Proline substitutions and threonine pseudophosphorylation of the SH3 ligand of 18.5-kDa myelin basic protein decrease its affinity for the Fyn-SH3 domain and alter process development and protein localization in oligodendrocytes

Journal of Neuroscience Research

Volumn 90, Issue 1, 2012, Pages 28-47

  Smith, Graham S T ^a   De Avila, Miguel ^a   Paez, Pablo M ^b   Spreuer, Vilma ^b   Wills, Melanie K B ^a   Jones, Nina ^a   Boggs, Joan M ^c   Harauz, George ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Calcium imaging; Fyn; Isothermal titration calorimetry; Myelin basic protein (MBP); Myelination; Oligodendrocytes; SH3 domain

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM ION; LIGAND; MYELIN BASIC PROTEIN; PROLINE; PROTEIN KINASE FYN; SH3 LIGAND; THREONINE; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL MEMBRANE; CELL NUCLEUS; CELL STRAIN HEK293; CELL STRUCTURE; CONTROLLED STUDY; CYTOPLASM; HUMAN; HUMAN CELL; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PSEUDOPHOSPHORYLATION; WILD TYPE;

AMINO ACID SEQUENCE; ANALYSIS OF VARIANCE; ANIMALS; CALCIUM; CALCIUM CHANNELS; CALCIUM SIGNALING; CALORIMETRY; CELL LINE, TRANSFORMED; CELL SIZE; GREEN FLUORESCENT PROTEINS; MICE; MYELIN BASIC PROTEINS; OLIGODENDROGLIA; PROLINE; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-FYN; SRC HOMOLOGY DOMAINS; THREONINE; TRANSFECTION;

EID: 80052434381     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22733     Document Type: Article

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