What challenges must be overcome before ultrasound elasticity imaging is ready for the clinic?

Imaging in Medicine

Volumn 3, Issue 4, 2011, Pages 433-444

  Palmeri, Mark L ^a,b   Nightingale, Kathryn R ^a  

^a Duke University   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

acoustic radiation force; elasticity; shear wave; stiffness; strain; ultrasound

Indexed keywords

ELASTOGRAPHY; HUMAN; MECHANICAL STRESS; MEDICAL TECHNOLOGY; PRIORITY JOURNAL; REVIEW; SOFT TISSUE;

EID: 80052449365     PISSN: 17555191     EISSN: 17555205     Source Type: Journal    
DOI: 10.2217/iim.11.41     Document Type: Review

References (97)

1. Lai R. Introduction to Continuum Mechanics. Butterworth-Heinmann, Woburn, MA, USA (1999).
2. Duck F. Physical Properties of Tissue, A Comprehensive Reference Book. Academic Press, NY, USA (1990).
3. Sarvazyan A, Skovaroda AR, Emelianov SY et al. Biophysical bases of elasticity imaging. Acoust. Imaging 21, 223-240 (1995).
4. Sarvazyan A. Elastic properties of soft tissue. In: Handbook of Elastic Properties of Solids, Liquids and Gases. 107-127 (2001).
5. Greenleaf JF, Fatemi M, Insana M. Selected methods for imaging elastic properties of biological tissues. Annu. Rev. Biomed. Eng. 5, 57-78 (2003). (Pubitemid 40125308)
6. Parker KJ, Taylor LS, Gracewski S, Rubens DJ. A unified view of imaging the elastic properties of tissue. J. Acoust. Soc. Am. 117(5), 2705-2712 (2005). (Pubitemid 40675135)
7. Heimdal A, Stoylen A, Torp H, Skjaerpe T. Real-time strain rate imaging of the left ventricle by ultrasound. J. Am. Soc. Echocardiogr. 11(11), 1013-1019 (1998). (Pubitemid 28543484)
8. Konofagou EE, D'Hooge J, Ophir J. Myocardial elastography - a feasibility study in vivo. Ultrasound Med. Biol. 28(4), 475-482 (2002). (Pubitemid 34603768)
9. D'hooge J, Bijnens B, Thoen J, Van de Werf F, Sutherland GR, Suetens P. Echocardiographic strain and strain-rate imaging: a new tool to study regional myocardial function. IEEE Trans. Med. Imaging 21(9), 1022-1030 (2002).
10. Sutherland GR, Di Salvo G, Calus P, D'hooge J, Bijnens B. Strain and strain rate imaging: a new clinical approach to quantifying regional myocardial function. J. Am. Soc. Echocardiogr. 17(7), 788-802 (2004). (Pubitemid 38858032)
11. de Korte CL, van der Steen AF. Intravascular ultrasound elastography: an overview. Ultrasonics 40(1-8), 859-865 (2002). (Pubitemid 34545420)
12. de Korte CL, Woutman HA, van der Steen AF, Pasterkamp G, Céspedes EI. Vascular tissue characterisation with IVUS elastography. Ultrasonics 38(1-8), 387-390 (2000). (Pubitemid 30592545)
13. Nyborg L. Acoustic Streaming. In:Physical Acoustics. Mason WP (Ed.).Academic Press Inc, NY, USA, 265-331 (1965).
14. Torr GR. The acoustic radiation force. Am. J. Phys. 52, 402-408 (1984).
15. Nightingale K, Palmeri M. Acoustic Radiation Force Impulse (ARFI) imaging: fundamental concepts and image formation. In:Biomedical Applications of Vibration and Acoustics in Imaging and Characterizations. Fatemi M, Al-Jumaily A (Eds.).ASME Press, NY, USA, 77-91 (2008).
