Synthesis and radiolabeling of chelator-RNA aptamer bioconjugates with copper-64 for targeted molecular imaging

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 13, 2011, Pages 4080-4090

  Rockey, William M ^a   Huang, Ling ^c   Kloepping, Kyle C ^a,b   Baumhover, Nicholas J ^a   Giangrande, Paloma H ^a   Schultz, Michael K ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c INTEGRATED DNA TECHNOLOGIES   (United States)

Author keywords

Aptamer; Chelator; Copper 64; Positron emission tomography; Prostate cancer; PSMA; RNA

Indexed keywords

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7 TRIACETIC ACID MONO N HYDROXYSUCCINIMIDE; 3,6,10,13,16,19 HEXAAZBICYCLO[6.6.6]ICOSANE 1,8 DIAMINE; 3,6,9,15 TETRAAZABICYCLO[9.3.1]PENTADECA 1(15),11 13 TRIEEN 3,6,9 TRIACETIC ACID; APTAMER; CHELATING AGENT; COPPER 64; PROSTATE SPECIFIC MEMBRANE ANTIGEN; RNA APTAMER; S 2 (4 ISOTHIOCYANATOBENZYL) 1,4,7 TRIAZACYCLONONANE 1,4,7 TRIACETIC ACID; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ARTICLE; CONJUGATION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; ISOTOPE LABELING; MALE; MOLECULAR IMAGING; PH; POSITRON EMISSION TOMOGRAPHY; PROSTATE CANCER; RADIOCHEMISTRY; RNA STABILITY; TEMPERATURE; TIME;

ANIMALS; APTAMERS, NUCLEOTIDE; CHELATING AGENTS; COPPER RADIOISOTOPES; HYDROGEN-ION CONCENTRATION; ISOTOPE LABELING; MALE; MICE; POSITRON-EMISSION TOMOGRAPHY; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; RADIOPHARMACEUTICALS; TEMPERATURE;

EID: 79959516872     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.05.010     Document Type: Article

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