메뉴 건너뛰기




Volumn 7, Issue 11, 2007, Pages 1529-1536

Management of Bcr-Abl-positive leukemias with dasatinib

Author keywords

Bcr Abl; Chronic myelogenous leukemia; Dasatinib; Imatinib

Indexed keywords

4 (3 DIMETHYLAMINO 1 PYRROLIDINYLMETHYL) 3 TRIFLUOROMETHYL N [4 METHYL 3 [[4 (5 PYRIMIDINYL) 2 PYRIMIDINYL]AMINO]PHENYL]BENZAMIDE; ALPHA INTERFERON; ANTINEOPLASTIC AGENT; BCR ABL PROTEIN; BOSUTINIB; CORTICOSTEROID; CYCLOPROPANECARBOXYLIC ACID [4 [4 (4 METHYL 1 PIPERAZINYL) 6 (5 METHYL 2H PYRAZOL 3 YLAMINO) 2 PYRIMIDINYLTHIO]PHENYL]AMIDE; DASATINIB; DIURETIC AGENT; IMATINIB; NILOTINIB; PROTEIN TYROSINE KINASE INHIBITOR; SGX 70430; TANESPIMYCIN; UNCLASSIFIED DRUG;

EID: 37349026929     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/14737140.7.11.1529     Document Type: Article
Times cited : (15)

References (51)
  • 1
    • 0037672877 scopus 로고    scopus 로고
    • Philadelphia chromosome-positive leukemias: From basic mechanisms to molecular therapeutics
    • Kurzrock R, Kantarjian HM, Druker BJ, Talpaz M. Philadelphia chromosome-positive leukemias: from basic mechanisms to molecular therapeutics. Ann. Intern. Med. 138, 819-830 (2003).
    • (2003) Ann. Intern. Med , vol.138 , pp. 819-830
    • Kurzrock, R.1    Kantarjian, H.M.2    Druker, B.J.3    Talpaz, M.4
  • 2
    • 32844461437 scopus 로고    scopus 로고
    • Chronic myeloid leukemia: Why does it evolve from chronic phase to blast transformation?
    • Mughal TI, Goldman JM. Chronic myeloid leukemia: why does it evolve from chronic phase to blast transformation? Front. Biosci. 11, 198-208 (2006).
    • (2006) Front. Biosci , vol.11 , pp. 198-208
    • Mughal, T.I.1    Goldman, J.M.2
  • 3
    • 0036435579 scopus 로고    scopus 로고
    • Cytogenetic and molecular genetic aspects of chronic myeloid leukaemia
    • Barnes DJ, Melo JV. Cytogenetic and molecular genetic aspects of chronic myeloid leukaemia. Acta Haematol. 108, 180-202 (2002).
    • (2002) Acta Haematol , vol.108 , pp. 180-202
    • Barnes, D.J.1    Melo, J.V.2
  • 4
    • 1142287358 scopus 로고    scopus 로고
    • Clinical and epidemiologic burden of chronic myelogenous leukemia
    • Redaelli A, Bell C, Casagrande J et al. Clinical and epidemiologic burden of chronic myelogenous leukemia. Expert Rev. Anticancer Ther. 4, 85-96 (2004).
    • (2004) Expert Rev. Anticancer Ther , vol.4 , pp. 85-96
    • Redaelli, A.1    Bell, C.2    Casagrande, J.3
  • 5
    • 0036341295 scopus 로고    scopus 로고
    • Recent approaches in acute lymphoblastic leukemia in adults
    • Gökbuget N, Hoelzer D. Recent approaches in acute lymphoblastic leukemia in adults. Rev. Clin. Erp. Hematol. 6, 114-141 (2002).
