The cannabinoid receptor inverse agonist AM251 regulates the expression of the EGF receptor and its ligands via destabilization of oestrogen-related receptor α protein

British Journal of Pharmacology

Volumn 164, Issue 3, 2011, Pages 1026-1040

  Fiori, J L ^a   Sanghvi, M ^a   O'Connell, M P ^a   Krzysik Walker, S M ^a   Moaddel, R ^a   Bernier, M ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

cancer; cell cycle; cell invasion; colony formation; EGF receptor; inverse agonist; orphan nuclear hormone receptors; signal transduction

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; BIOCHANIN A; DIETHYLSTILBESTROL; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTROGEN DERIVATIVE; ESTROGEN RELATED RECEPTOR ALPHA; MESSENGER RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; XCT 790;

ARTICLE; CANCER CELL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

CELL LINE, TUMOR; EPIDERMAL GROWTH FACTOR; GENISTEIN; HCT116 CELLS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; NITRILES; ORPHAN NUCLEAR RECEPTORS; PIPERIDINES; PROTEIN BINDING; PYRAZOLES; RECEPTOR, CANNABINOID, CB1; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, ESTROGEN; RNA, MESSENGER; THIAZOLES; UP-REGULATION;

EID: 80052584426     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01384.x     Document Type: Article

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