A quantitative correlation of the effect of density distributions in roller-compacted ribbons on the mechanical properties of tablets using ultrasonics and X-ray tomography

AAPS PharmSciTech

Volumn 12, Issue 3, 2011, Pages 834-853

  Akseli, Ilgaz ^a   Iyer, Srinivas ^a   Lee, Hwahsiung P ^a   Cuitiño, Alberto M ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

density distribution; elastic properties; nondestructive ultrasonic technique; roller compaction; tensile strength; x ray micro computed tomography

Indexed keywords

NANORIBBON;

ARTICLE; CONTROLLED STUDY; LUBRICATION; MICRO-COMPUTED TOMOGRAPHY; PARTICLE SIZE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TABLET PROPERTY; TENSILE STRENGTH; ULTRASOUND; X RAY;

CELLULOSE; DRUG COMPOUNDING; EXCIPIENTS; IMAGE PROCESSING, COMPUTER-ASSISTED; LUBRICANTS; LUBRICATION; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POROSITY; POWDERS; PRESSURE; SURFACE PROPERTIES; TABLETS; TENSILE STRENGTH; ULTRASONICS; X-RAY MICROTOMOGRAPHY;

EID: 80052604860     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-011-9640-z     Document Type: Article

References (41)

1. Miller RW. Roller compaction technology. In: Parikh DM, editor. Handbook of pharmaceutical granulation technology. New York: Marcel Dekker; 1997. p. 100-49.
2. MC Adeyeye 2000 Roller compaction and milling pharmaceutical unit processes: part I Am Pharm Rev 3 37 42 1:CAS:528:DC%2BD3MXhtVegtrg%3D
3. PJ Sheskey J Hendren 1999 The effects of roll compaction equipment variables granulation technique and HPMC polymer level on a controlled-release matrix model drug formulation Pharm Technol 23 90 106 1:CAS:528: DyaK1MXitVektrc%3D (Pubitemid 29135948)
4. O Simon P Guigon 2003 Correlation between powder-packing properties and roll press compact heterogeneity Powder technol 130 257 264 10.1016/S0032- 5910(02)00202-4 1:CAS:528:DC%2BD3sXhs1aksL4%3D (Pubitemid 36293201)
5. P Kleinebudde 2004 Roll compaction/dry granulation: pharmaceutical applications Eur J Pharm Biopharm 58 317 326 15296958 10.1016/j.ejpb.2004.04.014 1:CAS:528:DC%2BD2cXmsVGns7s%3D (Pubitemid 39037238)
6. AV Zinchuk MP Mullarney BC Hancock 2004 Simulation of roller compaction using a laboratory scale compaction simulator Int J Pharm 269 403 415 14706252 10.1016/j.ijpharm.2003.09.034 1:CAS:528:DC%2BD3sXhtVWjsr%2FP (Pubitemid 38045304)
7. W Weyenberg A Vermeire J Vandervoort JP Remon A Ludwig 2005 Effects of roller compaction settings on the preparation of bioadhesive granules on ocular minitablets Eur J Pharm Biopharm 59 527 536 15760734 10.1016/j.ejpb.2004.09.012 1:CAS:528:DC%2BD2MXit1Chs7o%3D (Pubitemid 40342527)
8. G Bindhumadhavan JPK Seville MJ Adams RW Greenwood S Fitzpatrick 2005 Roll compaction of a pharmaceutical excipient: experimental validation of rolling theory for granular solids Chem Eng Sci 60 3891 3897 10.1016/j.ces.2005.02.022 1:CAS:528:DC%2BD2MXktlCgtLk%3D (Pubitemid 40665418)
9. H Xiaorong JS Pamela EA Gregory 2007 Mechanistic study of the effect of roller compaction and lubricant on tablet mechanical strength J Pharm Sci 96 1342 1355 10.1002/jps.20938 (Pubitemid 46797493)
10. L Farber KP Hapgood JN Michaels XY Fu R Meyer MA Johnson F Li 2008 Unified compaction curve model for tensile strength of tablets made by roller compaction and direct compression Int J Pharm 346 17 24 17689211 10.1016/j.ijpharm.2007.06.022 1:CAS:528:DC%2BD2sXhtlWmsLbN (Pubitemid 350101988)