16. Pinton GF, Dahl JJ, Trahey GE. Rapid tracking of small displacements with ultrasound. IEEE Trans. Ultrason. Ferroelec. Freq. Contr. 53(6), 1103-1117 (2006).
17. Loupas T, Peterson R, Gill R. Experimental evaluation of velocity and power estimation for ultrasound blood flow imaging, by means of a two-dimensional autocorrelation approach. IEEE Trans. Ultrason. Ferroelec. Freq. Contr. 42(4), 689-699 (1995).
18. Kasai C, Namekawa K, Koyano A, Omoto R. Real-time two-dimensional blood flow imaging using an autocorrelation technique. IEEE Trans. Ultrason. Ferroelec. Freq. Contr. SU-32(3), 458-463 (1985).
19. Cobbold RS. Foundations of Biomedical Ultrasound. Oxford University Press, Oxford, UK (2007).
20. Barbone PE, Oberai AA. Elastic modulus imaging: some exact solutions of the compressible elastography inverse problem. Phys. Med. Biol. 52(6), 1577-1593 (2007). (Pubitemid 46646368)
21. Konofagou E, Harrigan T, Ophir J. Shear strain estimation and lesion mobility assessment in elastography. Ultrasonics 38, 400-404 (2000). (Pubitemid 30592542)
22. Thitaikumar A, Mobbs LM, Kraemer-Chant CM, Garra BS, Ophir J. Breast tumor classification using axial shear strain elastography: a feasibility study. Phys. Med. Biol. 53(17), 4809-4823 (2008).
23. Thittai A, Galaz B, Ophir J. Axial-shear strain distributions in an elliptical inclusion model: experimental validation and in vivo examples with implications to breast tumor classification. Ultrasound Med. Biol. 36(5), 814-820 (2010).
24. Kemper J, Sinkus R, Lorenzen J, Nolte-Ernsting C, Stork A, Adam G. MR elastography of the prostate: initial in-vivo application. Rofo 176(8), 1094-1099 (2004). (Pubitemid 39118849)
25. Sinkus R, Tanter M, Xydeas T, Catheline S, Bercoff J, Fink M. Viscoelastic shear properties of in vivo breast lesions measured by MR elastography. Magn. Reson. Imaging 23(2), 159-165 (2005).
26. Huwart L, Sempoux C, Salameh N et al. Liver fibrosis: non-invasive assessment with MR elastography. NMR Biomed. 19(2), 173-179 (2006).
27. Sarvazyan A, Rudenko OV, Swanson SD, Fowlkes JB, Emelianov SY. Shear wave elasticity imaging: a new ultrasonic technology of medical diagnostics. Ultrasound Med. Biol. 24(9), 1419-1435 (1998). (Pubitemid 29003664)
28. Palmeri ML, Wang MH, Dahl JJ, Frinkley KD, Nightingale KR. Quantifying hepatic shear modulus in vivo using acoustic radiation force. Ultrasound Med. Biol. 34(4), 546-558 (2008). (Pubitemid 351417692)
29. Chen S, Urban M, Pislaru C et al. Shearwave dispersion ultrasound vibrometry (SDUV) for measuring tissue elasticity and viscosity. IEEE Trans. Ultrason. Ferroelectr. Freq. Control. 56(1), 55-62 (2009).
30. Bercoff J, Tanter M, Fink M. Supersonic shear imaging: a new technique for soft tissue elasticity mapping. IEEE Trans. Ultrason. Ferroelectr. Freq. Control. 51(4), 396-409 (2004).
31. Sandrin L, Tanter M, Gennisson JL, Catheline S, Fink M. Shear elasticity probe for soft tissues with 1-D transient elastography. IEEE Trans. Ultrason. Ferroelectr. Freq. Control. 49(4), 436-446 (2002). (Pubitemid 34555341)
32. Taylor LS, Porter BC, Rubens DJ, Parker KJ. Three-dimensional sonoelastography: principles and practices. Phys. Med. Biol. 45, 1477-1494 (2000). (Pubitemid 30408913)
33. Ophir J, Céspedes I, Ponnekanti H, Yazdi Y, Li X. Elastography: a quantitative method for imaging the elasticity of biological tissues. Ultrasonic Imaging 13(2), 111-134 (1991).
