The effect of dietary hempseed on atherogenesis and contractile function in aortae from hypercholesterolemic rabbits

Acta Physiologica Hungarica

Volumn 98, Issue 3, 2011, Pages 273-283

  Gavel, N T ^a   Edel, A L ^a   Bassett, C M C ^a   Weber, A M ^a   Merchant, M ^a   Rodriguez Leyva, D ^b   Pierce, G N ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b Cardiovascular Research Division   (Cuba)

Author keywords

atherogenesis; contractile function in aortae; dietary hempseed; hypercholesterolemic rabbits

Indexed keywords

CANNABIS; CHOLESTEROL; COCONUT OIL; FATTY ACID; NITROPRUSSIDE SODIUM; NORADRENALIN; POTASSIUM CHLORIDE;

ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; DIET; DIET SUPPLEMENTATION; EXPERIMENTAL RABBIT; FATTY ACID ANALYSIS; GAS CHROMATOGRAPHY; HEART CONTRACTION; HEMPSEED; HYPERCHOLESTEROLEMIA; MALE; NONHUMAN; PLANT SEED; PROPHYLAXIS; VASCULAR RING;

ANALYSIS OF VARIANCE; ANIMALS; AORTA, ABDOMINAL; AORTIC DISEASES; ATHEROSCLEROSIS; CANNABIS; CHROMATOGRAPHY, GAS; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACIDS, UNSATURATED; HYPERCHOLESTEROLEMIA; LIPIDS; MALE; RABBITS; SEEDS; TIME FACTORS; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS;

EID: 80052528405     PISSN: 0231424X     EISSN: 15882683     Source Type: Journal    
DOI: 10.1556/APhysiol.98.2011.3.4     Document Type: Article

References (23)

1. Ander BP, Weber AR, Rampersad PP, Gilchrist JS, Pierce GN, Lukas A: Dietary flaxseed protects against ventricular fibrillation induced by ischemia-reperfusion in normal and hypercholesterolemic rabbits. J. Nutr. 134, 3250-3256 (2004) (Pubitemid 39602994)
2. Berry EM: Who's afraid of n-6 polyunsaturated fatty acids? Methodological considerations for assessing whether they are harmful. Nutr. Metab. Cardiovas. Dis. 11, 181-188 (2001) (Pubitemid 33686563)
3. Chichlowska J, Kliber A, Kozlowska J, Biskupski M, Grygorowicz Z: Insulin hormone levels and metabolic changes after treated rats with hemp milk. [http://www.hempreport.com/pdf/HempMilkStudy%5B1%5D.pdf] [December 10 2009]
4. Cunnane SC, Hamadeh MJ, Liede AC, Thompson LU, Wolever TM, Jenkins DJ: Nutritional attributes of traditional flaxseed in healthy young adults. Am. J. Clin. Nutr. 61, 62-68 (1995)
5. Dupasquier CMC, Dibrov E, Kneesh AL, Cheung PKM, Lee KGY, Alexander HK, Yeganeh BK, Moghadasian MH, Pierce GN: Dietary flaxseed inhibits atherosclerosis in the LDL receptor deficient mouse in part through anti-proliferative and anti-inflammatory actions. Am. J. Physiol. 293, H2394-H2402 (2007) (Pubitemid 47605886)
6. Dupasquier CMC, Weber AM, Ander BP, Rampersad PP, Steigerwald S, Wigle JT, Mitchell RW, Kroeger EA, Gilchrist JSC, Moghadasian MM, Lukas A, Pierce GN: The effects of dietary flaxseed on vascular contractile function and atherosclerosis in rabbits during prolonged hypercholesterolemia. Am. J. Physiol. 291, H2987-H2996 (2006) (Pubitemid 44904100)
7. Folch J, Lees M, Sloane GHS: A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226, 497-509 (1957)
8. Hu FB, Willett WC: Optimal diets for prevention of coronary heart disease. JAMA 288, 2569-2578 (2002) (Pubitemid 35386892)
9. Lepage G, Roy CC: Direct transesterification of all classes of lipids in a one-step reaction. J. Lipid Res. 27, 114-120 (1986) (Pubitemid 16045295)
10. Massaeli H, Austria J, Pierce GN: Chronic exposure of smooth muscle cells to minimally oxidized LDL results in depressed inositol 1,4,5-trisphosphate receptor density and Ca(2+) transients. Circulation Research 86, 515-523 (1999) (Pubitemid 29431952)
11. Moghadasian M: Pharmacological properties of plant sterols in vivo and in vitro observations. Life Sci. 67, 605-615 (2000) (Pubitemid 30451899)
12. Moghadasian M, Frohlich JJ: Effects of dietary phytosterols on cholesterol metabolism and atherosclerosis: Clinical and experimental evidence. Am. J. Med. 107 588-594 (1999)
13. Prociuk MA, Edel AL, Richard MN, Gavel NT, Ander BP, Dupasquier CMC, Pierce GN: Cholesterol-induced stimulation of platelet aggregation is prevented by a hempseed-enriched diet. Can. J. Physiol. Pharmacol. 86, 153-159 (2008) (Pubitemid 351536445)
14. Prociuk MA, Edel AL, Gavel N, Deniset J, Ganguly R, Austria JA, Ander BP, Lukas A, Pierce GN: The effects of dietary hempseed on cardiac ischemia/reperfusion injury in hypercholesterolemic rabbits. Exp. Clin. Cardiol. 11, 198-205 (2006) (Pubitemid 44540864)
15. Pugsley MK, Tabrizchi R: The vascular system. An overview of structure and function. J. Pharmacol. and Toxicol. Methods 44, 333-340 (2000) (Pubitemid 32452198)
16. Rodriguez-Leyva D, McCullough RS, Pierce GN (2011): Medicinal use of hempseed (Canabis sativa L.): Effects on platelet aggregation. In: Nuts and Seeds in Health and Disease. Eds. Preedy VR, Watson RR. and Patel VB. Academic Press - Elsevier Publ. In press
17. Rosamond W, Flegal K, Friday G, Furie K, Go A, Greenlund K: Heart disease and stroke statistics - 2007 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 115, 169-171 (2007)
18. Rose R: HempNut™ Nutrition. [http://www.hempfood.com/nutrition. html] [accessed September 17, 2009]
19. Simopoulos AP: The importance of the omega-6/omega-3 fatty acid ratio incardiovascular disease and other chronic diseases. Exp. Biol. Med. (Maywood), 233, 674-688 (2008)
20. Sreeharan N, Jayakody RL, Senaratne MP, Thomson AB, Kappagoda CT: Endothelium-dependent relaxation and experimental atherosclerosis in the rabbit aorta. Can. J. Physiol. Pharmacol. 64, 1451-1453 (1986) (Pubitemid 17224944)
21. Tanelian D: Hemp: Nature's forgotten nutraceutical. Natural Pharmacy Magazine. [http://www.globalhemp.com/Archives/Magazines/hemp-natures-forgotton. html] [accessed September 17, 2009]
22. World Health Organization 2008.World Health Statistics 2008. (March 10, 2010) http://www.who.int/whosis/ whostat/ [accessed: February 9, 2009]
23. Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F: Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): Case-control study. Lancet 364, 937-952 (2004) (Pubitemid 39208455)