leaf extract. Part IV. Gen. Pharmacol. 27: 431-434, 1996. (Pubitemid 26197892)
    • (1996) General Pharmacology , vol.27 , Issue.3 , pp. 431-434
    • Chattopadhyay, R.R.1
  • 6
    • 0031875056 scopus 로고    scopus 로고
    • Study of possible biochemical mode of anti-inflammatory action of Azadirachta indica in rats
    • Chattopadhyay, R.R. Study of possible biochemical mode of anti-inflammatory action of Azadirachta indica in rats. Indian J. Exp. Biol. 36: 418-420, 1998.
    • (1998) Indian J. Exp. Biol. , vol.36 , pp. 418-420
    • Chattopadhyay, R.R.1
  • 7
    • 0032888354 scopus 로고    scopus 로고
    • Possible mechanism of antihyperglycemic effect of Azadirachta indica leaf extract: Part V
    • DOI 10.1016/S0378-8741(99)00094-X, PII S037887419900094X
    • Chattopadhyay, R.R. Possible mechanism of antihyperglycaemic effect of Azadirachta indica leaf extract, Part V. J. Ethnopharmacol. 67: 373-376, 1999. (Pubitemid 29469750)
    • (1999) Journal of Ethnopharmacology , vol.67 , Issue.3 , pp. 373-376
    • Chattopadhyay, R.R.1
  • 8
    • 0034054733 scopus 로고    scopus 로고
    • On the ability of four flavonoids, baicilein, luteolin, naringenin, and quercetin, to suppress the fenton reaction of the iron-ATP complex
    • DOI 10.1023/A:1009229429250
    • Chen, L.E. and K. Breen. On the ability of four flavonoids, baicilein, luteolin, naringenin and quercetin to suppress the Fentone reaction of iron-ATP complex. Biometals 13: 77-83, 2000. (Pubitemid 30243039)
    • (2000) BioMetals , vol.13 , Issue.1 , pp. 77-83
    • Cheng, I.F.1    Breen, K.2
  • 9
    • 0018756482 scopus 로고
    • Glomerulopathy in rats with streptozotocin diabetes. Accumulation of glomerular basement membrane analogous to human diabetic nephropathy
    • Cohen, M.P. and C.V. Klein. Glomerulopathy in rats with streptozotocin diabetes: Accumulation of glomerular basement membrane analogous to human diabetic nephropathy. J. Exp. Med. 149: 623-631, 1979. (Pubitemid 9137676)
    • (1979) Journal of Experimental Medicine , vol.149 , Issue.3 , pp. 623-631
    • Cohen, M.P.1    Klein, C.V.2
  • 10
    • 0025313272 scopus 로고    scopus 로고
    • Increase in diacylglycerol mass in isolated glomeruli by glucose from de novo synthesis of glycerolipids
    • Craven, P.A., C.M. Davidson and F.R. DeRubertis. Increase in diacylglycerol mass in isolated glomeruli by glucose from de novo synthesis of glycerolipids. Diabetes 39: 667-674, 2001.
    • (2001) Diabetes , vol.39 , pp. 667-674
    • Craven, P.A.1    Davidson, C.M.2    DeRubertis, F.R.3
  • 11
    • 0032479204 scopus 로고    scopus 로고
    • Quercetin metabolites inhibit copper ion-induced lipid peroxidation in rat plasma
    • DOI 10.1016/S0014-5793(98)00709-1, PII S0014579398007091
    • da Silva, E.I., M.K. Piskula, N. Yamamoto, J.H. Moon and J. Terao. Quercetin metabolites inhibit copper ion-induced lipid peroxidation in rat plasma. FEBS Lett. 430: 405-408, 1998. (Pubitemid 28337954)
    • (1998) FEBS Letters , vol.430 , Issue.3 , pp. 405-408
    • Da Silva, E.L.1    Piskula, M.K.2    Yamamoto, N.3    Moon, J.-H.4    Terao, J.5
  • 12
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • Diabetes Control and Complication Trial Research Group
    • Diabetes Control and Complication Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. 329: 977-986, 1993.