34. Burnside ES, Hall TJ, Sommer AM et al. Differentiating benign from malignant solid breast masses with US strain imaging. Radiology 245(2), 401-410 (2007). (Pubitemid 47612520)
35. Hall TJ, Oberait AA, Barbone PE et al. Elastic nonlinearity imaging. Proc. IEEE Eng. Med. Biol. Soc. 1967-1970 (2009).
36. Rubin JM, Xie H, Kim K et al., Sonographic elasticity imaging of acute and chronic deep venous thrombosis in humans. J. Ultrasound Med. 25(9), 1179-1186 (2006). (Pubitemid 44316265)
37. Kim K, Johnson LA, Jia C. Noninvasive ultrasound elasticity imaging (UEI) of Crohn's disease: animal model. Ultrasound Med. Biol. 34(6), 902-912 (2008). (Pubitemid 351697605)
38. Aigner F, Pallwein L, Junker D et al. Value of real-time elastography targeted biopsy for prostate cancer detection in men with prostate specific antigen 125 ng/ml or greater and 400 ng/ml or less. J. Urol. 184(3), 913-917 (2010).
39. Aigner F, Mitterberger M, Rehder P et al. Status of transrectal ultrasound imaging of the prostate. J. Endourol. 24(5), 685-691 (2010).
40. Zhi H, Ou B, Luo BM, Feng X, Wen YL, Yang HY. Comparison of ultrasound elastography, mammography, and sonography in the diagnosis of solid breast lesions. J. Ultrasound Med. 26(6), 807-815 (2007). (Pubitemid 46870348)
41. Lazebnik RS. Tissue strain analytics and virtual touch tissue imaging and quantification. White Paper. (2008).
42. Fahey B, Nelson RC, Bradway DP, Hsu SJ, Dumont DM, Trahey GE. In vivo visualization of abdominal malignancies with acoustic radiation force elastography. Phys. Med. Biol. 53, 279-293 (2008).
43. Zhai L, Madden J, Foo WC, Palmeri ML, Mouraviev V, Polascik TJ, Nightingale KR. Acoustic radiation force impulse imaging of human prostates ex vivo. Ultrasound Med. Biol. 36(4), 576-588 (2010).
44. Congdon A, Soo MS, Trahey GE, Nightingale KR. Acoustic radiation force impulse (ARFI) imaging of in vivo breast masses. Proc. IEEE Eng. Med. Biol. Soc. 1, 728-731 (2004). (Pubitemid 40927217)
45. Palmeri ML, Frinkley K, Zhai L et al. Acoustic Radiation Force Impulse (ARFI) imaging of the gastrointestinal tract. Ultrasonic Imaging 27, 75-88 (2005). (Pubitemid 41407693)
46. Palmeri ML, Dahl JJ, MacLeod DB, Grant SA, Nightingale KR. Improving regional nerve visualization with acoustic radiation force impulse (ARFI) imaging. Presented at: ASA 2008 Annual Meeting. Orlando, FL, USA, 20 October 2008
47. Eyerly SA, Hsu SJ, Agashe SH, Trahey GE, Li Y, Wolf PD. An in vitro assessment of acoustic radiation force impulse imaging for visualizing cardiac radiofrequency ablation lesions. J. Cardiovasc. Electrophysiol. 21(5), 557-563 (2010).
