Gender differences in serotype 2 adeno-associated virus biodistribution after administration to rodent salivary glands

Human Gene Therapy

Volumn 18, Issue 11, 2007, Pages 1109-1118

  Voutetakis, A ^a   Zheng, C ^a   Wang, J ^a   Goldsmith, C M ^a   Afione, S ^a   Chiorini, J A ^a   Wenk, M L ^b   Vallant, M ^c   Irwin, R D ^c   Baum, B J ^a,d  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b Toxicology Division   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PARVOVIRUS VECTOR; RECOMBINANT ERYTHROPOIETIN;

ARTICLE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG SYNTHESIS; FEMALE; FLUID INTAKE; FOOD INTAKE; MALE; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; SALIVARY GLAND; SEX DIFFERENCE; SUBMANDIBULAR GLAND; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; WEIGHT GAIN;

ANIMALS; BLOOD; BODY WEIGHT; DEPENDOVIRUS; EATING; ERYTHROPOIETIN; FEMALE; GENE THERAPY; GENETIC VECTORS; HUMANS; INJECTIONS; LEUKOCYTE COUNT; MALE; MICE; MICE, INBRED BALB C; SALIVA; SEX CHARACTERISTICS; SUBMANDIBULAR GLAND; TISSUE DISTRIBUTION;

ADENO-ASSOCIATED VIRUS; ANIMALIA; MUS; RODENTIA;

EID: 36148970452     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2007.072     Document Type: Article

References (39)