    • (2002) Rev. Clin. Erp. Hematol , vol.6 , pp. 114-141
    • Gökbuget, N.1    Hoelzer, D.2
  • 7
    • 33747154547 scopus 로고    scopus 로고
    • Evolving concepts in the management of chronic myeloid leukemia. Recommendations from an expert panel on behalf of the European Leukemianet
    • Baccarani M, SagliO, G, Goldman J et al. Evolving concepts in the management of chronic myeloid leukemia. Recommendations from an expert panel on behalf of the European Leukemianet. Blood 108, 1809-1820 (2006).
    • (2006) Blood , vol.108 , pp. 1809-1820
    • Baccarani, M.1    SagliO, G.2    Goldman, J.3
  • 8
    • 34249664406 scopus 로고    scopus 로고
    • Drug treatment is superior to allografting as first line therapy in chronic myeloid leukemia
    • Hehlmann R, Berger U, Pfirrmann M et al. Drug treatment is superior to allografting as first line therapy in chronic myeloid leukemia. Blood 109, 4686-4692 (2007).
    • (2007) Blood , vol.109 , pp. 4686-4692
    • Hehlmann, R.1    Berger, U.2    Pfirrmann, M.3
  • 9
    • 21144451094 scopus 로고    scopus 로고
    • In vitro activity of Bcr-AbI inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants
    • Hare T, Walters DK, Stoffregen EP et al. In vitro activity of Bcr-AbI inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res. 65, 4500-4505 (2005).
    • (2005) Cancer Res , vol.65 , pp. 4500-4505
    • Hare, T.1    Walters, D.K.2    Stoffregen, E.P.3
  • 10
    • 33846847772 scopus 로고    scopus 로고
    • Resistance to targeted therapy in chronic myelogenous leukemia
    • Hochhaus A, Erben P, Ernst T, Mueller MC. Resistance to targeted therapy in chronic myelogenous leukemia. Semin. Hematol. 44, 15-24 (2007).
    • (2007) Semin. Hematol , vol.44 , pp. 15-24
    • Hochhaus, A.1    Erben, P.2    Ernst, T.3    Mueller, M.C.4
  • 11
    • 79959308232 scopus 로고    scopus 로고
    • Loss of response to imatinib: Mechanisms and management
    • Shah NP. Loss of response to imatinib: mechanisms and management. Hematology Am. Soc. Hematol. Educ. Program 183-187 (2005).
    • (2005) Hematology Am. Soc. Hematol. Educ. Program , vol.183-187
    • Shah, N.P.1
  • 12
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • O'Brien SG, Guilhot F, Larson RA et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N. Engl. J. Med. 348, 994-1004 (2003).
    • (2003) N. Engl. J. Med , vol.348 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3
  • 13
    • 37049028176 scopus 로고    scopus 로고
    • Most CML patients who have a suboptimal response to imatinib have low OCT-1 activity. Higher doses of imatinib may overcome the negative impact of low OCT-1 activity
    • DOI:10.1182/blood-2007-06-093617
    • White DL, Saunders VA, Dang P et al. Most CML patients who have a suboptimal response to imatinib have low OCT-1 activity. Higher doses of imatinib may overcome the negative impact of low OCT-1 activity. Blood DOI:10.1182/blood-2007-06-093617 (2007).
    • (2007) Blood
    • White, D.L.1    Saunders, V.A.2    Dang, P.3
  • 14
    • 37349061332 scopus 로고    scopus 로고
    • A Phase II study of nilotinib, a novel tyrosine kinase inhibitor administered to imatinib-resistant and -intolerant patients with Philadelphia-positive chronic myelogenous; leukemia in chronic phase
    • Martinelli G, Rosti G, le Coutre P et al. A Phase II study of nilotinib, a novel tyrosine kinase inhibitor administered to imatinib-resistant and -intolerant patients with Philadelphia-positive chronic myelogenous; leukemia in chronic phase. Heamatologica 92(Suppl. 1), 207 (2007).
