Cytokines in acute kidney injury (AKI)

Clinical Nephrology

Volumn 76, Issue 3, 2011, Pages 165-173

  Lee, D W ^a   Faubel, S ^a   Edelstein, C L ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Acute kidney injury; Cytokine; Inflammation biomarker; Lung injury

Indexed keywords

C REACTIVE PROTEIN; FRACTALKINE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 33; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; PADGEM PROTEIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECOMBINANT INTERLEUKIN 10; RECOMBINANT INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ANTIBODY;

ACUTE KIDNEY FAILURE; APOPTOSIS; ARTICLE; BRAIN INJURY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE MARKER; ENDOTHELIUM CELL; GRANULOMATOSIS; HEART INJURY; HUMAN; IMMUNE RESPONSE; INFLAMMATORY CELL; KIDNEY ISCHEMIA; KIDNEY TUBULE CELL; LEUKOCYTE; LIVER INJURY; LUNG INJURY; MACROPHAGE; NATURAL KILLER CELL; NEPHRECTOMY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PSORIASIS; RENAL PROTECTION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION;

ACUTE KIDNEY INJURY; ACUTE LUNG INJURY; ANIMALS; CHEMOKINE CX3CL1; CYTOKINES; HEART DISEASES; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKINS; LIVER DISEASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80052532270     PISSN: 03010430     EISSN: None     Source Type: Journal    
DOI: 10.5414/CN106921     Document Type: Article

References (82)

