Early EEG improvement after ketogenic diet initiation

Epilepsy Research

Volumn 94, Issue 1-2, 2011, Pages 94-101

  Kessler, Sudha Kilaru ^a   Gallagher, Paul R ^b   Shellhaas, Renée A ^c   Clancy, Robert R ^a   Bergqvist, A G Christina ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

EEG; Ketogenic diet; Power spectrum analysis; Spike index

Indexed keywords

ANTICONVULSIVE AGENT;

ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROENCEPHALOGRAPHY; EPILEPSY; EPILEPTIC DISCHARGE; FEMALE; FOCAL EPILEPSY; GENERALIZED EPILEPSY; HUMAN; KETOGENIC DIET; MALE; MIXED SEIZURE; PREDICTION; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; THERAPY EFFECT; THERAPY RESISTANCE; TREATMENT RESPONSE;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; ELECTROENCEPHALOGRAPHY; EPILEPSY; FEMALE; HUMANS; INFANT; KETOGENIC DIET; MALE; STATISTICS, NONPARAMETRIC;

EID: 79952442836     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2011.01.012     Document Type: Article

References (26)

1. Beniczky S., Jose Miranda M., Alving J., Heber Povlsen J., Wolf P. Effectiveness of the ketogenic diet in a broad range of seizure types and EEG features for severe childhood epilepsies. Acta Neurol. Scand. 2010, 121(1):58-62.
2. Bergqvist A.G., Chee C.M., Lutchka L.M., Brooks-Kayal A.R. Treatment of acquired epileptic aphasia with the ketogenic diet. J. Child Neurol. 1999, 14(11):696-701.
3. Bergqvist A.G., Schall J.I., Gallagher P.R., Cnaan A., Stallings V.A. Fasting versus gradual initiation of the ketogenic diet: a prospective, randomized clinical trial of efficacy. Epilepsia 2005, 46(11):1810-1819.
4. Bruni J., Wilder B.J., Bauman A.W., Willmore L.J. Clinical efficacy and long-term effects of valproic acid therapy on spike-and-wave discharges. Neurology 1980, 30(1):42-46.
5. Camfield P., Gordon K., Camfield C., Tibbles J., Dooley J., Smith B. EEG results are rarely the same if repeated within six months in childhood epilepsy. Can. J. Neurol. Sci. 1995, 22(4):297-300.
6. Cantello R., Varrasi C., Tarletti R., Cecchin M., D'Andrea F., Veggiotti P., Bellomo G., Monaco F. Ketogenic diet: electrophysiological effects on the normal human cortex. Epilepsia 2007, 48(9):1756-1763.
7. Caraballo R.H., Cersosimo R.O., Sakr D., Cresta A., Escobal N., Fejerman N. Ketogenic diet in patients with myoclonic-astatic epilepsy. Epileptic Disord. 2006, 8(2):151-155.
8. Dressler A., Stocklin B., Reithofer E., Benninger F., Freilinger M., Hauser E., Reiter-Fink E., Seidl R., Trimmel-Schwahofer P., Feucht M. Long-term outcome and tolerability of the ketogenic diet in drug-resistant childhood epilepsy-the Austrian experience. Seizure 2010, 19(7):404-408.
9. Eriksson A.S., Knutsson E., Nergardh A. The effect of lamotrigine on epileptiform discharges in young patients with drug-resistant epilepsy. Epilepsia 2001, 42(2):230-236.
10. Freeman J.M., Vining E.P., Kossoff E.H., Pyzik P.L., Ye X., Goodman S.N. A blinded, crossover study of the efficacy of the ketogenic diet. Epilepsia 2009, 50(2):322-325.
11. Hallbook T., Kohler S., Rosen I., Lundgren J. Effects of ketogenic diet on epileptiform activity in children with therapy resistant epilepsy. Epilepsy Res. 2007, 77(2-3):134-140.
12. Kilaru S., Bergqvist A.G. Current treatment of myoclonic astatic epilepsy: clinical experience at the Children's Hospital of Philadelphia. Epilepsia 2007, 48(9):1703-1707.
13. Korff C., Laux L., Kelley K., Goldstein J., Koh S., Nordli D. Dravet syndrome (severe myoclonic epilepsy in infancy): a retrospective study of 16 patients. J. Child Neurol. 2007, 22(2):185-194.
14. Kossoff E.H., Zupec-Kania B.A., Amark P.E., Ballaban-Gil K.R., Christina Bergqvist A.G., Blackford R., Buchhalter J.R., Caraballo R.H., Helen Cross J., Dahlin M.G., Donner E.J., Klepper J., Jehle R.S., Kim H.D., Christiana Liu Y.M., Nation J., Nordli D.R., Pfeifer H.H., Rho J.M., Stafstrom C.E., Thiele E.A., Turner Z., Wirrell E.C., Wheless J.W., Veggiotti P., Vining E.P. Optimal clinical management of children receiving the ketogenic diet: recommendations of the International Ketogenic Diet Study Group. Epilepsia 2009, 50(2):304-317.
15. Lefevre F., Aronson N. Ketogenic diet for the treatment of refractory epilepsy in children: a systematic review of efficacy. Pediatrics 2000, 105(4):E46.
16. Loscher W. Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy. CNS Drugs 2002, 16(10):669-694.
17. Martins da Silva A., Aarts J.H., Binnie C.D., Laxminarayan R., Lopes da Silva F.H., Meijer J.W., Nagelkerke N. The circadian distribution of interictal epileptiform EEG activity. Electroencephalogr. Clin. Neurophysiol. 1984, 58(1):1-13.
18. Neal E.G., Chaffe H., Schwartz R.H., Lawson M.S., Edwards N., Fitzsimmons G., Whitney A., Cross J.H. The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. Lancet Neurol. 2008, 7(6):500-506.
19. Neal E.G., Chaffe H., Schwartz R.H., Lawson M.S., Edwards N., Fitzsimmons G., Whitney A., Cross J.H. A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy. Epilepsia 2009, 50(5):1109-1117.
20. Nikanorova M., Miranda M.J., Atkins M., Sahlholdt L. Ketogenic diet in the treatment of refractory continuous spikes and waves during slow sleep. Epilepsia 2009, 50(5):1127-1131.
21. Oguni H., Tanaka T., Hayashi K., Funatsuka M., Sakauchi M., Shirakawa S., Osawa M. Treatment and long-term prognosis of myoclonic-astatic epilepsy of early childhood. Neuropediatrics 2002, 33(3):122-132.
22. Remahl S., Dahlin M.G., Amark P.E. Influence of the ketogenic diet on 24-hour electroencephalogram in children with epilepsy. Pediatr. Neurol. 2008, 38(1):38-43.
23. Ross D.L., Swaiman K.F., Torres F., Hansen J. Early biochemical and EEG correlates of the ketogenic diet in children with atypical absence epilepsy. Pediatr. Neurol. 1985, 1(2):104-108.
24. Than K.D., Kossoff E.H., Rubenstein J.E., Pyzik P.L., McGrogan J.R., Vining E.P. Can you predict an immediate, complete, and sustained response to the ketogenic diet?. Epilepsia 2005, 46(4):580-582.
25. Thiele E.A. Assessing the efficacy of antiepileptic treatments: the ketogenic diet. Epilepsia 2003, 44(Suppl 7):26-29.
26. Vining E.P., Freeman J.M., Ballaban-Gil K., Camfield C.S., Camfield P.R., Holmes G.L., Shinnar S., Shuman R., Trevathan E., Wheless J.W. A multicenter study of the efficacy of the ketogenic diet. Arch. Neurol. 1998, 55(11):1433-1437.