    • (2007) Heamatologica , vol.92 , Issue.SUPPL. 1 , pp. 207
    • Martinelli, G.1    Rosti, G.2    le Coutre, P.3
  • 15
    • 37349112422 scopus 로고    scopus 로고
    • Nilotinib monotherapy in patients with imatinib-resistant or -intolerant Ph+ chronic myelogenous leukemia in blast crisis or relapsed/reft-actory-Ph+ acute lymphoblastic leukemia
    • Epub ahead of print
    • Ottman O, Larson R, Kantarjian H et al. Nilotinib monotherapy in patients with imatinib-resistant or -intolerant Ph+ chronic myelogenous leukemia in blast crisis or relapsed/reft-actory-Ph+ acute lymphoblastic leukemia. Haematologica 92 (Suppl. 1), 207 (2007) (Epub ahead of print).
    • (2007) Haematologica , vol.92 , Issue.SUPPL. 1 , pp. 207
    • Ottman, O.1    Larson, R.2    Kantarjian, H.3
  • 16
    • 37349061332 scopus 로고    scopus 로고
    • A Phase II study of nilotinib, a novel tyrosine kinase inhibitor administered to imatinib-resistant or -intolerant patients with Philadelphia-positive chronic myelogenous leukemia in accelerated phase
    • le Coutre P, Larson R, Kantarjian H et al. A Phase II study of nilotinib, a novel tyrosine kinase inhibitor administered to imatinib-resistant or -intolerant patients with Philadelphia-positive chronic myelogenous leukemia in accelerated phase. Haematologica 92(Suppl. 1), 207-208 (2007).
    • (2007) Haematologica , vol.92 , Issue.SUPPL. 1 , pp. 207-208
    • le Coutre, P.1    Larson, R.2    Kantarjian, H.3
  • 17
    • 37349059598 scopus 로고    scopus 로고
    • Bosutinib (SKI-606) exhibits clinical activity in patients with philadelphia chromosome positive CML or ALL who failed imatinib
    • Bruemmendorf T, Cortes J, Kantaryan H et al. Bosutinib (SKI-606) exhibits clinical activity in patients with philadelphia chromosome positive CML or ALL who failed imatinib. Haematologica 92(Suppl. 1), 116 (2007).
    • (2007) Haematologica , vol.92 , Issue.SUPPL. 1 , pp. 116
    • Bruemmendorf, T.1    Cortes, J.2    Kantaryan, H.3
  • 18
    • 39049164641 scopus 로고    scopus 로고
    • A Phase I study of INNO-406, a dual inhibitor of Ab1 and Lyn kinases, in adult patients with Philadelphia chromosome positive (Ph+) chronic myelogenous leukemia (CML) or acute lymphocytic leukemia (ALL) relapsed, refractory, or intolerant of imatinib
    • S
    • Craig AR, Kantarjian HM, Cortes JE et al. A Phase I study of INNO-406, a dual inhibitor of Ab1 and Lyn kinases, in adult patients with Philadelphia chromosome positive (Ph+) chronic myelogenous leukemia (CML) or acute lymphocytic leukemia (ALL) relapsed, refractory, or intolerant of imatinib. J. Clin. Oncol. 25(Suppl. 18), S368 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.SUPPL. 18 , pp. 368
    • Craig, A.R.1    Kantarjian, H.M.2    Cortes, J.E.3
  • 19
    • 37349040325 scopus 로고    scopus 로고
    • Gleevec ®, prescribing information. Novartis Pharmaceuticals, NJ, USA (2007)
    • Gleevec ®, prescribing information. Novartis Pharmaceuticals, NJ, USA (2007)
  • 20
    • 37349112660 scopus 로고    scopus 로고
    • Sprycel® prescribing information. Bristol-Myers Squibb, NY, USA (2007).
    • Sprycel® prescribing information. Bristol-Myers Squibb, NY, USA (2007).
  • 21
    • 33745283618 scopus 로고    scopus 로고
    • The structure of dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants
    • Tokarski JS, Newitt JA, Chang CY et al. The structure of dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants. Cancer Res. 66, 5790-5797 (2006).