1. Kriegler M, Perez C, Defay K, Albert I, Lu SD. A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF. Cell. 1988; 53: 45-53.
2. Smith CA, Farrah T, Goodwin RG. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell. 1994; 76: 959-962.
3. Dinarello CA. The cytokine Handbook. In: Thomson AW (ed). Interleukin-1. New York: Academic Press; 1998. p. 36-72.
4. Goes N, Urmson J, Ramassar V, Halloran PF. Ischemic acute tubular necrosis induces as extensive local cytokine response: evidence for induction of interferon-γ, transforming growth factor-β1, granulocyte-macrophage colony-stimulating factor, interleukin-2, and interleukin-10. Transplantation. 1995; 59: 565-572.
5. Kielar ML, John R, Bennett M, Richardson JA, Shelton JM, Chen L, Jeyarajah DR, Zhou XJ, ZhouH, ChiquettB, Nagami GT, Lu CY. Maladap-tive role of IL-6 in ischemic acute renal failure. J Am Soc Nephrol. 2005; 16: 3315-3325.
6. Safirstein R, Megyesi J, Saggi SJ, Price PM, Poon M, Rollins BJ, Taubman MB. Expression of cytokine-like genes JE and KC is increased during renal ischemia. Am J Physiol. 1991; 261: 1095-1101.
7. Rice JC, Spence JS, Yetman DL, Safirstein RL. Monocyte chemoattractant protein-1 expression correlates with monocyte infiltration in the post-ischemic kidney. Ren Fail. 2002; 24: 703-723.
8. Faubel S, Lewis EC, Reznikov L, Ljubanovic D, Hoke TS, Somerset H, Oh DJ, LuL, Klein CL, Dinarello CA, Edelstein CL. Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney. J Pharmacol Exp Ther. 2007; 322: 8-15.
9. Edelstein CL, Schrier RW. Pathophysiology of ischemic acute renal injury. In: Schrier RW (ed). Diseases of the Kidney and Urinary Tract, Vol. 2, chapter 36, 8th edition; Philadelphia: Lippincott Williams & Wilkins; 2007. p. 930-961.
10. Bonventre JV, Zuk A. Ischemic acute renal failure: an inflammatory disease? Kidney Int. 2004; 66: 480-485.
11. Friedewald JJ, Rabb H. Inflammatory cells in ischemic acute renal failure. Kidney Int. 2004; 66: 486-491.
12. Molitoris BA, Sutton TA. Endothelial injury and dysfunction: role in the extension phase of acute renal failure. Kidney Int. 2004; 66: 496-499.
13. Umehara H, Goda S, Imai T, Nagano Y, Minami Y, Tanaka Y, Okazaki T, Bloom ET, Domae N. Fractal-kine, a CX3C-chemokine, functions predominantly as an adhesion molecule in monocytic cell line THP-1. Immunol Cell Biol. 2001; 79: 298-302.
14. Edelstein CL, Schrier RW. ARF: pathogenesis, diagnosis and management. In: Schrier RW (ed). Renal and Electrolyte Disorders, 6th edition. Philadelphia: Lippincott Williams & Wilkins; 2003. p. 401-455.
15. Nakamura K, Okamura H, Wada M, Nagata K, Tamura T. Endotoxin induced serum factor that stimulates gamma interferon production. Infect Immun. 1989; 57: 590-595.
16. Okamura H, Tsutsui H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nu-kada Y, Hattori K, Akita K, Namba M, Tanabe F, Konishi K, Fukuda S, Kurimoto M. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature. 1995; 378: 88-91.
17. Boraschi D, Dinarello CA. IL-18 in autoimmunity: review. Eur Cytokine Netw. 2006;/7: 224-252.
18. Melnikov VY, Ecder T, Fantuzzi G, Siegmund B, Lucia MS, Dinarello CA, Schrier RW, Edelstein CL. Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure. J Clin Invest. 2001; 107: 1145-1152.
19. He Z, Dursun B, Oh DJ, Lu L, Faubel S, Edelstein CL. Macrophages are not the source of injurious interleukin-18 in ischemic acute kidney injury in mice. Am J Physiol Renal Physiol. 2009; 296: 535-542.
20. Wu H, Craft ML, Wang P, Wyburn KR, Chen G, Ma J, Hambly B, Chadban SJ. IL-18 contributes to renal damage after ischemia-reperfusion. J Am Soc Nephrol. 2008; 19: 2331-2341.
21. He Z, Lu L, Altmann C, Hoke TS, Ljubanovic D, Jani A, Dinarello CA, Faubel S, Edelstein CL. Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury. Am J Physiol Renal Physiol. 2008; 295: 1414-1421.
22. Iilasa H Matsushima K. IL-8. In: Oppenheim JJ, Feldman M (eds). Cytokine Reference. New York: Academic Press; 2001. p. 1061-1067.
