Mucin granule-associated proteins in human bronchial epithelial cells: The airway goblet cell "granulome"

Respiratory Research

Volumn 12, Issue , 2011, Pages

  Raiford, Kimberly L ^b   Park, Joungjoa ^a   Lin, Ko Wei ^c   Fang, Shijing ^a   Crews, Anne L ^a   Adler, Kenneth B ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ACTIVATED CHLORIDE CHANNEL; CALCIUM CHANNEL; CYSTEINE STRING PROTEIN; HEAT SHOCK PROTEIN 70; MARCKS PROTEIN; MUCIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG; MEMBRANE PROTEIN;

ARTICLE; BRONCHUS MUCOSA; CELL DIFFERENTIATION; GOBLET CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOPRECIPITATION; ISOLATION PROCEDURE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEMBRANE; PROTEIN SECRETION; WESTERN BLOTTING; BRONCHUS; CELL CULTURE; CELL GRANULE; CHEMISTRY; COMPARATIVE STUDY; METABOLISM; RESPIRATORY TRACT MUCOSA; SECRETION; ULTRASTRUCTURE;

BRONCHI; CELLS, CULTURED; CYTOPLASMIC GRANULES; GOBLET CELLS; HUMANS; MEMBRANE GLYCOPROTEINS; MUCINS; RESPIRATORY MUCOSA;

EID: 80052599854     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-12-118     Document Type: Article

References (44)