    • (2006) Cancer Res , vol.66 , pp. 5790-5797
    • Tokarski, J.S.1    Newitt, J.A.2    Chang, C.Y.3
  • 22
    • 3142676436 scopus 로고    scopus 로고
    • Overriding imatinib resistance with a novel ABL kinase inhibitor
    • Shah NP, Tran C, Lee FY et al. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 305, 399-401 (2004).
    • (2004) Science , vol.305 , pp. 399-401
    • Shah, N.P.1    Tran, C.2    Lee, F.Y.3
  • 23
    • 37349005461 scopus 로고    scopus 로고
    • Centrosome aberrations, disturbed mitotic spindle formation and G1 arrest in normal and leukemic cells treated with the SRC/ABL inhibitor dasatinib
    • Fabarius A, Giehl M, Kraemer A et al. Centrosome aberrations, disturbed mitotic spindle formation and G1 arrest in normal and leukemic cells treated with the SRC/ABL inhibitor dasatinib. Blood 108, 614a-615a (2006).
    • (2006) Blood , vol.108
    • Fabarius, A.1    Giehl, M.2    Kraemer, A.3
  • 24
    • 33745243692 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival
    • Song L, Morris M, Bagui T et al. Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 66, 5542-5548 (2006).
    • (2006) Cancer Res , vol.66 , pp. 5542-5548
    • Song, L.1    Morris, M.2    Bagui, T.3
  • 25
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
    • Taipaz M, Shah NP, Kantarjian H et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N. Engl. J. Med. 354, 2531-2541 (2006).
    • (2006) N. Engl. J. Med , vol.354 , pp. 2531-2541
    • Taipaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 26
    • 23844515505 scopus 로고    scopus 로고
    • A Phase I study of BMS-354825 patients with imatinib-resistant and intolerant chronic phase chronic myeloid leukemia (CML, results from CA180002, 23(Suppl. 16 Pt 1) S
    • Talpaz M, Kantarjian HM, Paquette R et al. A Phase I study of BMS-354825 in patients with imatinib-resistant and intolerant chronic phase chronic myeloid leukemia (CML): results from CA180002. J. Clin. Oncol. 23(Suppl. 16 Pt 1) S564-S564 (2005).
    • (2005) J. Clin. Oncol
    • Talpaz, M.1    Kantarjian, H.M.2    Paquette, R.3
  • 27
    • 33947280081 scopus 로고    scopus 로고
    • Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of iniatinib therapy
    • Hochhaus A, Kantadian HM, Baccarani M et al. Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of iniatinib therapy. Blood 109, 2303-2309 (2007).
    • (2007) Blood , vol.109 , pp. 2303-2309
    • Hochhaus, A.1    Kantadian, H.M.2    Baccarani, M.3
  • 28
    • 37149036111 scopus 로고    scopus 로고
    • Dasatinib induces durable cytogenetic responses in patients with chronic-phase CML with resistance or intolerance to imatinib: Updated results of the CA180013 (START-C) trial
    • Guilhot F, Apperley J, Facon T et al. Dasatinib induces durable cytogenetic responses in patients with chronic-phase CML with resistance or intolerance to imatinib: updated results of the CA180013 (START-C) trial. Haematologica 92(Suppl. 1), 128 (2007).
    • (2007) Haematologica , vol.92 , Issue.SUPPL. 1 , pp. 128
    • Guilhot, F.1    Apperley, J.2    Facon, T.3
  • 29
    • 34248324467 scopus 로고    scopus 로고
    • Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phase
    • Guilbot F, Apperiey J, Kim DW et al. Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phase. Blood 109, 4143-4150 (2007).