23. Joannidis M, Truebsbach S, Bijuklic K, Schratz-berger P, Dunzedorfer S, Wintersteiger S, Lhotta K, Mayer G, Wiedermann CJ. Neutrophil transmigration in renal proximal tubular LLC-PK1 cells. Cell Physiol Biochem. 2004; 14: 101-112.
24. Bijuklic K, Jennings P, Kountchev J, Hasslacher J, Aydin S, Sturn D, Pfaller W, Patsch JR, Joannidis M. Migration of leukocytes across an endo-thelium-epithelium bilayer as a model of renal interstitial inflammation. Am J Physiol Cell Physiol. 2007; 293: 486-492.
25. Wada T, Tomosugi N, Naito T, Yokoyama H, Ko-bayashi K, Harada A, Mukaida N, Matsushima K. Prevention of proteinuria by administration of anti-interleukin-8 antibody in experimental acute immune complex-induced glomerulonephritis. J Exp Med. 1994; 180: 1135-1140.
26. Folkesson HG, Matthay MA, Hébert CA, Broad-dus VC. Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanism. J Clin Invest. 1995; 96: 107-116.
27. Miura M, Fu X, Zhang QW, Remick DG, Fairchild RL. Neutralization of Gro alpha and macrophage inflammatory protein-2 attenuates renal ischemia/reperfusion injury. Am J Pathol. 2001; 159: 2137-2145.
28. Cugini D, Azzollini N, Gagliardini E, Cassis P, Bertini R, Colotta F, Noris M, Remuzzi G, Benigni A. Inhibition of the chemokine receptor CXCR2 prevents kidney graft function deterioration due to ischemia/reperfusion. Kidney Int. 2005; 67: 1753-1761.
29. Oh DJ, Dursun B, He Z, Lu L, Hoke TS, Ljubanovic D, Faubel S, Edelstein CL. Fractalkine receptor (CX3CR1) inhibition is protective against ischemic acute renal failure in mice. Am J Physiol Renal Physiol. 2008; 294: 264-271.
30. Schor N. Acute renal failure and the sepsis syndrome. Kidney Int. 2002; 764-776.
31. Mebmer UK, Briner VA, Pfeilschifter J. Tumor necrosis factor-α and lipopolysaccharide induce apoptotic cell death in bovine glomerular endo-thelial cells. Kidney Int. 1999; 55: 2322-2337.
32. Bertani T, Abbate M, Zoja C, Corna D, Perico N, Ghezzi P, Remuzzi G. Tumor necrosis factor induces glomerular disease in the rabbit. Am J Pathol. 1989; 134: 419-430.
33. van der Ween AH, Seynhaeve AL, BreursJ, Nooi-jen PT, Marquet RL, Eggermont AM. In vivo isolated kidney perfusion with TNF-alpha in tumor bearing rats. Br J Cancer. 1989; 79: 433-439.
34. Knotek M, Rogachev B, Wang W, Ecder T, Melnikov V, Gengaro P, Esson M, Edelstein C, Dinarello CA, Schrier RW. Endotoxemic ARF in mice: role of tumor necrosis factor independent of inducible nitric oxide synthase. Kidney Int. 2001; 59: 2243-2249.
35. Fiedler VB, Loof I, Sander E, Voehringer V, Gala-nos C, Fournel MA. Monoclonal antibody to tumor necrosis factor-alpha prevents lethal endo-toxin sepsis in adult rhesus monkeys. J Lab Clin Med. 1992; 120: 574-588.
36. Cunningham PN, Dyanov HM, Park P, Wang J, Newell KA, Quigg RJ. Acute renal failure in en-dotoxemia is caused by TNF acting directly on TNFreceptor-1 in kidney. J Immunol. 2002; 168: 5817-5823.
37. Panacek EA, Marshall JC, Albertson TE, Johnson DH, Johnson S, MacArthur RD, Miller M, Bar-chuk WT, Fischkoff S, Kaul M, Teoh L, Van Meter L, Daum L, Lemeshow S, Hicklin G, Doig C. Monoclonal anti-TNF: a randomized controlled sepsis study investigators. Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit Care Med. 2004; 32: 2173-2182.
38. Klausner JD, Freedman VH, Kaplan G. Thalido-mide as an anti-TNF-α inhibitor: implications for clinical use (review). Clin Immunol Immuno-pathol. 1996; 81: 219-223.
39. Ramesh G, Reeves WB. TNF-α mediates chemo-kine and cytokine expression and renal injury in cisplatin nephrotoxicity. J Clin Invest. 2002; 110: 835-842.
40. Donnahoo KK, Meng X, Ayala A, Cain MP, Har-ken AH, Meldrum DR. Early kidney TNF-alpha expression mediates neutrophil infiltration and injury after renal ischemia-reperfusion. Am J Physiol. 1999; 277: 922-929.
41. Schmitz J, Owyang A, OldhamE, Song Y, Murphy E, McClanahan TK, Zurawski G, Moshrefi M, Qin J, Li X, Gorman DM, Bazan JF, Kastelein RA. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity. 2005; 23: 479-490.
42. Gabay C, McInnes IB. The biological and clinical importance of the 'new generation' cytokines in rheumatic diseases. Arthritis Res Ther. 2009; 11: 230.