48. Hsu SJ, Bouchard R, Dumont DM, Wolf PD, Trahey GE. In vivo assessment of myocardial stiffness with acoustic radiation force impulse imaging. Ultrasound Med. Biol. 33(11), 1706-1719 (2007). (Pubitemid 47632998)
49. Trahey GE, Palmeri ML, Bentley RC, Nightingale KR. Acoustic radiation force impulse imaging of the mechanical properties of arteries: in vivo and ex vivo results. Ultrasound Med. Biol. 30(9), 1163-1171 (2004). (Pubitemid 39531622)
50. Dumont D, Dahl J, Miller E, Allen J, Fahey B, Trahey G. Lower-limb vascular imaging with acoustic radiation force elastography: demonstration of in vivo feasibility. IEEE Trans. Ultrason. Ferroelectr. Freq. Control. 56(5), 931-944 (2009).
51. Dahl JJ, Dumont DM, Allen JD, Miller EM, Trahey GE. Acoustic radiation force impulse imaging for noninvasive characterization of carotid artery atherosclerotic plaques: a feasibility study. Ultrasound Med. Biol. 35(5), 707-716 (2009).
52. Cho S, Lee JY, Han JK, Choi BI. Acoustic radiation force impulse elastography for the evaluation of focal solid hepatic lesions: preliminary findings. Ultrasound Med. Biol. 36(2), 202-208 (2010).
53. Fatemi M, Greenleaf J. Vibro-acoustography: an imaging modality based on utrasound-stimulated acoustic emission. Proc. Natl Acad. Sci. USA 96, 6603-6608 (1999). (Pubitemid 29274929)
54. Vappou J, Maleke C, Konofagou EE. Quantitative viscoelastic parameters measured by harmonic motion imaging. Phys. Med. Biol. 54(11), 3579-3594 (2009).
55. Viola F, Kramer MD, Lawrence MB, Oberhauser JP, Walker WF. Sonorheometry: a noncontact method for the dynamic assessment of thrombosis. Ann. Biomed. Eng. 32(5), 696-705 (2004).
56. Barbone PE, Bamber JC. Quantitative elasticity imaging: what can and cannot be inferred from strain images. Phys. Med. Biol. 47(12), 2147-2164 (2002). (Pubitemid 34727499)
57. Nightingale K, Palmeri M, Trahey G. Analysis of contrast in images generated with transient acoustic radiation force. Ultrasound Med. Biol. 32(1), 61-72 (2006). (Pubitemid 41814862)
58. Palmeri ML, Sharma AC, Bouchard RR, Nightingale RW, Nightingale KR. A finite-element method model of soft tissue response to impulsive acoustic radiation force. IEEE Trans. Ultrason. Ferroelectr. Freq. Control. 52(10), 1699-1712 (2005). (Pubitemid 41729798)
59. Wang MH, Palmeri ML, Rotemberg VM, Rouze NC, Nightingale KR. Improving the robustness of time-of-flight based shear wave speed reconstruction methods using RANSAC in human liver in vivo. Ultrasound Med. Biol. 36(5), 802-813 (2010).
60. Rouze NC, Wang MH, Palmeri ML, Nightingale KR. Robust estimation of time-of-flight shear wave speed using a radon sum transformation. IEEE Trans. Ultrason. Ferroelectr. Freq. Control. 57(12), 2662-2670 (2010).
61. Palmeri ML, Wang MH, Rouze NC et al. Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease. J. Hepatol. DOI: 101016/j. jhep.201012019 (2011) (Epub ahead of print).
62. Yoneda M, Fujita K, Inamori M, Tamano M, Hiriishi H, Nakajima A. Transient elastography in patients with non-alcoholic fatty liver disease (NAFLD).Gut 56(9), 1330-1331 (2007). (Pubitemid 47300449)
63. Mariappan YK, Glaser KJ, Ehman RL. Magnetic resonance elastography: a review. Clin. Anat. 23(5), 497-511 (2010).
64. Wong VW, Vergniol J, Wong GL et al. Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease. Hepatology 51(2), 454-462 (2010).
65. Yoneda M, Suzuki K, Kato S et al. Nonalcoholic fatty liver disease: US-based acoustic radiation force impulse elastography. Radiology 256(2), 640-647 (2010).