    • (2007) Blood , vol.109 , pp. 4143-4150
    • Guilbot, F.1    Apperiey, J.2    Kim, D.W.3
  • 30
    • 34247543905 scopus 로고    scopus 로고
    • Dasatinib (SPRYCEL) in patients (pts) with chronic myelogenous leukemia in accelerated phase (AP-CML) that is imatinib-resistant (im-r) or -intolerant (im-i): Updated results of the CA 180-005 START-A Phase II study
    • Cortes J, Kim DW, Gullhot F et al. Dasatinib (SPRYCEL) in patients (pts) with chronic myelogenous leukemia in accelerated phase (AP-CML) that is imatinib-resistant (im-r) or -intolerant (im-i): updated results of the CA 180-005 START-A Phase II study. Blood 108, 613a (2006).
    • (2006) Blood , vol.108
    • Cortes, J.1    Kim, D.W.2    Gullhot, F.3
  • 31
    • 33947356135 scopus 로고    scopus 로고
    • Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis
    • Cortes J, Rousseiot P, Kim DW et al. Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis. Blood 109, 3207-3213 (2007).
    • (2007) Blood , vol.109 , pp. 3207-3213
    • Cortes, J.1    Rousseiot, P.2    Kim, D.W.3
  • 32
    • 33846819360 scopus 로고    scopus 로고
    • Dasatinib (SPRYCEL) efficacy and safety in patients (pts) with chronic myelogenous leukemia in lymphoid (CML-LB) or myeloid blast (CML-MB) phase who are imatinib-resistant (im-r) or -intolerant (im-i)
    • Martinelli G, Hochhaus A, Coutre S et al. Dasatinib (SPRYCEL) efficacy and safety in patients (pts) with chronic myelogenous leukemia in lymphoid (CML-LB) or myeloid blast (CML-MB) phase who are imatinib-resistant (im-r) or -intolerant (im-i). Blood 108, 224a (2006).
    • (2006) Blood , vol.108
    • Martinelli, G.1    Hochhaus, A.2    Coutre, S.3
  • 33
    • 34948829146 scopus 로고    scopus 로고
    • Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: Interim results of a Phase II study
    • Ottmann O, Dombret H, Martinelli G et al. Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a Phase II study. Blood 110(7), 2309-2315 (2007).
    • (2007) Blood , vol.110 , Issue.7 , pp. 2309-2315
    • Ottmann, O.1    Dombret, H.2    Martinelli, G.3
  • 34
    • 37349069514 scopus 로고    scopus 로고
    • Ottmann O, Hochhaus A, Saglio G et al. Dasatinib induces rapid and durable responses in patients with Ph+ ALL resistant or intolerant to imatimb: updated results from CA180015 (START-L) trial. Haematolooca 92 (Suppi. 1), 9-10 (2007).
    • Ottmann O, Hochhaus A, Saglio G et al. Dasatinib induces rapid and durable responses in patients with Ph+ ALL resistant or intolerant to imatimb: updated results from CA180015 (START-L) trial. Haematolooca 92 (Suppi. 1), 9-10 (2007).
  • 35
    • 34249074686 scopus 로고    scopus 로고
    • Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: A randomized Phase 2 trial
    • Kantarjian H, Pasquini R, Hamerschlak N et al. Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: a randomized Phase 2 trial. Blood 109, 5143-5150 (2007).
    • (2007) Blood , vol.109 , pp. 5143-5150
    • Kantarjian, H.1    Pasquini, R.2    Hamerschlak, N.3
  • 36
    • 37349126943 scopus 로고    scopus 로고
    • Dasatinib is safe and effective in patients with previously untreated chronic myelogenous leukemia in chronic phase
    • Quintas-Cardama A, Kantarjian H, O'Brien S et al. Dasatinib is safe and effective in patients with previously untreated chronic myelogenous leukemia in chronic phase. Haematologica 92 (Suppl. 1), 129 (2007).
