Enhancement of goblet cell hyperplasia and airway hyperresponsiveness by salbutamol in a rat model of atopic asthma

Thorax

Volumn 56, Issue 1, 2001, Pages 19-24

  Kamachi, A ^a   Munakata, M ^b   Nasuhara, Y ^a   Nishimura, M ^a   Ohtsuka, Y ^b   Amishima, M ^a   Takahashi, T ^a   Homma, Y ^a   Kawakami, Y ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Bronchial asthma; Goblet cell hyperplasia; Salbutamol

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; METHACHOLINE; METHYLPREDNISOLONE; SALBUTAMOL;

AIRWAY PRESSURE; ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHUS HYPERREACTIVITY; CELL COUNT; CELL HYPERPLASIA; CELL INFILTRATION; CONTROLLED STUDY; EOSINOPHIL; EPITHELIUM CELL; GOBLET CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN;

ADRENERGIC BETA-AGONISTS; ALBUTEROL; ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTHMA; BRONCHOCONSTRICTOR AGENTS; EOSINOPHILS; GOBLET CELLS; HYPERPLASIA; MALE; METHACHOLINE CHLORIDE; METHYLPREDNISOLONE; MODELS, ANIMAL; RATS; RESPIRATORY HYPERSENSITIVITY;

EID: 0035156580     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thorax.56.1.19     Document Type: Article

References (34)

1. Bronchial biopsy in chronic bronchitis and asthma
2. The pathology of asthma with special reference to changes in the bronchial mucosa
3. Cause of death and pathologic findings in 304 cases of bronchial asthma
4. A clinical and pathological study of fatal cases of status asthmatics
5. Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack
6. Induction, duration, and resolution of airway goblet cell hyperplasia in a murine model of atopic asthma: Effect of concurrent infection with respiratory syncytial virus and response to dexamethasone
7. Lung inflammation and epithelial changes in a murine model of atopic asthma
8. Epidermal growth factor system regulates mucin production in airways
9. Interleukin-13: Central mediator of allergic asthma
10. Immune regulation of goblet cell development
11. IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo
12. Requirement for IL-13 independently of IL-4 in experimental asthma
13. Goblet cell glycoprotein and tracheal gland hypertrophy in rat airways: The effect of tobacco smoke with or without the anti-inflammatory agent phenylmethyloxadiazole
14. Mitotic rates, goblet cell increase and histochemical changes in mucus in rat bronchial epithelium during exposure to sulphur dioxide
15. The effect of isoprenaline and pilocarpine on (a) bronchial mucus-secreting tissue and (b) pancreas, salivary glands, heart, thymus, liver and spleen
16. The development and persistence of bronchial gland hypertrophy and goblet-cell hyperplasia in the pig after injection of isoprenaline
17. Excessive stimulation of salivary gland growth by isoproterenol
18. Determination of salbutamol in plasma by high-performance liquid chromatography with fluorescence detection
19. Pharmacokinetics of intravenous and oral salbutamol and its sulphate conjugate
20. 2
21. β-Agonists and secretory cell number and intracellular glycoproteins in airway epithelium. The effect of isoproterenol and salbutamol
22. Enlargement of salivary gland in mice treated with isopropyl noradrenaline
23. TRFK-5 reverses established airway eosinophilia but not established hyperresponsiveness in a murine model of chronic asthma
24. The effect of an increase in inhaled allergen dose after rimiterol hydrobromide on the occurrence and magnitude of the late asthmatic response and the associated change in nonspecific bronchial responsiveness
25. 2 agonists
26. In vivo quantification of human pulmonary β-adrenoceptors: Effect of β-agonist therapy
27. Long-term exposure to norepinephrine results in down-regulation and reduced mRNA expression of pulmonary β-adrenergic receptors in guinea pigs
28. Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by antiallergic drugs and albuterol
29. Anti-inflammatory effect of beta 2-agonists: Inhibition of TNF-alpha release from human mast cells
30. Cyclic AMP-elevating agents inhibit mite-antigen-induced IL-4 and IL-13 release from basophil-enriched leukocyte preparation
31. 2-selective sympathomimetics
32. Salbutamol-induced airway hyperreactivity in guinea pigs is not due to a loss of its bronchodilator effect
33. Chronic fenoterol exposure increases in vivo and in vitro airway responses in guinea pigs
34. Airway responsiveness to inhaled mediators: Relationship to epithelial thickness and secretory cell number