66. Tanter M, Bercoff J, Athanasiou A et al. Quantitative assessment of breast lesion viscoelasticity: initial clinical results using supersonic shear imaging. Ultrasound Med. Biol. 34(9), 1373-1386 (2008).
67. McAleavey S, Collins E, Kelly J, Elegbe E, Menon M. Validation of SMURF estimation of shear modulus in hydrogels. Ultrasonic Imaging 31(2), 131-150 (2009).
68. McLaughlin J, Renzi D, Parker K, Wu Z. Shear wave speed recovery using moving interference patterns obtained in sonoelastography experiments. J. Acoust. Soc. Am. 121(4), 2438-2446 (2007). (Pubitemid 46548440)
69. McLaughlin J, Renzi D. Shear wave speed recovery in transient elastography and supersonic imaging using propagating fronts. Inverse Problems 22, 681-706 (2006).
70. McLaughlin J, Renzi D. Using level set based inversion of arrival times to recover shear wave speed in transient elastography and supersonic imaging. Inverse Problems 22, 707-725 (2006).
71. Muller M, Gennisson JL, Deffieux T, Tanter M, Fink M. Quantitative viscoelasticity mapping of human liver using supersonic shear imaging: preliminary in vivo feasibility study. Ultrasound Med. Biol. 35(2), 219-229 (2009).
72. Palmeri ML, Rouze NC, Wang MH, Ding X, Nightingale KR. Quantifying the impact of shear wavelength and kernel size on shear wave speed estimation. Proceedings of the IEEE Ultrasonic Symposium. San Diego, CA, USA, 11-14 October 2010
73. Fahey BJ, Nelson RC, Hsu SJ, Bradway DP, Dumont DM, Trahey GE. In vivo guidance and assessment of liver radio-frequency ablation with acoustic radiation force elastography. Ultrasound Med. Biol. 34(10), 1590-1603 (2008).
74. Fahey BJ, Hsu SJ, Wolf PD, Nelson RC, Trahey GE. Liver ablation guidance with acoustic radiation force impulse imaging: challenges and opportunities. Phys. Med. Biol. 51, 3785-3808 (2006). (Pubitemid 44131365)
75. Fahey BJ, Nightingale KR, Stutz DL, Trahey GE. Acoustic radiation force impulse imaging of thermally-and chemically-induced lesions in soft tissues: preliminary ex vivo results. Ultrasound Med. Biol. 30(3), 321-328 (2004). (Pubitemid 38456699)
76. Bharat S, Techavipoo U, Kiss MZ, Liu M, Varghese T. Monitoring stiffness changes in lesions after radiofrequency ablation at different temperatures and durations of ablation. Ultrasound Med. Biol. 31(3), 415-422 (2005). (Pubitemid 40327230)
77. Jiang J, Varghese T, Brace CL et al. Young's modulus reconstruction for radio-frequency ablation electrode-induced displacement fields: a feasibility study. IEEE Trans. Med. Imaging 28(8), 1325-1334 (2009).
78. Zhang M, Castaneda B, Christensen J et al. Real-time sonoelastography of hepatic thermal lesions in a swine model. Med. Phys. 35(9), 4132-4141 (2008).
79. Krouskop T, Wheeler TM, Kallel F, Garra BS, Hall T. Elastic moduli of breast and prostate tissues under compression. Ultrasonic Imaging 20, 260-274 (1998). (Pubitemid 29168827)
80. Skovoroda A, Klishko AN, Gusakian DA et al. Quantitative analysis of the mechanical characteristics of pathologically changed soft biological tissues. Biophysics 40(6), 1359-1364 (1995). (Pubitemid 126082898)
81. Sandrin L, Fourquet B, Hasquenoph JM et al.. Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. Ultrasound Med. Biol. 29(12), 1705-1713 (2003). (Pubitemid 38091720)
82. Di Ieva A, Grizzi F, Rognone E et al. Magnetic resonance elastography: a general overview of its current and future applications in brain imaging. Neurosurg. Rev. 33(2), 137-145 (2010).
