Effects of the histamine H 1 receptor antagonist hydroxyzine on h ERG K + channels and cardiac action potential duration

Acta Pharmacologica Sinica

Volumn 32, Issue 9, 2011, Pages 1128-1137

  Lee, Byung Hoon ^a,b   Lee, Seung Ho ^c   Chu, Daehyun ^d   Hyun, Jin Won ^e   Choe, Han ^d   Choi, Bok Hee ^c   Jo, Su Hyun ^a  

^a Kangwon National University   (South Korea)

^b Inje University   (South Korea)

^c Chonbuk National University Medical School   (South Korea)

^d University of Ulsan College of Medicine   (South Korea)

^e Jeju National University School of Medicine   (South Korea)

Author keywords

cardiomyocytes; h ERG channels; histamine antagonists; hydroxyzine; K + channel; proarrhythmic effects

Indexed keywords

HISTAMINE H1 RECEPTOR ANTAGONIST; HYDROXYZINE; POTASSIUM CHANNEL HERG; TYROSINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ELECTRIC CURRENT; FEMALE; GENE MUTATION; GUINEA PIG; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART PROARRHYTHMIA; HEART REPOLARIZATION; IC 50; MICROELECTRODE; MOLECULAR DOCKING; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PROTEIN DOMAIN; SIMULATION; STEADY STATE; TIME; VIRTUAL REALITY; VOLTAGE CLAMP; XENOPUS;

ACTION POTENTIALS; ANIMALS; CELL LINE; CELLS, CULTURED; ETHER-A-GO-GO POTASSIUM CHANNELS; GENE EXPRESSION; GUINEA PIGS; HISTAMINE H1 ANTAGONISTS; HUMANS; HYDROXYZINE; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; XENOPUS LAEVIS;

EID: 80052445992     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2011.66     Document Type: Article

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