11. AM Miguélez-Morán CY Wu H Dong JPK Seville 2009 Characterisation of density distributions in roller-compacted ribbons using micro-indentation and X-ray micro-computed tomography Eur J Pharm Biopharm 72 173 182 19130881 10.1016/j.ejpb.2008.12.005
12. SA Mitchell TD Reynolds TP Dasbach 2003 A compaction process to enhance dissolution of poorlywatersoluble drugs using hydroxypropyl methylcellulose Int J Pharm 250 3 11 12480268 10.1016/S0378-5173(02)00293-4 1:CAS:528: DC%2BD38Xpt12rurg%3D (Pubitemid 35447932)
13. Y Funakoshi T Asogawa E Satake 1977 Use of a novel roller compactor with a concavo-convex roller pair to obtain uniform compacting pressure Drug Dev Ind Pharm 6 555 573 10.3109/03639047709055633 (Pubitemid 8272661)
14. S Malkowska KA Khan 1983 Effect of recompression on the properties of tablets prepared by dry granulation Drug Dev Ind Pharm 9 331 347 10.3109/03639048309044678 1:CAS:528:DyaL3sXktFSrs7o%3D (Pubitemid 13128688)
15. RJ Roberts RC Rowe 1999 Relationships between the modulus of elasticity and tensile strength for pharmaceutical drugs and excipients J Pharm Pharmacol 51 975 977 10528978 10.1211/0022357991773438 1:CAS:528:DyaK1MXmslKhtbg%3D (Pubitemid 29462383)
16. F Podczeck KR Drake JM Newton I Haririan 2006 The strength of bilayered tablet Eur J Pharm Sci 29 361 366 16950605 10.1016/j.ejps.2006.07.005 1:CAS:528:DC%2BD28XhtF2qurzO (Pubitemid 44709859)
17. I Akseli G Mani C Cetinkaya 2008 Non-destructive acoustic defect detection in drug tablets Int J Pharm 360 65 76 18502061 10.1016/j.ijpharm.2008. 04.019 1:CAS:528:DC%2BD1cXos12ms7Y%3D
18. S Hein KM Picker-Freyer 2008 Simulation of roller compaction with subsequent tableting and characterization of lactose and microcrystalline cellulose Pharm Dev Technol 13 523 532 18728996 10.1080/10837450802288972 1:CAS:528:DC%2BD1cXht1ymsrbK
19. PJ Sheskey TD Cabelka RT Robb BM Boyce 1994 Use of roller compaction in the preparation of controlled-release hydrophilic matrix tablets containing methylcellulose and hydroxypropyl methylcellulose polymers Pharm Technol 9 133 150
20. CC Sun MW Himmelspach 2006 Reduced tabletability of roller compacted granules as a result of granule size enlargement J Pharm Sci 95 200 206 16315244 10.1002/jps.20531 1:CAS:528:DC%2BD28XlvVSgtg%3D%3D
21. G Alderborn C Nystrom 1982 Studies on direct compression of tablets. III. The effect on tablet strength of changes in particle shape and texture obtained by milling Acta Pharm Suec 19 147 156 7102353 1:CAS:528:DyaL38Xit1eitrw%3D
22. M Luangtana-Anan JT Fell 1990 Bonding mechanisms in tabletting Int J Pharm 60 197 202 10.1016/0378-5173(90)90073-D 1:CAS:528:DyaK3cXks1Giu7o%3D (Pubitemid 20179665)
23. MS Kadiri A Michrafy JA Dodds 2005 Pharmaceutical powders compaction: experimental and numerical analysis of the density distribution Powder Technol 157 176 182 10.1016/j.powtec.2005.05.025 1:CAS:528:DC%2BD2MXhtVyrsLfI (Pubitemid 41435532)
24. BC Hancock SD Clas K Christensen 2000 Micro-scale measurement of the mechanical properties of compressed pharmaceutical powders. 1: The elasticity and fracture behaviour of microcrystalline cellulose Int J Pharm 209 27 35 11084243 10.1016/S0378-5173(00)00541-X 1:CAS:528:DC%2BD3cXotVensb0%3D