    • (2007) Haematologica , vol.92 , Issue.SUPPL. 1 , pp. 129
    • Quintas-Cardama, A.1    Kantarjian, H.2    O'Brien, S.3
  • 37
    • 37149031172 scopus 로고    scopus 로고
    • Dasatinib dose and schedule optimization in chronic-phase CML resistant or intolerant to imatinib: Results from a randomized Phase-III trial (CA180034)
    • Hochhaus A, Kim DW, Rousselot P et al. Dasatinib dose and schedule optimization in chronic-phase CML resistant or intolerant to imatinib: results from a randomized Phase-III trial (CA180034). Haematoloogica 92(Suppl. 1), 128-129 (2007).
    • (2007) Haematoloogica , vol.92 , Issue.SUPPL. 1 , pp. 128-129
    • Hochhaus, A.1    Kim, D.W.2    Rousselot, P.3
  • 38
    • 37349115522 scopus 로고    scopus 로고
    • Dasatinib 140 mg QD vs 70 mg bid in advanced-phase CML or Ph(+) ALL resistant or intolerant to imatinib: Results from a randomized, Phase-III trial (CA180035)
    • Dombret H, Ottmann OG, Gob Y et al. Dasatinib 140 mg QD vs 70 mg bid in advanced-phase CML or Ph(+) ALL resistant or intolerant to imatinib: results from a randomized, Phase-III trial (CA180035). Haematologica 92 (Suppl. 1), 319 (2007).
    • (2007) Haematologica , vol.92 , Issue.SUPPL. 1 , pp. 319
    • Dombret, H.1    Ottmann, O.G.2    Gob, Y.3
  • 39
    • 37349092298 scopus 로고    scopus 로고
    • Efficacy of dasatinib in chronic phase chronic myelogenous leukemia patients after imatinib failure according to baseline BCR-ABL mutations
    • Mueller MC, Branford S, Radich J et al. Efficacy of dasatinib in chronic phase chronic myelogenous leukemia patients after imatinib failure according to baseline BCR-ABL mutations. Haematologica 92(Suppl. 1), 127 (2007).
    • (2007) Haematologica , vol.92 , Issue.SUPPL. 1 , pp. 127
    • Mueller, M.C.1    Branford, S.2    Radich, J.3
  • 41
    • 20944442975 scopus 로고    scopus 로고
    • Molecular responses in patients with chronic myelogenous leukemia in chronic phase treated with imatinib mesylate
    • Cortes J, Talpaz M, O'Brien S et al. Molecular responses in patients with chronic myelogenous leukemia in chronic phase treated with imatinib mesylate. Clin. Cancer Res. 11, 3425-3432 (2005).
    • (2005) Clin. Cancer Res , vol.11 , pp. 3425-3432
    • Cortes, J.1    Talpaz, M.2    O'Brien, S.3
  • 42
    • 37349130542 scopus 로고    scopus 로고
    • Druker BJ, Guilhot F, O'Brien S, Larson N, on behalf of the IRIS anternational Randomized IF. Long-term benefits of imtinib (IM) for patients newly diagnosed with chronic myelogenous leukemia in chronic phase (CML-CP): the 5-year update from the IRIS study. Proc. Am. Soc. Clin. Oncol. 24, S338 (2006).
    • Druker BJ, Guilhot F, O'Brien S, Larson N, on behalf of the IRIS anternational Randomized IF. Long-term benefits of imtinib (IM) for patients newly diagnosed with chronic myelogenous leukemia in chronic phase (CML-CP): the 5-year update from the IRIS study. Proc. Am. Soc. Clin. Oncol. 24, S338 (2006).
  • 43
    • 0348015863 scopus 로고    scopus 로고
    • The early molecular response to imatinib predicts cytogenetic and clinical outcome in chronic myeloid leukaemia
    • Wang L, Pearson K, Ferguson JE, Clark RE. The early molecular response to imatinib predicts cytogenetic and clinical outcome in chronic myeloid leukaemia. Br. J. Haematol. 120, 990-999 (2003).