43. Xu D, Jiang HR, Kewin P, Li Y, Mu R, FraserAR, Pitman N, Kurowska-Stolarska M, McKenzie AN, McInnes IB, Liew FY. IL-33 exacerbates antigen-induced arthritis by activating mast cells. Proc NatlAcadSci USA. 2008; 105: 10913-10918.
44. Sanada S, Hakuno D, Higgins LJ, Schreiter ER, McKenzie AN, Lee RT. IL-33 and ST2 comprise a critical biomechanically induced and cardiopro-tective signaling system. J Clin Invest. 2007; // 7: 1538-1549.
45. Fagundes CT, Amaral FA, Souza AL, Viera AT, Xu D, Liew FY, Souza DG, Teixeira MM. St2, an IL-1R family member, attenuates inflammation and intestinal ischemia and reperfusion. J. Leukoc Biol. 2007; 81: 492-499.
46. Nechemia-Arbely Y, Barkan D, Pizov G, Shriki A, Rose-John S, Galun E, Axelrod JH. IL-6/IL-6R axis plays a critical role in acute kidney injury. J Am Soc Nephrol. 2008; 19: 1106-1115.
47. Klein CL, Hoke TS, Fang WF, Altmann CJ, Douglas IS, Faubel S. Interleukin-6 mediates lung injury following ischemic acute kidney injury or bilateral nephrectomy Kidney Int. 2008; 74: 901-909.
48. Patel NS, Chatterjee PK, Di Paola R, Mazzon E, Britti D, De Sarro A, Cuzzocrea S, Thiemermann C Endogenous interleukin-6 enhances the renal injury, dysfunction, and inflammation caused by ischemia/reperfusion. J Pharmacol Exp Ther. 2005; 312: 1170-1178.
49. Deng J, Kohda Y, Chiao H, Wang Y,Hu X, Hewitt SM, Miyaji T, McLeroy P, Nibhanupudy B, Li S, Star RA. Interleukin-10 inhibits ischemic and cis-platin-induced acute renal injury. Kidney Int. 2001; 6:2118-2128.
50. Asadullah K, Sterry W, StephanekK, Jasulaitis D, Leupold M, Audring H, Volk HD, Döcke WD. IL-10 is a key cytokine in psoriasis. Proof of principle by IL-10 therapy: a new therapeutic approach. J Clin Invest. 1998; 101: 783-794.
51. Asadullah K, Docke WD, Ebeling M, Friedrich M, Belbe G, Audring H, Volk HD, Sterry W. Interleukin 10 treatment of psoriasis: clinical results of a phase 2 trial. Arch. Dermatol. 1999; 135: 187-192.
52. Yalavarthy R, Edelstein CL. Therapeutic and predictive targets of AKI. Clin Nephrol 2008; 70: 453-463.
53. Edelstein CL, Hoke TS, Somerset H, Fang W, Klein CL, Dinarello C, Faubel S. Proximal tubules from caspase-1 deficient mice are protected against hypoxia-induced membrane injury. Nephrol Dial Transplant. 2007; 22: 1052-1061.
54. Parikh CR, Abraham E, Ancukiewicz M, Edelstein CL. Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit. J Am Soc Nephrol. 2005; 16: 3046-3052.
55. Washburn KK, Zappitelli M, Arikan AA, Loftis L, Yalavarthy R, Parikh CR, Edelstein CL, Goldstein SL. Urinary interleukin-18 is an acute kidney injury biomarker in critically ill children. Nephrol Dial Transplant. 2008; 23: 566-572.
56. Parikh CR, Jani A, Mishra J, Ma Q, Kelly C, Barasch J, Edelstein CL, Devarajan P. Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation. Am J Transplant. 2006; 6: 1639-1645.
57. Hall IE, Yarlagadda SC, Coca SG, et al. IL-18 and NGAL predict dialysis and graft recovery after kidney transplantation. J A Soc Nephrol. 2010; 21: 189-197.
58. Parikh CR, Mishra J, Thiessen-Philbrook H, Dur-sun B, Ma Q, Kelly C, Dent C, Devarajan P, Edel-stein CL. Urinary IL-18 is an early predictive bio-marker of acute kidney injury after cardiac surgery. Kidney Int. 2006; 70: 199-203.
59. Molls RR, Savransky V, Liu M, Bevans S, Mehta T, Tuder RM et al. Keratinocyte-derived chemokine is an early biomarker of ischemic acute kidney injury. Am J Physiol Renal Physiol. 2006; 290: 1187-1193.
60. Liangos O, Kolyada A, Tighiouart H, Perianaya-gam MC, Wald R, Jaber BL. IL-8 and AKI following cardiopulmonary bypass: a prospective cohort study. Nephron Clin Pract. 2009; 113: 148-154.
61. Chawla LS, Seneff MG, Nelson DR, Williams M, Levy H Kimmel PL et al. Elevated plasma concentrations of IL-6 and elevated APACHE II score predict acute kidney injury in patients with severe sepsis. Clinical Journal of The American Society of Nephrology: CJASN. 2007; 2: 22-30.
62. Dennen P, Altmann C, Kaufman J, Klein C, Andres-Hernando A, Ahuja N, Edelstein CL, Cadna-paphornchai M, Keniston A, Faubel S. Urine IL-6 is an early biomarker of acute kidney injury in children undergoing cardiac surgery. Critical Care. 2010; 14: 181.
