Differences in tissue distribution of HBCD alpha and gamma between adult and developing mice

Toxicological Sciences

Volumn 123, Issue 1, 2011, Pages 256-263

  Szabo, David T ^a,b   Diliberto, Janet J ^b   Huwe, Janice K ^c   Birnbaum, Linda S ^d  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c U S DEPARTMENT OF AGRICULTURE   (United States)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Development; Distribution; Elimination age susceptibility; HBCD; Mice; Stereoisomers; Toxicokinetics

Indexed keywords

ALPHA HEXABROMOCYCLODODECANE; FAT; GAMMA HEXABROMOCYCLODODECANE; HEXABROMOCYCLODODECANE; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ARTICLE; BLOOD; BRAIN; DIASTEREOISOMER; DOSIMETRY; DRUG EXPOSURE; FEEDING; FEMALE; KIDNEY; LIPOPHILICITY; LIVER; LUNG; MOUSE; MUSCLE; NEWBORN; NONHUMAN; PERINATAL PERIOD; RADIOACTIVITY; RISK FACTOR; SINGLE DRUG DOSE; TISSUE DISTRIBUTION; TOXICOKINETICS;

AGE FACTORS; ANIMALS; BODY BURDEN; FEMALE; FLAME RETARDANTS; HYDROCARBONS, BROMINATED; MALE; MICE; MICE, INBRED C57BL; STEREOISOMERISM; TISSUE DISTRIBUTION;

ANIMALIA; MUS; RODENTIA;

EID: 80052449421     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr161     Document Type: Article

References (56)