    • (2003) Br. J. Haematol , vol.120 , pp. 990-999
    • Wang, L.1    Pearson, K.2    Ferguson, J.E.3    Clark, R.E.4
  • 44
    • 30844433972 scopus 로고    scopus 로고
    • Molecular monitoring of BCR-ABL as a guide to clinical management in chronic myeloid leukaemia
    • Hughes T, Branford S. Molecular monitoring of BCR-ABL as a guide to clinical management in chronic myeloid leukaemia. Blood Rev. 20, 29-41 (2006).
    • (2006) Blood Rev , vol.20 , pp. 29-41
    • Hughes, T.1    Branford, S.2
  • 45
    • 10744230175 scopus 로고    scopus 로고
    • The significance of myelosuppression during therapy with imatinib mesylate in patients with chronic myelogenous leukemia in chronic phase
    • Sneed TB, Kantarjian HM, Talpaz M et al. The significance of myelosuppression during therapy with imatinib mesylate in patients with chronic myelogenous leukemia in chronic phase. Cancer 100, 116-121 (2004).
    • (2004) Cancer , vol.100 , pp. 116-121
    • Sneed, T.B.1    Kantarjian, H.M.2    Talpaz, M.3
  • 46
    • 4344672552 scopus 로고    scopus 로고
    • Imatinib therapy in chronic myelogenous leukemia: Strategies to avoid and overcome resistance
    • Hochhaus A, La Rosée P. Imatinib therapy in chronic myelogenous leukemia: strategies to avoid and overcome resistance. Leukemia 18, 1321-1331 (2004).
    • (2004) Leukemia , vol.18 , pp. 1321-1331
    • Hochhaus, A.1    La Rosée, P.2
  • 47
    • 0036045378 scopus 로고    scopus 로고
    • Insights from pre-clinical studies for new combination treatment regimens with the Bcr-Abl kinase inhibitor imatinib mesylate (Gleevec/Glivec) in chronic myelogenous leukemia: A translational perspective
    • La Rosée P, O'Dwyer ME, Druker BJ. Insights from pre-clinical studies for new combination treatment regimens with the Bcr-Abl kinase inhibitor imatinib mesylate (Gleevec/Glivec) in chronic myelogenous leukemia: a translational perspective. Leukemia 16, 1213-1219 (2002).
    • (2002) Leukemia , vol.16 , pp. 1213-1219
    • La Rosée, P.1    O'Dwyer, M.E.2    Druker, B.J.3
  • 48
    • 14744274624 scopus 로고    scopus 로고
    • Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance
    • Burgess MR, Skaggs BJ, Shah NP, Lee FY, Sawyers CL. Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance. Proc. Natl Acad. Sci. USA 102, 3395-3400 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 3395-3400
    • Burgess, M.R.1    Skaggs, B.J.2    Shah, N.P.3    Lee, F.Y.4    Sawyers, C.L.5
  • 49
    • 34247891789 scopus 로고    scopus 로고
    • Emerging strategies for the treatment of mutant Bcr-Abl T315I myeloid leukemia
    • Mughat TI, Goldman JM. Emerging strategies for the treatment of mutant Bcr-Abl T315I myeloid leukemia. Clin. Lymphoma Myeloma 7(Suppl. 2), S81-S84 (2007).
    • (2007) Clin. Lymphoma Myeloma , vol.7 , Issue.SUPPL. 2
    • Mughat, T.I.1    Goldman, J.M.2
  • 51
    • 33750035763 scopus 로고    scopus 로고
    • The clinical challenge of imatinib resistance in chronic myeloid leukemia: Emerging strategies with new targeted agents
    • Jabbour E, Cortes J, Giles F, O'Brien S, Kantarjian H. The clinical challenge of imatinib resistance in chronic myeloid leukemia: emerging strategies with new targeted agents. Targ. Oncol. 1, 186-196 (2006).
    • (2006) Targ. Oncol , vol.1 , pp. 186-196
    • Jabbour, E.1    Cortes, J.2    Giles, F.3    O'Brien, S.4    Kantarjian, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.