1. BAUM, B.J., VOUTETAKIS, A., and WANG, J. (2004). Salivary glands: Novel target sites for gene therapeutics. Trends Mol. Med. 10, 585-590.
2. BERRAONDO, P., OCHOA, L., CRETTAZ, J., ROTELLAR, F., VALES, A., MARTINEZ-ANSO, E., ZARATIEGUI, M., RUIZ, J., GONZALEZ-ASEGUINOLAZA, G., and PRIETO, J. (2005). IFN-α gene therapy for woodchuck hepatitis with adenoassociated virus: Differences in duration of gene expression and antiviral activity using intraportal or intramuscular routes. Mol. Ther. 12, 68-76.
3. BERRAONDO, P., CRETTAZ, J., OCHOA, L., PANEDA, A., PRIETO, J., TROCONIZ, I.F., and GONZALEZ-ASEGUINOLAZA, G. (2006). Intrahepatic injection of recombinant adeno-associated virus serotype 2 overcomes gender-related differences in liver transduction. Hum. Gene Ther. 17, 601-610.
4. DAVIDOFF, A.M., NG, C.Y., ZHOU, J., SPENCE, Y., and NATHWANI, A.C. (2003). Sex significantly influences transduction of murine liver by recombinant adenoassociated viral vectors through an androgen-dependent pathway. Blood 102, 480-488.
5. DELPORTE, C., O'CONNELL, B.C., HE, X., LANCASTER, H.E., O'CONNELL, A.C., AGRE, P., and BAUM, B.J. (1997). Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands. Proc. Natl. Acad. Sci. U.S.A. 94, 3268-3273.
6. DENNY, P.C., BALL, W.D., and REDMAN, R.S. (1997). Salivary glands: A paradigm for diversity of gland development. Crit. Rev. Oral Biol. Med. 8, 51-75.
7. DING, W., ZHANG, L., YAN, Z., and ENGELHARDT, J.F. (2005). Intracellular trafficking of adeno-associated viral vectors. Gene Ther. 12, 873-880.
8. DODGE, J.C., CLARKE, J., PASSINI, M.A., SONG, A., O'RIORDAN, C.R., CHENG, S.H., and STEWART, G.R. (2005). Sex and estrous cycle stage influence the efficiency of AAV-mediated gene transfer in the rodent brain: American Society of Gene Therapy, 8th Annual Meeting. Mol. Ther. 11, S192-S193.
9. EATON, G.J., CUSTER, R.P., JOHNSON, F.N., and STABENOW, K.T. (1978). Dystrophic cardiac calcinosis in mice: Genetic, hormonal, and dietary influences. Am. J. Pathol. 90, 173-186.
10. GLUCKSMANN, A. (1974). Sexual dimorphism in mammals. Biol. Rev. 49, 423-475.
11. GRESIK, E.W. (1975). The postnatal development of the sexually dimorphic duct system and of amylase activity in the submandibular glands of mice. Cell Tissue Res. 157, 411-422.
12. GRESIK, E.W. (1994). The granular convoluted tubule (GCT) cell of rodent submandibular glands. Microsc. Res. Tech. 27, 1-24.
13. GRESIK, E.W., and BARKA, T. (1980). Precocious development of granular convoluted tubules in the mouse submandibular gland induced by thyroxine or by thyroxine and testosterone. Am. J. Anat. 159, 177-185.
14. GRIMM, D., KERN, A., RITTNER, K., and KLEINSCHMIDT, J.A. (1998). Novel tools for production and purification of recombinant adenoassociated virus vectors. Hum. Gene Ther. 9, 2745-2760.
15. HOSOI, K., UEHA, T., FUKUUCHI, H., KOHNO, M., and TAKAHASHI, T. (1990). Reversal of relative proteinase F activity and onset of androgen-dependent proteinases in the submandibular gland of postnatal mice. Biochem. Int. 22, 179-187.
16. JAYASINGHE, N.R., COPE, G.H., and JACOB, S. (1990). Morphometric studies on the development and sexual dimorphism of the submandibular gland of the mouse. J. Anat. 172, 115-127.
17. KAWEDIA, J.D., NIEMAN, M.L., BOIVIN, G.P., MELVIN, J.E., KIKUCHI, K., HAND, A.R., LORENZ, J.N., and MENON, A.G. (2007). Interaction between transcellular and paracellular water transport pathways through Aquaporin 5 and the tight junction complex. Proc. Natl. Acad. Sci. U.S.A. 104, 3621-3626.
18. KOK, M.R., YAMANO, S., LODDE, B.M., WANG, J., COUWENHOVEN, R.I., YAKAR, S., VOUTETAKIS, A., LEROITH, D., SCHMIDT, M., AFIONE, S., PILLEMER, S.R., TSUTSUI, M.T., TAK, P.P., CHIORINI, J.A., and BAUM, B.J. (2003). Local adenoassociated virus-mediated interleukin 10 gene transfer has disease modifying effects in a murine model of Sjogren's syndrome. Hum. Gene Ther. 14, 1605-1618.
