Dietary therapies for epilepsy: Future research

Epilepsy and Behavior

Volumn 22, Issue 1, 2011, Pages 17-22

  Kessler, Sudha K ^a   Neal, Elizabeth G ^a   Camfield, Carol S ^a   Kossoff, Eric H ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Children; Diet; Epilepsy; Ketogenic; Ketosis; Research

Indexed keywords

4 AMINOBUTYRIC ACID; ALPHA TOCOPHEROL; ANTICONVULSIVE AGENT; CARNITINE; CORTICOTROPIN; GLUCOSE; MAGNESIUM; MEDIUM CHAIN TRIACYLGLYCEROL; OMEGA 3 FATTY ACID; RETINOL; SELENIUM;

ACIDOSIS; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANTICONVULSANT THERAPY; AUTISM; BODY MASS; BRAIN DEPTH STIMULATION; BRAIN TUMOR; CALORIC RESTRICTION; CLINICAL RESEARCH; CONSTIPATION; DIET; DIET SUPPLEMENTATION; DIET THERAPY; DIETITIAN; DRUG SAFETY; DRUG TOLERABILITY; DRUG TREATMENT FAILURE; EPILEPSY; GASTROINTESTINAL SYMPTOM; GLUCOSE BLOOD LEVEL; GLYCEMIC INDEX; HUMAN; INTENTION TO TREAT ANALYSIS; INTRACTABLE EPILEPSY; KETOGENIC DIET; LENNOX GASTAUT SYNDROME; LIPID DIET; LOW CARBOHYDRATE DIET; MIGRAINE; MODIFIED ATKINS DIET; MYOCLONIC ASTATIC EPILEPSY; NONHUMAN; PARENTAL STRESS; PATIENT SAFETY; PROTEIN RESTRICTION; PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY; RANDOMIZED CONTROLLED TRIAL (TOPIC); RETROSPECTIVE STUDY; REVIEW; SEVERE MYOCLONIC EPILEPSY IN INFANCY; UPREGULATION;

EPILEPSY; HUMANS; KETOGENIC DIET;

EID: 80052492765     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2011.02.018     Document Type: Review

References (60)