    • (1993) N. Engl. J. Med. , vol.329 , pp. 977-986
  • 14
    • 48249116012 scopus 로고    scopus 로고
    • The antidiabetic efficacy of combined extracts from two continental plants: Azadirachta indica (A. Juss) (Neem) and Vernonia amygdalina (Del.) (African Bitter Leaf)
    • Ebong, P.E., I.J. Atangwho and G.E. Egbung. The antidiabetic efficacy of combined extracts from two continental plants: Azadirachta indica (A. Juss) (Neem) and Vernonia amygdalina (Del.) (African Bitter Leaf). Am. J. Biochem. Biotechnol. 4: 239-244, 2008.
    • (2008) Am. J. Biochem. Biotechnol. , vol.4 , pp. 239-244
    • Ebong, P.E.1    Atangwho, I.J.2    Egbung, G.E.3
  • 15
    • 0038627003 scopus 로고
    • Weteres uber diabetes mellitus, insbesondere uber die Complication desselben mit typhus abdominis
    • Ebstein, W. Weteres uber diabetes mellitus, insbesondere uber die Complication desselben mit typhus abdominis. Deutsches Arch. F. Klin. Med. 30: 1-44, 1882.
    • (1882) Deutsches Arch. F. Klin. Med. , vol.30 , pp. 1-44
    • Ebstein, W.1
  • 16
    • 0842328620 scopus 로고    scopus 로고
    • Protective role of extracts of neem seeds in diabetes caused by streptozotocin in rats
    • DOI 10.1016/j.jep.2003.09.024
    • Gupta, S., M. Kataria, P.K. Gupta, S. Murganandan and R.C. Yashroy. Protective role of extract of neem seeds in diabetes caused by streptozotocin in rats. J. Ethnopharmacol. 90: 185-189, 2004. (Pubitemid 38175412)
    • (2004) Journal of Ethnopharmacology , vol.90 , Issue.2-3 , pp. 185-189
    • Gupta, S.1    Kataria, M.2    Gupta, P.K.3    Murganandan, S.4    Yashroy, R.C.5
  • 17
    • 0016585544 scopus 로고
    • New colorimetric reaction for end-point, continuous- flow, and kinetic measurement of urea
    • Jung, D., H. Biggs, J. Erikson and P.U. Ledyard. New colorimetric reaction for end-point, continuous- flow, and kinetic measurement of urea. Clin. Chem. 21: 1136-1140, 1975.
    • (1975) Clin. Chem. , vol.21 , pp. 1136-1140
    • Jung, D.1    Biggs, H.2    Erikson, J.3    Ledyard, P.U.4
  • 18
    • 21144439198 scopus 로고    scopus 로고
    • Glycogen accumulation in renal tubules, a key morphological change in the diabetic kidney
    • Kang, J., X.S. Dai, T.B. Yu, B. Wen and Z.W. Yang. Glycogen accumulation in renal tubules, a key morphological change in the diabetic kidney. Acta Diabetol. 42: 110-116, 2005.
    • (2005) Acta Diabetol. , vol.42 , pp. 110-116
    • Kang, J.1    Dai, X.S.2    Yu, T.B.3    Wen, B.4    Yang, Z.W.5
  • 21
    • 0002437244 scopus 로고
    • Intercapillary lesions in the glomeruli of the kidney
    • Kimmelstiel, P. and C. Wilson. Intercapillary lesions in the glomeruli of the kidney. Am. J. Pathol. 12: 83-96, 1936.
    • (1936) Am. J. Pathol. , vol.12 , pp. 83-96
    • Kimmelstiel, P.1    Wilson, C.2
  • 22
    • 0028103781 scopus 로고
    • Armanni-Ebstein lesions of the kidney: Diagnostic of death in diabetic coma?
    • DOI 10.1016/0379-0738(94)90087-6
    • Kock, K.F. and V. Vestergaard. Armanni-Ebstein lesions of the kidney: Diagnostic of death in diabetic coma? Forensic Sci. Int. 67: 169-174, 1994. (Pubitemid 24291042)
    • (1994) Forensic Science International , vol.67 , Issue.3 , pp. 169-174
    • Kock, K.F.1    Vestergaard, V.2
  • 25
    • 0018227294 scopus 로고
    • A preliminary study on hypoglycaemic and antihyperglycaemic effect of Azadirachta indica
    • Murty, S.K., R.D. Narayana, R.D. Krishna and M.L. Gopalakrishna. A preliminary study on hypoglycaemic and antihyperglycaemic effect of Azadirachta indica. Indian J. Pharmacol. 10: 247-250, 1978.
