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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 19, 2011, Pages 5757-5761

Improved synthesis and biological evaluation of chelator-modified α-MSH analogs prepared by copper-free click chemistry

(7) Baumhover, Nicholas J a Martin, Molly E a Parameswarappa, Sharavathi G b Kloepping, Kyle C a O'Dorisio, M Sue a Pigge, F Christopher b Schultz, Michael K a

a UNIVERSITY OF IOWA (United States)

b University of Iowa (United States)

Author keywords

Copper free click chemistry; Copper 64; Cyclooctyne; Gallium 68; Melanocyte stimulating hormone; Molecular imaging; Peptide synthesis; PET; PRRT; Radionuclide therapy

Indexed keywords

1,4,7 TRIAZACYCLONONANE 1,4,7 TRIACETIC ACID; 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; ALPHA INTERMEDIN DERIVATIVE; CELL SURFACE RECEPTOR; CHELATING AGENT; COPPER 64; GALLIUM 68; UNCLASSIFIED DRUG;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; BINDING AFFINITY; CLICK CHEMISTRY; DRUG SPECIFICITY; DRUG SYNTHESIS; HORMONE SYNTHESIS; ISOTOPE LABELING; MOUSE; NONHUMAN; ROOM TEMPERATURE;

ALPHA-MSH; ANIMALS; AZIDES; CELL LINE, TUMOR; CHELATING AGENTS; CLICK CHEMISTRY; COPPER; COPPER RADIOISOTOPES; DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; GALLIUM RADIOISOTOPES; HETEROCYCLIC COMPOUNDS; HETEROCYCLIC COMPOUNDS, 1-RING; HUMANS; MICE; PROTEIN BINDING; RADIOPHARMACEUTICALS; SENSITIVITY AND SPECIFICITY;

EID: 80052604141 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.08.017 Document Type: Article

Times cited : (27)

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