Assessment of the safety and biodistribution of a regulated AAV2 gene transfer vector after delivery to murine submandibular glands

Toxicological Sciences

Volumn 123, Issue 1, 2011, Pages 247-255

  Zheng, Changyu ^a   Voutetakis, Antonis ^a   Goldstein, Benjamin ^a   Afione, Sandra ^a   Rivera, Victor M ^b   Clackson, Tim ^b   Wenk, Martin L ^c   Boyle, Molly ^d   Nyska, Abraham ^e   Chiorini, John A ^a   Vallant, Molly ^e   Irwin, Richard D ^e   Baum, Bruce J ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b ARIAD PHARMACEUTICALS INC   (United States)

^c Toxicology Division   (United States)

^d INTEGRATED LABORATORY SYSTEMS   (United States)

^e NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

AAV2 vector; Rapamycin; Regulated gene expression.; Safety; Salivary gland

Indexed keywords

RAPAMYCIN; RECOMBINANT ADENO ASSOCIATED VIRAL VECTOR; RECOMBINANT ERYTHROPOIETIN; UNCLASSIFIED DRUG; VIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CLINICAL CHEMISTRY; CONTROLLED STUDY; DRUG EFFECT; DRUG SAFETY; FEMALE; FLUID INTAKE; FOOD INTAKE; GENE CONTROL; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER; GENE VECTOR; HEMATOLOGY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; SUBMANDIBULAR GLAND; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; BODY WEIGHT; DEPENDOVIRUS; ERYTHROPOIETIN; FEMALE; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; MALE; MICE; MICE, INBRED BALB C; RISK ASSESSMENT; SEX FACTORS; SIROLIMUS; SUBMANDIBULAR GLAND; TOXICITY TESTS;

ANIMALIA; MURINAE; MUS;

EID: 80052473354     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr144     Document Type: Article

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