Relaxant effect and possible mechanism of 17-nor-subincanadine e in rabbit corpora cavernosa

Asian Journal of Andrology

Volumn 13, Issue 5, 2011, Pages 747-753

  Benvindo, Otacilio D ^a   Nascimento, Nilberto R F ^b   Santos, Claudia F ^b   Fonteles, Manasses C ^b   Silveira, Edilberto R ^a   Uchoa, Daniel E ^a   Campos, Adriana R ^a   Cunha, Karina M A ^a   Santos, Flavia A ^a   Rao, Vietla S ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b STATE UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

17 nor subincanadine E; cyclic nucleotides; electrical field stimulation; nitric oxide; rabbit corpus cavernosum; smooth muscle relaxation

Indexed keywords

17 NORSUBINCANADINE E; 1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; ALKALOID DERIVATIVE; ATROPINE; CALCIUM CHLORIDE; CYCLIC AMP; CYCLIC GMP; FORSKOLIN; GUANETHIDINE; N(G) NITROARGININE METHYL ESTER; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; POTASSIUM ION; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; DYSLIPIDEMIA; ELECTROSTIMULATION; ENDOTHELIAL DYSFUNCTION; ERECTILE DYSFUNCTION; HYPERTENSION; MALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; NONHUMAN; PENIS ERECTION; RABBIT;

ANIMALS; BLOOD VESSELS; INDOLE ALKALOIDS; MALE; PENIS; RABBITS; VASODILATOR AGENTS;

EID: 80052474687     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.1038/aja.2011.41     Document Type: Article

References (31)