    • (1978) Indian J. Pharmacol. , vol.10 , pp. 247-250
    • Murty, S.K.1    Narayana, R.D.2    Krishna, R.D.3    Gopalakrishna, M.L.4
  • 26
    • 1442325587 scopus 로고    scopus 로고
    • Initial Characterization of A Rat Model of Diabetic Nephropathy
    • DOI 10.2337/diabetes.53.3.735
    • Nobrega, M.A., S. Fleming, R.J. Roman, M. Shiozawa, N. Schlick, J. Lazar and H.J. Jacob. Initial characterisation of a rat model of diabetic nephropathy. Diabetes 53: 735-742, 2004. (Pubitemid 38270644)
    • (2004) Diabetes , vol.53 , Issue.3 , pp. 735-742
    • Nobrega, M.A.1    Fleming, S.2    Roman, R.J.3    Shiozawa, M.4    Schlick, N.5    Lazar, J.6    Jacob, H.J.7
  • 27
    • 0029147687 scopus 로고
    • Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: A randomized prospective 6-year study
    • Ohkubo, Y., H. Kishikawa and E. Araki. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: A randomized prospective 6-year study. Diabetes Res. Clin. Pract. 28: 103-107, 1995.
    • (1995) Diabetes Res. Clin. Pract. , vol.28 , pp. 103-107
    • Ohkubo, Y.1    Kishikawa, H.2    Araki, E.3
  • 28
    • 0024385058 scopus 로고
    • Hypoglycaemic effect of metformin in genetically obese (fa/fa) rats results from an increased utilization of blood glucose by intestine
    • Penicaud, L., Y. Hitier, P. Ferre and J. Girard. Hypoglycaemic effect of metformin in genetically obese (fa/fa) rats results from an increased utilization of blood glucose by intestine. Biochem. J. 262: 881-885, 1989. (Pubitemid 19225163)
    • (1989) Biochemical Journal , vol.262 , Issue.3 , pp. 881-885
    • Penicaud, L.1    Hitier, Y.2    Ferre, P.3    Girard, J.4
  • 29
    • 0027049764 scopus 로고
    • Oxidation markedly reduces bilirubin interference in the Jaffe creatinine assay
    • Rajs, G. and M. Mayer. Oxidation markedly reduces bilirubin interference in the Jaffe creatinine assay. Clin. Chem. 38: 2411-2413, 1992. (Pubitemid 23006202)
    • (1992) Clinical Chemistry , vol.38 , Issue.12 , pp. 2411-2413
    • Rajs, G.1    Mayer, M.2
  • 30
    • 0018595684 scopus 로고
    • Prevention of diabetic glomerulopathy in streptozotocin diabetic rats by insulin treatment. The mesangial regions
    • DOI 10.1007/BF01235861
    • Rasch, R. Prevention of diabetic glomerulopathy in streptozotocin- diabetic rats by insulin treatment: The mesangial regions. Diabetologia 17: 243-248, 1979. (Pubitemid 10189644)
    • (1979) Diabetologia , vol.17 , Issue.4 , pp. 243-248
    • Rasch, R.1
  • 31
    • 0001359534 scopus 로고
    • The pathology of Armanni-Ebstein nephropathy
    • Ritchie, S. and D. Waugh. The pathology of Armanni-Ebstein nephropathy. Am. J. Pathol. 33: 1035-1043, 1957.
