Novel molecular targets of Azadirachta indica associated with inhibition of tumor growth in prostate cancer

AAPS Journal

Volumn 13, Issue 3, 2011, Pages 365-377

  Mahapatra, Saswati ^a   Karnes, R Jeffrey ^a   Holmes, Michael W ^a   Young, Charles Y F ^a   Cheville, John C ^a   Kohli, Manish ^a   Klee, Eric W ^a   Tindall, Donald J ^a   Donkena, Krishna Vanaja ^a  

^a MAYO CLINIC   (United States)

Author keywords

gene expression profiles; neem leaf extract; therapeutic targets and prostate cancer; tumor models

Indexed keywords

2',3' DEHYDROSALANNOL; 6 DESACETYL NIMBINENE; AZADIRACHTA INDICA EXTRACT; HEME OXYGENASE 1; MESSENGER RNA; NIMOLINONE; OXIDOREDUCTASE; PLANT MEDICINAL PRODUCT; PROTEIN AKR1B10; PROTEIN AKR1C2; PROTEIN AKR1C3; UNCLASSIFIED DRUG;

AKR1B10 GENE; AKR1C2 GENE; AKR1C3 GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL DEATH; CONTROLLED STUDY; DNA RECOMBINATION; DNA REPAIR; DNA REPLICATION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; DRUG TUMOR LEVEL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HMOX1 GENE; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MALE; MICROARRAY ANALYSIS; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; ONCOGENE; PLANT LEAF; PROSTATE CANCER; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TIME OF FLIGHT MASS SPECTROMETRY; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; AZADIRACHTA; BLOTTING, WESTERN; CELL PROLIFERATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MICE; MICE, NUDE; PLANT EXTRACTS; PLANT LEAVES; PROSTATIC NEOPLASMS; REAL-TIME POLYMERASE CHAIN REACTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 80052583332     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-011-9279-4     Document Type: Article

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