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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 19, 2011, Pages 5870-5875

Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors

(9) Zeng, Hongbo a Belanger, David B a Curran, Patrick J a Shipps Jr , Gerald W a Miao, Hua a Bracken, Jack B a Arshad Siddiqui, M a Malkowski, Michael a Wang, Yan a

a MERCK RESEARCH LABORATORIES (United States)

Author keywords

Brk PTK6 kinase inhibitors; Cancer treatment; Imidazo 1,2 a pyrazin 8 amine

Indexed keywords

IMIDAZOLE DERIVATIVE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE 6; PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; RAT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BREAST NEOPLASMS; COMPUTER SIMULATION; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MELANOCYTES; MICE; MOLECULAR TARGETED THERAPY; NEOPLASM PROTEINS; ONCOGENES; PHENOTYPE; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENES; PYRAZINES; PYRIMIDINES; RNA-BINDING PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 80052584394 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.07.101 Document Type: Article

Times cited : (27)

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