1. Knight DA, Holgate ST. The airway epithelium: structural and functional properties in health and disease. Respirology 2003, 8:432-446. 10.1046/j.1440-1843.2003.00493.x, 14708552.
2. Kim KC, McCracken K, Lee BC, Shin CY, Jo MJ, Lee CJ, Ko KH. Airway goblet cell mucin: its structure and regulation of secretion. Eur Respir J 1997, 10:2644-2649. 10.1183/09031936.97.10112644, 9426108.
3. Rogers DF. Physiology of airway mucus secretion and pathophysiology of hypersecretion. Respir Care 2007, 52:1134-1146. discussion 1146-1139.
4. Fahy JV, B D. Airway mucus function and dysfunction. N Engl J Med 2010, 2:2233-2247.
5. Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, Donaldson DD. Interleukin-13: central mediator of allergic asthma. Science 1998, 282:2258-2261.
6. Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 2002, 8:885-889.
7. Li Y, Martin LD, Spizz G, Adler KB. MARCKS protein is a key molecule regulating mucin secretion by human airway epithelial cells in vitro. J Biol Chem 2001, 276:40982-40990. 10.1074/jbc.M105614200, 11533058.
8. Nakanishi A, Morita S, Iwashita H, Sagiya Y, Ashida Y, Shirafuji H, Fujisawa Y, Nishimura O, Fujino M. Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma. Proc Natl Acad Sci USA 2001, 98:5175-5180. 10.1073/pnas.081510898, 33183, 11296262.
9. Park J, Fang S, Crews AL, Lin KW, Adler KB. MARCKS regulation of mucin secretion by airway epithelium in vitro: interaction with chaperones. Am J Respir Cell Mol Biol 2008, 39:68-76. 10.1165/rcmb.2007-0139OC, 2438449, 18314541.
10. Krunkosky TM, Fischer BM, Martin LD, Jones N, Akley NJ, Adler KB. Effects of TNF-alpha on expression of ICAM-1 in human airway epithelial cells in vitro. Signaling pathways controlling surface and gene expression. Am J Respir Cell Mol Biol 2000, 22:685-692.
11. Wu TT, Castle JD. Evidence for colocalization and interaction between 37 and 39 kDa isoforms of secretory carrier membrane proteins (SCAMPs). J Cell Sci 1997, 110(Pt 13):1533-1541.
12. Lin H, Carlson DM, St George JA, Plopper CG, Wu R. An ELISA method for the quantitation of tracheal mucins from human and nonhuman primates. Am J Respir Cell Mol Biol 1989, 1:41-48.
13. Vaughn CP, Crockett DK, Lim MS, Elenitoba-Johnson KS. Analytical characteristics of cleavable isotope-coded affinity tag-LC-tandem mass spectrometry for quantitative proteomic studies. J Mol Diagn 2006, 8:513-520. 10.2353/jmoldx.2006.060036, 1867626, 16931593.
14. Peterman SM, Dufresne CP, Horning S. The use of a hybrid linear trap/FT-ICR mass spectrometer for on-line high resolution/high mass accuracy bottom-up sequencing. J Biomol Tech 2005, 16:112-124. 2291714, 16030318.
15. Guo Y, Singleton PA, Rowshan A, Gucek M, Cole RN, Graham DR, Van Eyk JE, Garcia JG. Quantitative proteomics analysis of human endothelial cell membrane rafts: evidence of MARCKS and MRP regulation in the sphingosine 1-phosphate-induced barrier enhancement. Mol Cell Proteomics 2007, 6:689-696. 10.1074/mcp.M600398-MCP200, 17210631.
16. Jethwaney D, Islam MR, Leidal KG, de Bernabe DB, Campbell KP, Nauseef WM, Gibson BW. Proteomic analysis of plasma membrane and secretory vesicles from human neutrophils. Proteome Sci 2007, 5:12. 10.1186/1477-5956-5-12, 2075486, 17692124.
17. Brunner Y, Coute Y, Iezzi M, Foti M, Fukuda M, Hochstrasser DF, Wollheim CB, Sanchez JC. Proteomics analysis of insulin secretory granules. Mol Cell Proteomics 2007, 6:1007-1017. 10.1074/mcp.M600443-MCP200, 17317658.
18. Leverkoehne I, Gruber AD. The murine mCLCA3 (alias gob-5) protein is located in the mucin granule membranes of intestinal, respiratory, and uterine goblet cells. J Histochem Cytochem 2002, 50:829-838. 10.1177/002215540205000609, 12019299.
19. Hauber HP, Tsicopoulos A, Wallaert B, Griffin S, McElvaney NG, Daigneault P, Mueller Z, Olivenstein R, Holroyd KJ, Levitt RC, Hamid Q. Expression of HCLCA1 in cystic fibrosis lungs is associated with mucus overproduction. Eur Respir J 2004, 23:846-850. 10.1183/09031936.04.00096504, 15218996.
20. Robichaud A, Tuck SA, Kargman S, Tam J, Wong E, Abramovitz M, Mortimer JR, Burston HE, Masson P, Hirota J, et al. Gob-5 is not essential for mucus overproduction in preclinical murine models of allergic asthma. Am J Respir Cell Mol Biol 2005, 33:303-314. 10.1165/rcmb.2004-0372OC, 15947424.
21. Pauli BU, Abdel-Ghany M, Cheng HC, Gruber AD, Archibald HA, Elble RC. Molecular characteristics and functional diversity of CLCA family members. Clin Exp Pharmacol Physiol 2000, 27:901-905. 10.1046/j.1440-1681.2000.03358.x, 11071307.