1. Wilder R.M. The effect of ketonemia on the course of epilepsy. Mayo Clin Bull 1921, 2:307-308.
2. Levy R., Cooper P. Ketogenic diet for epilepsy (Cochrane review). The Cochrane Library 2004, Issue 3. Wiley, Chichester.
3. Neal E.G., Chaffe H.M., Schwartz R., et al. The ketogenic diet in the treatment of epilepsy in children: a randomised controlled trial. Lancet Neurol 2008, 7:500-506.
4. Kossoff E.H., Zupec-Kania B.A., Amark P.E., et al. Optimal clinical management of children receiving the ketogenic diet: recommendations of the International Ketogenic Diet Study Group. Epilepsia 2009, 50:304-317.
5. Kilaru S., Bergqvist A.G. Current treatment of myoclonic astatic epilepsy: clinical experience at the Children's Hospital of Philadelphia. Epilepsia 2007, 48:1703-1707.
6. Kossoff E.H., Hedderick E.F., Turner Z., Freeman J.M. A case-control evaluation of the ketogenic diet versus ACTH for new-onset infantile spasms. Epilepsia 2008, 49:1504-1509.
7. Hong A.M., Turner Z., Hamdy R.F., Kossoff E.H. Infantile spasms treated with the ketogenic diet: prospective single-center experience in 104 consecutive infants. Epilepsia 2010, 51:1403-1407.
8. Nordli D.R., Kuroda M.M., Carroll J., et al. Experience with the ketogenic diet in infants. Pediatrics 2001, 108:129-133.
9. Eun S.H., Kang H.C., Kim D.W., Kim H.D. Ketogenic diet for treatment of infantile spasms. Brain Dev 2006, 28:566-571.
10. Bough K.J., Rho J.M. Anticonvulsant mechanisms of the ketogenic diet. Epilepsia 2007, 48:43-58.
11. Kim do Y., Vallejo J., Rho J.M. Ketones prevent synaptic dysfunction induced by mitochondrial respiratory complex inhibitors. J Neurochem 2010, 114:130-141.
12. Kossoff E.H., Krauss G.L., McGrogan J.R., Freeman J.M. Efficacy of the Atkins diet as therapy for intractable epilepsy. Neurology 2003, 61:1789-1791.
13. Pfeifer H.H., Thiele E.A. Low-glycemic-index treatment: a liberalized ketogenic diet for treatment of intractable epilepsy. Neurology 2005, 65:1810-1812.
14. Muzykewicz D.A., Lyczkowski D.A., Memon N., Conant K.D., Pfeifer H.H., Thiele E.A. Efficacy, safety, and tolerability of the low glycemic index treatment in pediatric epilepsy. Epilepsia 2009, 50:1118-1126.
15. Kossoff E.H., Dorward J.L., Turner Z., Pyzik P.L. Prospective study of the Modified Atkins Diet in combination with a ketogenic liquid supplement during the initial month. J Child Neurol 2011, 26:147-151.
16. Kossoff E.H., Turner Z., Bluml R.M., Pyzik P.L., Vining E.P.G. A randomized, crossover comparison of daily carbohydrate limits using the Modified Atkins Diet. Epilepsy Behav 2007, 10:432-436.
17. Seo J.H., Lee Y.M., Lee J.S., Kang H.C., Kim H.D. Efficacy and tolerability of the ketogenic diet according to lipid:nonlipid ratios: comparison of 3:1 with 4:1 diet. Epilepsia 2007, 48:801-805.
18. Kossoff E.H., Dorward J.L., Molinero M.R., Holden K.R. The Modified Atkins Diet: a potential treatment for developing countries. Epilepsia 2008, 49:1646-1647.
19. McNally M.A., Pyzik P.L., Rubenstein J.E., Hamdy R.F., Kossoff E.H. Empiric use of oral potassium citrate reduces symptomatic kidney stone incidence with the ketogenic diet. Pediatrics 2009, 124:e300-e304.
20. Nizamuddin J., Turner Z., Rubenstein J.E., Pyzik P.L., Kossoff E.H. Management and risk factors for dyslipidemia with the ketogenic diet. J Child Neurol 2008, 23:758-761.
21. Berry-Kravis E., Booth G., Sanchez A.C., Woodbury-Kolb J. Carnitine levels and the ketogenic diet. Epilepsia 2001, 42:1445-1451.
22. Bergqvist A.G., Chee C.M., Lutchka L., Rychik J., Stallings V.A. Selenium deficiency associated with cardiomyopathy: a complication of the ketogenic diet. Epilepsia 2003, 44:618-620.
23. Groesbeck D.K., Bluml R.M., Kossoff E.H. Long-term use of the ketogenic diet. Dev Med Child Neurol 2006, 48:978-981.
24. Patel A., Pyzik P.L., Turner Z., Rubenstein J.E., Kossoff E.H. Long-term outcomes of children treated with the ketogenic diet in the past. Epilepsia 2010, 51:1277-1282.
25. Hamdy R.F., Turner Z., Pyzik P.L., Kossoff E.H. Lack of influence of body mass index on the efficacy of the ketogenic diet. J Child Neurol 2007, 22:1167-1171.
26. Evangeliou A., Spilioti M., Doulioglou V., et al. Branched chain amino acids as adjunctive therapy to ketogenic diet in epilepsy: pilot study and hypothesis. J Child Neurol 2009, 24:1268-1272.
27. Freeman J.M., Vining E.P.G., Kossoff E.H., Pyzik P.L., Ye X., Goodman S.N. A blinded, crossover study of the ketogenic diet. Epilepsia 2009, 50:322-325.
28. Wirrell E.C., Darwish H.Z., Williams-Dyjur C., Blackman M., Lange V. Is a fast necessary when initiating the ketogenic diet?. J Child Neurol 2002, 17:179-182.
29. Kim D.W., Kang H.C., Park J.C., Kim H.D. Benefits of the nonfasting ketogenic diet compared with the initial fasting ketogenic diet. Pediatrics 2004, 114:1627-1630.
30. Bergqvist A.G., Schall J.I., Gallagher P.R., Cnaan A., Stallings V.A. Fasting versus gradual initiation of the ketogenic diet: a prospective, randomized clinical trial of efficacy. Epilepsia 2005, 46:1810-1819.