1. Johannes CB, Araujo AB, Feldman HA, Derby CA, Kleinmann KP et al. Incidence of erectile dysfunction in men 40-69 years old. Longitudinal Results from the Massachusetts Male Aging Study. J Urol 2000; 163: 460-3.
2. Maggi M, Filippi S, Leda F, Magini A, Forti G. Erectile dysfunction: from biochemical pharmacology to advences in medical therapy. Eur J Endocrinol 2000; 143: 143-54.
3. Seftel AD. Challenges in oral therapy for erectile dysfunction. J Androl 2002; 23: 729-36.
4. Ignarro LJ. Nitric oxide. A novel signal transduction mechanism for transcellular communication. Hypertension 1990; 16: 477-83.
5. Guirguis WR. Oral treatment of erectile-dysfunction: from herbal remedies to designer drugs. J Sex Marital Ther 1998; 24: 69-73.
6. El-Thaher TS, Khatib S, Saleem M, Shnoudeh A, Badwan AA. A novel compound JPM8: in vivo penile activity promotion in rats, effect on the relaxation and cGMP/cAMP accumulation in isolated rabbit corpora cavernosa. Int J Impot Res 2002; 14: 453-61.
7. Mas M. Molecular mechanisms of penile erection. Arch Esp Urol 2010; 63: 589-98.
8. Zaher TF. Papaverine plus PGE, versus PGE1 alone for intracorporeal injection therapy. Intl Urol Nephrol 1998; 30: 193-6.
9. Deutsch HF, Evenson MA, Drescher P, Sparwasser C, Madsen PO. Isolation and biological activity of aspidospermine and quebrachamine from Aspidosperma tree source. J Pharmaceut Biomed Anal 1994; 12: 1283-7.
10. Chiou WF, Chen J, Chen CF. Relaxation of corpus cavernosum and raised intracavernous pressure by berberine in rabbit. Br J Pharmacol 1998; 125: 1677-84.
11. Dinsmore WW. Available and future treatments for erectile dysfunction. Clin Cornerstone 2005; 7: 37-45.
12. Matsumoto K, Yoshida M, Andersson KE, Hedlund P. Effects in vitro and in vivo by apomorphine in the rat corpus cavernosum. Br J Pharmacol 2005; 146: 259-67.
13. Chen J, Liu JH, Wang T, Xiao HJ, Yin CP et al. Effectsof plant extract neferine oncyclic adenosine monophosphate and cyclic guanosine monophosphate levels in rabbit corpus cavernosum in vitro. Asian J Androl 2008; 10: 307-12.
14. Pereira MM, Jacome RL, Alcântara AF, Alves RB, Raslan DS. Alcalóides indólicos isolados de espécies do gênero Aspidosperma (Apocynaceae). Quim Nova 2007; 30: 970-83.
15. Campos AR, Lima Jú nior RCP, Uchoa DEA, Silveira ER, Santos FA et al. Pro-erectile effects of an alkaloidical rich fraction from Aspidosperma ulei root bark in mice. J Ethnopharmacol 2006; 104: 240-4.
16. Campos AR, Otacílio BD Jr, Ucho DEA, Silveira ER, Rao VS. 15R-16,17-Seco subincanadine E, a proerectile indole alkaloid isolated from Aspidosperma ulei stem Bark. Evid Based Complement Altern Med 2007; 4 (Suppl): 56-8.
17. Campos AR, Cunha KM, Santos FA, Silveira ER, Uchoa DE et al. Relaxant effects of an alkaloid-rich fraction from Aspidosperma ulei root bark on isolated rabbit corpus cavernosum. Int J Impot Res 2008; 20: 255-63.
18. Kobayashi J, Sekiguchi M, Shimamoto S, Shigemori H, Ishiyama H et al. Subincanadines A-C, novel quaternary indole alkaloids from Aspidosperma subincanum. J Org Chem 2002; 67: 6449-55.
19. Castillo JC, de Beer EJ. The tracheal chain-l. A preparation for the study of antispasmodics with particular reference to bronchodilator drugs. J Pharmacol Exp Ther 1947; 90:104-9.
20. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature (London) 1980; 288: 373-6.
21. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of protein-dye binding. Anal Biochem 1976; 72: 248-54.
22. Lin RJ, Wu BN, Shen KP, Lo YT, Huang CH et al. KMUP-1 relaxes rabbit corpus cavernosum smooth muscle in vitro and in vivo: involvement of cyclic GMP and K channels. Br J Pharmacol 2002; 135: 1159-66.
23. Filippi S, Luconi M, Granchi S, Natali A, Tozzi P et al. Endothelium-dependency of yohimbine-induced corpus cavernosum relaxation. Int J Impot Res 2002; 14: 295-307.
24. 21 sensitivity regulates contractility of rabbit corpus cavernosum smooth muscle. J Urol 2003; 169: 2412-6.
25. Sharabi FM, Daabees TT, El-Metwally MA, Senbel AM. Comparative effects of sildenafil, phentolamine, yohimbine and L-arginine on the rabbit corpus cavernosum. Fund Clin Pharmacol 2004; 18: 187-94.
26. Saito M, Broderick G, Wein AJ, Levin RM. Effect of alteration in the extracellular potassium and calcium on field-stimulated relaxation of the rabbit corpus cavernosum. Gen Pharmacol 1996; 27: 375-8.
27. Okamura T, Fujioka H, Ayajiki K. Effects of calcium antagonists on the nitrergic nerve function in canine corpus cavernosum. Jpn J Pharmacol 2001; 87: 208-13.
28. Hallén K, Wiklund NP, Gustafsson LE. Inhibitors of phosphodiesterase 5 (PDE 5) inhibit the nerve-induced release of nitric oxide from the rabbit corpus cavernosum. Br J Pharmacol 2007; 150: 353-60.
29. Zaccolo M, Movsesian MA. cAMP and cGMP signaling cross-talk: role of phosphodies-terases and implications for cardiac pathophysiology. Circ Resn 2007; 100: 1569-78.
30. Uckert S, Hedlund P, Waldkirch E, Sohn M, Jonas U et al. Interactions between cGMP-and cAMP-pathways are involved in the regulation of penile smooth muscle tone. World J Urol 2004; 22: 261-6.
31. Stief CG, Uckert S, Becker AJ, Harringer W, Truss MC et al. Effects of sildenafil on cAMP and cGMP levels in isolated human cavernous and cardiac tissue. Urology 2000; 55: 146-50.