1. Aniagu, S. O., Williams, T. D., Allen, Y., Katsiadaki, I., and Chipman, J. K. (2008). Global genomic methylation levels in the liver and gonads of the three-spine stickleback (Gasterosteus aculeatus) after exposure to hexabromocyclododecane and 17-beta oestradiol. Environ. Int. 34, 310-317.
2. Arnot, J. A., Armitage, J. M., McCarty, L. S., Wania, F., Cousins, I. T., and Toose-Reid, L. (2011). Toward a consistent evaluative framework for POP risk characterization. Environ. Sci. Technol. 45, 97-103.
3. Blanco, J. G., Harrison, P. J., Evans, W. E., and Relling, W. F. (2000). Human cytochrome P450 maximal activities in pediatric versus adult liver. Drug Metab. Dispos. 28, 379-382.
4. Bowers, T. S., and Cohen, J. T. (1998). Blood lead slope factor models for adults: comparisons of observations and predictions. Environ. Health Perspect. 106, 1569-1576.
5. Brandsma, S. H., Van der Ven, L. T., De Boer, J., and Leonards, P. E. (2009). Identification of hydroxylated metabolites of hexabromocyclododecane in wildlife and 28-days exposed Wistar rats. Environ. Sci. Technol. 43, 6058-6063.
6. Chengelis, C. (2001). In An oral (Gavage) 90 Day Toxicity Study of HBCD in Rats. Study No. WIL-186012. WIL Research Laboratories, Inc., Ashland, OH.
7. Clewell, H. J., Teeguarden, J., McDonald, T., Sarangapani, R., Lawrence, G., Covington, T., Gentry, R., and Shipp, A. (2002). Review and evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry. Crit. Rev. Toxicol. 32, 329-389.
8. Covaci, A., Gerecke, A. C., Law, R. J., Voorspoels, S., Kohler, M., Heeb, N. V., Leslie, H., Allchin, C. R., and De Boer, J. (2006). Hexabromocyclododecanes (HBCDs) in the environment and humans: a review. Environ. Sci. Technol. 40, 3679-3688.
9. Crump, D., Chiu, S., Egloff, C., and Kennedy, S. W. (2008). Effects of hexabromocyclododecane and polybrominated diphenyl ethers on mRNA expression in chickens (Gallus domesticus) hepatocytes. Toxicol. Sci. 106, 479-487.
10. Crump, D., Egloff, C., Chiu, S., Letcher, R. J., Chu, S., and Kennedy, S. W. (2010). Pipping success, isomer-specific accumulation, and hepatic mRNA expression in chicken embryos exposed to HBCD. Toxicol. Sci. 115, 492-500.
11. Cui, Y. J., Cheng, X., Weaver, Y. M., and Klaassen, D. C. (2009). Tissue distribution, gender-divergent expression, ontogeny, and chemical induction of multidrug resistance transporter genes (Mdr1a, Mdr1b, Mdr2) in mice. Drug Metab. Dispos. 37, 203-210.
12. de Wit, C. A. (2002). An overview of brominated flame retardants in the environment. Chemosphere 46, 583-624.
13. Deng, J., Yu, L., Liu, C., Yu, K., Shi, X., Yeung, L. W., Lam, P. K., Wu, R. S., and Zhou, B. (2009). Hexabromocyclododecane-induced developmental toxicity and apoptosis in zebrafish embryos. Aquat. Toxicol. 93, 29-36.
14. Dobbing, J., and Sands, J. (1979). Comparative. aspects of the brain growth spurt. Early Hum. Dev. 3, 79-83.
15. Ema, M., Fujii, S., Hirata-Koizumi, M., and Matsumoto, K. (2008). Twogeneration reproductive toxicity study of the flame retardant hexabromocyclododecane in rats. Reprod. Toxicol. 25, 335-351.
16. Eriksson, P., Fisher, C., Wallin, M., Jakobsson, E., and Fredriksson, A. (2006). Impaired behavior, learning and memory, in adult mice neonatally exposed to hexabromocyclododecane (HBCDD). Environ. Toxicol. Pharmacol. 21, 317-322.
17. Fery, Y., Mueller, S. O., and Schrenk, D. (2010). Development of stably transfected human and rat hepatoma cell lines for the species-specific assessment of xenobiotic response enhancer module (XREM)-dependent induction of drug metabolism. Toxicology 277, 11-19.
18. Fouts, J. R., and Adamson, R. H. (1959). Drug metabolism in the newborn rabbit. Science 129, 897-898.
19. Germer, S., Piersma, A. H., van der Ven, L., Kamyschnikow, A., Fery, Y., Schmitz, H. J., and Schrenk, D. (2006). Subacute effects of the brominated flame retardants hexabromocyclododecane and tetrabromobisphenol A on hepatic cytochrome P450 levels in rats. Toxicology 218, 229-236.
20. Giacoia, G. P. (1990). The future of neonatal therapeutic drug monitoring. Ther. Drug Monit. 12, 311-315.
21. Gibbs, J. P., Murray, G., Risler, L., Chien, J. Y., Dev, R., and Slattery, J. T. (1997). Age-dependent tetrahydrothiophenium ion formation in young children and adults receiving high dose busulfan. Cancer Res. 57, 5509-5516.
22. Ginsberg, G., Hattis, D., and Sonawane, B. (2004). Incorporating pharmacokinetic differences between children and adults in assessing children's risks to environmental toxicants. Toxicol. Appl. Pharmacol. 98, 164-183.
23. Haddow, J. E., Palomoki, G. E., Allan, W. C., Williams, J. R., Knight, G. J., and Gagnon, J. (1999). Maternal thyroid deficiency during pregnancy and subsequent development of the child. N. Engl. J. Med. 341, 549-555.
24. Haines, J. W., Naylor, G. P. L., Pottinger, H., and Harrison, J. D. (1993). Gastrointestinal absorption and retention of polonium in adult and newborn rats and guinea pigs. Int. J. Radiat. Biol. 64, 127-132.
25. Hale, R. C., La Guardia, M. J., Harvey, E., Gaylor, M. O., and Mainor, T. M. (2006). Brominated flame retardant concentrations and trends in abiotic media. Chemosphere 64, 181-186.
26. Hart, S. N., Cui, Y., Klaassen, C. D., and Zhong, X. B. (2009). Three patterns of cytochrome P450 gene expression during liver maturation in mice. Drug Metab. Dispos. 37, 116-121.
27. Heeb, N. V., Schweizer, W. B., Kohler, M., and Gerecke, A. C. (2005). Structure elucidation of hexabromocyclododecanes-a class of compounds with a complex stereochemistry. Chemosphere 61, 65-73.
28. Hoffman, H. (1982). Absorption of drugs and other xenobiotics during development in experimental animals, Pharmacol. Ther 16, 247-260.