63. Liu C, Altmann C, Smits G, Krawczeski CD, Edelstein CL, Devarajan P, Faubel S. Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study. Crit Care. 2009; 13: 104.
64. Liu KD, Glidden DV, Eisner MD, Parsons PE, Ware LB, Wheeler A, Korpak A, Thompson BT, Chertow GM, Matthay MA; the National Heart, Lung, and Blood Institute ARDS Network Clinical Trials Group. Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Crit Care Med. 2007; 35: 2755-2761.
65. Iglesias J, Marik PE, Levine JS, Norasept IS. Elevated serum levels of the type I and type II receptors for tumor necrosis factor-alpha as predictive factors for ARF in patients with septic shock. Am J of Kidney Dis. 2003; 41: 62-75.
66. Chvojka J, Sykora R, Karvunidis T, Radej J, Krouzecky A, Novak I, Matejovic M. New developments in septic acute kidney injury. Physiol Res. 2010 Jun 9. [Epub ahead of print].
67. Gogos CA, Drosou E, Bassaris HP, Skoutelis A. Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options. J Infect Dis. 2000; 181: 176-180.
68. Casey LC, Balk RA, Bone RC. Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann Intern Med 1993; 119:771-778.
69. Ahlstrom A, Hynninen M, Tallgren M, Kuusela P, Valtonen M, Orko R, Siitonen S, Takkunen O, Pet-tila V. Predictive value of interleukins 6, 8 and 10, and low HLA-DR expression in acute renal failure. ClinNephrol. 2004; 61: 103-110.
70. Simmons EM, Himmelfarb J, Sezer MT, Chertow GM, Mehta RL, Paganini EP, Soroko S, Freedman S, Becker K, Spratt D, Shyr Y, Ikizler TA; PICARD Study Group. Plasma cytokine levels predict mortality in patients with acute renal failure. Kidney Int. 2004; 65: 1357-1365.
71. Emmanuilidis K, Weighardt H, Matevossian E, Heidecke CD, Ulm K, Bartels H, Siewert JR, Holz-mann B. Differential regulation of systemic IL-18 and IL-12 release during postoperative sepsis: High serum IL-18 as an early predictive indicator of lethal outcome. Shock. 2002; 18: 301-305.
72. Siew ED, Ikizler TA, Gebretsadik T, Shintani A, Wickersham N, Bossert F, Peterson JF, Parikh CR, May AK, Ware LB. Elevated urinary IL-18 levels at the time of ICU admission predict adverse clinical outcomes. Clin J Am Soc Nephrol. 2010; 5: 1497-1505.
73. Hassoun HT, Grigoryev DN, Lie ML, Liu M, Cheadle C, Tuder RM, Rabb H. Ischemic acute kidney injury induces a distant organ functional and genomic response distinguishable from bilateral nephrectomy. Am J Physiol Renal Physiol. 2007; 293: 30-40.
74. Hoke TS, Douglas IS, Klein CL, He Z, Fang W, Thurman JM, Tao Y, Dursun B, Voelkel NF, Edelstein CL, Faubel S. Acute renal failure after bilateral nephrectomy is associated with cytokine-mediated pulmonary injury. J Am Soc Nephrol. 2007; 18: 155-164.
75. Kim do J, Park SH, Sheen MR, Jeon US, Kim SW, Koh ES, Woo SK. Comparison of experimental lung injury from acute renal failure with injury due to sepsis. Respiration. 2006; 73: 815-824.
76. Deng J, Hu X, Yuen PS, Star RA. Alpha-melanocyte-stimulating hormone inhibits lung injury after renal ischemia/reperfusion. Am J Respir Crit Care Med. 2004; 169: 749-756.
77. Faubel S. Pulmonary complications after acute kidney injury. Adv Chronic Kidney Dis. 2008; 15: 284-296.
78. Kelly KJ. Distant effects of experimental renal ischemia/reperfusion injury. J Am Soc Nephrol. 2003; 14: 1549-1558.
79. Liu M, Liang Y, Chigurupati S, Lathia JD, Plet-nikov M, Sun Z, Crow M, Ross CA, Mattson MP, Rabb H. Acute kidney injury leads to inflammation and functional changes in the brain. J Am Soc Nephrol. 2008; 19: 1360-1370.
80. Li X, Hassoun HT, Santora R, Rabb H. Organ crosstalk: the role of the kidney. Curr Opin Crit Care. 2009; 15: 481-487.
81. Golab F, Kadkhodaee M, Zahmatkesh Met al. Ischemic and nonischemic acute kidney injury cause hepatic damage. Kidney Int. 2009; 75: 783-792.
82. Serteser M, Koken T, Kahraman A et al. Changesin hepatic TNF-alpha levels, antioxidant status, and oxidation products after renal ischemia/reperfusion injury in mice. J Surg Res. 2002; 107: 234-240.