    • (1957) Am. J. Pathol. , vol.33 , pp. 1035-1043
    • Ritchie, S.1    Waugh, D.2
  • 32
    • 0023864255 scopus 로고
    • Flavonoids are scavengers of superoxide anions
    • DOI 10.1016/0006-2952(88)90169-4
    • Robak, J. and R.J. Gryglewski. Flavonoids are scavengers of superoxide anions. Biochem. Pharmacol. 37: 837-841, 1988. (Pubitemid 18058453)
    • (1988) Biochemical Pharmacology , vol.37 , Issue.5 , pp. 837-841
    • Robak, J.1    Gryglewski, R.J.2
  • 36
    • 4544270740 scopus 로고    scopus 로고
    • Tetracyclic triterpenoids from the leaves of Azadirachta indica
    • DOI 10.1016/j.phytochem.2004.04.031, PII S0031942204001906
    • Siddiqui, B.S., F. Afshan, T. Gulzar and M. Hanif. Tetracyclic triterpenoids from the leaves of Azadirachta indica. Phytochemistry 65: 2363-2367, 2004. (Pubitemid 39237253)
    • (2004) Phytochemistry , vol.65 , Issue.16 , pp. 2363-2367
    • Siddiqui, B.S.1    Afshan, F.2    Gulzar, T.3    Hanif, M.4
  • 37
    • 26444523926 scopus 로고    scopus 로고
    • Partial protective effect of rutin on multiple low dose streptozotocin-induced diabetes in mice [2]
    • Srinivasan, K., C.L. Kaul and P. Ramarao. Partial protective effect of rutin on multiple low dose streptozotocin-induced diabetes in mice. Indian J. Pharmacol. 37: 327-328, 2005. (Pubitemid 41434091)
    • (2005) Indian Journal of Pharmacology , vol.37 , Issue.5 , pp. 327-328
    • Srinivasan, K.1    Kaul, C.L.2    Ramarao, P.3
  • 38
    • 0034456212 scopus 로고    scopus 로고
    • Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats
    • DOI 10.1210/en.141.6.1936
    • Szayna, M., M.E. Doyle, J.A. Betkey, H.W. Holloway, R.G. Spencer, N.H. Greig and J.M. Egan. Exendin-4 decelerates food intake, weight gain and fat deposition in Zucker rats. Endocrinology 141: 1936-1941, 2000. (Pubitemid 32274340)
    • (2000) Endocrinology , vol.141 , Issue.6 , pp. 1936-1941
    • Szayna, M.1    Doyle, M.E.2    Betkey, J.A.3    Holloway, H.W.4    Spencer, R.G.S.5    Greig, N.H.6    Egan, J.M.7
  • 41
    • 0035720552 scopus 로고    scopus 로고
    • Chronic exposure of human mesangial cells to high glucose environments activates the p38 MAPK pathway
    • DOI 10.1046/j.1523-1755.2001.060003858.x
    • Wilmer, W.A., C.L. Dixon and C. Hebert. Chronic exposure of human mesangial cell to high glucose environment activates the p38 MAPK pathway. Kidney Int. 60: 858-871, 2001. (Pubitemid 34205786)
    • (2001) Kidney International , vol.60 , Issue.3 , pp. 858-871
    • Wilmer, W.A.1    Dixon, C.L.2    Hebert, C.3
  • 42
    • 0037246065 scopus 로고    scopus 로고
    • Advanced glycation end products inhibit de novo protein synthesis and induce TGF-β overexpression in proximal tubular cells
    • DOI 10.1046/j.1523-1755.2003.00752.x
    • Yamagishi, S.H., Y. Inagaki, T. Okamoto, S. Amano, K. Koga and M. Takeuchi. Advanced glycation end-products inhibit de novo protein synthesis and induce TGF-ß overexpression in proximal tubular cells. Kidney Int. 63: 464-473, 2003. (Pubitemid 36126793)
    • (2003) Kidney International , vol.63 , Issue.2 , pp. 464-473
    • Yamagishi, S.-I.1    Inagaki, Y.2    Okamoto, T.3    Amano, S.4    Koga, K.5    Takeuchi, M.6
  • 43
    • 0006155912 scopus 로고    scopus 로고
    • Involvement of TGF-ß and its receptors in the pathogenesis of diabetic nephropathy
    • Ziyadeh, F. and D.C. Han. Involvement of TGF-ß and its receptors in the pathogenesis of diabetic nephropathy. Kidney Int. 60(Suppl.): S7-S11, 1997.
    • (1997) Kidney Int. , vol.60 , Issue.SUPPL.
    • Ziyadeh, F.1    Han, D.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.