29. Ishida, T., Matsumoto, Y., Takeda, T., Koga, T., Ishii, Y., and Yamada, H. (2010). Distribution of 14C-2,3,7,8-tetrachlorodibenzo-p-dioxin to the brain and peripheral tissues of fetal rats and its comparison with adults. J. Toxicol. Sci. 35, 563-569.
30. Kearns, G. L., and Reed, M. D. (1989). Clinical pharmacokinetics in infants and children. A reappraisal. Clin. Pharmacokinet. 17, 29-67.
31. Kedderis, G. L., and Reed, M. D. (1997). Extrapolation of in vitro enzyme induction data to humans in vivo. Chem.-Biol. Interact. 107, 109-121.
32. Koibuchi, N., and Chin, W. W. (2000). Thyroid hormone action and brain development. Trends Endocrinol. Metab. 11, 123-128.
33. Kostial, K., Kello, D., Jugo, S., Rabar, I., and Maljkovic, T. (1978). Influence of age on metal metabolism and toxicity. Environ. Health Perspect. 25, 81-86.
34. Lau, C., Thibodeaux, J. R., Hanson, R. G., Rogers, J. M., Grey, B. E., Stanton, M. E., Butenhoff, J. L., and Stevenson, L. A. (2003). Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. II: postnatal evaluation. Toxicol. Sci. 74, 382-392.
35. Law, R. J., Herzke, D., Harrad, S., Morris, S., Bersuder, P., and Allchin, C. R. (2008). Levels and trends of HBCD and BDEs in the European and Asian environments, with some information for other BFRs. Chemosphere 73, 223-242.
36. Law, R. J., Kohler, M., Heeb, N. V., Gerecke, A. C., Schmid, P., and Voorspoels, S. (2005). Hexabromocyclododecane challenges scientists and regulators. Environ. Sci. Technol. 39, 281A-287A.
37. MacGregor, J., and Nixon, W. (2004). Final report. Determination of hexabromocyclododecane (HBCD) diastereomers using a generator column method. Wildlife International project number 439G138. Wildlife International, Ltd., Easton, MD.
38. Mariussen, E., and Fonnum, F. (2003). The effect of brominated flame retardants on neurotransmitter uptake into rat synaptosomes and vesicles. Neurochem. Int. 43, 533-542.
39. Morselli, P. L., and Fonnum, F. (1989). Clinical pharmacology of the perinatal period and early infancy. In Clin. Pharmacokinet., 17 (Suppl. 1), pp. 13-28. A26.
40. National Research Council (NRC). (1993). Pesticides in the Diets of Infants and Children. National Academy Press, Washington, DC.
41. Renwick, A. G., Dorne, J. L., and Walton, K. (2000). An analysis of the need for an additional uncertainty factor for infants and children. Regul. Toxicol. Pharmacol. 31, 286-296.
42. Saegusa, Y., Fujimoto, H., Woo, G. H., Inoue, K., Takahashi, M., Mitsumori, K., Hirose, M., Nishikawa, A., and Shibutani, M. (2009). Developmental toxicity of brominated flame retardants, tetrabromobisphenol A and 1,2,5,6,9,10-hexabromocyclododecane, in rat offspring after maternal exposure from midgestation through lactation. Reprod. Toxicol. 28, 456-467.
43. Saunders, N. R., Knott, G. W., and Dziegielewska, K. M. (2000). Barriers in the immature brain. Cell. Mol. Neurobiol. 20, 29-40.
44. Schiengold, M., Schwantes, L., Schwartsmann, G., Chies, J. A., and Nardi, N. B. (2001). Multidrug resistance gene expression during the murine ontogeny. Mech. Ageing Dev. 122, 255-270.
45. Staskal, D. F., Diliberto, J. J., and Birnbaum, L. S. (2006a). Disposition of BDE 47 in developing mice. Toxicol. Sci. 90, 309-316.
46. Staskal, D. F., Hakk, H., Bauer, D., Diliberto, J. J., and Birnbaum, L. S. (2006b). Toxicokinetics of polybrominated diphenyl ether congeners 47, 99, 100, and 153 in mice. Toxicol. Sci. 94, 28-37.
47. Szabo, D. T., Diliberto, J. J., Hakk, H., Huwe, J. K., and Birnbaum, L. S. (2010). Toxicokinetics of the flame retardant hexabromocyclododecane gamma: effect of dose, timing, repeated exposure and metabolism. Toxicol. Sci. 117, 282-293.
48. Szabo, D. T., Diliberto, J. J., Hakk, H., Huwe, J. K., and Birnbaum, L. S. (2011). Toxicokinetics of the flame retardant hexabromocyclododecane alpha: effect of dose, timing, repeated exposure and metabolism. Toxicol. Sci. 121, 234-244.
49. Teichberg, S., Isolauri, E., Wapnir, R. A., Roberts, B., and Lifshitz, F. (1990). Development of the neonatal rat small intestinal barrier to nonspecific macromolecular absorption: effect of early weaning to artificial diets. Pediatr. Res. 28, 31-37.
50. United States Environmental Protection Agency (U.S. EPA). (1994). Guidance Manual for the Integrated Exposure Uptake Biokinetic Model for Lead in Children EPA 540-R-93-081; PB93-963510.
51. van der Ven, L. T., van de Kuil, T., Leonards, P. E., Slob, W., Lilienthal, H., Litens, S., Herlin, M., Håkansson, H., Cantón, R. F., van den Berg, M., et al. (2009). Endocrine effects of hexabromocyclododecane (HBCD) in a onegeneration reproduction study in Wistar rats. Toxicol. Lett. 185, 51-62.
52. van der Ven, L. T., Verhoef, A., van der Kuil, T., Slob, W., Leonard, P. E., and Visser, T. J. (2006). A 28-day oral dose toxicity study enhanced to detect the endocrine effects of hexabromocyclododecane in Wister rats. Toxicol. Sci. 94, 281-292.
53. Walsh, C. T. (1982). The influence of age on the gastrointestinal absorption of mercuric chloride and methyl mercury chloride in the rat. Environ. Res. 27, 412-420.
54. Yen, P. M. (2001). Physiological and molecular basis of thyroid hormone action. Physiol. Rev. 81, 1097-1142.
55. Yu, C. C., and Atallah, Y. H. (1980). In Pharmacokinetics of HBCD in Rats. Velsicol Chemical Co, Rosemont, IL.
56. Zegers, B. N., Mets, A., Van Bommel, R., Minkenberg, C., Hamers, T., Kamstra, J. H., Pierce, G. J., and Boon, J. P. (2005). Levels of hexabromocyclododecane in harbor porpoises and common dolphins from western European seas, with evidence for stereoisomer-specific biotransformation by cytochrome p450. Environ. Sci. Technol. 39, 2095-2100.