KIOM-79 inhibits aldose reductase activity and cataractogenesis in Zucker diabetic fatty rats

Journal of Pharmacy and Pharmacology

Volumn 63, Issue 10, 2011, Pages 1301-1308

  Kim, Junghyun ^a   Kim, Chan Sik ^a   Sohn, Eunjin ^a   Lee, Yun Mi ^a   Kim, Jin Sook ^a  

^a Korea Institute of Oriental Medicine (KIOM)   (South Korea)

Author keywords

aldose reductase; diabetic cataract; KIOM 79; Zucker diabetic fatty rat

Indexed keywords

ALDEHYDE REDUCTASE; ANTIDIABETIC AGENT; KIOM 79; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACT; CATARACTOGENESIS; CELL DEGENERATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; EYE SWELLING; IN VITRO STUDY; MALE; MEMBRANE RUPTURE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN EXPRESSION; RAT; TREATMENT DURATION; ZUCKER DIABETIC FATTY RAT;

ALDEHYDE REDUCTASE; ANGIOSPERMS; ANIMALS; CATARACT; DIABETES MELLITUS, EXPERIMENTAL; EDEMA; ENZYME INHIBITORS; LENS, CRYSTALLINE; MALE; MEMBRANES; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, ZUCKER;

EID: 80052576355     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2011.01341.x     Document Type: Article

References (30)

1. Bhatnagar A, Srivastava SK,. Aldose reductase: congenial and injurious profiles of an enigmatic enzyme. Biochem Med Metab Biol 1992; 48: 91-121.
2. Gabbay KH,. The sorbitol pathway and the complications of diabetes. N Engl J Med 1973; 288: 831-836.
3. Varma SD, et al,. Implications of aldose reductase in cataracts in human diabetes. Invest Ophthalmol Vis Sci 1979; 18: 237-241. (Pubitemid 9111224)
4. Kyselova Z, et al,. Pharmacological prevention of diabetic cataract. J Diabetes Complications 2004; 18: 129-140. (Pubitemid 38559078)
5. Varma SD, Richards RD,. Etiology of cataracts in diabetics. Int Ophthalmol Clin 1984; 24: 93-110.
6. Kim YS, et al,. Inhibitory effect of KIOM-79 (a herbal prescription) on AGEs formation and expressions of type IV collagen and TGF-β1 in STZ-induced diabetic rats. Kor J Pharmacogn 2006; 37: 103-106.
7. Kim CS, et al,. Effects of KIOM-79 on hyperglycemia and diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats. J Ethnopharmacol 2007; 111: 240-247.
8. Sohn EJ, et al,. KIOM-79 prevents apoptotic cell death and AGEs accumulation in retinas of diabetic db/db mice. J Ethnopharmacol 2009; 121: 171-174.
9. Kim NH, et al,. KIOM-79 prevents xylose-induced lens opacity and inhibits TGF-beta2 in human lens epithelial cells cultured under high glucose. J Ethnopharmacol 2010; 130: 599-606.
10. Kim YS, et al,. Genistein inhibits aldose reductase activity and high glucose-induced TGF-beta2 expression in human lens epithelial cells. Eur J Pharmacol 2008; 594: 18-25.
11. Vasanth Rao P, Seetharam Bhat K,. Effect of riboflavin deficiency on sorbitol pathway in rat lens. Nutr Res 1989; 9: 1143-1149.
12. Halder N, et al,. Lens aldose reductase inhibiting potential of some indigenous plants. J Ethnopharmacol 2003; 86: 113-116. (Pubitemid 36398665)
13. Suryanarayana P, et al,. Inhibition of aldose reductase by tannoid principles of Emblica officinalis: implications for the prevention of sugar cataract. Mol Vis 2004; 10: 148-154. (Pubitemid 38658950)
14. Kinoshita JH,. A thirty year journey in the polyol pathway. Exp Eye Res 1990; 50: 567-573. (Pubitemid 20191282)
15. Nagaraj RH, Sady C,. The presence of a glucose-derived Maillard reaction product in the human lens. FEBS Lett 1996; 382: 234-238. (Pubitemid 26092198)
16. Van Heyningen R,. Formation of polyols by the lens of the rat with sugar cataract. Nature 1959; 184: 194-195.
17. Tomlinson DR, et al,. Aldose reductase inhibitors and their potential for the treatment of diabetic complications. Trends Pharmacol Sci 1994; 15: 293-297. (Pubitemid 24245679)
18. Varma SD, Kinoshita JH,. Sorbitol pathway in diabetic and galactosemic rat lens. Biochim Biophys Acta 1974; 338: 632-640.
19. Akagi Y, et al,. Immunohistochemical localization for aldose reductase in diabetic lenses. Invest Ophthalmol Vis Sci 1987; 28: 163-167. (Pubitemid 17230205)
20. Liu WH, et al,. Berberine ameliorates renal injury in streptozotocin-induced diabetic rats by suppression of both oxidative stress and aldose reductase. Chin Med J 2008; 121: 706-712.
21. Dvornik E, et al,. Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor. Science 1973; 182: 1146-1148.
22. Kim J, et al,. KIOM-79 prevents lens epithelial cell apoptosis and lens opacification in Zucker diabetic fatty rats. Evid Based Complement Alternat Med (accessed 7 Sep 2010, epub ahead of print) doi:10.1155/2011/717921.
23. Matsunaga T, et al,. Potent and selective inhibition of the tumor marker AKR1B10 by bisdemethoxycurcumin: probing the active site of the enzyme with molecular modeling and site-directed mutagenesis. Biochem Biophys Res Commun 2009; 389: 128-132.
24. Lee YS, et al,. Aldose reductase inhibitory compounds from Glycyrrhiza uralensis. Biol Pharm Bull 2010; 33: 917-921.
25. Feng CG, et al,. [Progress in research of aldose reductase inhibitors in traditional medicinal herbs]. Zhongguo Zhong Yao Za Zhi 2005; 30: 1496-1500 [in Chinese].
26. Terashima H, et al,. Effects of a new aldose reductase inhibitor on various tissues in vitro. J Pharmacol Exp Ther 1984; 229: 226-230. (Pubitemid 14082937)
27. Simard-Duquesne N, et al,. The effects of a new aldose reductase inhibitor (tolrestat) in galactosemic and diabetic rats. Metabolism 1985; 34: 885-892. (Pubitemid 15234464)
28. Ao S, et al,. Characterization of a novel aldose reductase inhibitor, FR74366, and its effects on diabetic cataract and neuropathy in the rat. Metabolism 1991; 40: 77-87.
29. Matsui T, et al,. Pharmacological profiles of a novel aldose reductase inhibitor, SPR-210, and its effects on streptozotocin-induced diabetic rats. Jpn J Pharmacol 1994; 64: 115-124. (Pubitemid 24091839)
30. Mizuno K, et al,. Effects of a new aldose reductase inhibitor, (2S, 4S)-6-fluoro-2′,5′-dioxospiro[chroman-4,4′-imidazolidine] -2-carboxamide (SNK-860), on the slowing of motor nerve conduction velocity and metabolic abnormalities in the peripheral nerve in acute streptozotocin-induced diabetic rats. Metabolism 1992; 41: 1081-1086.