22. Gruber AD, Gandhi R, Pauli BU. The murine calcium-sensitive chloride channel (mCaCC) is widely expressed in secretory epithelia and in other select tissues. Histochem Cell Biol 1998, 110:43-49. 10.1007/s004180050263, 9681688.
23. Gibson A, Lewis AP, Affleck K, Aitken AJ, Meldrum E, Thompson N. hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels. J Biol Chem 2005, 280:27205-27212. 10.1074/jbc.M504654200, 15919655.
24. Mundhenk L, Alfalah M, Elble RC, Pauli BU, Naim HY, Gruber AD. Both cleavage products of the mCLCA3 protein are secreted soluble proteins. J Biol Chem 2006, 281:30072-30080. 10.1074/jbc.M606489200, 16895902.
25. Singer M, Martin LD, Vargaftig BB, Park J, Gruber AD, Li Y, Adler KB. A MARCKS-related peptide blocks mucus hypersecretion in a mouse model of asthma. Nat Med 2004, 10:193-196. 10.1038/nm983, 14716307.
26. Yang PC, Luh KT, Kuo SH, Wu CW. Immunocytochemistry and ELISA quantitation of mucin for diagnosis of malignant pleural effusions. Am Rev Respir Dis 1992, 146:1571-1575.
27. Rogers DF. The airway goblet cell. Int J Biochem Cell Biol 2003, 35:1-6. 10.1016/S1357-2725(02)00083-3, 12467641.
28. Thevenod F. Ion channels in secretory granules of the pancreas and their role in exocytosis and release of secretory proteins. Am J Physiol Cell Physiol 2002, 283:C651-672.
29. Evans GJ, Wilkinson MC, Graham ME, Turner KM, Chamberlain LH, Burgoyne RD, Morgan A. Phosphorylation of cysteine string protein by protein kinase A. Implications for the modulation of exocytosis. J Biol Chem 2001, 276:47877-47885.
30. Evans GJ, Morgan A, Burgoyne RD. Tying everything together: the multiple roles of cysteine string protein (CSP) in regulated exocytosis. Traffic 2003, 4:653-659. 10.1034/j.1600-0854.2003.00127.x, 12956868.
31. Smith GB, Umbach JA, Hirano A, Gundersen CB. Interaction between constitutively expressed heat shock protein, Hsc 70, and cysteine string protein is important for cortical granule exocytosis in Xenopus oocytes. J Biol Chem 2005, 280:32669-32675. 10.1074/jbc.M501806200, 16055447.
32. Delanote V, Vandekerckhove J, Gettemans J. Plastins: versatile modulators of actin organization in (patho)physiological cellular processes. Acta Pharmacol Sin 2005, 26:769-779. 10.1111/j.1745-7254.2005.00145.x, 15960882.
33. Birkenfeld J, Kartmann B, Betz H, Roth D. Cofilin activation during Ca(2+)-triggered secretion from adrenal chromaffin cells. Biochem Biophys Res Commun 2001, 286:493-498. 10.1006/bbrc.2001.5435, 11511085.
34. Burgoyne RD, Geisow MJ. The annexin family of calcium-binding proteins. Review article. Cell Calcium 1989, 10:1-10. 10.1016/0143-4160(89)90038-9, 2659190.
35. de Graauw M, Tijdens I, Smeets MB, Hensbergen PJ, Deelder AM, van de Water B. Annexin A2 phosphorylation mediates cell scattering and branching morphogenesis via cofilin Activation. Mol Cell Biol 2008, 28:1029-1040. 10.1128/MCB.01247-07, 2223391, 18070928.
36. Sun HQ, Yamamoto M, Mejillano M, Yin HL. Gelsolin, a multifunctional actin regulatory protein. J Biol Chem 1999, 274:33179-33182. 10.1074/jbc.274.47.33179, 10559185.
37. Candiano G, Bruschi M, Pedemonte N, Caci E, Liberatori S, Bini L, Pellegrini C, Vigano M, O'Connor BJ, Lee TH, et al. Gelsolin secretion in interleukin-4-treated bronchial epithelia and in asthmatic airways. Am J Respir Crit Care Med 2005, 172:1090-1096. 10.1164/rccm.200409-1185OC, 16100010.
38. Reck-Peterson SL, Provance DW, Mooseker MS, Mercer JA. Class V myosins. Biochim Biophys Acta 2000, 1496:36-51. 10.1016/S0167-4889(00)00007-0, 10722875.
39. Langford GM. Myosin-V, a versatile motor for short-range vesicle transport. Traffic 2002, 3:859-865. 10.1034/j.1600-0854.2002.31202.x, 12453149.
40. Desnos C, Huet S, Fanget I, Chapuis C, Bottiger C, Racine V, Sibarita JB, Henry JP, Darchen F. Myosin va mediates docking of secretory granules at the plasma membrane. J Neurosci 2007, 27:10636-10645. 10.1523/JNEUROSCI.1228-07.2007, 17898234.
41. Lin KW, Fang S, Park J, Crews AL, Adler KB. MARCKS and related chaperones bind to unconventional myosin V isoforms in airway epithelial cells. Am J Respir Cell Mol Biol 2010, 43:131-136. 10.1165/rcmb.2010-0016RC, 2937227, 20203291.
42. Holst J, Sim AT, Ludowyke RI. Protein phosphatases 1 and 2A transiently associate with myosin during the peak rate of secretion from mast cells. Mol Biol Cell 2002, 13:1083-1098. 10.1091/mbc.01-12-0587, 99621, 11907284.
43. Clarke PR, Siddhanti SR, Cohen P, Blackshear PJ. Okadaic acid-sensitive protein phosphatases dephosphorylate MARCKS, a major protein kinase C substrate. FEBS Lett 1993, 336:37-42. 10.1016/0014-5793(93)81604-X, 8262213.
44. Chen YA, Scheller RH. SNARE-mediated membrane fusion. Nat Rev Mol Cell Biol 2001, 2:98-106. 10.1038/35052017, 11252968.