KIOM-79 prevents apoptotic cell death and AGEs accumulation in retinas of diabetic db/db mice

Journal of Ethnopharmacology

Volumn 121, Issue 1, 2009, Pages 171-174

  Sohn, Eun Jin ^a   Kim, Young Sook ^a   Kim, Chan Sik ^a   Lee, Yun Mi ^a   Kim, Jin Sook ^a  

^a Korea Institute of Oriental Medicine (KIOM)   (South Korea)

Author keywords

AGEs; Apoptosis; Diabetic retinopathy; KIOM 79

Indexed keywords

ADVANCED GLYCATION END PRODUCT; CASPASE 3; GLYCYRRHIZA URALENSIS EXTRACT; KIOM 79; MAGNOLIA OFFICINALIS EXTRACT; PUERARIA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BARK; CELL DEATH; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC RETINOPATHY; DRUG ISOLATION; DRUG MIXTURE; HISTOPATHOLOGY; IMMUNOCHEMISTRY; MALE; MOUSE; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; RETINA GANGLION CELL;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CASPASE 3; CELL DEATH; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; DISEASE MODELS, ANIMAL; GLYCOSYLATION END PRODUCTS, ADVANCED; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MICE; MICE, INBRED C57BL; PLANT EXTRACTS; RETINA; RETINAL GANGLION CELLS;

ANIMALIA; MUS;

EID: 58049123856     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2008.09.036     Document Type: Article

References (25)

1. Barber A.J., Lieth E., Khin S.A., et al. Neural apoptosis in the retina during experimental and human diabetes: early onset and effect of insulin. The Journal of Clinical Investigation 102 (1998) 783-791
2. Bode C., and Wolfrum U. Caspase-3 inhibitor reduces apoptotic photoreceptor cell death during inherited retinal degeneration in tubby mice. Molecular Vision 9 (2003) 144-150
3. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 414 (2001) 813-820
4. Chen B.H., Jiang D.Y., and Tang L.S. Advanced glycation end-products induce apoptosis invloving the signal pathways of oxidative stress in bovine retinal pericytes. Life Science 79 (2006) 1040-1048
5. Denis U., Lecomte M., Paget C., Ruggiero D., Wiemsperger N., and Lagarde M. Advanced glycation end-products induce apoptosis of bovine retinal pericytes in culture: involvement of diacylglycerol/ceramide production and oxidative stress induction. Free Radical Biology & Medicine 33 (2002) 236-247
6. Gavrieli Y., Sherman Y., and Ben-Sasson S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Journal of Cell Biology 119 (1992) 493-501
7. Hammes H.P., Wellensiek B., Kloting I., Sickel E., Bretzel R.G., and Brownlee M. The relationship of glycaemic level to advanced glycation endproduct (AGEs) accumulation and retinal pathology in the spontaneous diabetic hamster. Diabetologia 41 (1998) 165-170
8. Hur J. Donguibogam Parallel Version. Committee of Dongui Bogam Translation (1999), Bupin Publishes Co., Seoul, Korea p. 1979
9. Jeon Y.J., Li M.H., Lee K.Y., Kim J.S., You H.J., Lee S.K., and Jang I.Y. KIOM-79 inhibits LPS-induced iNOS gene expression by blocking NF-B/Rel and p38 kinase in murine macrophages. Journal of Ethnopharmacology 108 (2006) 38-45
10. Kang K.A., Lee K.H., Kim S.Y., Kim H.S., Kim J.S., and Hyun J.W. Cytoprotective effects of KIOM-79 on streptozotocin induced cell damage by inhibiting ERK and AP-1. Biological & Pharmaceutical Bulletin 30 (2007) 852-858
11. Kim J.H., Kim C.S., Sohn E.J., Kim O.S., Lee Y.M., Jang D.S., and Kim J.S. Effects of KIOM-79 on diabetic retinopathy in Zucker diabetic fatty rat. Diabetes 57 (2008) A572 (abstract)
12. Kim J.S., Kim H.J., and Ko J.H. Studies on the processing of herbal medicines (3)-HPLC analysis of magnolol and inhibitory effects on the formation of advanced glycation endproducts (AGEs) in vitro of unprocessed- and processed Magnolia bark. Korean Journal of Pharmacognosy 33 (2002) 308-311
13. Kim Y.S., Lee Y.M., Kim C.S., Shon E.J., Jang D.S., and Kim J.S. Inhibitory effect of KIOM-79, a new herbal prescription, on AGEs formation and expressions of type 4 collagen and TGF-β1 in STZ-induced diabetic rats. Korean Journal of Pharmacognosy 37 (2006) 103-109
14. Kim C.S., Sohn E.J., Kim Y.S., Jung D.H., Jang D.S., Lee Y.M., Kim D.H., and Kim J.S. Effects of KIOM-79 on hyperglycemia and diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats. Journal of Ethnopharmacology 111 (2007) 240-247
15. Kim Y.S., Jung D.H., Kim N.H., Lee Y.M., Jang D.S., Song G.Y., and Kim J.S. KIOM-79 inhibits high glucose or AGEs-induced VEGF expression in human retinal pigment epithelial cells. Journal of Ethnopharmacology 112 (2007) 166-172
16. Kjørholt C., Akerfeldt M.C., Biden T.J., and Laybutt D.R. Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes. Diabetes 54 (2005) 2755-2763
17. Kowluru R.A., and Koppolu P. Diabetes-induced activation of caspase-3 in retina: effect of antioxidant therapy. Free Radical Research 36 (2002) 993-999
18. Kowluru R.A. Effect of advanced glycation end products on accelerated apoptosis of retinal capillary cells under in vitro conditions. Life Science 14 (2005) 1051-1060
19. Oshitari T., and Roy S. Diabetes: a potential enhancer of retinal injury in rat retinas. Neuroscience Letter 16 (2005) 25-30
20. Stennicke H.R., and Salvesen G.S. Biochemical characteristics of caspases-3, -6, -7, and -8. Journal of Biology Chemistry 272 (1997) 25719-25723
21. Stitt A.W., Gardiner T.A., Alderson N.L., et al. The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes. Diabetes 51 (2002) 2826-2832
22. Stitt A.W. The role of advanced glycation in the pathogenesis of diabetic retinopathy. Experimental and Molecular Pathology 75 (2003) 95-108
23. Su J., Lucchesi P.A., Gonzalez-Villalobos R.A., Palen D.I., Rezk B.M., Suzuki Y., Boulares H.A., and Matrougui K. Role of advanced glycation end products with oxidative stress in resistance artery dysfunction in type 2 diabetic mice. Arteriosclerosis, Thrombosis, and Vascular Biology 28 (2008) 1432-1438
24. Yatoh S., Mizutani M., Yokoo T., Kozawa T., Sone H., Toyoshima H., Suzuki S., Shimano H., Kawakami Y., Okuda Y., and Yamada N. Antioxidants and an inhibitor of advanced glycation ameliorate death of retinal microvascular cells in diabetic retinopathy. Diabetes Metabolism Research and Reviews 22 (2006) 38-45
25. Yamagishi S., Amano S., Inagaki Y., Okamoto T., Koga K., Sasaki N., Yamamoto H., Takeuchi M., and Makita Z. Advanced glycation endproducts-induced apoptosis and overexpression of vascular endothelial growth factor in bovine retinal pericytes. Biochemical and Biophysical Research Communications 290 (2002) 973-978