19. LACASSAGNE, A. (1940). Dimorphisme sexuel de la glande sousmaxillaire chez la Souris. C. R. Soc. Biol. (Paris) 133, 180-181.
20. MARONPOT, R.R., GOORMAN, F.A., and GAUL, B.W., eds. (1999). Pathology of the Mouse. Cache River Press (St. Louis, MO).
21. NATHWANI, A.C., DAVIDOFF, A., HANAWA, H., ZHOU, J.F., VANIN, E.F., and NIENHUIS, A.W. (2001). Factors influencing in vivo transduction by recombinant adeno-associated viral vectors expressing the human factor IX cDNA. Blood 97, 1258-1265.
22. PINKSTAFF, C.A. (1979). The cytology of salivary glands. Int. Rev. Cytol. 63, 141-261.
23. PINKSTAFF, C.A. (1998). Salivary gland sexual dimorphism: A brief review. Eur. J. Morphol. 36, 31-34.
24. SANLIOGLU, S., MONICK, M.M., LULECI, G., HUNNINGHAKE, G.W., and ENGELHARDT, J.F. (2001). Rate limiting steps of AAV transduction and implications for human gene therapy. Curr. Gene Ther. 1, 137-147.
25. SATO, S., MARUYAMA, S., and AZUMA, T. (1981). Androgenic action of glucocorticoids on the granular ducts of mouse submandibular glands. J. Endocrinol. 89, 267-274.
26. SAWADA, K., and NOUMURA, T. (1991). Effects of castration and sex steroids on sexually dimorphic development of the mouse submandibular gland. Acta Anat. (Basel) 140, 97-103.
27. SULLIVAN, D.A., and EDWARDS, J.A. (1997). Androgen stimulation of lacrimal gland function in mouse models of Sjogren's syndrome. J. Steroid Biochem. Mol. Biol. 60, 237-245.
28. SUMMERFORD, C., and SAMULSKI, R.J. (1998). Membrane-associated heparin sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions. J. Virol. 72, 1438-1445.
29. TANDLER, B. (1993). Introduction to mammalian salivary glands. Microsc. Res. Tech. 26, 1-4.
30. TREISTER, N.S., RICHARDS, S.M., LOMBARDI, M.J., ROWLEY, P., JENSEN, R.V., and SULLIVAN, D.A. (2005a). Sex-related differences in gene expression in salivary glands of BALB/c mice. J. Dent. Res. 84, 160-165.
31. TREISTER, N.S., RICHARDS, S.M., SUZUKI, T., JENSEN, R.V., and SULLIVAN, D.A. (2005b). Influence of androgens on gene expression in the BALB/c mouse submandibular gland. J. Dent. Res. 84, 1187-1192.
32. TREISTER, N.S., RICHARDS, S.M., ROWLEY, P., JENSEN, R.V., and SULLIVAN, D.A. (2006). Influence of testosterone on gene expression in the ovariectomized mouse submandibular gland. Eur. J. Oral Sci. 114, 328-336.
33. VOUTETAKIS, A., KOK, M.R., ZHENG, C., BOSSIS, I., WANG, J., COTRIM, A.P., MARRACINO, N., GOLDSMITH, C.M., CHIORINI, J.A., LOH, Y.P., NIEMAN, L.K., and BAUM, B.J. (2004). Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics. Proc. Natl. Acad. Sci. U.S.A. 101, 3053-3058.
34. VOUTETAKIS, A., BOSSIS, I., KOK, M.R., ZHANG, W., WANG, J., COTRIM, A.P., ZHENG, C., CHIORINI, J.A., NIEMAN, L.K., and BAUM, B.J. (2005). Salivary glands as a potential gene transfer target for gene therapeutics of some monogenetic endocrine disorders. J. Endocrinol. 185, 363-372.
35. WANG, J., VOUTETAKIS, A., MINESHIBA, F., ILLEI, G.G., DANG, H., YEH, C.K., and BAUM, B.J. (2006). Effect of serotype 5 adenoviral and serotype 2 adeno-associated viral vector-mediated gene transfer to salivary glands on the composition of saliva. Hum. Gene Ther. 17, 455-463.
36. WHITACRE, CC. (2001). Sex differences in autoimmune disease. Nat. Immunol. 2, 777-780.
37. WHITACRE, C.C, REINGOLD, S.C., and O'LOONEY, P.A. (1999). A gender gap in autoimmunity. Science 283, 1277-1278.
38. WIZEMANN, T.M., and PARDUE M.L., eds. (2001). Exploring the Biological Contributions to Human Health: Does Sex Matter? Committee on Understanding the Biology of Sex and Gender Differences. (National Academies Press, Washington, D.C.).
39. ZHENG, C., GOLDSMITH, C.M., MINESHIBA, F., CHIORINI, J.A., KERR, A., WENK, M.L., VALLANT, M., IRWIN, R.D., and BAUM, B.J. (2006). Toxicity and biodistribution of a first-generation recombinant adenoviral vector, encoding aquaporin-1, after retroductal delivery to a single rat submandibular gland. Hum. Gene Ther. 17, 1122-1133.