Molecular mechanisms of penile erection;Bases moleculares de la erección

Archivos Espanoles de Urologia

Volumn 63, Issue 8, 2010, Pages 589-598

  Mas, Manuel ^a  

^a UNIVERSIDAD DE LA LAGUNA   (Spain)

Author keywords

Calcium sensitization; Corpus cavernosum; Cyclic nucleotides; Erectile dysfunction; Nitric Oxide; Phosphodiesterases; Smooth muscle

Indexed keywords

ARTICLE; HISTOLOGY; HUMAN; MALE; METABOLISM; PENIS; PENIS ERECTION; PHYSIOLOGY; SIGNAL TRANSDUCTION; SMOOTH MUSCLE;

HUMANS; MALE; MUSCLE, SMOOTH; PENILE ERECTION; PENIS; SIGNAL TRANSDUCTION;

EID: 78149236796     PISSN: 00040614     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Sáenz de Tejada I, Angulo J, Cellek S, González-Cadavid N, Heaton J, Pickard R, et al. Physiology of erectile function. J Sex Med 2004; 1: 254-265
2. Simonsen U, García-Sacristán A, Prieto D. Penile arteries and erection. J Vasc Res, 2002; 39: 283-303.
3. Andersson K-E. Erectile physiological and pathophysiological pathways involved in erectile dysfunction. J Urol 2003; 170: S6-S14.
4. Dean RC, Lue TF. Physiology of penile erection and pathophysiology of erectile dysfunction. Urol Clin North Am 2005 ; 32: 379-395.
5. a Ed, pp.1172- 1183, Madrid: McGraw Hill-Interamericana, 2010.
6. a Ed, pp. 268-285, Barcelona: Elsevier España; 2009.
7. Mas M. A close look at the endothelium: Its role in the regulation of vasomotor tone. Eur Urol Suppl 2009; 8: 48-57.
8. Hirano K. Current topics in the regulatory mechanism underlying the Ca2+ sensitization of the contractile apparatus in vascular smooth muscle. J Pharmacol Sci 2007; 104: 109-115
9. Karaki H. The intracellular calcium-force relationship in vascular smooth muscle. Time- and stimulus- dependent dissociation. Am J Hypertens 1990; 3 (Pt 2): 253S-256S.
10. Chitaley K, Webb RC, Mills TM. The ups and downs of Rho-kinase and penile erection: upstream regulators and downstream substrates of rho-kinase and their potential role in the erectile response. Int J Impot Res 2003; 15: 105-109
11. Jin L, Burnett AL. RhoA/Rho-kinase in erectile tissue: mechanisms of disease and therapeutic insights. Clin Sci 2006; 110: 153-165.
12. Wang H, Eto M, Steers WD, Somlyo AP, Somlyo AV. RhoA-mediated Ca2+ sensitization in erectile function. J Biol Chem 2002; 277: 30614-30621
13. Kaneko T, Amano M, Maeda A, Goto H, Takahashi K, Ito M, et al. Identification of calponin as a novel substrate of Rho-kinase. Biochem Biophys Res Commun 2000; 273: 110-116
14. Ghalayini IF. Nitric oxide-cyclic GMP pathway with some emphasis on cavernosal contractility. Int J Impot Res 2004; 16: 459-469
15. Gur S, Hellstrom WJG. Activation of P2Y1 and P2Y2 nucleotide receptors by adenosine 5-triphosphate analogues augmented nerve-mediated relaxation of human corpus cavernosum. Can Urol Assoc J 2009; 3: 314-318
16. Lin C-S, Lin G, Lue TF. Cyclic nucleotide signaling in cavernous smooth muscle. J Sex Med 2005; 2: 478-491
17. Sauzeau V, Le Jeune H, Cario-Toumaniantz C, Smolenski A, Lohmann SM, Bertoglio J, et al. Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle. J Biol Chem 2000; 275: 21722-21729
18. Chitaley K, Webb RC, Mills TM. RhoA/Rho-kinase: a novel player in the regulation of penile erection. Int J Impot Res 2001; 13:67-72.
19. Ito M, Nakano T, Erdodi F, Hartshorne DJ. Myosin phosphatase: structure, regulation and function. Mol Cell Biochem 2004; 259:197-209.
20. Corbin JD. Mechanisms of action of PDE5 inhibition in erectile dysfunction. Int J Impot Res 2004; 16 (Suppl 1): S4-S7.
21. Lin C-S. Phosphodiesterase type 5 regulation in the penile corpora cavernosa. J Sex Med 2009; 6(suppl 3): 203-209
22. Oelke M, Hedlund P, Albrecht K, Ellinghaus P,Stief CG, Jonas U, et al. Expression of cAMP and cGMP-phosphodiesterase isoenzymes 3, 4, and 5 in the human clitoris: immunohistochemical and molecular biology study. Urology 2006; 67: 1111-1116
23. Waldkirch E, Uckert S, Yildirim H, Sohn M, Jonas U, Stief CG, et al. Cyclic AMP-specific and cyclic GMP-specific phosphodiesterase isoenzymes in human cavernous arteries- immunohistochemical distribution and functional significance. World J Urol 2005; 23: 405-410
24. Francis SH, Morris GZ, Corbin JD. Molecular mechanisms that could contribute to prolonged effectiveness of PDE5 inhibitors to improve erectile function. Int J Impot Res 2008; 20: 333-342
25. Uckert S, Hedlund P, Waldkirch E, Sohn M, Jonas U, Andersson KE et al. Interactions between cGMP- and cAMP-pathways are involved in the regulation of penile smooth muscle tone. World J Urol 2004; 22: 261-266
26. Kim NN, Huang Y, Moreland RB, Kwak SS, Goldstein I, Traish A. Cross-regulation of intracellular intracellular cGMP and cAMP in cultured human corpus cavernosum smooth muscle cells. Mol Cell Biol Res Commun 2000; 4:10-14
27. Escrig A, Marín R, Mas M. Repeated PGE1 treatment enhances nitric oxide and erection responses to nerve stimulation in the rat penis by upregulating constitutive NOS isoforms. J Urol 1999;162: 2205-2210
28. Gutiérrez P, Hernández P, Mas M. Combining programmed intracavernous PGE1 injections and sildenafil on demand to salvage sildenafil non-responders. Int J Impot Res 2005; 17: 354-358