25. SJ Eichhorn RJ Young 2001 The Young's modulus of microcrystalline cellulose Cellulose 8 197 207 10.1023/A:1013181804540 1:CAS:528: DC%2BD38Xht1Wlt70%3D (Pubitemid 34068210)
26. I Akseli C Libordi C Cetinkaya 2008 Real-time acoustic elastic property monitoring of compacts during compaction J Pharm Innov 3 134 140 10.1007/s12247-008-9029-z
27. I Akseli DC Becker C Cetinkaya 2009 Ultrasonic determination of Young's Moduli's of the coat and core of a drug tablet Int J Pharm 370 17 25 19059326 10.1016/j.ijpharm.2008.11.003 1:CAS:528:DC%2BD1MXislKisb4%3D
28. I Akseli BC Hancock C Cetinkaya 2009 Anisotropic mechanical property testing for the development of pharmaceutical dosage forms Int J Pharm 377 35 44 19426791 10.1016/j.ijpharm.2009.04.040 1:CAS:528:DC%2BD1MXotlOlsLY%3D
29. I Akseli D Dey C Cetinkaya 2010 Mechanical property characterization of bilayered tablets using nondestructive air-coupled acoustics AAPS PharmSciTech 11 90 102 20063078 10.1208/s12249-009-9352-9 1:CAS:528:DC%2BC3cXovFahsrw%3D
30. V Busignies B Leclerc P Porion P Evesque G Couarraze P Tchoreloff 2006 Quantitative measurements of localized density variations in cylindrical tablets using X-ray microtomography Eur J Pharm Biopharm 64 38 50 16621489 10.1016/j.ejpb.2006.02.007 1:CAS:528:DC%2BD28XnsFygtb4%3D (Pubitemid 44150597)
31. IC Sinka SF Burch JH Tweed JC Cunningham 2004 Measurement of density variations in tablets using X-ray computed tomography Int J Pharm 271 215 224 15129988 10.1016/j.ijpharm.2003.11.022 1:CAS:528:DC%2BD2cXhtVeku7o%3D (Pubitemid 38210099)
32. BC Hancock MP Mullarney 2005 X-ray microtomography of solid dosage forms Pharmaceut Tech. 2 92 100 (Pubitemid 40575702)
33. AC Kak 1979 Computerized tomography with X-ray, emission and ultrasound sources Proc IEEE 67 1245 1272 10.1109/PROC.1979.11440 (Pubitemid 9244877)
34. BC Hancock JT Colvin PM Mullarney AV Zinchuk 2003 The relative densities of pharmaceutical powders, blends, dry granulations, and immediate-release tablets Pharm Technol 27 64 80 1:CAS:528:DC%2BD3sXjsVOmtrs%3D
35. RW Heckel 1961 Density-pressure relationships in powder compaction Trans Metall Soc AIME 221 671 675 1:CAS:528:DyaF3MXht1ertb0%3D
36. PJ Denny 2002 Compaction equations: a comparison of the Heckel and Kawakita equations Powder Technol 127 162 172 10.1016/S0032-5910(02)00111-0 1:CAS:528:DC%2BD38XnvVOhtbg%3D
37. Hersey, J.A. and Rees, J.E., 1970. The effect of particle size on the consolidation of powders during compaction. Particle Size Analysis Conference, 2nd edn. University of Bradford: Bradford, UK
38. JT Fell JM Newton 1970 Determination of tablet strength by the diametral-compression test J Pharm Sci 59 688 691 5446428 10.1002/jps.2600590523 1:CAS:528:DyaE3cXkt1yrtbw%3D
39. I Krycer DV Pope JA Hersey 1982 An evaluation of the techniques employed to investigate powder compaction behavior Int J Pharm 12 113 134 10.1016/0378-5173(82)90112-0 1:CAS:528:DyaL3sXit1WlsQ%3D%3D (Pubitemid 12037336)
40. B Johansson G Alderborn 1996 Degree of pellet deformation during compaction and its relationship to the tensile strength of tablets formed of microcrystalline cellulose pellets Int J Pharm 132 207 220 10.1016/0378-5173(95) 04373-X 1:CAS:528:DyaK28XjtFSkt74%3D (Pubitemid 26160313)
41. ME Aulton HG Tebby PJ White 1974 Indentation hardness testing of tablets J Pharm Pharmacol 26 Suppl 59P 60P 4156738 10.1111/j.2042-7158.1974.tb10081.x