31. Barborka C.J. Epilepsy in adults: results of treatment by ketogenic diet in one hundred cases. Arch Neurol 1930, 6:904-914.
32. Sirven J., Whedon B., Caplan D., et al. The ketogenic diet for intractable epilepsy in adults: preliminary results. Epilepsia 1999, 40:1721-1726.
33. Kossoff E.H., Rowley H., Sinha S.R., Vining E.P.G. A prospective study of the Modified Atkins Diet for intractable epilepsy in adults. Epilepsia 2008, 49:316-319.
34. Carrette E., Vonck K., de Herdt V., et al. A pilot trial with Modified Atkins' Diet in adult patients with refractory epilepsy. Clin Neurol Neurosurg 2008, 110:797-803.
35. Barañano K.W., Hartman A.L. The ketogenic diet: uses in epilepsy and other neurologic illnesses. Curr Treat Options Neurol 2008, 10:410-419.
36. Henderson S.T. Ketone bodies as a therapeutic for Alzheimer's disease. Neurotherapeutics 2008, 5:470-480.
37. Schwartz R.H., Eaton J., Bower B.D., Aynsley-Green A. Ketogenic diets in the treatment of epilepsy: short term clinical effects. Dev Med Child Neurol 1989, 31:145-151.
38. Neal E.G., Chaffe H.M., Schwartz R., et al. A randomised trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy. Epilepsia 2009, 50:1109-1117.
39. Vining E.P.G., Pyzik P., McGrogan J., et al. Growth of children on the ketogenic diet. Dev Med Child Neurol 2002, 44:796-802.
40. Liu Y.M., Williams S., Basualdo-Hamond C., Stephens D., Curtis R. A prospective study: growth and nutritional status of children treated with the ketogenic diet. J Am Diet Assoc 2003, 103:107-112.
41. Peterson S.J., Tangey C.C., Pimentel-Zablah E.M., Hjelmgren B., Booth G., Berry-Kravis E. Changes in growth and seizure reduction in children on the ketogenic diet as a treatment for intractable epilepsy. J Am Diet Assoc 2005, 105:725-726.
42. Neal E.G., Chaffe H.M., Edwards N., Lawson M., Schwartz R., Cross J.H. Growth of children on classical and MCT ketogenic diets. Pediatrics 2008, 122:e334-e340.
43. Christodoulides SS, Neal EG, Fitzsimmons G, et al. The effect of the classical and medium chain triglyceride ketogenic diet on vitamin and mineral levels. J Hum Nutr Diet in press.
44. Dressler A., Stocklin B., Reithofer E., et al. Long-term outcome and tolerability of the ketogenic diet in drug-resistant childhood epilepsy: the Austrian experience. Seizure 2010, 19:404-408.
45. Freeman J.M., Vining E.P., Pillas D.J., Pyzik P.L., Casey J.C., Kelly L.M. The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 children. Pediatrics 1998, 102:1358-1363.
46. Berg A.T., Kelly M.M. Defining intractability: comparisons among published definitions. Epilepsia 2006, 47:431-436.
47. Leen W.G., Klepper J., Verbeek M.M., et al. Glucose transporter-1 deficiency syndrome: the expanding clinical and genetic spectrum of a treatable disorder. Brain 2010, 133:655-670.
48. Wexler I.D., Hemalatha S.G., McConnell J., et al. Outcome of pyruvate dehydrogenase deficiency treated with ketogenic diets: studies in patients with identical mutations. Neurology 1997, 49:1655-1661.
49. Caraballo R.H., Cersosimo R.O., Sakr D., Cresta A., Escobal N., Fejerman N. Ketogenic diet in patients with Dravet syndrome. Epilepsia 2005, 46:1539-1544.
50. Caraballo R.H., Cersosimo R.O., Sakr D., Cresta A., Escobal N., Fejerman N. Ketogenic diet in patients with myoclonic-astatic epilepsy. Epileptic Disord 2006, 8:151-155.
51. Korff C., Laux L., Kelley K., Goldstein J., Koh S., Nordli D. Dravet syndrome (severe myoclonic epilepsy in infancy): a retrospective study of 16 patients. J Child Neurol 2007, 22:185-194.
52. Laux L.C., Devonshire K.A., Kelley K.R., Goldstein J., Nordli D.R. Efficacy of the ketogenic diet in myoclonic epilepsy of Doose. Epilepsia 2004, 45(Suppl. 7):251.
53. Oguni H., Tanaka T., Hayashi K., et al. Treatment and long-term prognosis of myoclonic-astatic epilepsy of early childhood. Neuropediatrics 2002, 33:122-132.
54. Coppola G., Veggiotti P., Cusmai R., et al. The ketogenic diet in children, adolescents and young adults with refractory epilepsy: an Italian multicentric experience. Epilepsy Res 2002, 48:221-227.
55. Kang H.C., Kim Y.J., Kim D.W., Kim H.D. Efficacy and safety of the ketogenic diet for intractable childhood epilepsy: Korean multicentric experience. Epilepsia 2005, 46:272-279.
56. Than K.D., Kossoff E.H., Rubenstein J.E., Pyzik P.L., McGrogan J.R., Vining E.P. Can you predict an immediate, complete, and sustained response to the ketogenic diet?. Epilepsia 2005, 46:580-582.
57. Beniczky S., Jose Miranda M., Alving J., Heber Povlsen J., Wolf P. Effectiveness of the ketogenic diet in a broad range of seizure types and EEG features for severe childhood epilepsies. Acta Neurol Scand 2010, 21:58-62.
58. Vining E.P., Freeman J.M., Ballaban-Gil K., et al. A multicenter study of the efficacy of the ketogenic diet. Arch Neurol 1998, 55:1433-1437.
59. Kessler S.K., Gallagher P.R., Shellhaas R.A., Clancy R.R., Bergqvist A.G. Early EEG improvement after ketogenic diet initiation. Epilepsy Res 2011, 94:94-101.
60. Cantello R., Varrasi C., Tarletti R., et al. Ketogenic diet: electrophysiological effects on the normal human cortex. Epilepsia 2007, 48:1756-1763.