83. Siegmann KC, Xydeas T, Sinkus R, Kraemer B, Vogel U, Claussen CD. Diagnostic value of MR elastography in addition to contrast-enhanced MR imaging of the breast-initial clinical results. Eur. Radiol. 20(2), 318-325 (2010).
84. Chopra R, Arani A, Huang YX et al. In vivo MR elastography of the prostate gland using a transurethral actuator. Magn. Reson. Med. 62(3), 665-671 (2009).
85. Tanter M, Bercoff J, Athanasiou A et al. Quantitative assessment of breast lesion viscoelasticity: initial clinical results using supersonic shear imaging. Ultrasound Med. Biol. 34(9), 1373-1386 (2008).
86. Righetti R, Righetti M, Ophir J, Krouskop TA. The feasibility of estimating and imaging the mechanical behavior of poroelastic materials using axial strain elastography. Phys. Med. Biol. 52(11), 3241-3259 (2007). (Pubitemid 46795258)
87. Righetti R, Garra BS, Mobbs LM, Kraemer-Chant CM, Ophir J, Krouskop TA. The feasibility of using poroelastographic techniques for distinguishing between normal and lymphedematous tissues in vivo. Phys. Med. Biol. 52(21), 6525-6541 (2007). (Pubitemid 350093179)
88. Leiderman R, Barbone PE, Oberai AA, Bamber JC. Coupling between elastic strain and interstitial fluid flow: ramifications for poroelastic imaging. Phys. Med. Biol. 51(24), 6291-6313 (2006). (Pubitemid 46217623)
89. Berry GP, Bamber JC, Mortimer PS, Bush NL, Miller NR, Barbone PE. The spatio-temporal strain response of oedematous and nonoedematous tissue to sustained compression in vivo. Ultrasound Med. Biol. 34(4), 617-629 (2008). (Pubitemid 351417690)
90. Zipparo M, Bing K, Nightingale K, Ultrasound imaging arrays with improved transmit power capability. IEEE Trans. Ultrason. Ferroelectr. Freq. Control. 57(9), 2076-2090 (2010).
91. Zheng Y, Chen S, Tan W, Kinnick R, Greenleaf JF. Detection of tissue harmonic motion induced by ultrasonic radiation force using pulse-echo ultrasound and Kalman filter. IEEE Trans. Ultrason. Ferroelectr. Freq. Control. 54(2), 290-300 (2007).
92. Urban MW, Chen S, Greenleaf JF. Error in estimates of tissue material properties from shear wave dispersion ultrasound vibrometry. IEEE Trans. Ultrason. Ferroelectr. Freq. Control. 56(4), 748-758 (2009).
93. Jiang J, Hall TJ. A generalized speckle tracking algorithm for ultrasonic strain imaging using dynamic programming. Ultrasound Med. Biol. 35(11), 1863-1879 (2009).
94. Bigelow TA, Church CC, Sandstrum K et al. The thermal index: its strengths, weaknesses, and proposed improvements. J. Ultrasound Med. 30, 714-734 (2011).
95. American Institue of Ultrasound in Medicine. Consensus report on potential bioeffects of diagnostic ultrasound. J. Ultrasound Med.27, 503-515 (2008).
96. Church CC, Carstensen EL, Nyborg WL, Carson PL, Frizzel LA, Bailey MR. The risk of exposure to diagnostic ultrasound in postnatal subjects: nonthermal mechanisms. J. Ultrasound Med. 27, 565-592 (2008). (Pubitemid 351489679)
97. O'Brien WD, Deng CX, Harris GR et al. The risk of exposure to diagnostic ultrasound in postnatal subjects: thermal effects. J. Ultrasound Med. 27(4), 517-535 (2008). (Pubitemid 351489677)